Full Text Journal Articles about
Lattice Corneal Dystrophy

Advertisement

Find full text journal articles






Fingolimod-associated macular edema controlled with nepafenac non-steroidal anti-inflammatory opthalmologic applications.

Rachel Husmann, John B Davies, Malik Ghannam, Brent Berry, Praful Kelkar,

Background:Fingolimod, an immunomodulatory agent, is used for the treatment of relapsing-remitting multiple sclerosis (RRMS). Fingolimod-associated macular edema (FAME) is a known complication with an incidence of 0.4%. The current recommendation for treatment of FAME is cessation of fingolimod. There are few case reports with management of FAME with steroid eye ... Read more >>

Clin Mol Allergy (Clinical and Molecular Allergy : CMA)
[2020, 18:3]

Cited: 0 times

View full text PDF listing >>



Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies.

Nadia Sukusu Nielsen, Ebbe Toftgaard Poulsen, Marie V Lukassen, Connie Chao Shern, Emilie Hage Mogensen, Christian E Weberskov, Larry DeDionisio, Leif Schauser, Tara C B Moore, Daniel E Otzen, Jesper Hjortdal, Jan J Enghild,

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, binding partners, and functions of human TGFBIp. To date, 74 mutations in the transforming growth factor-β-induced gene (TGFBI) ... Read more >>

Prog Retin Eye Res (Progress in retinal and eye research)
[2020, :100843]

Cited: 0 times

View full text PDF listing >>



Advertisement

Amyloidosis and Ocular Involvement: an Overview.

Rosanna Dammacco, Giampaolo Merlini, Walter Lisch, Tero T Kivelä, Ermete Giancipoli, Angelo Vacca, Franco Dammacco,

Purpose: To describe the ophthalmic manifestations of amyloidosis and the corresponding therapeutic measures.Methods: The 178 patients included in the study had different types of amyloidosis, diagnosed at a single internal medicine institution (Bari, Italy). To provide a comprehensive review of the types of amyloidosis that can be associated with ocular ... Read more >>

Semin Ophthalmol (Seminars in ophthalmology)
[2020, 35(1):7-26]

Cited: 0 times

View full text PDF listing >>



Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair.

Kohdai Kitamoto, Yukako Taketani, Wataru Fujii, Aya Inamochi, Tetsuya Toyono, Takashi Miyai, Satoru Yamagami, Masahiko Kuroda, Tomohiko Usui, Yasuo Ouchi,

Mutations in transforming growth factor-beta-induced (TGFBI) gene cause clinically distinct types of corneal dystrophies. To delineate the mechanisms driving these dystrophies, we focused on the R124C mutation in TGFBI that causes lattice corneal dystrophy type1 (LCD1) and generated novel transgenic mice harbouring a single amino acid substitution of arginine 124 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2000]

Cited: 0 times

View full text PDF listing >>



Distinct ocular surface soluble factor profile in human corneal dystrophies.

Rohit Shetty, Jagadeesh R Naidu, Archana Padmanabhan Nair, Tanuja Arun Vaidya, Sharon D'Souza, Himanshu Matalia, Vrushali Deshpande, Swaminathan Sethu, Arkasubhra Ghosh, Koushik Chakrabarty,

PURPOSE:Corneal dystrophies (CD) are classified as rare eye diseases that results in visual impairment and requires corneal transplant in advanced stages. Ocular surface inflammatory status in different types of CD remains underexplored. Hence, we studied the levels of tear soluble factors in the tears of patients with various types of ... Read more >>

Ocul Surf (The ocular surface)
[2020, 18(2):237-248]

Cited: 0 times

View full text PDF listing >>



Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases.

Brett D Story, Matthew E Miller, Allison M Bradbury, Emily D Million, Dongsheng Duan, Toloo Taghian, Dominik Faissler, Deborah Fernau, Sidney J Beecy, Heather L Gray-Edwards,

Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or ... Read more >>

Front Vet Sci (Frontiers in Veterinary Science)
[2020, 7:80]

Cited: 0 times

View full text PDF listing >>



Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs.

Jessica A Martinez, Franck Chiappini, Denis Barritault,

Superficial corneal ulcers that fail to heal within a normal time period and are refractory to conventional therapy in dogs are common in veterinary practice. Different etiologies can lead to this result, including spontaneous chronic corneal epithelial defects (SCCEDs) and ulcerative keratitis associated with bullous keratopathy. Thus, there is an ... Read more >>

Vet Sci (Veterinary sciences)
[2019, 6(4):]

Cited: 0 times

View full text PDF listing >>



Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis.

Gabriella Ortiz, Ophélie Vacca, Romain Bénard, Bénédicte Dupas, Florian Sennlaub, Xavier Guillonneau, Sahel Ja, Ramin Tadayoni, Alvaro Rendon, Audrey Giocanti-Aurégan,

Purpose:The aim of this study was to define the role of dystrophin Dp71 in corneal angiogenesis. Methods:Inflammation-induced corneal neovascularization experiments were performed in Dp71-null mice and C57BL/6J wild-type mice. Results:The corneal neovascular area covered by neovascularization was larger in the injured corneas of the Dp71-null mice compared to the corneas ... Read more >>

Mol. Vis. (Molecular vision)
[2019, 25:714-721]

Cited: 0 times

View full text PDF listing >>



Effect of osmolytes on in-vitro aggregation properties of peptides derived from TGFBIp.

Anandalakshmi Venkatraman, Elavazhagan Murugan, Shu Jun Lin, Gary Swee Lim Peh, Lakshminarayanan Rajamani, Jodhbir S Mehta,

Protein aggregation has been one of the leading triggers of various disease conditions, such as Alzheimer's, Parkinson's and other amyloidosis. TGFBI-associated corneal dystrophies are protein aggregation disorders in which the mutant TGFBIp aggregates and accumulates in the cornea, leading to a reduction in visual acuity and blindness in severe cases. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4011]

Cited: 0 times

View full text PDF listing >>



TRPM3_miR-204: a complex locus for eye development and disease.

Alan Shiels,

First discovered in a light-sensitive retinal mutant of Drosophila, the transient receptor potential (TRP) superfamily of non-selective cation channels serve as polymodal cellular sensors that participate in diverse physiological processes across the animal kingdom including the perception of light, temperature, pressure, and pain. TRPM3 belongs to the melastatin sub-family of ... Read more >>

Hum. Genomics (Human genomics)
[2020, 14(1):7]

Cited: 0 times

View full text PDF listing >>



Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.

Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli,

Network medicine is a molecular-bioinformatic approach analyzing gene-gene interactions that can perturb the human interactome. This review focuses on epigenetic changes involved in several ocular diseases, such as DNA methylation, histone and nonhistone post-translational modifications, and noncoding RNA regulators. Although changes in aberrant DNA methylation play a major role in ... Read more >>

J Ophthalmol (Journal of ophthalmology)
[2019, 2019:2424956]

Cited: 0 times

View full text PDF listing >>



Clinical outcomes and time to recurrence of phototherapeutic keratectomy in Japan.

Osamu Hieda, Satoshi Kawasaki, Kiyoshi Yamamura, Mina Nakatsukasa, Shigeru Kinoshita, Chie Sotozono,

To assess the indications, outcomes and time to recurrence of phototherapeutic keratectomy (PTK) for anterior corneal pathology.This study involved 714 eyes of 477 consecutive patients (mean age: 66.0 ± 15.2 years; range: 6-101 years) who underwent PTK as the initial surgical intervention for an anterior corneal pathology. In case of each patient, ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(27):e16216]

Cited: 0 times

View full text PDF listing >>



Novel Mutations Associated With Various Types of Corneal Dystrophies in a Han Chinese Population.

Jing Zhang, Dan Wu, Yue Li, Yidan Fan, Huiyu Chen, Jiaxu Hong, Jianjiang Xu,

Aims: To study the genetic spectra of corneal dystrophies (CDs) in Han Chinese patients using next-generation sequencing (NGS). Methods: NGS-based targeted region sequencing was performed to evaluate 71 CD patients of Han Chinese ethnicity. A custom-made capture panel was designed to capture all coding exons and untranslated regions plus 25 ... Read more >>

Front Genet (Frontiers in Genetics)
[2019, 10:881]

Cited: 0 times

View full text PDF listing >>



Combined Descemet stripping automated endothelial keratoplasty and intravitreal dexamethasone implant for concomitant pseudophakic bullous keratopathy and cystoid macular edema.

Gabriella Cirigliano, Marco R Pastore, Alberto A Perrotta, Chiara De Giacinto, Daniele Tognetto,

Int J Ophthalmol (International journal of ophthalmology)
[2019, 12(5):866-869]

Cited: 0 times

View full text PDF listing >>



Peripheral iridectomy for preventing iris-related complications in glued intraocular lens surgery in children.

Divya Balakrishnan, Avadhesh Oli, Remya M Paulose, Hasnat Ali,

Purpose:To assess the role of surgical peripheral iridectomy (PI) in preventing iris-related complications associated with glued intraocular lens (GIOL) surgery in children with bilateral ectopia lentis. Methods:Nonrandomized interventional case series of 34 eyes of 17 children (<15 years of age) who underwent pars plana lensectomy (PPL) and GIOL surgery between ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2020, 68(3):466-470]

Cited: 0 times

View full text PDF listing >>



Therapeutic efficacy of mesenchymal stem cells for the treatment of congenital and acquired corneal opacity.

Mindy Call, Mohamed Elzarka, Mary Kunesh, Nanki Hura, David E Birk, Winston W Kao,

Purpose:Maintenance of a transparent corneal stroma is imperative for proper vision. The corneal stroma is composed of primarily collagen fibrils, small leucine-rich proteoglycans (SLRPs), as well as sparsely distributed cells called keratocytes. The lattice arrangement and spacing of the collagen fibrils that allows for transparency may be disrupted due to ... Read more >>

Mol. Vis. (Molecular vision)
[2019, 25:415-426]

Cited: 1 time

View full text PDF listing >>



Transforming growth factor beta-induced p.(L558P) variant is associated with autosomal dominant lattice corneal dystrophy type IV in a large cohort of Spanish patients.

Ezequiel Campos-Mollo, Yago Varela-Conde, Pedro Arriola-Villalobos, Rubén Cabrera-Beyrouti, José-Manuel Benítez-Del-Castillo, Miguel J Maldonado, Julio Escribano,

IMPORTANCE:Rare transforming growth factor beta-induced (TGFBI) gene variants are involved in autosomal dominant corneal dystrophies (CDs) with heterogeneous clinical features. BACKGROUND:The purpose of this study was to analyse TGFBI gene variants and genotype-phenotype correlations in a cohort affected by atypical stromal CD. DESIGN:Retrospective cohort study (from May 2014 to September ... Read more >>

Clin. Experiment. Ophthalmol. (Clinical & experimental ophthalmology)
[2019, 47(7):871-880]

Cited: 0 times

View full text PDF listing >>



Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease.

Patrice Tankam, Zhiguo He, Gilles Thuret, Holly B Hindman, Cristina Canavesi, Johana Coyoc Escudero, Thierry Lépine, Philippe Gain, Jannick P Rolland,

To identify the microstructural modification of the corneal layers during the course of the disease, optical technologies have been pushing the boundary of innovation to achieve cellular resolution of deep layers of the cornea. Gabor-domain optical coherence microscopy (GD-OCM), an optical coherence tomography-based technique that can achieve an isotropic of ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2019, 24(4):1-17]

Cited: 0 times

View full text PDF listing >>



Clinical and Ultrastructural Studies of Gelatinous Drop-Like Corneal Dystrophy (GDLD) of a Patient with TACSTD2 Gene Mutation.

Ali Masmali, Aljoharah Alkanaan, Hind M Alkatan, Omar Kirat, Abdullah Ayidh Almutairi, Turki Almubrad, Saeed Akhtar,

Purpose:To describe clinical, molecular genetics, histopathologic and ultrastructural findings of gelatinous drop-like corneal dystrophy (GDLD) (OMIM #204870) in a Sudanese patient. Method:An ocular examination revealed the onset of GDLD in a Sudanese patient (50 years old) at King Khalid Specialist Hospital, Riyadh. The 333 sequence variants in 13 GDLD genes of ... Read more >>

J Ophthalmol (Journal of ophthalmology)
[2019, 2019:5069765]

Cited: 0 times

View full text PDF listing >>



Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty.

Pavlina Skalicka, Lubica Dudakova, Michalis Palos, Lukas J Huna, Cerys J Evans, Gabriela Mahelkova, Martin Meliska, Tomas Stopka, Stephen Tuft, Petra Liskova,

PURPOSE:To describe the ocular findings of 12 subjects with paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS). METHODS:Ocular examination included corneal spectral domain optical coherence tomography. In three individuals with an initial diagnosis of a lattice or Thiel-Behnke corneal dystrophy, the TGFBI gene was screened by conventional Sanger ... Read more >>

Acta Ophthalmol (Acta ophthalmologica)
[2019, 97(7):e987-e992]

Cited: 1 time

View full text PDF listing >>



Repressed Wnt Signaling Accelerates the Aging Process in Mouse Eyes.

Yujin Zhang, Joseph Jeffrey, Fei Dong, Jianhua Zhang, Winston W-Y Kao, Chia-Yang Liu, Yong Yuan,

Purpose:Ocular aging is a natural process of functional decline in vision. When the process reaches a point that compromised vision affects normal daily activity, it manifests as age-related ocular diseases, such as age-related macular degeneration, cataracts, glaucoma, and pseudoexfoliation syndrome. We previously reported that repressed Wnt signaling accelerated the maturation ... Read more >>

J Ophthalmol (Journal of ophthalmology)
[2019, 2019:7604396]

Cited: 0 times

View full text PDF listing >>



Impaired Autophagic Degradation of Transforming Growth Factor-β-Induced Protein by Macrophages in Lattice Corneal Dystrophy.

Ji Han, Ming Zhang, Hai-Yan Lin, Feng-Ying Huang, Ying-Ying Lin, Guang-Hong Tan, Zhen-You Zheng,

Purpose:Lattice corneal dystrophy (LCD) is related to the denaturation of transforming growth factor-β-induced protein (TGFBIp). Autophagic degradation of the denatured proteins by macrophages is one pathway to remove the denatured proteins. Thus, we investigated the role of autophagy in the degradation of mutant (MU) TGFBIp in macrophages. Methods:Corneas from participants ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2019, 60(4):978-989]

Cited: 0 times

View full text PDF listing >>



Association of unilateral lattice corneal dystrophy on slit lamp and bilateral confocal microscopy features with H572R mutation in the TGFBI gene.

Ricardo De Sousa Peixoto, Stacey Mutch, Jacqueline Eason, Kaie Jaakson, Eneli Haamer, Veerabahu Senthil Maharajan,

Eye (Lond) (Eye (London, England))
[2019, 33(12):1973-1975]

Cited: 0 times

View full text PDF listing >>



Finnish gelsolin amyloidosis causes significant disease burden but does not affect survival: FIN-GAR phase II study.

Eeva-Kaisa Schmidt, Tuuli Mustonen, Sari Kiuru-Enari, Tero T Kivelä, Sari Atula,

BACKGROUND:Hereditary gelsolin (AGel) amyloidosis is an autosomal dominantly inherited systemic amyloidosis that manifests with the characteristic triad of progressive ophthalmological, neurological and dermatological signs and symptoms. The National Finnish Gelsolin Amyloidosis Registry (FIN-GAR) was founded in 2013 to collect clinical data on patients with AGel amyloidosis, including altogether approximately one ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):19]

Cited: 0 times

View full text PDF listing >>



Evaluation of TGFBI corneal dystrophy and molecular diagnostic testing.

Connie Chao-Shern, Lawrence A DeDionisio, Jun-Heok Jang, Clara C Chan, Vance Thompson, Kathleen Christie, M Andrew Nesbit, C B Tara McMullen,

To date, 70 different TGFBI mutations that cause epithelial-stromal corneal dystrophies have been described. At present one commercially available test examines for the five most common of these mutations: R124H, R124C, R124L, R555W, and R555Q. To expand the capability of identifying the causative mutation in the remaining cases, 57 mutations ... Read more >>

Eye (Lond) (Eye (London, England))
[2019, 33(6):874-881]

Cited: 1 time

View full text PDF listing >>



Advertisement

Disclaimer
1.9593 s