Full Text Journal Articles about
Leptomeningeal Carcinomatosis

Advertisement

Find full text journal articles






Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival: A Case Report.

Koki Nakashima, Yoshiki Demura, Masahiro Oi, Mio Tabata, Toshihiko Tada, Kohei Shiozaki, Masaya Akai, Tamotsu Ishizuka,

We herein report a 66-year-old woman with advanced lung adenocarcinoma (PD-L1 tumor proportion score 60%) lacking driver oncogenes in whom meningeal carcinomatosis, along with sudden onset dizziness, deafness, and consciousness disturbance, appeared after second-line chemotherapy. Whole-brain radiation therapy (WBRT) and Pembrolizumab were subsequently administered, and third-line chemotherapy with Pembrolizumab is ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2020, :]

Cited: 0 times

View full text PDF listing >>



[Bilateral optic nerve infiltration by carcinomatous meningitis].

V Bielefeld, S Assad, C Guguen, F Goupil, G Le Meur, P Lebranchu, R Laballe,

J Fr Ophtalmol (Journal francais d'ophtalmologie)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

CYFRA 21-1 levels in cerebrospinal fluid as a putative therapeutic monitoring biomarker for patients with leptomeningeal carcinomatosis: A pilot study.

Ho Jin Kim,

BACKGROUND:To investigate the feasibility of cerebrospinal fluid (CSF) CYFRA 21-1 levels as a therapeutic monitoring biomarker in leptomeningeal carcinomatosis (LMC) patients undergoing ventriculo-lumbar perfusion (VLP) chemotherapy. METHODS:The levels of CYFRA 21-1 in 42 CSF samples from 15 LMC patients were analyzed using an electrochemiluminescence immunoassay. Samples were collected at individual ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Nivolumab efficacy in leptomeningeal metastasis of renal cell carcinoma: a case report.

Lucia Bonomi, Anna Cecilia Bettini, Ermenegildo Arnoldi, Alessandra Chirco, Laura Ghilardi, Ornella Manara, Marco Roscigno, Luigi Filippo Da Pozzo, Carlo Alberto Tondini,

BACKGROUND:Meningeal carcinomatosis is rare in patients with kidney cancer and treatment options are limited. Few patients treated with systemic approaches have been reported. We describe a case of complete remission of leptomeningeal metastasis in a patient with renal cell carcinoma treated with nivolumab. To our knowledge, this is the first ... Read more >>

Tumori (Tumori)
[2020, :300891620904411]

Cited: 0 times

View full text PDF listing >>



[Case of isolated neurosarcoidosis requiring differentiation from tuberculous meningitis].

Ichiro Deguchi, Takashi Osada, Tomonari Suzuki, Shinya Tabata, Eiichi Arai, Akira Uchino, Takeshi Hayashi, Shinichi Takahashi, Suketaka Momoshima, Masaki Takao,

A 62-year-old woman was transported to our hospital for management of generalized clonic seizures. Cerebrospinal fluid examination showed an increased monocyte-dominant cell count, high protein concentration, and low glucose concentration that was 17% of the plasma glucose concentration. Contrast-enhanced cranial magnetic resonance imaging revealed diffuse leptomeningeal enhancement with multiple nodular ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2020, 60(3):213-218]

Cited: 0 times

View full text PDF listing >>



Leptomeningeal Carcinomatosis in a Patient with Pancreatic Cancer Responding to Nab-Paclitaxel plus Gemcitabine.

Garry Ceccon, Michael Wollring, Anna Brunn, Martina Deckert, Dirk Waldschmidt, Gereon R Fink, Norbert Galldiks,

Leptomeningeal carcinomatosis is an extremely rare, but devastating complication in pancreatic cancer patients with a poor prognosis despite multimodal treatment. We present a 51-year-old male patient with the very rare condition of leptomeningeal carcinomatosis originating from pancreatic cancer. He presented to our hospital with severe headache and neck stiffness 30 ... Read more >>

Case Rep Oncol (Case reports in oncology)
[2020, 13(1):35-42]

Cited: 0 times

View full text PDF listing >>



Mortality, Morbidity, and Prognostic Factors in the Surgical Resection of Brain Metastases: A Contemporary Cohort Study.

Helder Picarelli, Marcelo de Lima Oliveira, Gustavo Nader Marta, Davi J Fontoura Solla, Manoel Jacobsen Teixeira, Eberval Gadelha Figueiredo,

OBJECTIVE: Despite advances in systemic therapy and radiotherapy (RT), neurosurgical resection (NSR) remains a mainstay of the treatment of brain metastases (BMs). Although it is unequivocal in instances of diagnostic doubt, radioresistance, and risk of death due to neurologic causes, NSR may be controversial in other situations. Many aspects related to ... Read more >>

J Neurol Surg A Cent Eur Neurosurg (Journal of neurological surgery. Part A, Central European neurosurgery)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Leptomeningeal metastasis from solid tumors.

Jigisha P Thakkar, Priya Kumthekar, Karan S Dixit, Roger Stupp, Rimas V Lukas,

Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, 411:116706]

Cited: 0 times

View full text PDF listing >>



Cauda equina syndrome due to leptomeningeal carcinomatosis: a medical dilemma.

Leila Izadi Firouzabadi, Paul Mead, Jonathan Berry, Sheharyar Hanif,

BMJ Case Rep (BMJ case reports)
[2020, 13(2):]

Cited: 0 times

View full text PDF listing >>



Venous Sinus Stenting for Transverse Sinus Stenosis Associated with Leptomeningeal Carcinomatosis in a Patient with Epidermal Growth Factor Receptor-Mutated Lung Cancer: A Case Report.

Yasuhiro Kawabata, Norio Nakajima, Hidenori Miyake, Yasumasa Yamamoto, Shintaro Toda, Yasuji Terada, Mamoru Takahashi, Masafumi Kurimoto,

BACKGROUND Cerebral venous sinus obstruction associated with leptomeningeal carcinomatosis is an extremely rare complication of advanced non-small-cell lung cancer. There is little information available on the efficacy of therapeutic options because of its rarity and extremely poor prognosis. CASE REPORT A 57-year-old man presented with severe headache, vomiting, and visual ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e918488]

Cited: 0 times

View full text PDF listing >>



ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases.

Priya Kumthekar, Shou-Ching Tang, Andrew J Brenner, Santosh Kesari, David E Piccioni, Carey K Anders, Jose A Carrillo, Pavani Chalasani, Peter Kabos, Shannon L Puhalla, Katherine H R Tkaczuk, Agustin Garcia, Manmeet S Ahluwalia, Jeffrey S Wefel, Nehal Lakhani, Nuhad K Ibrahim,

PURPOSE:ANG1005, a novel taxane derivative, consists of 3 paclitaxel molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via LRP1 transport system. Preclinical and clinical evidence of efficacy with ANG1005 has been previously shown. EXPERIMENTAL DESIGN:A multi-center, open-label phase 2 study ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Adnexal Tumor-Related Neurobehavioral Alterations: A Rare Case Report.

Gabriel Ferrante Abou Murad, Francisco Faria Hatanaka, Tamires de Menezes França, Maria Gabriela Baumgarten Kuster Uyeda, Manoel João Batista Castello Girão, Marair Gracio Ferreira Sartori,

Associations between neuropsychotic changes and oncologic disease are often described as late-onset symptoms, secondary to the instituted treatment. However, neurocognitive symptoms as a clinical manifestation of adnexal tumors are still little discussed, despite the importance of these in the gynecology practice. In this article, we present a case of adnexal ... Read more >>

Case Rep Obstet Gynecol (Case reports in obstetrics and gynecology)
[2020, 2020:3802940]

Cited: 0 times

View full text PDF listing >>



Long-term complete response to intrathecal trastuzumab in a patient with leptomeningeal carcinomatosis due to her2- overexpressing breast cancer: Case report.

Francisco José Valdivia García, Natalia Palazón Carrión, Luis de la Cruz-Merino,

INTRODUCTION:Leptomeningeal dissemination due to HER2-overexpressing breast cancer is a rare and hard to treat complication with short-term dismal prognosis. PATIENT CONCERNS:A 34-year-old female previously treated because of HER2+ breast cancer is admitted to the Neurology Department in December 2016 due to sensory-motor neurological semiology. DIAGNOSIS:A wide set of diagnostic tests ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(1):e18298]

Cited: 0 times

View full text PDF listing >>



Prognosis in young women less than 40 years of age with brain metastasis from breast cancer.

A Mustillo, J P Ayoub, D Charpentier, L Yelle, M Florescu,

Background:Brain metastasis from breast cancer (bca) in young women is doubly devastating because both quality of life and life expectancy are significantly reduced. With new radiation technology and drugs that have emerged, survival is expected to increase for these young women. Methods:Using the oacis and sardo patient databases, we identified ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2020, 27(1):39-45]

Cited: 0 times

View full text PDF listing >>



Osimertinib Overcomes Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis Model of ALK-Rearranged Lung Cancer.

Sachiko Arai, Shinji Takeuchi, Koji Fukuda, Hirokazu Taniguchi, Akihiro Nishiyama, Azusa Tanimoto, Miyako Satouchi, Kaname Yamashita, Koshiro Ohtsubo, Shigeki Nanjo, Toru Kumagai, Ryohei Katayama, Makoto Nishio, Mei-Mei Zheng, Yi-Long Wu, Hiroshi Nishihara, Takushi Yamamoto, Mitsutoshi Nakada, Seiji Yano,

INTRODUCTION:Leptomeningeal carcinomatosis (LMC) occurs frequently in anaplastic lymphoma kinase (ALK)-rearranged NSCLC and develops acquired resistance to ALK tyrosine kinase inhibitors (ALK TKIs). This study aimed to clarify the resistance mechanism to alectinib, a second-generation ALK TKI, in LMC and test a novel therapeutic strategy. METHODS:We induced alectinib resistance in an ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Impact of clinicopathologic features on leptomeningeal metastasis from lung adenocarcinoma and treatment efficacy with epidermal growth factor receptor tyrosine kinase inhibitor.

Byoung Soo Kwon, Young Hyun Cho, Shin-Kyo Yoon, Dae Ho Lee, Sang-We Kim, Do Hoon Kwon, Jae Cheol Lee, Chang-Min Choi,

BACKGROUND:We investigated the risk factors for leptomeningeal carcinomatosis (LMC) and compared clinical efficacies of various treatment modalities including intrathecal (IT) chemotherapy in patients with lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutations. METHODS:Using clinical research data from the Asan Medical Center, we retrospectively analyzed data of patients diagnosed with ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(2):436-442]

Cited: 0 times

View full text PDF listing >>



Advanced metastatic gastric adenocarcinoma identified within the placenta: a case report with literature review.

Shajadi Patan, Taras Benzar, Gabrielle Sanford, Mindie Kavanaugh,

We present an extremely rare case of a multiparous women age 32 in her 35th week of gestation who was admitted to our hospital for evaluation of back pain and was incidentally found to have metastatic gastric adenocarcinoma, diagnosed from a routine placental specimen. The coexistence of gastric carcinoma with ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2020, 11(1):127-132]

Cited: 0 times

View full text PDF listing >>



Phase II, open-label, multicenter trial of crizotinib in Japanese patients with advanced non-small cell lung cancer harboring a MET gene alteration: Co-MET study.

Mototsugu Shimokawa, Kaname Nosaki, Takashi Seto, Kadoaki Ohashi, Masahiro Morise, Hidehito Horinouchi, Jun Sakakibara, Haruyasu Murakami, Seiji Yano, Miyako Satouchi, Shingo Matsumoto, Koichi Goto, Kiyotaka Yoh,

BACKGROUND:MET-deregulated non-small cell lung cancer represents an urgent clinical need because of the lack of specific therapies. Although recent studies have suggested a potential role for crizotinib in patients harboring MET gene alterations, no conclusive data are currently available. Therefore, we designed the Co-MET study, a single-arm phase II study ... Read more >>

Trials (Trials)
[2020, 21(1):298]

Cited: 0 times

View full text PDF listing >>



Metastatic meningeal carcinomatosis from lung cancer: Report of a rare case.

Hui Liu, Li Liu, Xiaochen Zhang, Song Jin,

Meningeal carcinomatosis (MC) refers to the diffuse or multifocal spread or infiltration of malignant tumors in the pia mater. It is a special distribution type of metastatic tumors in the central nervous system and one of the important reasons of death caused by metastatic malignant tumors. Here, we report a ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(1):173-175]

Cited: 0 times

View full text PDF listing >>



Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions.

Isabella C Glitza, Keiran S M Smalley, Priscilla K Brastianos, Michael A Davies, Ian McCutcheon, James K C Liu, Kamran A Ahmed, John A Arrington, Brittany R Evernden, Inna Smalley, Zeynep Eroglu, Nikhil Khushalani, Kim Margolin, Harriet Kluger, Michael B Atkins, Hussein Tawbi, Adrienne Boire, Peter Forsyth,

In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published ... Read more >>

Pigment Cell Melanoma Res (Pigment cell & melanoma research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Durable response to pulsatile icotinib for central nervous system metastases from EGFR-mutated non-small cell lung cancer: A case report.

Hui-Ying Li, Yu Xie, Ting-Ting Yu, Yong-Juan Lin, Zhen-Yu Yin,

BACKGROUND:Central nervous system (CNS) metastases are a catastrophic complication of non-small cell lung cancer (NSCLC), including brain and leptomeningeal carcinomatosis, and are always accompanied by a poor prognosis. Despite the continuous development of existing treatments, the therapy of CNS metastases remains challenging. CASE SUMMARY:We report a patient who was definitively ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(2):370-376]

Cited: 0 times

View full text PDF listing >>



Leptomeningeal Metastasis from Adrenocortical Carcinoma: A Case Report.

Anna R Schreiber, Adwitiya Kar, Andrew E Goodspeed, Nikita Pozdeyev, Hilary Somerset, Christopher D Raeburn, Aik-Choon Tan, Stephen Leong, Margaret E Wierman, Katja Kiseljak-Vassiliades,

Adrenocortical carcinoma (ACC) is an uncommon endocrine malignancy with limited treatment options. While the overall 5-year survival rate in patients with ACC is 35%, the disease is often rapidly progressive with long-term survival in only 5% of patients. Although tumor stage, grade, and excess hormonal activity predict unfavorable prognosis, additional ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(3):bvaa017]

Cited: 0 times

View full text PDF listing >>



Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis.

Pedro Exman, Robert M Mallery, Nancy U Lin, Heather A Parsons,

Leptomeningeal carcinomatosis (LC) is a devastating complication of metastatic cancer that disproportionately affects patients with advanced breast cancer. Moreover, those with BRCA1/2-mutated disease more often experience leptomeningeal metastasis. Treatment options for LC are limited and often include significant toxicities. PARP inhibitors offer an important potential treatment for patients with BRCA1/2-mutated ... Read more >>

NPJ Breast Cancer (NPJ breast cancer)
[2019, 5:46]

Cited: 0 times

View full text PDF listing >>



The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes: a prospective observation study.

Toshimichi Nakano, Hidefumi Aoyama, Hirotake Saito, Satoshi Tanabe, Kensuke Tanaka, Katsuya Maruyama, Tomoya Oshikane, Atsushi Ohta, Eisuke Abe, Motoki Kaidu,

BACKGROUND:We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for brain metastasis. METHODS:We categorized the patients by the changes of NCF into groups of improvement versus deterioration if at least one domain ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):66]

Cited: 0 times

View full text PDF listing >>



Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer.

Todd M Bauer, Alice T Shaw, Melissa L Johnson, Alejandro Navarro, Justin F Gainor, Holger Thurm, Yazdi K Pithavala, Antonello Abbattista, Gerson Peltz, Enriqueta Felip,

BACKGROUND:Lorlatinib is a potent, third-generation ALK/ROS1 tyrosine kinase inhibitor (TKI) designed to penetrate the blood-brain barrier. OBJECTIVE:We report the cumulative incidence of central nervous system (CNS) and non-CNS progression with lorlatinib in patients with ALK-positive non-small-cell lung cancer (NSCLC) previously treated with ALK TKIs. PATIENTS AND METHODS:In an ongoing phase ... Read more >>

Target Oncol (Targeted oncology)
[2020, 15(1):55-65]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
2.6731 s