Full Text Journal Articles about
LSD Toxicity

Advertisement

Find full text journal articles






Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases.

Antonio Monaco, Alessandro Fraldi,

Many neurodegenerative conditions are characterized by the deposition of protein aggregates (mainly amyloid-like) in the central nervous system (CNS). In post-mitotic CNS cells protein aggregation causes cytotoxicity by interfering with various cellular functions. Mutations in different genes may directly cause protein aggregation. However, genetic factors together with aging may contribute ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2020, 13:]

Cited: 0 times

View full text PDF listing >>



Lysergic acid diethylamide causes mouse retinal damage by up-regulating p-JAK1/p-STAT1.

Kang Chen, Xiangyu He, Chen Li, Yangjin Ou, Yiru Li, Jia Lai, Meng Lv, Xuqing Li, Ping Ran, Ying Li,

Purpose: Lysergic acid diethylamide (LSD) is a powerful hallucinogen with high potential for abuse. There is far less known about its effects on the retina, especially the underlying mechanisms. This study was to investigate the acute toxicity of LSD on the retina of C57 mice and its mechanisms of action.Methods: ... Read more >>

Cutan Ocul Toxicol (Cutaneous and ocular toxicology)
[2020, :1-5]

Cited: 0 times

View full text PDF listing >>



Advertisement

Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats.

Yafei Wang, Yuqing Tang, Zhou Li, Qihang Hua, Li Wang, Xin Song, Baobo Zou, Min Ding, Jinshun Zhao, Chunlan Tang,

To explore the joint toxicity and bio-accumulation of multi-heavy metals and potential chemoprevention strategies, Male Sprague Dawley (SD) rats (n = 30) were treated orally once a week for six months with 500mg/kg•bw of eight heavy metals which were commonly identified in aquatic products in the Ningbo area including chromium, ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(4):]

Cited: 0 times

View full text PDF listing >>



NBOMes-Highly Potent and Toxic Alternatives of LSD.

Jolanta B Zawilska, Monika Kacela, Piotr Adamowicz,

Recently, a new class of psychedelic compounds named NBOMe (or 25X-NBOMe) has appeared on the illegal drug market. NBOMes are analogs of the 2C family of phenethylamine drugs, originally synthesized by Alexander Shulgin, that contain a N-(2-methoxy)benzyl substituent. The most frequently reported drugs from this group are 25I-NBOMe, 25B-NBOMe, and ... Read more >>

Front Neurosci (Frontiers in Neuroscience)
[2020, 14:78]

Cited: 0 times

View full text PDF listing >>



25I-NBOME (2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine)-A HARMFUL HALLUCINOGEN REVIEW.

Kamińska Katarzyna, Świt Paweł, Malek Kamilla,

NBOMes are N-benzylmethoxy derivatives of the 2C family compounds with N-2-methoxy-benzyl moiety substituted by the methoxy group at the 2- and 5- position and the halogen group at the 4- position of the phenyl ring. These substances are a new class of potent serotonin 5-HT2A receptor agonist hallucinogens with potential ... Read more >>

J Anal Toxicol (Journal of analytical toxicology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Lysosomal Abnormalities in Cardiovascular Disease.

Congwu Chi, Andrew S Riching, Kunhua Song,

The lysosome, a key organelle for cellular clearance, is associated with a wide variety of pathological conditions in humans. Lysosome function and its related pathways are particularly important for maintaining the health of the cardiovascular system. In this review, we highlighted studies that have improved our understanding of the connection ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

Cited: 0 times

View full text PDF listing >>



Modulation of Cadmium Tolerance in Rice: Insight into Vanillic Acid-Induced Upregulation of Antioxidant Defense and Glyoxalase Systems.

M H M Borhannuddin Bhuyan, Khursheda Parvin, Sayed Mohammad Mohsin, Jubayer Al Mahmud, Mirza Hasanuzzaman, Masayuki Fujita,

Cadmium (Cd) is a toxic heavy metal that enters the human food chain from the soil via plants. Increased Cd uptake and translocation in plants alters metabolism andreduces crop production. Maintaining crop yield therefore requires both soil remediation andenhanced plant tolerance to Cd. In this study, we investigated the effects ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(2):]

Cited: 0 times

View full text PDF listing >>



Nitrate improves hackberry seedling growth under cadmium application.

Mansoure Hatamian, Abdolhossein Rezaei Nejad, Mohsen Kafi, Mohammad Kazem Souri, Karim Shahbazi,

The environmental toxicity of heavy metals in particular cadmium is a public concern. Cadmium is toxic for all living organisms including plants; however, plant species may show different tolerance to the presence of cadmium in their root medium. Adopting practical strategies may reduce cadmium bioavailability or increase the plant tolerance. ... Read more >>

Heliyon (Heliyon)
[2020, 6(1):e03247]

Cited: 0 times

View full text PDF listing >>



Exogenous Brassinolide Alleviates Salt Stress in Malus hupehensis Rehd. by Regulating the Transcription of NHX-Type Na+(K+)/H+ Antiporters.

Qiufang Su, Xiaodong Zheng, Yike Tian, Caihong Wang,

Brassinolide (BL) mediates various physiological processes and improves plant tolerance to abiotic stresses. However, the effects and mechanism of exogenous BL on the salt tolerance of apple seedlings remain unclear. Herein, we investigated the role of BL in the salt stress response of Malus hupehensis Rehd., a widely grown apple ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2020, 11:38]

Cited: 0 times

View full text PDF listing >>



Nickel Toxicity Induced Changes in Nutrient Dynamics and Antioxidant Profiling in Two Maize (Zea mays L.) Hybrids.

Muhammad Amjad, Hasan Raza, Behzad Murtaza, Ghulam Abbas, Muhammad Imran, Muhammad Shahid, Muhammad Asif Naeem, Ali Zakir, Muhammad Mohsin Iqbal,

Abstract: Nickel (Ni) is among the essential micronutrient heavy metals utilized by plants. However, an elevated level of Ni causes serious concerns for plants' physiology and their survival. This study evaluated the mechanisms influencing the growth, physiology, and nutrient dynamics in two commercial maize hybrids (Syngenta and Pioneer) exposed to ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2019, 9(1):]

Cited: 0 times

View full text PDF listing >>



β-Aminobutyric Acid Pretreatment Confers Salt Stress Tolerance in Brassica napus L. by Modulating Reactive Oxygen Species Metabolism and Methylglyoxal Detoxification.

Jubayer Al Mahmud, Mirza Hasanuzzaman, M Iqbal Raza Khan, Kamrun Nahar, Masayuki Fujita,

Salinity is a serious environmental hazard which limits world agricultural production by adversely affecting plant physiology and biochemistry. Hence, increased tolerance against salt stress is very important. In this study, we explored the function of β-aminobutyric acid (BABA) in enhancing salt stress tolerance in rapeseed (Brassica napus L.). After pretreatment ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(2):]

Cited: 0 times

View full text PDF listing >>



Effect of biodegradable chelators on induced phytoextraction of uranium- and cadmium- contaminated soil by Zebrina pendula Schnizl.

Li Chen, Dan Wang, Chan Long, Zheng-Xu Cui,

This study investigated the effect of ethylenediamine-N,N'-disuccinic acid (EDDS), oxalic acid (OA), and citric acid (CA) on phytoextraction of U- and Cd-contaminated soil by Z. pendula. In this study, the biomass of tested plant inhibited significantly following treatment with the high concentration (7.5 mmol·kg-1) EDDS treatment. Maximum U and Cd concentration ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19817]

Cited: 0 times

View full text PDF listing >>



Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish.

Chuanrui Zheng, Letian Shan, Peijian Tong, Thomas Efferth,

Although artesunate (ART) is generally accepted as a safe and well-tolerated first-line treatment of severe malaria, cases of severe side effects and toxicity of this compound are also documented. This study applied larval zebrafishes to determine the acute toxicity and efficacy of ART and performed RNA-sequencing analyses to unravel the ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(1):1559325819897180]

Cited: 0 times

View full text PDF listing >>



Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats.

Katarina Baralić, Aleksandra Buha Djordjevic, Katarina Živančević, Evica Antonijević, Milena Anđelković, Dragana Javorac, Marijana Ćurčić, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić,

Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 -ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(3):]

Cited: 0 times

View full text PDF listing >>



[Neurotrophic mechanisms of psychedelic therapy].

Rémi Corne, Raymond Mongeau,

Psychedelic drugs, often referred to as hallucinogens, are quite distinct from other classes of psychotropic drugs. Although the subjective and behavioral effects they induce are quite dramatic, they possess little addictive potential when compared to nicotine, alcohol or opiates. Since the discovery of ketamine antidepressant effects, there has been growing ... Read more >>

Biol Aujourdhui (Biologie aujourd'hui)
[2019, 213(3-4):121-129]

Cited: 0 times

View full text PDF listing >>



The Hydroalcoholic Extract of Saffron Protects PC12 Cells against Aluminum-Induced Cell Death and Oxidative Stress in Vitro.

Shokofeh Rahmani, Jamileh Saberzadeh, Mohammad Ali Takhshid,

Background:Aluminum (Al) exposure is among the environmental risk factors that may involve in the pathogenesis of neurodegenerative diseases. Oxidative stress has a critical role in the Al-induced toxicity. Saffron is a plant with potent radical scavenging and anti-oxidative properties. This investigation was designed to evaluate the possible protective effects of ... Read more >>

Iran J Med Sci (Iranian journal of medical sciences)
[2020, 45(1):59-66]

Cited: 0 times

View full text PDF listing >>



Long-Term Exposure to Benzo[a]Pyrene Affects Sexual Differentiation and Embryos Toxicity in Three Generations of Marine Medaka (Oryzias Melastigma).

Dong Sun, Qi Chen, Bo Zhu, Yu Lan, Shunshan Duan,

Benzo[a]pyrene (BaP) is a common environmental disrupting chemical that can cause endocrine disorders in organisms. However, the continued interference effects of BaP on multi-generation fish needs further research. In this study, we performed different periods (G1F1-3, G2F2-3, G3F3) of BaP exposure on marine medaka. We determined the embryo toxicity, and ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(3):]

Cited: 0 times

View full text PDF listing >>



Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.

Simona Di Martino, Piero Tardia, Vincenzo Cilibrasi, Samantha Caputo, Marco Mazzonna, Debora Russo, Ilaria Penna, Natalia Realini, Natasha Margaroli, Marco Migliore, Daniela Pizzirani, Giuliana Ottonello, Sine Mandrup Bertozzi, Andrea Armirotti, Duc Nguyen, Ying Sun, Ernesto R Bongarzone, Peter Lansbury, Min Liu, Renato Skerlj, Rita Scarpelli,

Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Postpartum histoplasmosis in an HIV-negative woman: a case report and phylogenetic characterization by internal transcribed spacer region analysis.

Lisandra Serra Damasceno, Antônio Mauro Barros Almeida Júnior, Bárbara de Oliveira Aguiar, Mauro de Medeiros Muniz, Marcos de Abreu Almeida, Rosely Maria Zancopé-Oliveira, Terezinha do Menino Jesus Silva Leitão,

The present report describes the first case of postpartum disseminated histoplasmosis in a 24-year-old HIV-negative woman. On the tenth day after vaginal delivery, the patient presented with dyspnea, fever, hypotension, tachycardia, and painful hepatomegaly. Yeast-like Histoplasma capsulatum features were isolated in the buffy coat. The phylogenetic analysis demonstrated that the ... Read more >>

Rev. Soc. Bras. Med. Trop. (Revista da Sociedade Brasileira de Medicina Tropical)
[2020, 53:e20190364]

Cited: 0 times

View full text PDF listing >>



Serotonin Syndrome in the Emergency Department.

Michelle Hernandez, Michael Walsh, Trilok Stead, Anines Quinones, Latha Ganti,

With the widespread use of serotonergic agents including many antidepressants, antiemetics, illicit drugs, and even some herbal supplements, serotonin syndrome is a condition seen more frequently. It can appear abruptly and, if untreated, can progress to a life-threatening state. Prompt recognition and treatment is imperative to avoid complications. The presentation ... Read more >>

Cureus (Cureus)
[2019, 11(12):e6307]

Cited: 0 times

View full text PDF listing >>



Anthracene phytotoxicity in the freshwater flagellate alga Euglena agilis Carter.

Sreejith Kottuparambil, Jihae Park,

The freshwater flagellate alga Euglena agilis Carter was exposed to the polycyclic aromatic hydrocarbon (PAH) anthracene for 96 h under optimal photosynthetically active radiation (PAR), and responses of growth, photosynthetic pigment production, and photosynthetic efficiency were assessed. Anthracene reduced the growth rate (μ) and levels of chlorophyll a (Chl a), chlorophyll ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15323]

Cited: 0 times

View full text PDF listing >>



Autophagy in the Central Nervous System and Effects of Chloroquine in Mucopolysaccharidosis Type II Mice.

Mitsuyo Maeda, Toshiyuki Seto, Chiho Kadono, Hideto Morimoto, Sachiho Kida, Mitsuo Suga, Motohiro Nakamura, Yosky Kataoka, Takashi Hamazaki, Haruo Shintaku,

Mucopolysaccharidosis type II (MPS II) is a rare lysosomal storage disease (LSD) involving a genetic error in iduronic acid-2-sulfatase (IDS) metabolism that leads to accumulation of glycosaminoglycans within intracellular lysosomes. The primary treatment for MPS II, enzyme replacement therapy, is not effective for central nervous system (CNS) symptoms, such as ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(23):]

Cited: 0 times

View full text PDF listing >>



The chemotactic properties of various topical brimonidine tartrate ophthalmic preparations.

Ruiz Simonato Alonso, Helena Parente Solari, Eduardo de França Damasceno, Miguel Noel Nascentes Burnier, Marcelo Palis Ventura,

BackgroundThe study aimed to evaluate and compare the leukocyte chemotactic activities of various brimonidine tartrate (BT) eye drop formulations.MethodsA 96-well dot-blot platet using a Boyden-style well was used to study the chemotactic effects of BT ophthalmic preparations. A modification was made to create blind wells where the tested agents were ... Read more >>

BMC Pharmacol Toxicol (BMC Pharmacology & Toxicology)
[2020, 21:]

Cited: 0 times

View full text PDF listing >>



Targeting Macromolecules to CNS and Other Hard-to-Treat Organs Using Lectin-Mediated Delivery.

Walter Acosta, Carole L Cramer,

The greatest challenges for therapeutic efficacy of many macromolecular drugs that act on intracellular are delivery to key organs and tissues and delivery into cells and subcellular compartments. Transport of drugs into critical cells associated with disease, including those in organs protected by restrictive biological barriers such as central nervous ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

Cited: 0 times

View full text PDF listing >>



DARK Classics in Chemical Neuroscience: NBOMes.

Christian B M Poulie, Anders A Jensen, Adam L Halberstadt, Jesper L Kristensen,

N-Benzylphenethylamines, commonly known as NBOMes, are synthetic psychedelic compounds derived from the phenethylamine class of psychedelics (2C-X compounds), which originally have been derived from the naturally occurring alkaloid mescaline. Analogously to their parent compounds and other classical psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), NBOMes are believed to ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2019, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
2.8622 s