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Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans.

Carlos Chávez-Pérez, Niusha Jafari, Brendan T Keenan, David M Raizen, Alex M Rohacek,

The interneurons ALA and RIS both regulate stress induced sleep in <i>C. elegans</i> but their roles in awake animal movement has been reported to differ. We describe the development of a motivated mobility-based assay that distinguishes between animals mutant for ALA function and those mutant for RIS function. ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review.

Xiaojiang Qin, Xinrong Xu, Xiaomin Hou, Ruifeng Liang, Liangjing Chen, Yuxuan Hao, Anqi Gao, Xufeng Du, Liangyuan Zhao, Yiwei Shi, Qingshan Li,

<h4>Context</h4>Farrerol, a typical natural flavanone isolated from the traditional Chinese herb 'Man-shan-hong' [<i>Rhododendron dauricum</i> L. (Ericaceae)] with phlegm-reducing and cough-relieving properties, is widely used in China for treating bronchitis and asthma.<h4>Objective</h4>To present the anti-inflammatory, antioxidant, vasoactive, antitumor, and antimicrobial effects of farrerol and its underlying molecular mechanisms.<h4>Methods</h4>The literature was reviewed ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):9-16]

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Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.

Yanling Jin, Wei Liu, Fengxia Wang, Min Wang, Kai Xu, Aijun Yang, Chenyu Wang, Lihan Zhang, Fangfang Zhang, Min Li,

Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human umbilical vein endothelial cells (HUVECs). MDA-MB-231 cells expressed the ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2021, 15(1):74-83]

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Effects of two different types of single exercise modes on salivary C-reactive protein concentration, oxidative stress and antioxidant capacity in post-myocardial infarction patients.

Anna Gawron-Skarbek, Jacek Chrzczanowicz, Dariusz Nowak, Rafał Gawor, Tomasz Kostka,

<h4>Objectives</h4>The aim of the study was to determine the effects of two different types of single cardiac rehabilitation (CR) exercise modes on the inflammation status, oxidative stress and total antioxidant capacity (TAC) of saliva.<h4>Methods</h4>The study involved two groups of CR patients: group A (<i>n</i> = 21) used a cycloergometer, and group B ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):29-34]

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Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke.

Yao-Hua Ma, Wen-Jing Deng, Zhi-Yi Luo, Jing Jing, Peng-Wei Pan, Yao-Bing Yao, Yan-Bo Fang, Jun-Fang Teng,

MicroRNAs (miRNAs) regulate protein expression by antagonizing the translation of mRNAs and are effective regulators of normal nervous system development, function, and disease. MicroRNA-29b (miR-29b) plays a broad and critical role in brain homeostasis. In this study, we tested the function of miR-29b in animal and cell models by inhibiting ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):433-439]

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The inhibition of circular RNA circNOLC1 by propofol/STAT3 attenuates breast cancer stem cells function via miR-365a-3p/STAT3 signaling.

Yi-Ping Liu, Jin-Yu Heng, Xin-Yu Zhao, En-You Li,

<h4>Background</h4>Breast cancer remains one of the most dreadful female malignancies globally, in which cancer stem cells (CSCs) play crucial functions. Circular RNAs have drawn great attention in cancer research area and propofol is a widely applied intravenous anesthetic agent.<h4>Methods</h4>In the current study, we explored the function of circular RNA nucleolar ... Read more >>

J Transl Med (Journal of translational medicine)
[2021, 19(1):467]

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Single-cell DNA and RNA sequencing of circulating tumor cells.

Masato Kojima, Takanori Harada, Takahiro Fukazawa, Sho Kurihara, Isamu Saeki, Shinya Takahashi, Eiso Hiyama,

Single-cell sequencing of circulating tumor cells can precisely represent tumor heterogeneity and provide useful information for cancer treatment and research. After spiking TGW neuroblastoma cells into blood derived from healthy volunteer, the cells were isolated by fluorescence-activated cell sorting. DNA and mRNA were amplified by four different whole-genome amplifications (WGA) ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):22864]

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Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study.

Shabnam Sharmin, Md Mizanur Rahaman, Miquel Martorell, Jorge Sastre-Serra, Javad Sharifi-Rad, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu, Mohammad Torequl Islam,

Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):612]

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Toe pressure and toe brachial index are predictive of cardiovascular mortality regardless of the most diseased arterial segment in symptomatic lower-extremity artery disease-A retrospective cohort study.

V Koivunen, M Juonala, M Venermo, M Laivuori, J M Jalkanen, H H Hakovirta,

<h4>Objective</h4>Although lower extremity arterial disease (LEAD) is most often multisegmental, the predominant disease location and risk factors differ between patients. Ankle-brachial index (ABI), toe-brachial index (TBI), and toe pressure (TP) are predictive of outcome in LEAD patients. Previously, we reported a classification method defining the most diseased arterial segment (MDAS); ... Read more >>

PLoS One (PloS one)
[2021, 16(11):e0259122]

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Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells.

Pritpal Kaur, Shreya Nagar, Madhura Bhagwat, Mohammad Uddin, Yan Zhu, Ivana Vancurova, Ales Vancura,

Heme is an essential cofactor for enzymes of the electron transport chain (ETC) and ATP synthesis in mitochondrial oxidative phosphorylation (OXPHOS). Heme also binds to and destabilizes Bach1, a transcription regulator that controls expression of several groups of genes important for glycolysis, ETC, and metastasis of cancer cells. Heme synthesis ... Read more >>

PLoS One (PloS one)
[2021, 16(11):e0260400]

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Comparison of the antioxidant activities of nonfumigated and sulphur-fumigated Chrysanthemum morifolium cv. Hang-ju induced by oxidative stress.

Hongyan Ma, Shanshan Liu, Wenshan Qu, Qi Huang, Linyuan Li, Fujiang Chu, Yuyun Zhu, Xinlin Lv, Zhimin Wang, Jingjing Zhu,

<h4>Context</h4>The traditional drying method, sun drying, for <i>Chrysanthemum morifolium</i> Ramat. cv. Hang-ju (Compositae) (HJ) is widely replaced by sulphur fumigation (SF), which has an unknown effect on its efficacy.<h4>Objective</h4>To investigate protective effects of nonfumigated HJ (NHJ) and sulphur-fumigated HJ (SHJ) water extracts against oxidative stress and lipid peroxidation.<h4>Materials and methods</h4>Sprague-Dawley ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):40-46]

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Psoriatic patients treated with secukinumab reach high levels of minimal disease activity: results from the SUPREME study.

Anna Campanati, Federico Diotallevi, Giulia Radi, Elisa Molinelli, Valerio Brisigotti, Emanuela Martina, Matteo Paolinelli, Tommaso Bianchelli, Cristiano Covi, Marta Bartezaghi, Annamaria Offidani,

<h4>Background</h4>Achieving minimal disease activity (MDA) represents an ambitious and sustainable therapeutic goal in psoriasis. Clear criteria for defining MDA in psoriasis are lacking.<h4>Objectives</h4>The primary outcome was to evaluate the effect of 300 mg secukinumab in achieving MDA in patients with psoriasis and identify the most useful criteria to define MDA in ... Read more >>

Eur J Dermatol (European journal of dermatology : EJD)
[2021, :]

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Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway.

Yue Shi, Chong Liu,

<h4>Background</h4>Breast cancer (BC) is one of the major malignancies worldwide. Circular ribonucleic acids (circRNAs) are a class of conserved ribonucleic acid (RNA) molecules that play important roles in various diseases. Recently, circRNAs have been suggested to have diagnostic value and may function as potential diagnostic biomarkers for BC. Previously, hsa_circ_0043278 ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1249]

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Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1.

Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou,

LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, <i>ENST00000508435</i>, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of <i>ENST00000508435</i> was positively correlated with tumor ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2021, 15(1):140-151]

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PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis.

Zhongwei Li, Diandian Wang, Xintian Chen, Wenwen Wang, Pengfei Wang, Pingfu Hou, Minle Li, Sufang Chu, Shuxi Qiao, Junnian Zheng, Jin Bai,

Protein arginine methyltransferase 1 (PRMT1) is able to promote breast cancer cell proliferation. However, the detailed mechanisms of PRMT1-mediated breast cancer cell proliferation are largely unknown. In this study, we reveal that PRMT1-mediated methylation of EZH2 at the R342 site (meR342-EZH2) has a great effect on PRMT1-induced cell proliferation. We ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(11):1080]

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Community control strategies for scabies: A cluster randomised noninferiority trial.

Myra Hardy, Josaia Samuela, Mike Kama, Meciusela Tuicakau, Lucia Romani, Margot J Whitfeld, Christopher L King, Gary J Weil, Tibor Schuster, Anneke C Grobler, Daniel Engelman, Leanne J Robinson, John M Kaldor, Andrew C Steer,

<h4>Background</h4>Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale.<h4>Methods and ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(11):e1003849]

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What is the impact of acquired immunity on the transmission of schistosomiasis and the efficacy of current and planned mass drug administration programmes?

Klodeta Kura, Robert J Hardwick, James E Truscott, Roy M Anderson,

Schistosomiasis causes severe morbidity in many countries with endemic infection with the schistosome digenean parasites in Africa and Asia. To control and eliminate the disease resulting from infection, regular mass drug administration (MDA) is used, with a focus on school-aged children (SAC; 5-14 years of age). In some high transmission ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2021, 15(12):e0009946]

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Contribution of miRNAs in the Pathogenesis of Breast Cancer.

Soudeh Ghafouri-Fard, Ali Khanbabapour Sasi, Atefe Abak, Hamed Shoorei, Ali Khoshkar, Mohammad Taheri,

Breast cancer is the most frequently diagnosed cancer among females. Gene expression profiling methods have shown the deregulation of several genes in breast cancer samples and have confirmed the heterogeneous nature of breast cancer at the genomic level. microRNAs (miRNAs) are among the recently appreciated contributors in breast carcinogenic processes. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:768949]

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Predicting miRNA-Disease Associations Through Deep Autoencoder With Multiple Kernel Learning.

Feng Zhou, Meng-Meng Yin, Cui-Na Jiao, Jing-Xiu Zhao, Chun-Hou Zheng, Jin-Xing Liu,

Determining microRNA (miRNA)-disease associations (MDAs) is an integral part in the prevention, diagnosis, and treatment of complex diseases. However, wet experiments to discern MDAs are inefficient and expensive. Hence, the development of reliable and efficient data integrative models for predicting MDAs is of significant meaning. In the present work, a ... Read more >>

IEEE Trans Neural Netw Learn Syst (IEEE transactions on neural networks and learning systems)
[2021, PP:]

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Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.

Francesca Lessi, Paolo Aretini, Milena Rizzo, Mariangela Morelli, Michele Menicagli, Sara Franceschi, Chiara Maria Mazzanti,

MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2021, 15(1):180-201]

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GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience.

Chih-Wei Tseng, Kao-Lun Wang, Pin-Kuei Fu, Cheng-Yi Huang, Tsu-Yi Hsieh, Chia-Wei Hsieh, Kuo-Lung Lai, Wei-Ting Hung, Ching-Tsai Lin, Kuo-Tung Tang, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen,

<h4>Background</h4>Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is associated with respiratory failure and death in patients with idiopathic inflammatory myositis (IIM) and interstitial lung disease (ILD). This study aimed to investigate clinical parameters associated with mortality in anti-MDA-5 antibody-positive patients.<h4>Methods</h4>We retrospectively reviewed the clinical and laboratory data, and pulmonary function test ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(22):]

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Factors influencing mass drug administration adherence and community drug distributor opportunity costs in Liberia: a mixed-methods approach.

Efundem Agboraw, Fred Sosu, Laura Dean, Alice Siakeh, Rachael Thomson, Karsor Kollie, Eve Worrall,

<h4>Background</h4>Preventive chemotherapy delivered via mass drug administration (MDA) is essential for the control of neglected tropical diseases (NTDs), including lymphatic filariasis (LF), schistosomiasis and onchocerciasis. Successful MDA relies heavily on community drug distributor (CDD) volunteers as the interface between households and the health system. This study sought to document and ... Read more >>

Parasit Vectors (Parasites & vectors)
[2021, 14(1):557]

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Monocytes secrete CXCL7 to promote breast cancer progression.

Yi-Hsiang Wang, Chia-Yi Shen, Sheng-Chieh Lin, Wen-Hung Kuo, Yuan-Ting Kuo, Yu-Ling Hsu, Wen-Ching Wang, Kai-Ti Lin, Lu-Hai Wang,

Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(12):1090]

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Social and Behaviour Change Communication Intervention Improves Coverage and Acceptance of Ivermectin Mass Drug Administration in Onchocerciasis Endemic Communities in Ghana: A Quasi Experimental Design

Francis Adjei Osei, Sam Newton, Isaac Nyanor, Eugene Osei-Yeboah, Evans Xorse Amuzu, Nicholas Karikari Mensah, Obed Ofori Nyarko, Ernest Amanor, Samuel Frimpong Odoom, Suraj Yawnumah Abubakar, Mathias Dongyele, Aliyu Mohammed, Ofeibea Asare, Stephanie Boadi, Peter Furu, Dan Wolf Meyrowitsch, Ellis Owusu-Dabo,

<h4>Background: </h4> Poor community awareness and social mobilization serve as a major barrier by increasing absenteeism and downplaying the relevance of the ivermectin mass distribution by community members. Inadequate awareness also creates confusion among community members especially when one intervention is mistaken for the other. MethodsWe designed a targeted Social ... Read more >>

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"Sharp downward, blunt upward": district maternal death audits' challenges to formulate evidence-based recommendations in Indonesia - a qualitative study.

Ratnasari D Cahyanti, Widyawati Widyawati, Mohammad Hakimi,

<h4>Background</h4>Indonesia, the largest archipelago globally with a decentralized health system, faces a stagnant high maternal mortality ratio (MMR). The disparity factors among regions and inequities in access have deterred the local assessments in preventing similar maternal deaths. This study explored the challenges of district maternal death audit (MDA) committees to ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):730]

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