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Kernicterus

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Maternal Instruction About Jaundice and the Incidence of Acute Bilirubin Encephalopathy in Nigeria.

Richard P Wennberg, Stephen Oguche, Zainab Imam, Zubaida L Farouk, Isa Abdulkadir, Paul D Sampson, Tina M Slusher, Fidelia Bode-Thomas, Bose O Toma, Christopher S Yilgwan, David Shwe, Akinyemi O Ofakunrin, Udochukwu M Diala, Chris Isichei, Victor Pam, Zuwaira Hassan, Shehu U Abdullahi, Fatima Usman, Binta W Jibir, Idris Y Mohammed, Hadiza A Usman, Muhammed Abdusalam, Aisha Kuliya-Gwarzo, Fatima I Tsiga-Ahmad, Laila Umar, William N Ogala, Fatimatu Abdullahi, Laila Hassan, Saratu Purdue, Troy Lund, Carlos D Coda-Zabetta,

OBJECTIVE:To evaluate whether teaching mothers about neonatal jaundice will decrease the incidence of acute bilirubin encephalopathy among infants admitted for jaundice. STUDY DESIGN:This was a multicenter, before-after and cross-sectional study. Baseline incidences of encephalopathy were obtained at 4 collaborating medical centers between January 2014 and May 2015 (Phase 1). Structured ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2020, :]

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Management strategies of neonatal jaundice during the coronavirus disease 2019 outbreak.

Xiao-Lu Ma, Zheng Chen, Jia-Jun Zhu, Xiao-Xia Shen, Ming-Yuan Wu, Li-Ping Shi, Li-Zhong Du, Jun-Fen Fu, Qiang Shu,

The outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV) has become a most challenging health emergency. Owing to rigorous quarantine and control measures taken in China, routine neonatal health surveillance and follow-up have become challenging. Without follow-up surveillance, some rapid and progressive newborn diseases, such as bilirubin encephalopathy, may be ... Read more >>

World J Pediatr (World Journal of Pediatrics)
[2020, :]

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Maternal Instruction on Neonatal Jaundice: What Can we Learn from the Stop Kernicterus in Nigeria (SKIN) Experience?

Jon F Watchko,

J. Pediatr. (The Journal of pediatrics)
[2020, :]

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Management strategies of neonatal jaundice during the coronavirus disease 2019 outbreak.

Xiao-Lu Ma, Zheng Chen, Jia-Jun Zhu, Xiao-Xia Shen, Ming-Yuan Wu, Li-Ping Shi, Li-Zhong Du, Jun-Fen Fu, Qiang Shu,

The outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV) has become a most challenging health emergency. Owing to rigorous quarantine and control measures taken in China, routine neonatal health surveillance and follow-up have become challenging. Without follow-up surveillance, some rapid and progressive newborn diseases, such as bilirubin encephalopathy, may be ... Read more >>

World J Pediatr (World Journal of Pediatrics)
[0, :1-4]

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Case study on the use of intensive pediatric neurorehabilitation in the treatment of kernicterus.

Jessie Mann, Dory A Wallace, Stephanie DeLuca,

Background:Kernicterus Spectrum Disorder (KSD) is the result of prolonged bilirubin toxicity resulting in widespread neurological injury. Once the bilirubin levels are normalized the encephalopathy becomes static, however the consequences of the injury can have life-long effects. The sequelae of KSD include motor impairments, auditory deficits, dental dysplasia, and potentially cognitive ... Read more >>

J Clin Mov Disord (Journal of clinical movement disorders)
[2020, 7:1]

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A questionnaire survey on the efficacy of various treatments for dyskinetic cerebral palsy due to preterm bilirubin encephalopathy.

Yukihiro Kitai, Satori Hirai, Naomi Okuyama, Mika Hirotsune, Shizuka Nishimoto, Satoshi Mizutani, Akihisa Okumura, Satoko Kumada, Hiroshi Arai,

OBJECTIVES:Preterm children with severe dyskinetic cerebral palsy due to bilirubin encephalopathy often suffer from marked generalised hypertonus as they age. We performed a questionnaire survey to investigate patient-reported outcomes of treatments for improving their activities of daily life. METHODS:A mail questionnaire was administered to the caregivers of 67 children with ... Read more >>

Brain Dev. (Brain & development)
[2020, 42(4):322-328]

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A case report of a novel 22 bp duplication within exon 1 of the UGT1A1 in a Sudanese infant with Crigler-Najjar syndrome type I.

Sailaja Valmiki, Kiran Kumar Mandapati, Leela Krishna Vamsee Miriyala, Chayarani Chandrashekhar Kelgeri, Mohamed Rela, Naresh P Shanmugam, Durga Rao Vegulada,

BACKGROUND:Crigler Najjar type 1 is a rare autosomal recessive condition caused by the absence of UDPGT enzyme due to mutations in the UGT1A1 gene. This enzyme is responsible for elimination of unconjugated bilirubin from the body by glucuronidation. Affected individuals are at risk for kernicterus and require lifelong phototherapy. Liver ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2020, 20(1):62]

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Increased serum total bilirubin-albumin ratio was associated with bilirubin encephalopathy in neonates.

Yan Wang, Guangyao Sheng, Lina Shi, Xiuyong Cheng,

We performed the present study to summarize the recent epidemiological characteristics of bilirubin encephalopathy and assess the role of total bilirubin-albumin ratio in the bilirubin encephalopathy. We retrospectively collected clinical data of 669 neonates with hyperbilirubinemia from the First Affiliated Hospital of Zhengzhou University between January 2015 and July 2018, ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, 40(1):]

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Bilirubin disrupts calcium homeostasis in neonatal hippocampal neurons: a new pathway of neurotoxicity.

Rossana Rauti, Mohammed Qaisiya, Claudio Tiribelli, Laura Ballerini, Cristina Bellarosa,

Severe hyperbilirubinemia leads to bilirubin encephalopathy in neonates, causing irreversible neurological sequelae. We investigated the nature of neuronal selective vulnerability to unconjugated bilirubin (UCB) toxicity. The maintenance of intracellular calcium homeostasis is crucial for neuron survival. Calcium release from endoplasmic reticulum (ER) during ER-stress can lead to apoptosis trough the ... Read more >>

Arch. Toxicol. (Archives of toxicology)
[2020, 94(3):845-855]

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A clinical prediction rule for acute bilirubin encephalopathy in neonates with extreme hyperbilirubinemia: A retrospective cohort study.

Fanhui Zhang, Lihua Chen, Shiqiang Shang, Kewen Jiang,

To establish a clinical prediction rule for acute bilirubin encephalopathy (ABE) in term/near-term neonates with extreme hyperbilirubinemia.A retrospective cohort study was conducted between January 2015 and December 2018. Six hundred seventy-three out of 26,369 consecutive neonates with extreme hyperbilirubinemia were enrolled in this study. Data included demographic characteristics, total serum ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(9):e19364]

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Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000-2015.

Mette Line Donneborg, Bo Moelholm Hansen, Pernille Kure Vandborg, María Rodrigo-Domingo, Finn Ebbesen,

OBJECTIVE:To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015. STUDY DESIGN:We identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB <0.30, gestational age ≥35 ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, 40(2):194-202]

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Bilirubin Induced Encephalopathy.

Parvaneh Karimzadeh, Minoo Fallahi, Mohammad Kazemian, Naeeme Taslimi Taleghani, Shamsollah Nouripour, Mitra Radfar,

Hyperbilirubinemia is one of the most common neonatal disorders. Delayed diagnosis and treatment of the pathologic and progressive indirect hyperbilirubinemia lead to neurological deficits, defined as bilirubin induced encephalopathy (BIE) (2). The incidence of this disorder in underdeveloped countries is much more than developed areas. All neonates with the risk factors for ... Read more >>

Iran J Child Neurol (Iranian journal of child neurology)
[2020, 14(1):7-19]

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Management of neonatal jaundice in low- and middle-income countries.

Tina M Slusher, Yvonne E Vaucher,

Abbreviations: ABE: acute bilirubin encephalopathy; ABR: auditory evoked brainstem response; BIND: bilirubin-induced neurological dysfunction; EBT: exchange blood transfusions; HIC: high-income countries; KSD: kernicterus spectrum disorder; LED: light-emitting diode; LMIC: low- and middle-income countries; SNH: severe neonatal jaundice or hyperbilirubinaemia; TcB: transcutaneous bilirubinometry; TSB: total serum bilirubin. ... Read more >>

Paediatr Int Child Health (Paediatrics and international child health)
[2020, 40(1):7-10]

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TcB, FFR, phototherapy and the persistent occurrence of kernicterus spectrum disorder.

Jon F Watchko,

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, 40(2):177-179]

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50 Years Ago in TheJournalofPediatrics: Studies in Kernicterus III. The Saturation of Serum Proteins with Bilirubin During Neonatal Life and Its Relationship to Brain Damage at Five Years.

Jon F Watchko,

J. Pediatr. (The Journal of pediatrics)
[2020, 216:108]

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Efficacy of double versus single phototherapy in treatment of neonatal jaundice: a meta-analysis.

Muhammad Abdullah Nizam, Abdul Salam Alvi, Muhammad Maaz Hamdani, Ali Salem Lalani, Syed Asad Sibtain, Nabeel Ali Bhangar,

To assess the efficacy of double phototherapy in managing neonatal jaundice compared to single phototherapy in infants with different birth weight and gestational age. CENTRAL, PubMed, clinicaltrials.gov, and gray literature sources were searched from date of inception of these databases till August 2019. Primary outcome was decline of total serum ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, :]

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Severe neonatal hyperbilirubinemia in the southeast region of Turkey

Özlem Bozkurt, Ebru Yücesoy, Baran Oğuz, Ömür Akinel, Mehmet Fatih Palali, Nurgül Ataş,

Background/aim:Severe neonatal hyperbilirubinemia is an important cause of morbidity and mortality in developing countries. The aim was to assess etiologic reasons for development of severe hyperbilirubinemia and define risk factors for exchange transfusion and acute bilirubin encephalopathy (ABE) in Şanlıurfa located in the southeast region of Turkey. Materials and methods:An ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(1):103-109]

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Improving the Bilirubin Management Program in the Newborn Nursery: Background, Aims, and Protocol.

Timothy M Bahr, Julie H Shakib, Carole H Stipelman, Kensaku Kawamoto, Kelly Cail, Sara Lauer, Robert D Christensen,

BACKGROUND:Practices to detect and manage hyperbilirubinemia in newborn nurseries are highly variable. American Academy of Pediatrics guidelines in 1999, 2004, and 2009 have generated, perhaps unintentionally, divergent practices that might not all be of equivalent value. Evidence-based progress is needed to define less invasive, less expensive, uniform, and safe methods ... Read more >>

Neonatology (Neonatology)
[2020, :1-7]

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Review of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders.

Steven M Shapiro, Sean M Riordan,

Previously in Part I of this two-part review, we discussed the current and recent advances in the understanding of the molecular biology and neuropathology of bilirubin neurotoxicity (BNTx). Here in Part II, we summarize current treatment options available to treat the severely jaundiced infants to prevent significant brain damage and ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, 87(2):332-337]

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Neonatal Jaundice: awareness, perception and preventive practices in expectant mothers.

Kokou H Amegan-Aho, Catherine I Segbefia, Naa Djama O Glover, Gloria A Ansa, Taiba J Afaa,

Background:Neonatal jaundice (NNJ) is a preventable cause of neonatal morbidity and mortality. Improving mothers' knowledge will help with early recognition of NNJ, prompt and appropriate intervention. This study highlights the knowledge, attitude and practice regarding neonatal jaundice among expectant mothers attending the antenatal clinics of Korle-Bu Teaching Hospital and Mamprobi ... Read more >>

Ghana Med J (Ghana medical journal)
[2019, 53(4):267-272]

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The spectrum of bilirubin neurotoxicity in term and near-term babies with hyperbilirubinemia: Does outcome improve with time?

Sarah S ElTatawy, Esraa A Elmazzahy, Amira M El Shennawy, Hanan A Madani, Hazem Abou Youssef, Iman F Iskander,

BACKGROUND:While neonatal jaundice is generally a common benign condition; severe hyperbilirubinemia has a devastating potential for brain injury. AIM:To detect the impact of severe neonatal hyperbilirubinemia on motor and mental development and its progress over time in the first year of life using the Bayley scales of infant development (BSID) ... Read more >>

Early Hum. Dev. (Early human development)
[2019, 140:104909]

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Minor blood group incompatibility due to blood groups other than Rh(D) leading to hemolytic disease of fetus and newborn: a need for routine antibody screening during pregnancy.

Anika Agrawal, Karamalla Saddam Hussain, Ajay Kumar,

Minor blood group incompatibility due to blood groups other than Rh(D), although an uncommon cause of neonatal hyperbilirubinemia, has the potential to cause severe hyperbilirubinemia and its sequelae in infants, if left undiagnosed and untreated. Here, we describe clinical presentation, diagnosis and treatment of three cases of minor blood group ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2020, 9(1):43-47]

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Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease.

Sean M Riordan, Steven M Shapiro,

Despite the availability of successful prevention strategies to prevent excessive hyperbilirubinemia, the neurological sequelae of bilirubin neurotoxicity (BNTx) still occur throughout the world. Kernicterus, encephalopathy due to BNTx, is now understood to be a spectrum of severity and phenotypes known as kernicterus spectrum disorder (KSD). A better understanding of the ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, 87(2):327-331]

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High Direct Bilirubin Associated With Levoffoxacin Use in a Neonate.

Amy P Holmes, Charles E Hartis, Laurie J Rollins,

Limited data exist regarding the use of fluoroquinolones in the neonatal population. Levofloxacin has some utility in this population because it is one of a very limited number of antibiotics with activity against Stenotrophomonas maltophilia. We describe the successful treatment of S maltophilia tracheitis in a premature neonate using levofloxacin ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2020, 25(1):64-67]

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Legal Briefs: Multiple Missteps and System Failures Cause Kernicterus in 2 Infants.

Maureen E Sims,

Neoreviews (NeoReviews)
[2019, 20(11):e683-e686]

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