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The C. elegans pseudogene sspt-16 (F55A3.7) is required to safeguard germ cells against reprogramming.

Andreas Ofenbauer, Clara Maria Kraus, Baris Tursun,

We recently identified FAcilitates Chromatin Transcription (FACT) as a reprogramming barrier of transcription factor (TF) mediated conversion of germ cells into neurons in <i>C. elegans</i>. FACT is a conserved heterodimer consisting of SPT16 and SSRP1 in mammals. Duplication events during evolution in <i>C. elegans</i> generated two SSRP1 homologs named HMG-3 ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.

Mackenzie L Morshead, Christine A Sedore, E Grace Jones, David Hall, W Todd Plummer, Theo Garrett, Mark Lucanic, Max Guo, Monica Driscoll, Patrick C Phillips, Gordon Lithgow,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 1 time

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C. elegans VWA-8 is a mitochondrial protein.

Ming Zhu, Andrew D Chisholm, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 0 times

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Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue.

Briana Brown Rackley, Evan Kiely, Chang-Soo Seong, Manali Rupji, Melissa Gilbert-Ross,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 0 times

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LOC496300 is expressed in the endoderm of developing Xenopus laevis embryos.

Maria Stewart, Kelsey Donahue, Elizabeth Wilke, Emily Shifley,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 0 times

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A robust method to isolate Drosophila fat body nuclei for transcriptomic analysis.

Vanika Gupta, Brian P Lazzaro,

Gene expression profiles are typically described at the level of the tissue or, often in <i>Drosophila</i>, at the level of the whole organism. Collapsing the gene expression of entire tissues into single measures averages over potentially important heterogeneity among the cells that make up that tissue. The advent of single-cell ... Read more >>

Fly (Austin) (Fly)
[2022, 16(1):62-67]

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All roads lead to Rome - a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer's disease.

Yi-Yao Liang, Li-Dan Zhang, Xi Luo, Li-Li Wu, Zhao-Wei Chen, Guang-Hao Wei, Kai-Qing Zhang, Ze-An Du, Ren-Zhi Li, Kwok-Fai So, Ang Li,

Age-related neurodegenerative disorders such as Alzheimer's disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, impractical, and expensive. Many studies have shown that a variety ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1210-1227]

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Self-renewal of peripheral nerve resident macrophage: does it represent a unique activation status?

Maricris Bautista, Anand Krishnan,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):999-1000]

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The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics.

Leon G Coleman,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1020-1022]

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Amyotrophic lateral sclerosis, a neurodegenerative motor neuron disease with retinal involvement.

Ana I Ramirez, Rosa de Hoz, Pilar Rojas, Juan J Salazar,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1011-1012]

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In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas.

Bo-Yan Liu, Jun-Li Xue, Qian-Qian Gu, Min Zhao, Meng-Yu Zhang, Ming-Yue Wang, Yun Wang, Shu-Cun Qin,

Medical effects of hydrogen have been reported in many studies. Due to difficulties in measuring hydrogen concentration in vivo after intake and high explosive risks of hydrogen, studies about dose-response relationships and tissue concentrations of hydrogen are few. Here, for the first time, we monitored real-time hydrogen concentrations in different ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(3):107-112]

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Comparison of Non-Invasive Clinical Algorithms for Liver Fibrosis in Patients With Chronic Hepatitis B to Reduce the Need for Liver Biopsy: Application of Enhanced Liver Fibrosis and Mac-2 Binding Protein Glycosylation Isomer.

Mina Hur, Mikyoung Park, Hee-Won Moon, Won Hyeok Choe, Chae Hoon Lee,

<h4>Background</h4>Non-invasive clinical algorithms for the detection of liver fibrosis (LF) can reduce the need for liver biopsy (LB). We explored the implementation of two serum biomarkers, enhanced liver fibrosis (ELF) and Mac-2 binding protein glycosylation isomer (M2BPGi), in clinical algorithms for LF in chronic hepatitis B (CHB) patients.<h4>Methods</h4>Two clinical algorithms ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):249-257]

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Non-invasive gene delivery across the blood-brain barrier: present and future perspectives.

Seigo Kimura, Hideyoshi Harashima,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):785-787]

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Pentadecapeptide BPC 157 and the central nervous system.

Jakša Vukojevic, Marija Milavić, Darko Perović, Spomenko Ilić, Andrea Zemba Čilić, Nataša Đuran, Sanja Štrbe, Zoran Zoričić, Igor Filipčić, Petrana Brečić, Sven Seiverth, Predrag Sikirić,

We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC 157, three very recent demonstrations that may be essential in the gut-brain and brain-gut axis operation, and therapy application in the central nervous system disorders, in particular. Firstly, given in the reperfusion, BPC 157 counteracted bilateral clamping of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):482-487]

Cited: 2 times

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Endoscopic Ultrasound-Guided Liver Biopsy.

Ishaan K Madhok, Nasim Parsa, Jose M Nieto,

Endoscopic ultrasound-guided liver biopsy (EUS-LB) has emerged as a safe and effective alternative to percutaneous and trans-jugular approaches for hepatic tissue acquisition. It has shown superior diagnostic yield for the targeted approach of focal lesions, less sampling variability, improved patient comfort, and safety profile. These advantages have contributed to the ... Read more >>

Clin Liver Dis (Clinics in liver disease)
[2022, 26(1):127-138]

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Brief electrical nerve stimulation enhances intrinsic repair capacity of the focally demyelinated central nervous system.

Lydia Ayanwuyi, Nataliya Tokarska, Nikki A McLean, Jayne M Johnston, Valerie M K Verge,

Our lab has shown that brief electrical nerve stimulation (ES) has a dramatic impact on remyelination of lysophosphatidyl choline (LPC)-induced focally demyelinated rat peripheral nerves, while also inducing an axon-protective phenotype and shifting macrophages from a predominantly pro-inflammatory toward a pro-repair phenotype. Whether this same potential exists in the central ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1042-1050]

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Endoscopic Ultrasound Evaluation of Portal Pressure.

Enrico O Souto,

Portal hypertension is a complex syndrome with multiple clinical manifestations that develop in a variety of conditions and diseases. The spectrum of portal hypertension manifestations is wide and dependent on the physiologic site of increased portal resistance (pre-, post-, and sinusoidal or intrahepatic), as well as the presence of hepatocellular ... Read more >>

Clin Liver Dis (Clinics in liver disease)
[2022, 26(1):e1-e10]

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Management of Decompensated Cirrhosis and Associated Syndromes.

Shaun Chandna, Eduardo Rodríguez Zarate, Juan F Gallegos-Orozco,

Patients with cirrhosis account for 3% of intensive care unit admissions with hospital mortality exceeding 50%; however, improvements in survival among patients with acutely decompensated cirrhosis and organ failure have been described when treated in specialized liver transplant centers. Acute-on-chronic liver failure is a distinct clinical syndrome characterized by decompensated ... Read more >>

Surg Clin North Am (The Surgical clinics of North America)
[2022, 102(1):117-137]

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Improving Diagnostic Yield in Indeterminate Biliary Strictures.

David J Restrepo, Chris Moreau, Cyrus V Edelson, Ameesh Dev, Shreyas Saligram, Hari Sayana, Sandeep N Patel,

Indeterminate biliary strictures are defined as a narrowing of the bile duct that cannot be differentiated as malignant or benign after performing cross-sectional imaging and an ERCP. Identifying the etiology of a bile duct stricture is the single most important step in determining whether a complex and potentially morbid surgical ... Read more >>

Clin Liver Dis (Clinics in liver disease)
[2022, 26(1):69-80]

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Amebiasis and Amebic Liver Abscess in Children.

Shipra Gupta, Layne Smith, Adriana Diakiw,

Although rare in the developed world, amebiasis continues to be a leading cause of diarrhea and illness in developing nations with crowding, poor sanitation, and lack of clean water supply. Recent immigrants or travelers returning from endemic regions after a prolonged stay are at high risk of developing amebiasis. A ... Read more >>

Pediatr Clin North Am (Pediatric clinics of North America)
[2022, 69(1):79-97]

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Effects of Iranian Polyherbal Syrup (Zufa syrup) on oxygen saturation and clinical symptoms in suspected patients with COVID-19: a triple-blinded, randomized, placebo-controlled trial.

Razieh Borujerdi, Seyed Hasan Adeli, Abolfazl Mohammadbeigi, Fatemeh Aliasl, Akram Asghari, Ahmad Hormati, Hosein Moradi Dehnavi, Farhad Hoseini, Majid Asghari,

Coronavirus disease 2019 (COVID-19) pandemic has caused an urgent need for investigating potential treatments. Traditional medicine offers many potential remedies that have been historically used and have the advantage of bypassing the cultural obstacles in the practice of medicine. We aimed to investigate the efficacy of Zufa syrup in the ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(2):44-50]

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The role of nursing care in the type 2 diabetes treatment associated with chronic liver diseases.

Bai Yu Fu, Xue Jiao Wang,

<h4>Objective</h4>Diabetes is the fifth leading cause of death in the People's Republic of China. The aim of the article is to compare the effects of nursing care on the laboratory findings and ultrasound results of diabetic patients with chronic liver diseases (CLD) who were treated with antiglycemic drugs.<h4>Methods</h4>Diabetic were patients ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2022, 34(1):104-111]

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Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling.

Silvia Marchianò, Michele Biagioli, Rosalinda Roselli, Angela Zampella, Cristina Di Giorgio, Martina Bordoni, Rachele Bellini, Elva Morretta, Maria Chiara Monti, Eleonora Distrutti, Stefano Fiorucci,

Farnesoid-x-receptor (FXR) agonists, currently trialed in patients with non-alcoholic steatosis (NAFLD), worsen the pro-atherogenic lipid profile and might require a comedication with statin. Here we report that mice feed a high fat/high cholesterol diet (HFD) are protected from developing a pro-atherogenic lipid profile because their ability to dispose cholesterol through ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(1):e22060]

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Emerging small-molecule therapeutic approaches for Alzheimer's disease and Parkinson's disease based on targeting microRNAs.

Somaya A Abdelrahman, Moustafa T Gabr,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):336-337]

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Pre-clinical study of human umbilical cord mesenchymal stem cell transplantation for the treatment of traumatic brain injury: safety evaluation from immunogenic and oncogenic perspectives.

Gang Wang, Hua-Ling Wu, Yue-Ping Liu, De-Qi Yan, Zi-Lin Yuan, Li Chen, Qian Yang, Yu-Song Gao, Bo Diao,

Stem cell therapy is a promising strategy for the treatment of traumatic brain injury (TBI). However, animal experiments are needed to evaluate safety; in particular, to examine the immunogenicity and tumorigenicity of human umbilical cord mesenchymal stem cells (huMSCs) before clinical application. In this study, huMSCs were harvested from human ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):354-361]

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