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Full Text Journal Articles about
Lymphomatoid Granulomatosis

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Pathobiology and Treatment of Lymphomatoid Granulomatosis; A Rare EBV-Driven Disorder.

Christopher Melani, Elaine S Jaffe, Wyndham H Wilson,

Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus (EBV)-driven B-cell lymphoproliferative disease (LPD). This disease is hypothesized to result from defective immune surveillance of EBV with most patients showing evidence of immune dysfunction despite no known primary immunodeficiency. Pathologically, LYG is graded by the number and density of EBV+ atypical ... Read more >>

Blood (Blood)
[2020, :]

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IgG4-related disease in the differential diagnosis of lung nodules.

Hiroki Ishikawa, Hironori Uruga, Takeshi Fujii, Atsuko Kurosaki, Nasa Morokawa, Hisashi Takaya,

IgG4-related disease is an evolving entity of immune-mediated origin. We report a case of IgG4-related disease mimicking lung cancer with pleural dissemination. A 76-year-old male non-smoker was admitted to our hospital because of chest X-ray abnormality. Chest computed tomography scan showed a lung nodule measuring 26 × 14 mm with tiny nodules on ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(4):e00550]

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[A Case of Primary Central Nervous System Lymphomatoid Granulomatosis that was Completely Ameliorated by Corticosteroid Treatment].

Takayuki Nakao, Shuichi Izumoto, Naohiro Tsuyuguchi, Amami Kato, Hideaki Yokoo, Eisuke Enoki,

Lymphomatoid granulomatosis (LYG) is an angiocentric, angiodestructive lymphoreticular proliferative disease that usually affects the lungs but it has been speculated to also effect the central nervous system (CNS). However, unique primary LYG of the CNS has rarely been reported in the literature. Herein, we describe a clinical case of a ... Read more >>

Brain Nerve (Brain and nerve = Shinkei kenkyu no shinpo)
[2020, 72(2):159-165]

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Pulmonary Lymphomatoid Granulomatosis With Hemophagocytic Lymphohistiocytosis as the Initial Manifestation.

Li Xu, Xuan Zhang, Ying-Juan Lu, Yan-Hua Zheng, Guang-Xun Gao,

Lymphomatoid granulomatosis (LYG) is an extremely rare angio-centric and angio-destructive B-cell lymphoproliferative disease. Driven by Epstein-Barr virus (EBV), LYG predominantly involves the bilateral lungs. Commonly presenting as multiple nodules in the lung, pulmonary LYG can masquerade as various infectious diseases, vasculitis, lung cancer, or other metastatic neoplasm. It is difficult ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:34]

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A rapidly enlarging painful neck mass in a 59-year-old woman.

Priti V Nath, Mohamed Shakir, Thanh D Hoang, April E Bergeron, Babette C Glistercarlson,

Primary care physicians and endocrinologists should be aware that neck masses with concerning features like, in this case, a delay in evaluation and treatment may dramatically shorten a patient's life. ... Read more >>

Clin Case Rep (Clinical Case Reports)
[2020, 8(3):570-571]

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Necrotizing Sarcoid Granulomatosis: A Disease Not to be Forgotten.

A I Parejo-Morón, M L Tornero-Divieso, M R Férnandez-Díaz, L Muñoz-Medina, O Preda, N Ortego-Centeno,

Sarcoidosis is a systemic granulomatous disease of unknown aetiology characterised by the appearance of noncaseifying epithelioid granulomas in the affected organs, most commonly the lungs, skin, and eyes (Iannuzzi et al. 2007). Necrotizing Sarcoid Granulomatosis (NGS) is a rare and little-known form of disease, which also presents nodular lung lesions, ... Read more >>

Case Rep Med (Case Reports in Medicine)
[2020, 2020:5730704]

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A 4-Year-Old Boy With Prolonged Cough and Fever.

Andrew S Handel, James Davis, Joshua Glass, Laura Hogan, Susan Schuval, Christy Beneri,

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, 9(1):92-95]

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Isolated lymphomatoid granulomatosis of the central nervous system: A case report and literature review.

Chao He, Yunxia Wang, Leyi Zhang, Chenglong Lu, Wei Ge, Qingkui Zhang, Qiuping Gui, Ruozhuo Liu, Shengyuan Yu,

Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoproliferative disease which can involve multiple organs of the body and is most common in the lungs. Its pathological features are proliferation of large atypical B-cells related to Epstein-Barr virus, T-cell infiltration and tissue necrosis. This disease is rare, and LYG which ... Read more >>

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2019, 39(6):479-488]

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Diffuse large B-cell lymphoma variants: an update.

Narittee Sukswai, Kirill Lyapichev, Joseph D Khoury, L Jeffrey Medeiros,

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma, representing approximately one-third of all cases worldwide. In the World Health Organization (WHO) classification of lymphomas, most cases of DLBCL are designated as not otherwise specified (NOS). About 20% of cases, however, are designated as specific variants of ... Read more >>

Pathology (Pathology)
[2020, 52(1):53-67]

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Brain miliary enhancement.

Joseph C J Bot, Linda Mazzai, Rogier E Hagenbeek, Silvia Ingala, Bob van Oosten, Esther Sanchez-Aliaga, Frederik Barkhof,

PURPOSE:Miliary enhancement refers to the presence of multiple small, monomorphic, enhancing foci on T1-weighted post-contrast MRI images. In the absence of a clear clinical presentation, a broad differential diagnosis may result in invasive procedures and possibly brain biopsy for diagnostic purposes. METHODS:An extensive review of the literature is provided for ... Read more >>

Neuroradiology (Neuroradiology)
[2020, 62(3):283-300]

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Multiple Neurologic Deficits and Cognitive Decline in a Young Woman.

Arunmozhimaran Elavarasi, Jacob George, Mehar Chand Sharma, Kalpana Kumari, Ajay Garg, Awadh Kishor Pandit, Abhishek Satapathy, Vinay Goyal,

We present the clinicopathologic conference of a 34-year-old lady with history of facial palsy 14 years ago who developed new deficits of mononeuritis multiplex, maculopapular rash, pancytopenia, splenomegaly, lung involvement and cognitive decline rapidly over three years. Investigations revealed pancytopenia, reversal of albumin globulin ratio, mediastinal adenopathy, ANA positivity, low ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2019, 22(4):506-512]

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An atypical case of a pulmonary mass in an immunocompromised patient.

Nina Cardinaels, Winand Van Rompaey, Saskia Bos, Hannelore Bode, Thomas Tousseyn, Pascal Van Bleyenbergh,

Objectives Pulmonary lymphomatoid granulomatosis (PLG) is a rare angiocentric and angiodestructive EBV-associated lymphoproliferative disorder which almost always affects the lungs. PLG is more commonly diagnosed in patients with immunodeficiency and is associated with Epstein-Barr virus (EBV). 'Drug induced PLG' or 'iatrogenic immunodeficiency-associated lymphoproliferative disorder' is a special form of PLG ... Read more >>

Acta Clin Belg (Acta clinica Belgica)
[2019, :1-5]

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Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase.

Matthew K Howe, Kennichi Dowdell, Amitava Roy, Julie E Niemela, Wyndham Wilson, Joshua J McElwee, Jason D Hughes, Jeffrey I Cohen,

Interleukin-2-inducible T cell kinase (ITK) is critical for T cell signaling and cytotoxicity, and control of Epstein-Barr virus (EBV). We identified a patient with a novel homozygous missense mutation (D540N) in a highly conserved residue in the kinase domain of ITK who presented with EBV-positive lymphomatoid granulomatosis. She was treated ... Read more >>

Front Immunol (Frontiers in Immunology)
[2019, 10:2000]

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Simultaneous Presentation of Lymphomatoid Granulomatosis and Multiple myeloma in an Immunodeficient Patient with Rheumatoid Arthritis.

Shin Lee, Eiju Negoro, Hisashi Oki, Yoshiaki Imamura, Takahiro Yamauchi,

A 75-year-old Japanese woman with a 20-year history of rheumatoid arthritis presented with symptomatic bilateral pleural effusion and lung and brain tumors. She had received methotrexate for five years and tacrolimus for one year. A brain biopsy specimen showed the pathological features of lymphoproliferative disease, but a bone marrow biopsy ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2019, 58(19):2845-2849]

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A Case of Methotrexate-Associated Lymphoproliferative Disorder (Lymphomatoid Granulomatosis) of the Skin.

Haruto Nishida, Yuzo Oyama, Takahiro Kusaba, Hiroko Kadowaki, Motoki Arakane, Shigeo Yokoyama, Yutaka Hatano, Tsutomu Daa,

Iatrogenic lymphoproliferative disorder (LPD) can develop in patients treated with immunosuppressive drugs for autoimmune or other inflammatory diseases. Here, we report a case of lymphomatoid granulomatosis of the skin that occurred as a methotrexate (MTX)-associated LPD. We also review the relevant literature. A 73-year-old woman presented to our department with ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2019, 41(6):448-452]

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EBV-Associated Lymphoproliferative Disorders: Update in Classification.

Sherif A Rezk, Lawrence M Weiss,

Although about 90% of the world's population is infected by EBV only a small subset of the related infections result in neoplastic transformation. EBV is a versatile oncogenic agent involved in a multitude of hematopoietic, epithelial, and mesenchymal neoplasms, but the precise role of EBV in the pathogenesis of many ... Read more >>

Surg Pathol Clin (Surgical pathology clinics)
[2019, 12(3):745-770]

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A rare lymphoproliferative disorder associated with immunomodulating therapy in Crohn's disease.

Eduardo López Fernández, María Curieses Luengo, Pilar Varela Trastoy,

Lymphomatoid granulomatosis is a rare lymphoproliferative disorder associated with immunosuppressive therapy in inflammatory bowel disease. We present the case of a patient with Crohn's disease and treated azathioprine that develops lymphomatoid granulomatosis, as well as its diagnostic process and the chosen treatment. Lymphomatoid granulomatosis is a serious disease barely described ... Read more >>

Rev Esp Enferm Dig (Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva)
[2019, 111(6):491]

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Chest imaging using signs, symbols, and naturalistic images: a practical guide for radiologists and non-radiologists.

Alessandra Chiarenza, Luca Esposto Ultimo, Daniele Falsaperla, Mario Travali, Pietro Valerio Foti, Sebastiano Emanuele Torrisi, Matteo Schisano, Letizia Antonella Mauro, Gianluca Sambataro, Antonio Basile, Carlo Vancheri, Stefano Palmucci,

Several imaging findings of thoracic diseases have been referred-on chest radiographs or CT scans-to signs, symbols, or naturalistic images. Most of these imaging findings include the air bronchogram sign, the air crescent sign, the arcade-like sign, the atoll sign, the cheerios sign, the crazy paving appearance, the comet-tail sign, the ... Read more >>

Insights Imaging (Insights into imaging)
[2019, 10(1):114]

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An update on IgG4-related lung disease.

Angelica Torres Morales, Andrea Guerrero Cignarella, Isma Safayeth Jabeen, Jamie S Barkin, Mehdi Mirsaeidi,

IgG4-related disease (IgG4-RD) is an autoimmune disorder characterized by substantial infiltration of plasma cells with IgG4 in target organs. Lung manifestations predominantly present as inflammatory pseudotumor, interstitial pneumonitis, organizing pneumonia, and lymphomatoid granulomatosis. There is no specific diagnostic test for IgG4-related lung disease (IgG4-RLD), and excluding diseases that mimic IgG4-RLD ... Read more >>

Eur. J. Intern. Med. (European journal of internal medicine)
[2019, 66:18-24]

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Case-based discussion: a case of misdiagnosis of primary lung malignancy.

Ran Wang, Thomas Lightburn, John Howells, Ihssan Tahan, Mohamad Bittar, Lipsita Patnaik, Reuben Tooze, Syed B Mehdi,

Thorax (Thorax)
[2019, 74(10):1003-1005]

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Refractory Central Neurogenic Hyperventilation: A Novel Approach Utilizing Mechanical Dead Space.

Alexander J Sweidan, Matthew M Bower, Jeffrey Paullus, Michelle Sterpi, Sara Stern-Nezer, Cyrus Dastur, Wengui Yu, Leonid I Groysman,

This report describes the successful management of a case of central neurogenic hyperventilation (CNH) refractory to high dose sedation by increasing the mechanical dead space. A 46-year-old male presented with a history of multiple neurological symptoms. Following an extensive evaluation, he was diagnosed with primary diffuse CNS lymphoma and started ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:937]

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Destructive Upper Airway Disease from Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Very First Case.

Biplab Saha, Aditi Saha, Fernanda Cordeiro-Rudnisky, Boris Shkolnik, Scott Beegle,

Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystem vasculitic disorder that predominantly affects medium- and small-sized blood vessels. EGPA belongs to a group of vasculitides known as anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV). Upper airway involvement is seen in all ANCA-associated vasculitides, but destructive upper airway disease has never ... Read more >>

Case Rep Rheumatol (Case reports in rheumatology)
[2019, 2019:6173869]

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Primary lymphomatoid granulomatosis in the central nervous system: A report of three cases.

Guido Ahle, Emmanuelle Uro-Coste, Guillaume Taieb, Thomas de Broucker,

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2019, 39(2):168-169]

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The Role and Pitfall of F18-FDG PET/CT in Surveillance of High Grade Pulmonary Lymphomatoid Granulomatosis.

Ming Yang, Allison C Rosenthal, Jonathan B Ashman, Fiona E Craig,

Lymphomatoid granulomatosis (LYG) is an uncommon angiocentric and angiodestructive T-cell rich, Epstein-Barr virus (EBV) positive B-cell multisystem lymphoproliferative disorder, predominately affecting the lungs. Since both clinical presentation and radiographic imaging findings, including X-ray and computed tomographic (CT), are nonspecific, the ultimate diagnosis of LYG relies on lung tissue sample diagnosis ... Read more >>

Curr Probl Diagn Radiol (Current problems in diagnostic radiology)
[2019, :]

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Recommendations for Therapeutic Apheresis by the Section "Preparative and Therapeutic Hemapheresis" of the German Society for Transfusion Medicine and Immunohematology.

Nina Worel, Behrouz Mansouri Taleghani, Erwin Strasser,

The section "Preparative and Therapeutic Hemapheresis" of the German Society for Transfusion Medicine and Immunohematology (DGTI) has reviewed the actual literature and updated techniques and indications for evidence-based use of therapeutic apheresis in human disease. The recommendations are mostly in line with the "Guidelines on the Use of Therapeutic Apheresis ... Read more >>

Transfus Med Hemother (Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie)
[2019, 46(6):394-406]

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