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Lacunar Syndrome

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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrPSc). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

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Haemorrhagic transformation following ischaemic stroke: A retrospective study.

S D Pande, M M Win, A A Khine, E M Zaw, N Manoharraj, L Lolong, A S Tin,

The aim of this study was to identify the prevalence of haemorrhagic transformation (HT) in patients with ischaemic stroke, and evaluate its association with medical comorbidities, stroke subtypes, premorbid medication, and long-term survival. To achieve this, we performed a retrospective analysis of 527 consecutive stroke rehabilitation patients. Of these, 102 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5319]

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Differentiation of Pontine Infarction by Size.

Lei Yang, Wei Qin, Yue Li, Shuna Yang, Hua Gu, Wenli Hu,

Purpose:We hypothesized that the current criteria may be unsuitable for lacunar pontine infarctions (LPI) diagnosis and that size criteria may indicate different stroke mechanisms. Methods:A total of 102 patients with isolated pontine infarctions were divided into a parent artery disease (PAD) and non-PAD groups according to stenosis of basilar artery. ... Read more >>

Open Med (Wars) (Open medicine (Warsaw, Poland))
[2020, 15:160-166]

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Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults.

Yiping Chen, Neil Wright, Yu Guo, Iain Turnbull, Christiana Kartsonaki, Ling Yang, Zheng Bian, Pei Pei, Dongxia Pan, Yidan Zhang, Haiqiang Qin, Yilong Wang, Jun Lv, Ming Liu, Zilong Hao, Yongjun Wang, Canqing Yu, Richard Peto, Rory Collins, Liming Li, Robert Clarke, Zhengming Chen, ,

BACKGROUND:Stroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis and treatment, little is known about the short-term and long-term prognosis after a first stroke in low-income and middle-income countries, including China. We aimed to assess the short-term and long-term risk of recurrent stroke and ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2020, 8(4):e580-e590]

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Effects of hyperhomocysteinemia on ischemic cerebral small vessel disease and analysis of inflammatory mechanisms.

Liming Cao, Yi Guo, Zhishan Zhu,

Purpose: Hyperhomocysteinemia is closely related to, but is not a confirmed risk factor of, cerebral small vessel disease (CSVD). This study aimed to determine whether hyperhomo-cysteinemia is correlated significantly with CSVD.Materials and methods: This cross-sectional study compared the homocysteine (Hcy) levels of patients with and without CSVD. High-sensitivity C-reactive protein ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-8]

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Mental disorder or conscious disturbance in epidermal growth factor receptor-tyrosine kinase inhibitor treatment of advanced lung adenocarcinoma.

Jing Zhu, Rui Zhou, Heng Xiao,

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are currently recommended by international guidelines as first-line treatment in patients with advanced EGFR-mutant non-small-cell lung cancer. With the availability of drugs, more and more patients choose EGFR-TKI treatment. However, pharmaceutical drugs used in clinical practice have side effects, such as diarrhea, paronychia, ... Read more >>

EXCLI J (EXCLI Journal)
[2020, 19:230-238]

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Expression and Significance of MicroRNA155 in Serum of Patients with Cerebral Small Vessel Disease.

Ying Guo, Dongxue Li, Jiapei Li, Nan Yang, Deyun Wang,

Objective:This study aimed to investigate the changes and significance of microRNA155 levels in serum of patients with cerebral small vessel disease (CSVD). Methods:Thirty patients with CSVD who met the inclusion criteria were selected and divided into eight patients with lacunar infarction (LI) group and 22 patients with multiple lacunar infarction ... Read more >>

J Korean Neurosurg Soc (Journal of Korean Neurosurgical Society)
[2020, :]

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Retinal Vascular Signs and Cerebrovascular Diseases.

Tyler Hyungtaek Rim, Alvin Wei Jun Teo, Henrik Hee Seung Yang, Carol Y Cheung, Tien Yin Wong,

BACKGROUND:Cerebrovascular disease (CeVD), including stroke, is a leading cause of death globally. The retina is an extension of the cerebrum, sharing embryological and vascular pathways. The association between different retinal signs and CeVD has been extensively evaluated. In this review, we summarize recent studies which have examined this association. EVIDENCE ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2020, 40(1):44-59]

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Corrigendum: Lateral Symmetry of Synergies in Lower Limb Muscles of Acute Post-stroke Patients After Robotic Intervention.

Chun Kwang Tan, Hideki Kadone, Hiroki Watanabe, Aiki Marushima, Masashi Yamazaki, Yoshiyuki Sankai, Kenji Suzuki,

[This corrects the article DOI: 10.3389/fnins.2018.00276.]. ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:113]

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Proportion of acute ischaemic strokes attributable to a cardiac aetiology in an unselected young patient population: A single centre experience.

Rahul Bahl, Magdalena Kubiak, Syarah Yusoff, Hsiu Tung, James Stirrup, André van Wyk, Kiruba Nagaratnam, Neil Ruparelia,

The incidence of acute ischaemic stroke in young patients is increasing and identifying the underlying cause is critically important with regards to their optimal management. The true proportion of cardiac causes of stroke in young patients is poorly defined. We aimed to determine the proportion of strokes attributable to cardiac ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(2):174-177]

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Risk factors associated with progressive lacunar strokes and benefit from dual antiplatelet therapy.

A Berberich, C Schneider, C Herweh, T Hielscher, T Reiff, M Bendszus, C Gumbinger, P Ringleb,

BACKGROUND AND PURPOSE:Early neurological deterioration (END) occurs in 20%-30% of patients with lacunar stroke and challenges their clinical management. This retrospective cohort study analyzed clinical and neuroimaging risk factors predicting the occurrence of END, the functional outcome after END and potential benefit from dual antiplatelet therapy (DAPT) in patients with ... Read more >>

Eur. J. Neurol. (European journal of neurology)
[2020, :]

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A Patient with Combined CADASIL and MTHFR Homozygosity.

Sidonie Ibrikji, Tarek El Halabi, Bassem Yamout,

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited disorder caused by a mutation in the NOTCH 3 gene, characterized by early onset of subcortical lacunar infarcts in the absence of vascular risk factors and cerebral microbleeds. Homozygosity for the factor Methylenetetrahydrofolate Reductase (MTHFR) is also ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:4980847]

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Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study.

Jihui Wang, Xiaodong Chen, Jinchi Liao, Li Zhou, Hongying Han, Jiong Tao, Zhengqi Lu,

BACKGROUND:Sleep fragmentation was shown to be positively associated with cognitive impairment in patients with cerebral small vessel disease (CSVD); however, the underlying mechanisms are not well characterized. In this study, we sought to clarify this issue by investigating the relationship between non breathing-related sleep fragmentation and brain imaging markers in ... Read more >>

BMC Neurol (BMC Neurology)
[2020, 20(1):98]

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Fiber Connectivity Density in Cerebral Small-Vessel Disease Patients With Mild Cognitive Impairment and Cerebral Small-Vessel Disease Patients With Normal Cognition.

Chengxia Liu, Lin Shi, Wenhao Zhu, Shiqi Yang, Pan Sun, Yuanyuan Qin, Xiangyu Tang, Shun Zhang, Yihao Yao, Zhenxiong Wang, Wenzhen Zhu, Defeng Wang,

Abnormal structural connectivity of cerebral small-vessel disease (CSVD) is associated with cognitive impairment. But the different characteristics of structural connectivity have not been elucidated in early CSVD patients. The current study aimed to investigate the potential differences of structural connectivity in CSVD patients with mild cognitive impairment (MCI) and CSVD ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:83]

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Increased platelet procoagulant potential predicts recurrent stroke and TIA after lacunar infarction.

Angelia C Kirkpatrick, Andrea S Vincent, George L Dale, Calin I Prodan,

BACKGROUND:Mean levels of coated-platelets, a subset of highly procoagulant platelets, are decreased in patients with lacunar as compared to those with non-lacunar stroke. Elevated coated-platelets are associated with increased risk for recurrent infarction in non-lacunar stroke and predict incident stroke after transient ischemic attack (TIA). OBJECTIVE:We investigated if coated-platelet levels ... Read more >>

J. Thromb. Haemost. (Journal of thrombosis and haemostasis : JTH)
[2020, 18(3):660-668]

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The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study.

Md Maruf Haque Khan, Akira Fujiyoshi, Akihiko Shiino, Takashi Hisamatsu, Sayuki Torii, Sentaro Suzuki, Ayako Kunimura, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima, ,

AIM:Coronary artery calcification (CAC) is an independent predictor of stroke and dementia, in which subclinical cerebrovascular diseases (SCVDs) play a vital pathogenetic role. However, few studies have described the association between CAC and SCVDs. Therefore, the aim of this study was to assess the clinical relationship between CAC and SCVDs ... Read more >>

J. Atheroscler. Thromb. (Journal of atherosclerosis and thrombosis)
[2020, :]

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Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke.

Jason P Appleton, Lisa J Woodhouse, Alessandro Adami, Jennifer L Becker, Eivind Berge, Lesley A Cala, Ana M Casado, Valeria Caso, Hanne K Christensen, Robert A Dineen, John Gommans, Panos Koumellis, Szabolcs Szatmari, Nikola Sprigg, Philip M Bath, Joanna M Wardlaw, ,

OBJECTIVE:To assess the association of baseline imaging markers of cerebral small vessel disease (SVD) and brain frailty with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. METHODS:ENOS randomized 4,011 patients with acute stroke (<48 hours of onset) to transdermal glyceryl trinitrate (GTN) or ... Read more >>

Neurology (Neurology)
[2020, 94(5):e439-e452]

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Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study.

Kamini Rakkar, Othman Othman, Nikola Sprigg, Philip Bath, Ulvi Bayraktutan,

Ischemic stroke is a devastating, life altering event which can severely reduce patient quality of life. Despite years of research there have been minimal therapeutic advances. Endothelial progenitor cells (EPCs), stem cells involved in both vasculogenesis and angiogenesis, may be a potential therapeutic target. After a stroke, EPCs migrate to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1300-1307]

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The study on analysis of risk factors for severity of white matter lesions and its correlation with cerebral microbleeds in the elderly with lacunar infarction.

Yu-Ni Zhou, Hao-Yuan Gao, Fang-Fang Zhao, Ying-Chun Liang, Yuan Gao, Xin-Hong Liu, Tao Wang, Zhi-Gao Wang, Qing-Jian Wu,

This study aimed to explore the risk factors for severity of white matter lesions and its correlation with in the elderly with lacunar infarction.Patients (range, 70-85 years) with lacunar infarction treated in a hospital in China from 2016 to 2017were enrolled. Fazekas rating scale (0-6 points) was used to assess ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(4):e18865]

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RNA expression studies in stroke: what can they tell us about stroke mechanism?

Sarina Falcione, Joseph Kamtchum-Tatuene, Gina Sykes, Glen C Jickling,

PURPOSE OF REVIEW:Diagnosis of stroke and understanding the mechanism of stroke is critical to implement optimal treatment. RNA expressed in peripheral blood cells is emerging as a precision biomarker to aid in stroke diagnosis and prediction of stroke cause. In this review, we summarize available data regarding the role of ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, 33(1):24-29]

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Atherosclerosis Can Be Mitochondrial: A Review.

Josef Finsterer,

One of the systems that are potentially affected in mitochondrial disorders, but hardly get systematically investigated, are the arteries. One of the phenotypic manifestations in arteries is atherosclerosis. This review focuses on the current knowledge and recent advances of mitochondrial atherosclerosis. We conducted a systematic literature review via PubMed using ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6987]

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Abnormal blood pressure circadian rhythms are relevant to cerebral infarction and Leukoaraiosis in hypertensive patients.

Kang Yang, Xiaodong Zhu, Yulan Feng, Fanxia Shen, Jie Chen, Ningzhen Fu, Jialan Sun, Yi Fu,

BACKGROUND:To investigate the relationships between blood pressure (BP) circadian rhythms and acute cerebral infarction (ACI), silent cerebral infarction (SCI) and the severity of leukoaraiosis in hypertensive patients. METHODS:A retrospective case-control study was performed among hypertensive patients with 24-h ambulatory blood pressure monitoring (ABPM) and cranial magnetic resonance imaging (MRI). RESULTS:A ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):36]

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Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker.

Sophie Lemmens, Astrid Devulder, Karel Van Keer, Johan Bierkens, Patrick De Boever, Ingeborg Stalmans,

Introduction: Ocular manifestations in several neurological pathologies accentuate the strong relationship between the eye and the brain. Retinal alterations in particular can serve as surrogates for cerebral changes. Offering a "window to the brain," the transparent eye enables non-invasive imaging of these changes in retinal structure and vasculature. Fractal dimension ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:16]

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Identifying Gaps and Missed Opportunities for Intravenous Thrombolytic Treatment of Inpatient Stroke.

Karan Topiwala, Karan Tarasaria, Ilene Staff, Dawn Beland, Erica Schuyler, Amre Nouh,

Background: Inpatient stroke-codes (ISC) have traditionally seen low treatment rates with IV-thrombolytic (IVT). The purpose of this study was to identify the predictors of true stroke, prevalent IVT-treatment gap and study the factors associated with such missed treatment opportunities (MTO). Methods: A retrospective chart review identified ISC from March 2017 ... Read more >>

Front Neurol (Frontiers in Neurology)
[2020, 11:134]

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Successful thrombolytic therapy with recombinant tissue plasminogen activator in ischemic stroke after idarucizumab administration for reversal of dabigatran: a case report.

Toshiyuki Ohtani, Ryosuke Sintoku, Tasuku Yajima, Naoyuki Kaneko,

BACKGROUND:Idarucizumab is a specific antidote for the anticoagulant dabigatran. Although its efficacy has been recently reported, the drug is still in postmarketing surveillance and requires case data in different emergency settings. A newer intravenous thrombolytic therapy with recombinant tissue plasminogen activator has been proposed after injection of idarucizumab in patients ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2019, 13(1):390]

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