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Lung Abscess

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Identification of cytochrome P450 isoenzymes involved in the metabolism of 23-hydroxybetulinic acid in human liver microsomes.

Ying Zhou, Jinhua Wen, Guangji Wang,

Context: 23-Hydroxybetulinic acid (23-HBA), a major active constituent of Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), exhibits potential antitumor activity. Its metabolism, however, has not yet been studied.Objective: This study focuses on the metabolism of 23-HBA in vitro by human liver microsomes.Materials and methods: The metabolic kinetics of 23-HBA (0.5-100 µM) and the effects ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):60-63]

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The value of chest magnetic resonance imaging compared to chest radiographs with and without additional lung ultrasound in children with complicated pneumonia.

Philip Konietzke, Jan Mueller, Felix Wuennemann, Willi L Wagner, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Mirjam Stahl, Marcus A Mall, Mark O Wielpütz, Olaf Sommerburg,

INTRODUCTION:In children with pneumonia, chest x-ray (CXR) is typically the first imaging modality used for diagnostic work-up. Repeated CXR or computed tomography (CT) are often necessary if complications such as abscesses or empyema arise, thus increasing radiation exposure. The aim of this retrospective study was to evaluate the potential of ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230252]

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RFA of primary and metastatic lung tumors: long-term results.

Stefano Giusto Picchi, Giulia Lassandro, Andrea Bianco, Andrea Coppola, Anna Maria Ierardi, Umberto G Rossi, Francesco Lassandro,

The aim of our study is a retrospective evaluation of effectiveness and safety of Computed Tomography (CT)-guided radiofrequency ablation (RFA) therapy of primary and metastatic lung lesions in patients that cannot be considered surgical candidates. From February 2007 to September 2017, we performed 264 CT-guided ablation sessions on 264 lesions ... Read more >>

Med. Oncol. (Medical oncology (Northwood, London, England))
[2020, 37(5):35]

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Evaluation of endobronchial volatile sulfur compounds for rapid diagnosis of lung abscesses caused by obligate anaerobes using Oral Chroma™: A pilot study.

Takahiro Takazono, Yoshifumi Imamura, Masayasu Kitamura, Reiko Furugen, Tatsuro Hirayama, Masato Tashiro, Tomomi Saijo, Kazuko Yamamoto, Taiga Miyazaki, Toshiyuki Saito, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae,

Endobronchial volatile sulfur compounds in patients with lung abscess or lung cancer were measured using the Oral Chroma™ gas chromatograph. High levels of hydrogen sulfide and methyl mercaptan were observed in some patients with lung abscess but not in patients with lung cancer. Measuring endobronchial volatile sulfur compounds could be ... Read more >>

Respir Investig (Respiratory investigation)
[2020, :]

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Percutaneous lung abscess drainage: revisiting the old gold standard.

Alessandro Matarese, Mario Tamburrini, Unnati Desai, Umberto Zuccon,

Lung abscess is defined as the necrosis of lung tissue with cavity formation due to varied etiology. The treatment of lung abscesses is medical involving antibiotics and chest physiotherapy. The failure of medical line of management requires an invasive surgical or percutaneous approach for drainage and control of infection. While ... Read more >>

Monaldi Arch Chest Dis (Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace)
[2020, 90(1):]

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COMPLICATED PNEUMONIA WITH EMPYEMA CAUSED BY STREPTOCOCCUS ANGINOSUS IN A CHILD.

Ana Reis-Melo, Diana Soares, Manuel Ferreira Magalhães, Catarina Ferraz, Luísa Vaz,

OBJECTIVE:To highlight the pathogenicity of Streptococcus anginosus, which is rare in pediatric patients, but can cause severe infections that are known to have a better outcome when treated early with interventional procedures and prolonged antibiotic therapy. CASE:description: The patient is a 6-year-old boy with global developmental delay, examined in the ... Read more >>

Rev Paul Pediatr (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo)
[2020, 38:e2018258]

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Clinical and Pathologic Features of Spontaneous Klebsiella pneumoniae Infection in 9 Rhesus Macaques (Macaca mulatta).

Rebekah I Keesler, Angela Colagross-Schouten, J Rachel Reader,

Klebsiella pneumoniae is a gram-negative bacterium found in the environment and as a commensal in humans and animals. In humans, K. pneumoniae is one of the most serious nosocomial infections encountered currently and is characterized by liver abscesses, pneumonia, and bacteremia resulting in meningoencephalitis and endophthalmitis. K. pneumoniae in veterinary ... Read more >>

Comp. Med. (Comparative medicine)
[2020, 70(2):183-189]

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A rare case of Blastomyces dermatitidis brain abscess in an immunocompetent host.

Magdalena Slomka, James Doub,

Here we present a case of a 41-year old immunocompetent female from central Maryland, who presented with new onset seizures. Magnetic resonance imaging of brain revealed a solitary ring-enhancing lesion. Stereotactic brain biopsy confirmed Blastomyces dermatitidis brain abscess. Patient's clinical course was complicated by voriconazole-induced pancytopenia that prompted surgical resection ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2020, 28:8-11]

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Enterococcus faecalis-associated lung abscess in a male adolescent- a case report.

Ana Raquel Mendes, António Costa, Helena Ferreira, Cristina Ferreira,

BACKGROUND:Enterococci are rarely considered pulmonary pathogens; they are usually regarded as colonizers of the airway. The authors present the case of a previously healthy male adolescent, with complaints of fatigue and chest pain, who was diagnosed with Enterococcus faecalis-associated acute primary lung abscess. CASE PRESENTATION:A previously healthy 17-year old boy ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):98]

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Mucor pulmonary embolism in a patient with myelodysplastic syndrome.

T Kakuwa, A Ariga, J Takasaki, M Kato, T Igari, Y Shida, T Okafuji, S Nakamura, Y Miyazaki, H Katano, M Iikura, S Izumi, H Sugiyama,

Mucormycosis is a life-threatening infectious disease that occurs most commonly in immunocompromised patients such as those with hematological malignancies. Its clinical symptoms and associated radiological findings vary and specific biomarkers and culture characteristics have not been defined. An 85-year-old man who had been treated for myelodysplastic syndrome and tuberculosis for ... Read more >>

Respir Med Case Rep (Respiratory medicine case reports)
[2020, 30:101035]

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Three New Cases of Melioidosis, Guadeloupe, French West Indies.

Bénédicte Melot, Sylvaine Bastian, Nathalie Dournon, Eric Valade, Olivier Gorgé, Anne Le Fleche, Charlotte Idier, Mireille Vernier, Elisabeth Fernandes, Bruno Hoen, Sébastien Breurec, Michel Carles,

Melioidosis has been detected in the Caribbean, and an increasing number of cases has been reported in the past few decades, but only 2 cases were reported in Guadeloupe during the past 20 years. We describe 3 more cases that occurred during 2016-2017 and examine arguments for increasing endemicity. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(3):617-619]

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Acrophialophora levis brain abscess in a kidney transplant patient: A case report and review of the literature.

Chelsea E. Modlin, Lauren F. Collins, Eileen M. Burd, Shawn R. Lockhart, G. Marshall Lyon,

We report the first case of Acrophialophora levis causing cerebral phaeohyphomycosis in a solid organ transplantation recipient. A. levis is a rare cause of invasive dematiaceous fungal infection among immunocompromised persons. We describe the clinical course of a kidney transplant patient who presented with acute hemiplegia due to a brain ... Read more >>

Med Mycol Case Rep (Medical Mycology Case Reports)
[2020, 28:12-15]

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Use of 18F-FDG PET/CT to differentiate ectopic adrenocorticotropic hormone-secreting lung tumours from tumour-like pulmonary infections in patients with ectopic Cushing syndrome

Fang Li, Xin Cheng, Guozhu Hou, Yuanyuan Jiang,

<title>Abstract</title> <p> Purpose: Ectopic adrenocorticotropic hormone (ACTH)-secreting lung tumours represent the most common cause of ectopic Cushing syndrome (ECS). Pulmonary opportunistic infections are associated with ECS and occasionally difficult to differentiate from tumours by using computed tomography (CT) alone. The aim of the present study was to evaluate ... Read more >>

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Serious bacterial infections and antibiotic prescribing in primary care: cohort study using electronic health records in the UK.

Martin C Gulliford, Xiaohui Sun, Judith Charlton, Joanne R Winter, Catey Bunce, Olga Boiko, Robin Fox, Paul Little, Michael Moore, Alastair D Hay, Mark Ashworth, ,

OBJECTIVE:This study evaluated whether serious bacterial infections are more frequent at family practices with lower antibiotic prescribing rates. DESIGN:Cohort study. SETTING:706 UK family practices in the Clinical Practice Research Datalink from 2002 to 2017. PARTICIPANTS:10.1 million registered patients with 69.3 million patient-years' follow-up. EXPOSURES:All antibiotic prescriptions, subgroups of acute and repeat antibiotic ... Read more >>

BMJ Open (BMJ open)
[2020, 10(2):e036975]

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Brain Abscess Associated with Polymicrobial Infection after Intraoral Laceration: A Pediatric Case Report.

Fumihiro Ochi, Hisamichi Tauchi, Toyohisa Miyata, Tomozo Moritani, Toshiyuki Chisaka, Junpei Hamada, Kozo Nagai, Minenori Eguchi-Ishimae, Mariko Eguchi,

Brain abscesses, infections within the brain parenchyma, can arise as complications of various conditions including infections, trauma, and surgery. However, brain abscesses due to polymicrobial organisms have rarely been reported in children. We herein report a case of a 9-year-old girl with unresolved congenital cyanotic heart disease (CCHD) presenting with ... Read more >>

(Case Reports in Pediatrics)
[2020, 2020:]

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Failure to extubate and delayed reintubation in elective lumbar fusion: An analysis of 57,677 cases.

Yaroslav Gelfand, Michael Longo, Rafael De la Garza Ramos, Zachary T Sharfman, Murray Echt, Mousa Hamad, Merritt Kinon, Reza Yassari, David C Kramer,

OBJECTIVES:There is a scarcity of literature exploring the consequences of Failure To Extubate (FTE) and Delayed Reintubation (DRI) in spine surgery. While it is reasonable to believe that patients who FTE or undergo DRI after Posterior Lumbar Fusion (PLF) and Transforaminal Lumbar Interbody Fusion (TLIF) are at risk for graver ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 193:105771]

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Incidental discovery of an interstitial emphysematous cystitis with liver abscess: A report of hematogenous spread of infection.

Emad Rajih, Ayman Sayed A, Sarah Mahrous, Abdullah Alharthi, Abdulrahman Alswaid, Abdulaziz Bakhsh,

Emphysematous cystitis is an unusual urological emergency in clinical practice. The disease characteristics are still underreported. It is characterized by the presence of gas in the urinary bladder wall secondary to gas forming organism. We report an incidental finding of emphysematous cystitis in a 35-year-old secondary to a huge liver ... Read more >>

Urol Case Rep (Urology case reports)
[2020, 31:101134]

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Raoultella ornithinolytica and Klebsiella oxytoca pyogenic liver abscess presenting as chronic cough.

Asif Surani, Eliza M Slama, Samantha Thomas, Robert W Ross, Steven C Cunningham,

Raoultella ornithinolytica is a Gram-negative rod belonging to the Enterobacteriaceae family and closely related to Klebsiella spp. It is commonly present in aquatic environments. Human infections caused by R. ornithinolytica are being increasingly recognized. It has been documented to cause various hospital-acquired infections including but not limited to gastrointestinal, skin, ... Read more >>

IDCases (IDCases)
[2020, 20:e00736]

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Staphylococcal lung abscess in a child with cystic fibrosis: Case report & review of literature.

P Edwards, M Brener, A Isles, N Kapur,

With contemporary cystic fibrosis (CF) care, a lung abscess is an uncommon occurrence. We describe a case of a staphylococcal lung abscess in a teenage girl with CF who presented with a two-week history of non-specific malaise followed by two days of left posterior chest pain and fever. A chest ... Read more >>

Respir Med Case Rep (Respiratory medicine case reports)
[2020, 29:101024]

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Increased respiratory morbidity in individuals with interstitial lung abnormalities.

Nils Hoyer, Laura H Thomsen, Mathilde M W Wille, Torgny Wilcke, Asger Dirksen, Jesper H Pedersen, Zaigham Saghir, Haseem Ashraf, Saher B Shaker,

BACKGROUND:Interstitial lung abnormalities (ILA) are common in participants of lung cancer screening trials and broad population-based cohorts. They are associated with increased mortality, but less is known about disease specific morbidity and healthcare utilisation in individuals with ILA. METHODS:We included all participants from the screening arm of the Danish Lung ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):67]

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Isolated central nervous system Aspergillosis infection in a chronic lymphocytic leukemia patient on Ibrutinib: A case report.

Thuy-Hong Le, Vikas Kumar, Khubaib Gondal, Martin Barnes, Haseeb Siddique, Barjinder Buttar, Alan Kaell,

BACKGROUND:In patients at high risk of opportunistic infections who present with isolated. neurological symptoms, it is lifesaving to consider Central Nervous System Aspergillosis (CNS-A). Ibrutinib use in chronic lymphocytic leukemia (CLL) has previously been associated with CNS-A. We provide a case report of a patient that presented with primary CNS-A ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):175]

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Postoperative bronchopleural fistula: Does one size fit all?

Valliappan Muthu, Kuruswamy Thurai Prasad, Ritesh Agarwal,

Lung India (Lung India : official organ of Indian Chest Society)
[2020, 37(2):97-99]

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Risk factors of infectious complications after endobronchial ultrasound-guided transbronchial biopsy.

Tomohide Souma, Tomoyuki Minezawa, Hiroshi Yatsuya, Takuya Okamura, Kumiko Yamatsuta, Sayako Morikawa, Tomoya Horiguchi, Shingo Maeda, Yasuhiro Goto, Masamichi Hayashi, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi,

BACKGROUND:Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. METHODS:We retrospectively reviewed the medical records of 1,045 consecutive patients who had ... Read more >>

Chest (Chest)
[2020, :]

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Descending necrotizing mediastinitis caused by Streptococcus constellatus in an immunocompetent patient: case report and review of the literature.

Rui-Hai Ye, Jun-Chao Yang, Hui-Hua Hong, Yu-Ping Mao, Yuan-Hong Zhu, Yu Cao, Zhen Wang,

Descending necrotizing mediastinitis is a severe infection of the mediastinum. This syndrome manifests as fever and chest pain following cough and sputum production. A 49-year-old woman presented with fever and a 14-day history of pneumonia. CT showed mediastinal abscesses with a giant calcified mediastinal lymph node (21 × 18 mm) and pneumonia. Bronchoscopy ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):43]

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Chitinophaga vietnamensis sp. nov., a multi-drug resistant bacterium infecting humans.

Thi Le Quyen Tran, Hussein Anani, Ho Tinh Trinh, Thi Phuong Thao Pham, Van Khoa Dang, Viet My Ho, Nguyen Hai Linh Bui, Nhu Hung Nguyen, Didier Raoult, Thanh Trung Trinh, Pierre Edouard Fournier,

We describe a new multidrug resistant Chitinophaga species that was isolated from patients with type 2 diabetes in Vietnam. Strain BD 01T was cultivated in 2017 from a blood sample of a patient suffering from bacteremia. Strain VP 7442 was isolated in 2018 from a pleural fluid sample of a ... Read more >>

Int. J. Syst. Evol. Microbiol. (International journal of systematic and evolutionary microbiology)
[2020, 70(3):1758-1768]

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