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The MLK-1/SCD-4 Mixed Lineage Kinase/MAP3K functions to promote dauer formation upstream of DAF-2/InsR.

Neal R Rasmussen, Harold E Smith, David J Reiner,

The <i>C. elegans</i> dauer is an alternative third stage larva induced by dense population and adverse environmental conditions. Genes whose mutants caused dauer formation constitutive (Daf-c) and dauer formation defective (Daf-d) phenotypes were ordered via epistasis into a signaling network, with upstream DAF-7/TGF-beta and DAF-11/receptor guanylyl cyclase defining sensory branches ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Saul-Wilson Syndrome Missense Allele Does Not Show Obvious Golgi Defects in a C. elegans Model.

Isabella Zafra, Benjamin Nebenfuehr, Andy Golden,

Saul-Wilson Syndrome is an ultra-rare skeletal syndrome caused by a mutation in the COG4 gene resulting in a glycine-to-arginine substitution at amino acid position 516. The COG4 gene encodes one of 8 subunits of the conserved oligomeric Golgi complex. Using CRISPR-Cas9, our lab generated a <i>C. elegans</i> model for Saul-Wilson ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 1 time

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Expression of an endosome-excluded Cd63 prevents axis elongation in Xenopus.

Jennifer Kreis, Ramona Bonß, Kerstin Feistel, Philipp Vick,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Pharyngeal pumping phenotypes of common fluorescently-tagged C. elegans strains.

Rosemary Bauer, Andy Golden,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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fs(1)A13041 is a 5' UTR deletion of the essential gene small ovary in Drosophila.

Myles Hammond, Jillian G Gomez, Brian Oliver, Steve Kucera, Leif Benner,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The fasn-1(g14ts) allele is a Gly1830Arg missense mutation in C. elegans FASN-1.

Xiaofei Bai, David Woodbury, Andy Golden,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The mir-35-42 binding site in the nhl-2 3'UTR is dispensable for development and fecundity.

Bing Yang, Katherine McJunkin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 1 time

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Resolving a contradiction: full gene deletion of kqt-3 by CRISPR does not lead to pharyngeal pumping defects.

Rosemary Bauer, Benjamin Nebenfuehr, Andy Golden,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 0 times

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Drosophila balancer reengineering using polycistronic gRNA for CRISPR/Cas9 gene editing.

Leif Benner, Brian Oliver,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

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Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response.

Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han,

<h4>Context</h4>Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs). Aspirin could prevent cardiomyocyte damage by inducing heat shock response.<h4>Objective</h4>This study investigates the effect of aspirin on alleviating VSMC calcification.<h4>Materials and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):17-24]

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The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics.

Leon G Coleman,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1020-1022]

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In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas.

Bo-Yan Liu, Jun-Li Xue, Qian-Qian Gu, Min Zhao, Meng-Yu Zhang, Ming-Yue Wang, Yun Wang, Shu-Cun Qin,

Medical effects of hydrogen have been reported in many studies. Due to difficulties in measuring hydrogen concentration in vivo after intake and high explosive risks of hydrogen, studies about dose-response relationships and tissue concentrations of hydrogen are few. Here, for the first time, we monitored real-time hydrogen concentrations in different ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(3):107-112]

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Biomarker Rule-in or Rule-out in Patients With Acute Diseases for Validation of Acute Kidney Injury in the Emergency Department (BRAVA): A Multicenter Study Evaluating Urinary TIMP-2/IGFBP7.

Hyun Suk Yang, Mina Hur, Kyeong Ryong Lee, Hanah Kim, Hahn Young Kim, Jong Won Kim, Mui Teng Chua, Win Sen Kuan, Horng Ruey Chua, Chagriya Kitiyakara, Phatthranit Phattharapornjaroen, Anchalee Chittamma, Thiyapha Werayachankul, Urmila Anandh, Sanjeeva Herath, Zoltan Endre, Andrea Rita Horvath, Paola Antonini, Salvatore Di Somma, ,

<h4>Background</h4>Urine tissue inhibitor of metalloproteinases-2/insulin-like growth factor-binding protein 7 (TIMP-2/IGFBP7) (NephroCheck, Ortho Clinical Diagnostics, Raritan, NJ, USA) is a US Food and Drug Administration-approved biomarker for risk assessment of acute kidney injury (AKI) in critically ill adult patients in intensive care units; however, its clinical impact in the emergency department ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):178-187]

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Management of Acute Kidney Injury/Renal Replacement Therapy in the Intensive Care Unit.

Salma Shaikhouni, Lenar Yessayan,

Common causes of acute kidney injury (AKI) in the ICU setting include acute tubular necrosis (due to shock, hemolysis, rhabdomyolysis, or procedures that compromise renal perfusion), abdominal compartment syndrome, urinary retention, and interstitial nephritis. Treatment is geared toward addressing the underlying cause. Dialysis may be required if renal injury does ... Read more >>

Surg Clin North Am (The Surgical clinics of North America)
[2022, 102(1):181-198]

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Diagnostic Characteristics of Urinary Red Blood Cell Distribution Incorporated in UF-5000 for Differentiation of Glomerular and Non-Glomerular Hematuria.

Hanwool Cho, Jaeeun Yoo, Hyunjung Kim, Hyunsik Jang, Yonggoo Kim, Hyojin Chae,

<h4>Background</h4>Automated urine sediment analysis has been developed to address the limitations of microscopic examination of dysmorphic red blood cells (RBCs). We evaluated the urinary RBC distribution (URD) parameter of a recently launched automated urinary flow cytometry analyzer, UF-5000 (Sysmex, Kobe, Japan), to differentiate glomerular hematuria (GH) from non-GH (NGH).<h4>Methods</h4>Samples submitted ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):160-168]

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Novel approaches to hypoglycemia and burnt-out diabetes in chronic kidney disease.

Connie M Rhee, Kamyar Kalantar-Zadeh, Katherine R Tuttle,

<h4>Purpose of review</h4>Diabetes mellitus is a leading cause of chronic kidney disease (CKD) that confers faster kidney disease progression, higher mortality, and various metabolic derangements including hypoglycemia.<h4>Recent findings</h4>Even in the absence of diabetes mellitus, growing research demonstrates that CKD patients are at heightened risk for hypoglycemia via multiple pathways. In ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):72-81]

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Novel monitoring of renal function and medication levels in saliva and capillary blood of patients with kidney disease.

Manal Beshay, Connie M Rhee, Kamyar Kalantar-Zadeh,

<h4>Purpose of review</h4>Serum creatinine, urea, and cystatin C are the main biomarkers used to estimate glomerular filtration rates in persons with and without chronic kidney disease (CKD). Frequent measurements of these assays are needed to identify patients with earlier stages of CKD, detect episodes of acute kidney injury (AKI), and ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):100-108]

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Kidney in the net of acute and long-haul coronavirus disease 2019: a potential role for lipid mediators in causing renal injury and fibrosis.

Kate C Chiang, John D Imig, Kamyar Kalantar-Zadeh, Ajay Gupta,

<h4>Purpose of review</h4>Severe COVID-19 disease is often complicated by acute kidney injury (AKI), which may transition to chronic kidney disease (CKD). Better understanding of underlying mechanisms is important in advancing therapeutic approaches.<h4>Recent findings</h4>SARS-CoV-2-induced endothelial injury initiates platelet activation, platelet-neutrophil partnership and release of neutrophil extracellular traps. The resulting thromboinflammation causes ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):36-46]

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Kidney dysfunction requiring dialysis is a heterogeneous syndrome: we should treat it like one.

Mariana Murea, Jennifer E Flythe, Rastogi Anjay, Abdel-Rahman M Emaad, Nupur Gupta, Cassandra Kovach, Tushar J Vachharajani, Kamyar Kalantar-Zadeh, Francesco G Casino, Carlo Basile,

<h4>Purpose of review</h4>Advanced kidney failure requiring dialysis, commonly labeled end-stage kidney disease or chronic kidney disease stage 5D, is a heterogeneous syndrome -a key reason that may explain why: treating advanced kidney dysfunction is challenging and many clinical trials involving patients on dialysis have failed, thus far. Treatment with dialytic ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):92-99]

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Nutritional and dietary interventions to prolong renal allograft survival after kidney transplantation.

Ekamol Tantisattamo, Kamyar Kalantar-Zadeh, Miklos Z Molnar,

<h4>Purpose of review</h4>Diet plays an important role in slowing progression of chronic kidney disease in native and transplanted kidneys. There is limited evidence on the association on dietary intake with renal allograft function. Mechanisms of major nutrients and dietary patterns with focusing on a plant-based diet related to kidney transplant ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):6-17]

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Novel approach to unpleasant symptom clusters surrounding pruritus in patients with chronic kidney disease and on dialysis therapy.

Rebecca S Ahdoot, Kamyar Kalantar-Zadeh, James O Burton, Mark B Lockwood,

<h4>Purpose of review</h4>Chronic kidney disease-associated-pruritus (CKD-aP) is a common symptom in patients with end-stage kidney disease (ESKD) undergoing dialysis. CKD-aP typically occurs alongside other debilitating symptoms and may comprise so-called 'symptom clusters' which have synergistic effects that adversely impact patient health-related quality of life (HRQoL). Importantly, symptoms in a cluster ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):63-71]

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Current status of the assessment of sarcopenia, frailty, physical performance and functional status in chronic kidney disease patients.

Yuhei Otobe, Connie M Rhee, Matthew Nguyen, Kamyar Kalantar-Zadeh, Joel D Kopple,

<h4>Purpose of review</h4>Low physical function, frailty, and sarcopenia are common complications of chronic kidney disease (CKD). In this article, we review the epidemiology and pathogenesis of low physical function, as well as its associations with adverse outcomes in CKD patients. Additionally, we present various traditional and novel methods for assessment ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):109-128]

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Editorial: Novel therapeutic approaches in chronic kidney disease and kidney transplantation: the draw of evolving integrated multimodal approaches in the targeted therapy era.

Ekamol Tantisattamo, Ramy M Hanna, Kamyar Kalantar-Zadeh,

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):1-5]

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Reconciling Systolic Blood Pressure Intervention Trial with Eighth Joint National Commission: a nuanced view of optimal hypertension control in the chronic kidney disease population.

Ekamol Tantisattamo, Anum Hamiduzzaman, Peter Sohn, Rebecca Ahdoot, Ramy M Hanna,

<h4>Purpose of review</h4>Universally lowering blood pressure (BP) may adversely affect some populations especially in the older population. Recent landmark trials revealed cardiovascular benefits of tight controlling systolic BP (SBP) more than several recent BP targets. Implementing the evidence from the studies and guidelines in some populations is reviewed.<h4>Recent findings</h4>Eighth Joint ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2022, 31(1):57-62]

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Value of cemiplimab in progressive metastatic cutaneous squamous cell carcinoma after kidney transplantation: a case report.

G Geidel, A Rünger, S W Schneider, C Gebhardt,

Cutaneous squamous cell carcinoma (CSCC) is the most frequent post-transplant tumour entity resulting from immunosuppression treatment that is needed to prevent organ rejection. Solid organ transplant (SOT) recipients are at higher risk for CSCC and vulnerable for aggressive disease or a fatal course. Here, we report on a case of ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2022, 36 Suppl 1:49-52]

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