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Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.

Mackenzie L Morshead, Christine A Sedore, E Grace Jones, David Hall, W Todd Plummer, Theo Garrett, Mark Lucanic, Max Guo, Monica Driscoll, Patrick C Phillips, Gordon Lithgow,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 1 time

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C. elegans VWA-8 is a mitochondrial protein.

Ming Zhu, Andrew D Chisholm, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 0 times

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Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue.

Briana Brown Rackley, Evan Kiely, Chang-Soo Seong, Manali Rupji, Melissa Gilbert-Ross,

(microPublication biology)
[2020, 2020:]

Cited: 0 times

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LOC496300 is expressed in the endoderm of developing Xenopus laevis embryos.

Maria Stewart, Kelsey Donahue, Elizabeth Wilke, Emily Shifley,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 0 times

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Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines.

Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Armando Rossello, Marina Fabbi, Flavio Ballante, Gabriella Ortore, Grazia Carbotti, Francesco Campelli, Irene Banti, Rosaria Gangemi, Garland R Marshall, Elisabetta Orlandini,

Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment for UM, alone or in association with other chemotherapeutic agents. Here we synthesised a ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):34-47]

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Myricetin reduces cytotoxicity by suppressing hepcidin expression in MES23.5 cells.

Han Deng, Shang Liu, Dong Pan, Yi Jia, Ze-Gang Ma,

Multiple studies implicate iron accumulation in the substantia nigra in the degeneration of dopaminergic neurons in Parkinson's disease. Indeed, slowing of iron accumulation in cells has been identified as the key point for delaying and treating Parkinson's disease. Myricetin reportedly plays an important role in anti-oxidation, anti-apoptosis, anti-inflammation, and iron ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(6):1105-1110]

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Targeted Next-Generation Sequencing of Plasma Cell-Free DNA in Korean Patients with Hepatocellular Carcinoma.

Hyojin Chae, Pil Soo Sung, Hayoung Choi, Ahlm Kwon, Dain Kang, Yonggoo Kim, Myungshin Kim, Seung Kew Yoon,

Background:Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer-related deaths worldwide, and an accurate and non-invasive biomarker for the early detection and monitoring of HCC is required. We assessed pathogenic variants of HCC driver genes in cell-free DNA (cfDNA) from HCC patients who had not undergone systemic therapy. Methods:Plasma cfDNA ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2021, 41(2):198-206]

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Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liver.

Yeojin Lee, Juliana Leslie, Ying Yang, Lei Ding,

The liver maintains hematopoietic stem cells (HSCs) during development. However, it is not clear what cells are the components of the developing liver niche in vivo. Here, we genetically dissected the developing liver niche by systematically determining the cellular source of a key HSC niche factor, stem cell factor (SCF). ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2021, 218(3):]

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The Role of Tacrolimus Nanomicelles in Acute Rejection After Liver Transplantation in Rats.

Zhantao Xie, Huibo Zhao, Yuan Chen, Sidong Wei, Jianjun Sun, Gaofeng Tang, Weiwei Wang, Guoyong Chen, Raymond E Samuel, Robert Wermter,

Although there is some progress in immunosuppressive therapy of acute rejection, there is still a lack of standardized diagnosis and treatment. For the acute rejection after liver transplantation, there is still a lack of an exact treatment at this stage. Tacrolimus (TAC) side effects will also affect the survival rate ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1061-1069]

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Preparation of Galactosyl Nanoparticles and Their Targeting Efficiency to Hepatocellular Carcinoma.

Wei Liao, Yan Tang, Zhengcui Hu, Chunyan Wang, Yi Chen, Yi Zhang, Wenhan Fan, Bernd Klaubert, Jeremy D Hoisak,

Liver diseases seriously endanger people's physical health, especially liver cancer, and its morbidity and mortality have increased year by year. The reason why liver cancer is difficult to cure is that in addition to the low lethality of cancer drugs to cancer cells, another important factor is that the drugs ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):987-994]

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Construction of Lycetin Nanocarriers and Its Effect on the Proliferation and Apoptosis of Hepatocellular Carcinoma Cells by Regulating Nuclear Factor E2 Related Factor/Antioxidant Response Element Pathway.

Ming Jiang, Jing Jin, Xiaohui Ye, Jing Wang, Hongbo Shen, Jie Zhen, Yinong Zhou, Chiba Hiroyuki, K Uberla,

This article explores the role of lysin nanocarriers in inducing apoptosis of human hepatocellular carcinoma cells and the possible molecular mechanisms. Cytotoxicity tests were performed in human fibroblast cell line MRC-5. Anti-cancer activity was tested in liver cancer cell lines HepG2 and HCCLM3. The results show that nanocarriers have a ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1054-1060]

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Anti-fibrotic effect of intravenous umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection in experimental rats induced liver fibrosis.

Taufik Sungkar, Agung Putra, Dharma Lindarto, Rosita Juwita Sembiring,

Aim To investigate the effect of umbilical cord-derived mesenchymal stem cells (UC-MSCs) administration among liver fibrosis experimental rat model via the regulation of angiotensin II type 1 receptor (AT1R) and platelet-derived growth factor-β (PDGF-β) due to their therapeutic potential to replace liver transplantation for advanced liver fibrosis. Yet the mechanism ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2021, 18(1):]

Cited: 0 times

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Pulmonary Manifestations of Gastrointestinal, Pancreatic, and Liver Diseases in Children.

Emily R Le Fevre, Kathleen H McGrath, Dominic A Fitzgerald,

Pulmonary manifestations of gastrointestinal (GI) diseases are often subtle, and underlying disease may precede overt symptoms. A high index of suspicion and a low threshold for consultation with a pediatric pulmonologist is warranted in common GI conditions. This article outlines the pulmonary manifestations of different GI, pancreatic, and liver diseases ... Read more >>

Pediatr Clin North Am (Pediatric clinics of North America)
[2021, 68(1):41-60]

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Upper Gastrointestinal Bleeding.

Nicholas J Costable, David A Greenwald,

Upper gastrointestinal (GI) bleeding is a common reason for hospital admission in older adult patients and carries a high morbidity and mortality if not properly managed. Risk factors include advanced age, Helicobacter pylori infection, medication use, smoking, and history of liver disease. Patients with known or suspected liver disease and ... Read more >>

Clin Geriatr Med (Clinics in geriatric medicine)
[2021, 37(1):155-172]

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Application of Abdominal Imaging Based on Nano Drug Delivery System for Diagnosis and Treatment of Liver Cancer.

Zhenzhen Fan, Qingsheng Liu, Fangfang Lu, Zhihui Dong, Peng Gao, Nassima Bouadem, Bashir Yahya,

Liver cancer has a high incidence and a poor prognosis, which seriously affects human health. Doxorubicin is one of the chemotherapeutics used in the treatment of tumours, but its severe adverse reactions, especially cardiac toxicity, have limited its clinical application. The nanometre drug delivery system enables drug-loaded nanoparticles to be ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):824-832]

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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.

Emir Trnačević, Nermin Salkić, Alma Trnačević, Anja Divković, Fatima Hukić, Nusret Butković, Amra Serak, Amer Mujkanović,

Aim To assess concordance of eight frequently used serology-based scoring indices for liver fibrosis and cirrhosis with transient elastography (TE) in chronic hepatitis C (CHC) patients in order to determine serum indices with the highest concordance and clinical usability in clinical practice. Methods In this prospective study, 63 CHC patients ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2021, 18(1):]

Cited: 0 times

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Non-alcoholic Fatty Liver Disease and Diabetes Mellitus.

Gebran Khneizer, Syed Rizvi, Samer Gawrieh,

Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading liver disease globally. NAFLD patients can have a progressive phenotype, non-alcoholic steatohepatitis (NASH) that could lead to cirrhosis, liver failure and cancer. There is a close bi-directional relationship between NAFLD and type 2 diabetes mellitus (T2DM); NAFLD increases the risk ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1307:417-440]

Cited: 0 times

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COVID-19: an emergent cause of liver injury?

Jean-François Cadranel, Noémi Reboux, Jean-Baptiste Nousbaum,

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):1-3]

Cited: 0 times

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Nonalcoholic fatty liver disease is associated with intrahepatic cholangiocarcinoma and not with extrahepatic form: definitive evidence from meta-analysis and trial sequential analysis.

Salvatore Corrao, Giuseppe Natoli, Christiano Argano,

<b>Background:</b>Cholangiocarcinoma is a cancer with poor prognosis. The detection of risk factors is fundamental to identify subjects at higher risk of cholangiocarcinoma. Nonalcoholic fatty liver disease (NAFLD) represents a leading cause of chronic liver disease worldwide. Recent data suggested that NAFLD increases the risk of cholangiocarcinoma development. However, it is ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):62-68]

Cited: 0 times

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Clinical progress of auxiliary liver transplantation.

Jiang Li, Da-Zhi Tian, Wen-Tao Jiang, Zhong-Yang Shen,

After half a century of development, auxiliary liver transplantation (ALT) technology gradually matured and major indications of ALT have been gradually expanded. This review summarized the history of ALT and introduced indications for ALT which including metabolic liver disease, fulminant hepatic failure, highly sensitized kidney transplantation, prevention of hepatic resection ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):4-8]

Cited: 0 times

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Characteristics and outcome of nosocomial bloodstream infection in patients with acute-on-chronic liver failure.

Haibin Su, Jingjing Tong, Xiaoyan Liu, Chen Li, Jing Chen, Xiang Xu, Chongdan Guan, Yuhui Peng, Lilong Yan, Peng Ning, Hui Li, Lina Zhang, Jinhua Hu,

<b>Aim:</b>Patients with acute-on-chronic liver failure (ACLF) have a high risk of developing infections while hospitalized. Nosocomial bloodstream infection (BSI) is not uncommon, particular in patients who receive invasive operation, which may have negative impact on prognosis. In this study, we aim to investigate the characteristics and short-term outcome of nosocomial ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):83-88]

Cited: 0 times

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A nomogram for discrimination of non-alcoholic fatty liver disease in patients with chronic hepatitis B.

Yanping Chen, Dan Cao, Chunyan Li, Pingping Zhang, Xiaoyun Wang, Na Li, Qunying Han, Zhengwen Liu,

<b>Objectives:</b>Comorbid of non-alcoholic fatty liver disease (NAFLD) in chronic hepatitis B (CHB) patients is common but no simple noninvasive diagnostic methods are available for the identification. This study aims to develop a noninvasive nomogram for accurate detection of NAFLD in CHB patients.<br><br><b>Patients and methods:</b>This study included 535 liver biopsy-proven CHB ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):69-75]

Cited: 0 times

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Current treatment paradigms and emerging therapies for NAFLD/NASH.

Sana Raza, Sangam Rajak, Aditya Upadhyay, Archana Tewari, Rohit Anthony Sinha,

Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, may culminate into cirrhosis and hepatocellular cancer (HCC) and is presently a leading cause of liver transplant. Although a steady progress is seen in understanding of ... Read more >>

Front Biosci (Landmark Ed) (Frontiers in bioscience (Landmark edition))
[2021, 26:206-237]

Cited: 0 times

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Glucose Lowering Efficacy and Pleiotropic Effects of Sodium-Glucose Cotransporter 2 Inhibitors.

Mohammad Shafi Kuchay, Khalid Jamal Farooqui, Sunil Kumar Mishra, Ambrish Mithal,

In type 2 diabetes, the maladaptive upregulation of sodium-glucose cotransporter 2 (SGLT2) protein expression and activity contribute to the maintenance of hyperglycemia. By inhibiting these proteins, SGLT2 inhibitors increase urinary glucose excretion (UGE) that leads to fall in plasma glucose concentrations and improvement in all glycemic parameters. Clinical studies have ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1307:213-230]

Cited: 1 time

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Chronic liver disease is not associated with severity or mortality in Coronavirus disease 2019 (COVID-19): a pooled analysis.

Giuseppe Lippi, Maria Helena Santos de Oliveira, Brandon Michael Henry,

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):114-115]

Cited: 6 times

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