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Low Grade Astrocytoma

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Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Jianhong Sun, Wanpo Zhang, Zhongyuan Tan, Caishang Zheng, Yan Tang, Xianliang Ke, Yuan Zhang, Yan Liu, Penghui Li, Qinxue Hu, Hanzhong Wang, Panyong Mao, Zhenhua Zheng,

Zika virus (ZIKV) infection in the human central nervous system (CNS) causes Guillain-Barre syndrome, cerebellum deformity, and other diseases. Astrocytes are immune response cells in the CNS and an important component of the blood-brain barrier. Consequently, any damage to astrocytes facilitates the spread of ZIKV in the CNS. Connective tissue ... Read more >>

Virulence (Virulence)
[2020, 11(1):113-131]

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The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction.

Peter J G Cussell, Margarita Gomez Escalada, Nathaniel G N Milton, Andrew W J Paterson,

N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family. FPRs are expressed within neuronal tissues and markedly in the central nervous system, where FPR interactions with endogenous ligands have been implicated ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1191-1198]

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Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth.

N Leventoux, M Augustus, S Azar, S Riquier, J P Villemin, S Guelfi, L Falha, L Bauchet, C Gozé, W Ritchie, T Commes, H Duffau, V Rigau, J P Hugnot,

IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are ill-defined. Previous studies revealed that 20% of these tumours already have transformation foci. These foci offer opportunities to better understand malignant progression. We used immunohistochemistry and high throughput RNA profiling to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5504]

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Low expression of FOSL1 is associated with favorable prognosis and sensitivity to radiation/pharmaceutical therapy in lower grade glioma.

Jin Zhu, Ya-Peng Zhao, Yu-Qi Zhang,

Objectives: FOSL1 is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG).Methods: Cox coefficients were examined to compare FOSL1 expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate ... Read more >>

Neurol. Res. (Neurological research)
[2020, :1-6]

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Pediatric low-grade glioma in the era of molecular diagnostics.

Scott Ryall, Uri Tabori, Cynthia Hawkins,

Low grade gliomas are the most frequent brain tumors in children and encompass a spectrum of histologic entities which are currently assigned World Health Organisation grades I and II. They differ substantially from their adult counterparts in both their underlying genetic alterations and in the infrequency with which they transform ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):30]

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Expression patterns and the prognostic value of the EMILIN/Multimerin family members in low-grade glioma.

Yonghui Zhao, Xiang Zhang, Junchao Yao, Zhibin Jin, Chen Liu,

Managing low-grade gliomas (LGG) remains a major medical challenge due to the infiltrating nature of the tumor and failure of surgical resection to eliminate the disease. EMILIN/Multimerins contain the gC1q signature, which is involved in many tumor processes. However, the expression and prognostic value of EMILIN/Multimerins in LGG remains unclear. ... Read more >>

PeerJ (PeerJ)
[2020, 8:e8696]

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Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis.

Catherine Hanna, Theresa A Lawrie, Ewelina Rogozińska, Ashleigh Kernohan, Sarah Jefferies, Helen Bulbeck, Usama M Ali, Tomos Robinson, Robin Grant,

BACKGROUND:A glioblastoma is a fatal type of brain tumour for which the standard of care is maximum surgical resection followed by chemoradiotherapy, when possible. Age is an important consideration in this disease, as older age is associated with shorter survival and a higher risk of treatment-related toxicity. OBJECTIVES:To determine the ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 3:CD013261]

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Integrated Transcriptome Analyses and Experimental Verifications of Mesenchymal-Associated TNFRSF1A as a Diagnostic and Prognostic Biomarker in Gliomas.

Biao Yang, Yuan-Bo Pan, Yan-Bin Ma, Sheng-Hua Chu,

Gliomas are the most prevalent malignant primary brain tumors with poor outcome, and four different molecular subtypes (Mesenchymal, Proneural, Neural, and Classical) are popularly applied in scientific researches and clinics of gliomas. Public databases contain an abundant genome-wide resource to explore the potential biomarker and molecular mechanisms using the informatics ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:]

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Postoperative Tetraplegia to a Child after Cerebellar Pilocytic Astrocytoma Excision at Prone Position: Case Report and Literature Review.

Dimitrios Panagopoulos, Elias Antoniades, Ploutarchos Karydakis, Dimitrios Giakoumettis, Marios Themistocleous,

BACKGROUND Various factors have been implicated in the pathogenesis of infarction after posterior fossa surgery such as venous air embolism, patient's position (seated or prone), hyperflexion of the neck, excessive spinal cord traction, cervical canal stenosis, and systemic arterial hypotension. The main aim of this case report was to elucidate ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e920213]

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QuaDMutNetEx: a method for detecting cancer driver genes with low mutation frequency.

Yahya Bokhari, Areej Alhareeri, Tomasz Arodz,

BackgroundCancer is caused by genetic mutations, but not all somatic mutations in human DNA drive the emergence or growth of cancers. While many frequently-mutated cancer driver genes have already been identified and are being utilized for diagnostic, prognostic, or therapeutic purposes, identifying driver genes that harbor mutations occurring with low ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2020, 21:]

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LCK expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme.

Le Ge, Lixia Xu, Shan Lu, Hua Yan,

Glioblastoma multiforme (GBM) and primary central nervous system lymphoma (PCNSL) are both malignant cerebral tumors; however, their treatments are vastly different. Early and precise diagnosis is vital for subsequent adequate treatment to improve prognosis. Reliable biomarkers that can easily distinguish GBM and PCNSL are urgently needed. We evaluated the diagnostic ... Read more >>

FEBS Open Bio (FEBS open bio)
[2020, :]

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Prospective study to assess the survival outcomes of planned irradiation of ipsilateral subventricular and periventricular zones in glioblastoma.

Deepthi Valiyaveettil, Monica Malik, Kothwal Syed Akram, Syed Fayaz Ahmed, Deepa M Joseph,

Purpose/objective(s)Retrospective evidence suggests that the irradiation of stem cells in the periventricular zone (PVZ), specifically the subventricular zone (SVZ), to higher doses may be associated with improved outcomes.Materials/methodsThis was a prospective study, done from 2012 to 2017 in glioblastoma patients to assess the efficacy of planned irradiation of ipsilateral PVZ ... Read more >>

Ecancermedicalscience (ecancermedicalscience)
[2020, 14:]

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The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation.

Rui-Chao Chai, Yao-Wu Zhang, Yu-Qing Liu, Yu-Zhou Chang, Bo Pang, Tao Jiang, Wen-Qing Jia, Yong-Zhi Wang,

Due to the rare incidence of spinal cord astrocytomas, their molecular features remain unclear. Here, we characterized the landscapes of mutations in H3 K27M, isocitrate dehydrogenase 1 (IDH1) R132H, BRAF V600E, and the TERT promoter in 83 diffuse spinal cord astrocytic tumors. Among these samples, thirty-five patients had the H3 ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):40]

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Exothermic transitions in the heat capacity profiles of human cerebrospinal fluid.

Borislava Antonova, Emanuil Naydenov, Rumiana Koynova, Kalina Tumangelova-Yuzeir, Boris Tenchov,

In this work, we examined by DSC protein denaturation heat capacity profiles for two body fluids, cerebrospinal fluid (CSF) and blood plasma obtained from brain tumor (mainly glioblastoma) patients and healthy volunteers. We observed large distinctions between the heat capacity profiles of CSF and blood plasma, although their protein compositions ... Read more >>

Eur. Biophys. J. (European Biophysics Journal)
[2020, :]

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FGFR- gene family alterations in low-grade neuroepithelial tumors.

Tejus A Bale,

The discovery of fibroblast growth factor receptor (FGFR) gene family alterations as drivers of primary brain tumors has generated significant excitement, both as potential therapeutic targets as well as defining hallmarks of histologic entities. However, FGFR alterations among neuroepithelial lesions are not restricted to high or low grade, nor to ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):21]

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Low-grade developmental and epilepsy associated brain tumors: a critical update 2020.

Rutger Juriaan Slegers, Ingmar Blumcke,

Brain tumors represent the second most frequent etiology in patients with focal seizure onset before 18 years of age and submitted to epilepsy surgery. Hence, this category of brain tumors, herein defined as low-grade, developmental, epilepsy-associated brain tumors (LEAT) is different from those frequently encountered in adults as (A): 77% of ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):27]

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Improved Prediction of Surgical Resectability in Patients with Glioblastoma using an Artificial Neural Network.

Adam P Marcus, Hani J Marcus, Sophie J Camp, Dipankar Nandi, Neil Kitchen, Lewis Thorne,

In managing a patient with glioblastoma (GBM), a surgeon must carefully consider whether sufficient tumour can be removed so that the patient can enjoy the benefits of decompression and cytoreduction, without impacting on the patient's neurological status. In a previous study we identified the five most important anatomical features on ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5143]

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Disparities in glioblastoma survival by case volume: a nationwide observational study.

Rahul Raj, Karri Seppä, Tapio Luostarinen, Nea Malila, Matti Seppälä, Janne Pitkäniemi, Miikka Korja,

INTRODUCTION:High hospital case volumes are associated with improved treatment outcomes for numerous diseases. We assessed the association between academic non-profit hospital case volume and survival of adult glioblastoma patients. METHODS:From the nationwide Finnish Cancer Registry, we identified all adult (≥ 18 years) patients with histopathological diagnoses of glioblastoma from 2000 to 2013. ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2020, 147(2):361-370]

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Incidental Findings in TMJ Imaging.

Kaan Orhan, Seçil Aksoy, Ismail Hakan Avsever, Kaan Gündüz,

For years, the conventional imaging modalities are generally used in dental practice routine. They provide precious information about dentomaxillofacial region; they also have some limitations such as superimpositions, magnifications, distortions, and low-image quality. Because of these limitations, some pathologies, calcifications, and anatomical variations may be missed. Any findings on a ... Read more >>

(Imaging of the Temporomandibular Joint)
[0, :205-246]

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Prognostic prediction model for glioblastoma: a metabolic gene signature and independent external validation

Yu Wang, Chuxiang Lei, Wenlin Chen, Yuekun Wang, Binghao Zhao, Penghao Liu, Ziren Kong, Delin Liu, Congxin Dai, Yaning Wang, Wenbin Ma,

<title>Abstract</title> <p> Background. Glioblastoma (GBM) is the most common primary malignant intracranial tumor and is closely related to metabolic alterations. However, few accepted prognostic models are currently available, especially models based on metabolic genes. Methods . Transcriptome data were obtained for all patients diagnosed with GBM from the ... Read more >>

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Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives.

Bas Weenink, Pim J French, Peter A E Sillevis Smitt, Reno Debets, Marjolein Geurts,

Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care treatment with radiation in combination with temozolomide, the overall prognosis of newly diagnosed patients remains poor, with a 2-year survival rate of less than 20%. The remarkable survival benefit gained with immunotherapy in several extracranial tumor types spurred a variety of ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(3):]

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Dual-targeting and excretable ultrasmall SPIONs for T1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein.

Chengjuan Du, Xianping Liu, Hui Hu, Huiming Li, Luodan Yu, Daoying Geng, Yu Chen, Jun Zhang,

A precise delineation of the intracranial glioblastoma boundary is urgently required for pre-surgical operations, due to the tumor-inherent infiltrative character of a tumor and the difficulty to completely remove the tumor. Magnetic resonance (MR) imaging is the leading clinical diagnostic tool for brain tumors, where a safe MR contrast agent ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(11):2296-2306]

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Bioinformatics Analysis of the Expression of ATP Binding Cassette Subfamily C Member 3 (ABCC3) in Human Glioma.

Zelin Sun, Xiaoyuan Qi, Yan Zhang,

Objective:To investigate the expression of the ABCC3 gene in human glioma and its correlation with the patient's prognosis. Methods:The cancer genome atlas (TCGA) database was used to analyze the differential expression of the ABCC3 gene in human glioma. The STRING database was used to construct the protein-protein interaction (PPI) network ... Read more >>

Open Med (Wars) (Open medicine (Warsaw, Poland))
[2020, 15:107-113]

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Bacterial delivery of the anti-tumor azurin-like protein Laz to glioblastoma cells.

Manar Mansour, Shehab Ismail, Khaled Abou-Aisha,

Salmonella typhimurium VNP-20009 (VNP) is a non-pathogenic attenuated strain, which, as a facultative anaerobe, preferentially accumulates in hypoxic regions of solid tumors. Here, VNP was utilized as a delivery vehicle of the anti-tumor protein Lipidated azurin, Laz, which is produced by the meningitis-causing bacterium Neisseria meningitides. In brain cancer cells, ... Read more >>

AMB Express (AMB Express)
[2020, 10(1):59]

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Risk stratification in pediatric low-grade glioma and glioneuronal tumor treated with radiation therapy: An integrated clinicopathologic and molecular analysis.

Sahaja Acharya, Jo-Fen Liu, Ruth G Tatevossian, Jason Chiang, Ibrahim Qaddoumi, Amar Gajjar, David Walker, Julie Harreld, Thomas E Merchant, David W Ellison,

BACKGROUND:Management of unresectable pediatric low-grade glioma and glioneuronal tumor (LGG/LGGNT) is controversial. There are no validated prognostic features to guide use of radiation therapy (RT). Our study aimed to identify negative prognostic features in patients treated with RT using clinicopathologic and molecular data and validate these findings in an external ... Read more >>

Neuro-oncology (Neuro-oncology)
[2020, :]

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