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Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases.

Mustafa Durgun, Cüneyt Türkeş, Mesut Işık, Yeliz Demir, Ali Saklı, Ali Kuru, Abdussamat Güzel, Şükrü Beydemir, Suleyman Akocak, Sameh M Osman, Zeid AlOthman, Claudiu T Supuran,

Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, 13C NMR, 1H NMR, LC-MS and elemental analysis. Their inhibitory effect on AChE, and carbonic anhydrase I and II enzyme activities was investigated. Their antioxidant activity was determined using ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):950-962]

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25 years of yeast prions.

Frank Shewmaker, Dan Masison,

Prion (Prion)
[2020, 14(1):29-30]

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The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study.

K N Kose, S Yilmaz, U Noyan, B Kuru, H S Yildirim, O B Agrali, H O Ozener, L Kuru,

Background:Amlodipine, calcium channel blocker (CCB), is used in the management of cardiovascular diseases which causes gingival overgrowth (GO). The growth factors may have a role in the pathogenesis of amlodipine-induced GO. Objectives:This pilot study aimed to investigate the growth factors including transforming growth factor-b1 (TGF-b1), platelet-derived growth factor-BB (PDGF-BB), and ... Read more >>

Niger J Clin Pract (Nigerian journal of clinical practice)
[2020, 23(4):561-567]

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Determination of the Prevalence From Clinical Diagnosis of Sacroiliac Joint Dysfunction in Patients With Lumbar Disc Hernia and an Evaluation of the Effect of This Combination on Pain and Quality of Life.

Hilal Telli, Berrin Hüner, Ömer Kuru,

STUDY DESIGN:A prospective cross-sectional study. OBJECTIVE:To evaluate the prevalence of sacroiliac joint dysfunction in patients with lumbar disc hernia and examine the variations in clinical parameters cause by this combination. SUMMARY OF BACKGROUND DATA:Although one of the many agents leading to lumbar pain is sacroiliac dysfunction, little progress has still ... Read more >>

Spine (Spine)
[2020, 45(8):549-554]

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Recent kuru-induced female gene flow disrupted the coevolution of genes and languages in the Papua New Guinea highlands.

Mian Li, Kate L DeRosa, Hayley Mann, Rita Spathis, Amanda Roome, Daniel Castellanos, Kyle Gowen, Timothy S de Smet, Jessica Echard, Kalen Casey, Michel Shamoon-Pour, Ralph M Garruto, Koji Lum,

OBJECTIVES:The island of New Guinea was settled by modern human over 50,000 years ago, and is currently characterized by a complex landscape and contains one-seventh of the world's languages. The Eastern Highlands of New Guinea were also the home to the devastating prion disease called kuru that primarily affected Fore-speaking populations, ... Read more >>

Am. J. Phys. Anthropol. (American journal of physical anthropology)
[2020, :]

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Comparison of Root Surface Wear and Roughness Resulted from Different Ultrasonic Scalers and Polishing Devices Applied on Human Teeth: An In-Vitro Study.

Muhammed Bedir Mahiroglu, Erkut Kahramanoglu, Mustafa Ay, Leyla Kuru, Omer Birkan Agrali,

The aim of the present study was to compare the root surface wear and roughness, resulted from the professional dental hygiene instruments, including ultrasonic dental scalers, rubber prophy cups, and nylon bristle brushes, on the extracted human mandibular incisor teeth. Teeth (n = 80) were randomly assigned into eight groups ... Read more >>

Healthcare (Basel) (Healthcare (Basel, Switzerland))
[2020, 8(1):]

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Comment on Liberski, Gajos, Sikorska, and Lindenbaum: "Kuru, the First Human Prion Disease" Viruses 2019, 11, 232.

William Arens,

I would like to comment on an unsupported charge published in Viruses [...]. ... Read more >>

Viruses (Viruses)
[2020, 12(3):]

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The importance of mesorectum motion in determining PTV margins in rectal cancer patients treated with neoadjuvant radiotherapy.

Zumre Arican Alickikus, Ahmet Kuru, Barbaros Aydin, Dogukan Akcay, Ilknur Bilkay Gorken,

New precision radiotherapy (RT) techniques reduce the uncertainties in localizing soft and moving tumors. However, there are still many uncontrollable internal organ movements. In our study, patients who underwent neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer were evaluated to determine inter-fraction mesorectum motion and dosimetric changes. Fourteen patients treated with NA-CRT ... Read more >>

J. Radiat. Res. (Journal of radiation research)
[2020, 61(2):335-342]

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Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study.

Gamze Kavuncu, Ayse Mine Yilmaz, Betul Karademir Yilmaz, Pinar Yilmaz Atali, Elif Cigdem Altunok, Leyla Kuru, Omer Birkan Agrali,

The aim of this study is to determine the cytotoxicity of three different nano composite resins (CRs) on human gingival fibroblast (hGF) and periodontal ligament fibroblast (hPDLF) cell lines. These CRs selected were nanohybrid organic monomer-based Admira Fusion (AF), nanohybrid Bis-(acryloyloxymethyl) tricyclo 5.2.1.0.sup.2,6 decane-based Charisma Topaz (CT), and supra nano ... Read more >>

Biomedicines (Biomedicines)
[2020, 8(3):]

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Intelligent autonomous treatment of bedwetting using non-invasive wearable advanced mechatronics systems and MEMS sensors : Intelligent autonomous bladder monitoring to treat NE.

Kaya Kuru, Darren Ansell, Martin Jones, Benjamin Jon Watkinson, Noreen Caswell, Peter Leather, Andrew Lancaster, Paula Sugden, Eleanor Briggs, Carl Davies, Teik Chooi Oh, Kina Bennett, Christian De Goede,

Post-void alarm systems to monitor bedwetting in nocturnal enuresis (NE) have been deemed unsatisfactory. The aim of this study is to develop a safe, comfortable and non-invasive pre-void wearable alarm and associated technologies using advanced mechatronics. Each stage of development includes patient and public involvement and engagement (PPI). The early ... Read more >>

Med Biol Eng Comput (Medical & biological engineering & computing)
[2020, :]

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Effects of early mobilization and weight bearing on postoperative walking ability and pain in geriatric patients operated due to hip fracture: a retrospective analysis.

Tolgahan Kuru, Haci Ali Olçar,

Background/aim:Hip fractures in older adults are associated with high morbidity, mortality, and subsequent hospital costs and decreased quality of life. The objective of this study was to evaluate geriatric patients who underwent partial prosthesis surgery following hip fracture and effects of early mobilization and weight bearing on postoperative walking ability ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(1):117-125]

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Is it possible to discriminate pulmonary carcinoids from hamartomas based on CT features?

Aysegul Gursoy Coruh, Melahat Kul, Diğdem Kuru Öz, Bülent Yenigün, Cevriye Cansız Ersöz, Funda Özalp Ateş, Çetin Atasoy,

PURPOSE:The purpose of this study was to determine whether the computed tomography (CT) features might be used in distinguishing pulmonary carcinoids from hamartomas. MATERIALS AND METHODS:Ninety solid pulmonary nodules (43 carcinoids and 47 hamartomas) in 90 patients were evaluated. The following CT scan features were evaluated: size, location (peripheral/central), contour ... Read more >>

Clin Imaging (Clinical imaging)
[2020, 62:49-56]

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The INTERNET STUDY: A phase II study of everolimus in patients with fluorodeoxyglucose (18 F) positron-emission tomography positive intermediate grade pancreatic neuroendocrine tumors.

Mei Sim Lung, Rodney J Hicks, Nick Pavlakis, Emma Link, Michael Jefford, Benjamin Thomson, David K Wyld, Winston Liauw, Timothy Akhurst, Narmatha Kuru, Michael Michael,

AIMS:This multicenter phase II trial evaluates the efficacy of everolimus in poor prognosis grade 2 (G2) pancreatic neuroendocrine tumors (PNETs), defined by 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) avidity. FDG-PET avidity in NETs is associated with a significantly higher risk of death, outperforming Ki-67 index or liver metastases as a poor ... Read more >>

Asia Pac J Clin Oncol (Asia-Pacific journal of clinical oncology)
[2020, :]

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Patient Engagement in Medical Device Design: Refining the Essential Attributes of a Wearable, Pre-Void, Ultrasound Alarm for Nocturnal Enuresis.

Noreen Caswell, Kaya Kuru, Darren Ansell, Martin J Jones, Benjamin Jon Watkinson, Peter Leather, Andrew Lancaster, Paula Sugden, Eleanor Briggs, Carl Davies, Chooi Oh, Kina Bennett, Christian DeGoede,

BACKGROUND:To date, no pre-void wearable alarm exists to treat nocturnal enuresis (NE)-night-time bedwetting, and children with NE and their families are disappointed in relation to the post-void moisture alarms and medicine currently available. Development of a safe, comfortable and non-invasive wearable pre-void alarm and associated technology, using advanced mechatronics, is ... Read more >>

Pharmaceut Med (Pharmaceutical medicine)
[2020, 34(1):39-48]

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Profilometric Analysis of Periodontally Diseased Root Surfaces After Application of Different Instrumentation Tools: An In Vitro Study.

Hare Gürsoy, Ogul Leman Tunar, Gizem Ince Kuka, Ebru Ozkan Karaca, Hazel Kocabaş, Bahar Eren Kuru,

Objective: The topography of the root surface plays an important role in plaque accumulation, cell adhesion, and periodontal healing. The aim of this study is to profilometrically evaluate the root surface changes following the instrumentation using different tools. Methods: Forty dentin blocks of buccal and lingual root surfaces were obtained ... Read more >>

Photobiomodul Photomed Laser Surg (Photobiomodulation, photomedicine, and laser surgery)
[2020, 38(3):181-185]

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Peri-implantitis and Severity Level.

Eser Elemek, Omer Birkan Agrali, Bahar Kuru, Leyla Kuru,

OBJECTIVES: Different diagnostic criteria were used for diagnosis of peri-implant diseases. The aim of this cross-sectional study was to explore prevalence of peri-implant diseases and subclassify peri-implantitis based on different levels of radiographic and clinical findings. MATERIALS AND METHODS: Two hundred patients having 655 dental implants were included in this study. In ... Read more >>

Eur J Dent (European journal of dentistry)
[2020, 14(1):24-30]

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[Study of care practices for patients with myotonic dystrophy in Japan-Nationwide patient survey].

Masanori P Takahashi, Risa Yamamoto, Tomoya Kubota, Tohru Matsuura, Keiko Ishigaki, Yoshihide Sunada, Hirofumi Komaki, Hiroto Takada, Satoshi Kuru, Tsuyoshi Matsumura,

We conducted a comprehensive anonymous questionnaire survey on medical care and treatment for patients with myotonic dystrophy, who registered in the Japanese national registry (Remudy) or were undergoing care in seven hospitals specializing neuromuscular diseases. The questionnaire consisted of 49 questions were distributed to 813 patients, and 342 valid responses ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2020, 60(2):130-136]

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Evaluation of the Quality and Reliability of YouTube Videos on Rotator Cuff Tears.

Tolgahan Kuru, H Yener Erken,

Introduction The objective of this study was to investigate quality and scientific accuracy of videos related to rotator cuff tear on YouTube. Methods Term of "rotator cuff tear" was entered to the searching bar of YouTube and the first 50 YouTube videos about rotator cuff tear with the highest view ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6852]

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Surgical Trends in Breast Cancer in Turkey: An Increase in Breast-Conserving Surgery.

Güldeniz Karadeniz Çakmak, Selman Emiroğlu, Atakan Sezer, Nuh Zafer Canturk, Levent Yeniay, Bekir Kuru, Hasan Karanlık, Aykut Soyder, Şehsuvar Gökgöz, Gürhan Sakman, Muhammed Ucuncu, Mufide Nuran Akcay, Sadullah Girgin, Sibel Ozkan Gurdal, Mustafa Emiroglu, Serdar Ozbas, Abdullah Bahadir Öz, Cumhur Arici, Osman Toktas, Orhan Demircan, Adnan Çalık, Ayfer Kamali Polat, Gokturk Maralcan, Seher Demirer, Vahit Ozmen,

PURPOSE:Breast cancer is the most frequent cancer in women, and there is a great variability in surgical practice for treating that cancer in different countries. The aims of this study were to analyze the effect of guidelines from the Turkish Federation of Breast Diseases Societies on academic institutions that have ... Read more >>

JCO Glob Oncol (JCO global oncology)
[2020, 6:285-292]

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History of pancreatic surgery in Japan: Respect to the Japanese pioneers of pancreatic surgery.

Hiroki Yamaue,

AbstractThe first report of pancreatoduodenectomy was the abstract of Japan Surgical Society in 1946 by Kuru, followed by a publication by Yoshioka (Geka, 1950). The first report of total pancreatectomy was done by Honjo in 1950 (Shujutsu). Thus, the history of pancreatic surgery in Japan dawned in the 1950s. From ... Read more >>

Ann Gastroenterol Surg (Annals of Gastroenterological Surgery)
[2020, 4(2):118-125]

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Plaque Inhibitory Effect of Hyaluronan-Containing Mouthwash in a 4-Day Non-Brushing Model.

Begüm Gizligoz, Gizem Ince Kuka, Ogul Leman Tunar, Ebru Ozkan Karaca, Hare Gursoy, Bahar Kuru,

PURPOSE:Despite being the gold standard antiplaque agent, chlorhexidine (CHX) has many adverse effects that make scientists search for new agents to combat biofilms as effective as CHX. Hyaluronan, also known as hyaluronic acid (HA), is a natural polysaccharide with anti-inflammatory, antioxidant and bacteriostatic properties. The objectives were to evaluate the ... Read more >>

Oral Health Prev Dent (Oral health & preventive dentistry)
[2020, 18(1):61-69]

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The impact of the presence of fibromyalgia on fatigue in patients with psoriatic arthritis: comparison with controls.

Yasemin Ulus, Yesim Akyol, Ayhan Bilgici, Omer Kuru,

BACKGROUND:Coexisting fibromyalgia (FM) to psoriatic arthritis (PsA) has been identified and it has been associated with more severe symptoms, impaired function, and greater disability. It was aimed to explore the effect of the presence of FM on fatigue in patients with PsA comparing with controls. METHODS:Fifty patients with PsA and ... Read more >>

Adv Rheumatol (Advances in rheumatology (London, England))
[2019, 60(1):1]

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Professional care team burden scale: cross-cultural adaptation and psychometric properties of the Turkish version.

Bilge Kalanlar, Nilgün Kuru Alici,

INTRODUCTION:Care teams in nursing homes have to meet the expectations of the people they care for, their relatives and the institutions. This affects the quality of the care. An increased care burden may negatively affect the quality of work, lives and the health of formal caregivers. OBJECTIVES:This methodological cross-sectional study ... Read more >>

Scand J Caring Sci (Scandinavian journal of caring sciences)
[2019, :]

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Erratum for the Report: "Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division" by A. W. Bisson-Filho, Y.-P. Hsu, G. R. Squyres, E. Kuru, F. Wu, C. Jukes, Y. Sun, C. Dekker, S. Holden, M. S. VanNieuwenhze, Y. V. Brun, E. C. Garner.

Science (Science (New York, N.Y.))
[2020, 367(6475):]

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Assessment of Spatiotemporal Gait Parameters in Patients with Lumbar Disc Herniation and Patients with Chronic Mechanical Low Back Pain.

Masoud Bonab, Tugba Kuru Colak, Zafer Orkun Toktas, Deniz Konya,

AIM:To assess spatiotemporal gait parameters in patients with lumbar disc herniation (LDH) and chronic mechanical low back pain (CMLBP), and compare with healthy control group. MATERIAL AND METHODS:A total of 70 patients was enrolled in this prospective, controlled cross-sectional study, of which 25 with LDH, 25 with CMLBP and 20 ... Read more >>

Turk Neurosurg (Turkish neurosurgery)
[2020, 30(2):277-284]

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