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Leprosy Neuropathy

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Orthopedic Surgical Foot Management in Hansen Disease.

Jose Carlos Cohen, Silvana Teixeira de Miranda,

Hansen disease remains a common problem worldwide with 750,000 new cases diagnosed each year. Nerve injury is a central feature of the pathogenesis because of the unique tendency of Mycobacterium leprae to invade Schwann cells and the peripheral nervous system, that can be permanent and develop into disabilities. The orthopedic ... Read more >>

Orthop. Clin. North Am. (The Orthopedic clinics of North America)
[2020, 51(2):279-291]

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Sarcoidosis with cutaneous perineural granulomas and neurological manifestations: A potential mimicker of leprosy.

Rashek Kazi, Viktoryia Kazlouskaya, Jonhan Ho, Arivarasan Karunamurthy,

Sarcoidosis is a granulomatous condition with diverse clinical presentations, including neurological findings. It was previously hypothesized that perineural sarcoidal granulomas in the skin may be an explanation of small-fiber neuropathy. Herein, we present a case of a 55 year old female with anesthetic cutaneous lesions mimicking leprosy clinically and histopathologically ... Read more >>

J. Cutan. Pathol. (Journal of cutaneous pathology)
[2020, :]

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Cytokine Levels in Neural Pain in Leprosy.

Débora Bartzen Moraes Angst, Roberta Olmo Pinheiro, Joyce Soares da Silva Vieira, Roberta Arnoldi Cobas, Mariana de Andréa Vilas-Boas Hacker, Izabela Jardim Rodrigues Pitta, Louise Mara Giesel, Euzenir Nunes Sarno, Márcia Rodrigues Jardim,

Pain is a frequent symptom in leprosy patients. It may be predominantly nociceptive, as in neuritis, or neuropathic, due to injury or nerve dysfunction. The differential diagnosis of these two forms of pain is a challenge in clinical practice, especially because it is quite common for a patient to suffer ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:23]

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Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India.

Niranjan Prakash Mahajan, Mallika Lavania, Itu Singh, Saraswati Nashi, Veeramani Preethish-Kumar, Seena Vengalil, Kiran Polavarapu, Chevula Pradeep-Chandra-Reddy, Muddasu Keerthipriya, Anita Mahadevan, Tagaduru Chickabasaviah Yasha, Bevinahalli Nanjegowda Nandeesh, Krishnamurthy Gnanakumar, Gareth J Parry, Utpal Sengupta, Atchayaram Nalini,

Resistance to anti-leprosy drugs is on the rise. Several studies have documented resistance to rifampicin, dapsone, and ofloxacin in patients with leprosy. We looked for point mutations within the folP1, rpoB, and gyrA gene regions of the Mycobacterium leprae genome predominantly in the neural form of leprosy. DNA samples from ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2020, 102(3):547-552]

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"Buruli ulcer and leprosy, they are intertwined": Patient experiences of integrated case management of skin neglected tropical diseases in Liberia.

Mateo Prochazka, Joseph Timothy, Rachel Pullan, Karsor Kollie, Emerson Rogers, Abednego Wright, Jennifer Palmer,

BACKGROUND:Skin neglected tropical diseases (NTDs) such as Buruli ulcer (BU) and leprosy produce significant stigma and disability. Shared clinical presentations and needs for care present opportunities for integrated case management in co-endemic areas. As global policies are translated into local integrated services, there remains a need to monitor what new ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(2):e0008030]

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Disabilities in leprosy: an open, retrospective analyses of institutional records.

Santoshdev P Rathod, Ashish Jagati, Pooja Chowdhary,

BACKGROUND AND OBJECTIVES:Leprosy remains a leading cause of peripheral neuropathy and disability in the world. Primary objective of the study was to determine the incidence of deformities present at a time of diagnosis and new deformities that patients develop over follow up period. MATERIAL AND METHODS:An open, retrospective cohort study ... Read more >>

An Bras Dermatol (Anais brasileiros de dermatologia)
[2020, 95(1):52-56]

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Management Strategies of Melkersson-Rosenthal Syndrome: A Review.

Sumeet R Dhawan, Arushi G Saini, Pratibha D Singhi,

Melkerrson-Rosenthal syndrome is a rare disorder of unknown aetiology and characterized by the triad of oro-facial edema, facial nerve palsy, and furrowing of the tongue. Two or more of the above are essential for making a clinical diagnosis. The mainstay of treatment is corticosteroids. Intralesional triamcinolone acetonide may be used ... Read more >>

Int J Gen Med (International journal of general medicine)
[2020, 13:61-65]

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Clinical characteristics of neuropathic pain in leprosy and associated somatosensory profiles: a deep phenotyping study in India.

Omer M O Haroun, Jan Vollert, Diana N Lockwood, David L H Bennett, Vivek V Pai, Vanaja Shetty, Anju V Wakade, Ashish S Khodke, Andreas Schilder, Doreen Pfau, Elena K Enax-Krumova, Christoph Maier, Rolf-Detlef Treede, Andrew S C Rice,

This study investigated the clinical characteristics and somatosensory profiles of patients suffering from leprosy in Mumbai, India. A cross-sectional deep profiling study was conducted in 86 patients with leprosy (with and without pain) using an extensive battery of phenotyping measures including structured clinical examination, psychological state (General Health Questionnaire [GHQ-12]), ... Read more >>

Pain Rep (Pain reports)
[2019, 4(6):e743]

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Case report: Hansen's disease in an active duty soldier presenting with type 1 reversal reaction.

Nathan K Jansen, Timothy A Durso, Justin P Bandino, Barbara M Stryjewska, David A Lindholm,

Leprosy, or Hansen's disease (HD), is caused by the bacterium Mycobacterium leprae and is a significant cause of morbidity worldwide. Clinical manifestations range from isolated skin rash to severe peripheral neuropathy. Treatment involves a prolonged course of multiple antimicrobials. Although rare in the U.S., with only 168 new cases reported ... Read more >>

MSMR (MSMR)
[2019, 26(12):2-6]

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Ulcers in leprosy patients, an unrecognized clinical manifestation: a report of 8 cases.

Denis Miyashiro, Carolina Cardona, Neusa Yuriko Sakai Valente, João Avancini, Gil Benard, Maria Angela Bianconcini Trindade,

BACKGROUND:Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae. It is a polymorphic disease with a wide range of cutaneous and neural manifestations. Ulcer is not a common feature in leprosy patients, except during reactional states, Lucio's phenomenon (LP), or secondary to neuropathies. CASES PRESENTATION:We report eight patients with ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):1013]

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Anterior tarsal tunnel syndrome: an atypical involvement in primary neural leprosy.

Diogo Fernandes Dos Santos, Raquel Campos Pereira, Isabela Maria Bernardes Goulart,

Arq Neuropsiquiatr (Arquivos de neuro-psiquiatria)
[2019, 77(10):754-755]

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The neurology clinic needs monkey research.

Michael E Goldberg,

This report discusses how a number of currently incurable diseases might be treated by advances developed as the result of current ongoing research on monkeys. The diseases discussed include Parkinson's disease, amyotrophic lateral sclerosis, spinal cord injury, peripheral neuropathy, and stroke. Finally, the report discusses the devastating effect the animal ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2019, :]

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Instruments of Choice for Assessment and Monitoring Diabetic Foot: A Systematic Review.

Raúl Fernández-Torres, María Ruiz-Muñoz, Alberto J Pérez-Panero, Jerónimo García-Romero, Manuel Gónzalez-Sánchez,

Diabetic foot is the most frequent disorder among the chronic complications of diabetes, happening in 25% of patients. Objective clinical outcome measures are tests or clinical instruments that provide objective values for result measurement. The aim of this study was to carry out a systematic review of specific objective clinical ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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Forgotten, but not gone: the threat of leprosy.

EClinicalMedicine (EClinicalMedicine)
[2019, 16:1]

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Nail changes in acro-osteolysis: A case report and review of the literature.

Nicola Anne Gray, Christiaan Scott, Reginald Mzudumile Ngwanya, Komala Pillay, Thuraya Isaacs,

JAAD Case Rep (JAAD case reports)
[2019, 5(12):1033-1036]

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Introduction for special issue on pain in developing countries.

Daniel Ciampi de Andrade,

Pain Rep (Pain reports)
[2019, 4(6):e800]

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Late-onset ulnar neuritis following treatment of lepromatous leprosy infection.

Trevor Wellington, Christina Schofield,

Neuritis is a frequent complication of Myocobacteria leprae infection and treatment due to the variety of mechanisms through which it can occur. Not only can mycobacterial invasion into peripheral nerves directly cause damage and inflammation, but immune-mediated inflammatory episodes (termed leprosy reactions) can also manifest as neuritis at any point ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2019, 13(8):e0007684]

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Myelin breakdown favours Mycobacterium leprae survival in Schwann cells.

Bruno Siqueira Mietto, Beatriz Junqueira de Souza, Patricia Sammarco Rosa, Maria Cristina Vidal Pessolani, Flavio Alves Lara, Euzenir Nunes Sarno,

Leprosy neuropathy is a chronic degenerative infectious disorder of the peripheral nerve caused by the intracellular obligate pathogen Mycobacterium leprae (M. leprae). Among all nonneuronal cells that constitute the nerve, Schwann cells are remarkable in supporting M. leprae persistence intracellularly. Notably, the success of leprosy infection has been attributed to ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2019, :e13128]

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Fibrosis: a distinguishing feature in the pathology of neural leprosy.

Sérgio Luiz Gomes Antunes, Márcia Rodrigues Jardim, Robson Teixeira Vital, Bernardo Miguel de Oliveira Pascarelli, José Augusto da Costa Nery, Thaís Porto Amadeu, Anna Maria Sales, Eduardo Alves Freire da Costa, Euzenir Nunes Sarno,

BACKGROUND:Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers. OBJECTIVES:The present study describes the frequency of fibrosis along with its characterisation and ... Read more >>

Mem. Inst. Oswaldo Cruz (Memorias do Instituto Oswaldo Cruz)
[2019, 114:e190056]

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A Case of Lepromatous Leprosy Clinically Masquerading as Vasculitis.

Ali Sadeghinia, Shadi Azizzadeh-Roodpishi, Maryam Daneshpazhooh, Kambiz Kamyab, Amin Kiani, Hamidreza Mahmoudi,

Dermatol Pract Concept (Dermatology practical & conceptual)
[2019, 9(3):222-224]

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Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study.

Maria Tió-Coma, Anouk van Hooij, Kidist Bobosha, Jolien J van der Ploeg-van Schip, Sayera Banu, Saraswoti Khadge, Pratibha Thapa, Chhatra B Kunwar, Isabela M Goulart, Yonas Bekele, Deanna A Hagge, Milton O Moraes, Rosane M B Teles, Roberta Olmo Pinheiro, Erik W van Zwet, Jelle J Goeman, Abraham Aseffa, Mariëlle C Haks, Tom H M Ottenhoff, Robert L Modlin, Annemieke Geluk,

Early diagnosis of leprosy is challenging, particularly its inflammatory reactions, the major cause of irreversible neuropathy in leprosy. Current diagnostics cannot identify which patients are at risk of developing reactions. This study assessed blood RNA expression levels as potential biomarkers for leprosy. Prospective cohorts of newly diagnosed leprosy patients, including reactions, ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17931]

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Tingling hand: magnetic resonance imaging of median nerve pathologies within the carpal tunnel.

Ashwini Kumari, Sapna Singh, Anju Garg, Anjali Prakash, Sumit Sural,

Compressive neuropathy of the median nerve at the level of the carpal tunnel, known as carpal tunnel syndrome, is the most common entrapment neuropathy, affecting about 0.1-1% of the general population. Magnetic resonance reliably imaged the flexor retinaculum and carpal bones and thus defined the borders of the carpal tunnel. ... Read more >>

Pol J Radiol (Polish journal of radiology)
[2019, 84:e484-e490]

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Greater Auricular Neuropathy in Hansen’s Disease.

Suryanarayana Sharma, Amit Kulkarni, Vijay K. Sharma,

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2019, 101(4):730-731]

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Tuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.

G Kama, G K L Huang, M Taune, R Arura, L Morris, B Kombuk, A Marome, D P O'Brien,

Co-infection with tuberculosis (TB) and leprosy is thought to occur infrequently, but has been reported in settings highly endemic for both infectious diseases. We report for the first time a case where treatment for multidrug-resistant TB (MDR-TB) led to the 'unmasking' of clinically silent leprosy through the precipitation of a ... Read more >>

Public Health Action (Public health action)
[2019, 9(Suppl 1):S83-S85]

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Subcutaneous phaeohyphomycosis from Medicopsis romeroi in a diabetic patient.

Pattriya Chanyachailert, Charussri Leeyaphan, Sumanas Bunyaratavej, Piriyaporn Chongtrakool,

Dematiaceous fungi can cause subcutaneous phaeohyphomycosis, an uncommon fungal infection of the dermis and subcutaneous tissues. Medicopsis romeroi is an emerging organism that can infect patients with subcutaneous phaeohyphomycosis, especially immunocompromised patients. The present case involved subcutaneous phaeohyphomycosis caused by Medicopsis romeroi in an 80-year-old Thai male with poorly controlled ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2019, 26:69-72]

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