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Reasons to consider early treatment in chronic hepatitis B patients.

Apostolos Koffas, Jörg Petersen, Patrick T Kennedy,

In spite of a decrease in the prevalence and incidence seen in recent years, chronic hepatitis B (CHB) still remains a major healthcare challenge, prevalent mostly in developing but also in developed regions. CHB is associated with significant morbidity and mortality, secondary to the complications of disease progression; cirrhosis and ... Read more >>

Antiviral Res. (Antiviral research)
[2020, :104783]

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Administration and Dosing of Systemic Antifungal Agents in Pediatric Patients.

Kevin J Downes, Brian T Fisher, Nicole R Zane,

Neonates and immunosuppressed/immunocompromised pediatric patients are at high risk of invasive fungal diseases. Appropriate antifungal selection and optimized dosing are imperative to the successful prevention and treatment of these life-threatening infections. Conventional amphotericin B was the mainstay of antifungal therapy for many decades, but dose-limiting nephrotoxicity and infusion-related adverse events ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(2):165-188]

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Thirty-Day Readmissions After Carotid Artery Stenting Versus Endarterectomy: Analysis of the 2013-2014 Nationwide Readmissions Database.

Fabio V Lima, Dhaval Kolte, Kevin F Kennedy, Lily J Wang, J Dawn Abbott, Peter A Soukas, Herbert D Aronow,

BACKGROUND:Contemporary, nationally representative 30-day readmissions data after carotid artery stenting (CAS) and carotid endarterectomy (CEA) are lacking. METHODS:Patients undergoing CAS or CEA were identified from the 2013 to 2014 Nationwide Readmissions Databases. Propensity matching was used to balance baseline clinical characteristics. Thirty-day nonelective readmission rates, length of stay, and causes ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2020, 13(4):e008508]

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Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia.

Shungang Zhang, Joshua D Breidenbach, Fatimah K Khalaf, Prabhatchandra R Dube, Chrysan J Mohammed, Apurva Lad, Stanislaw Stepkowski, Terry D Hinds, Sivarajan Kumarasamy, Andrew Kleinhenz, Jiang Tian, Deepak Malhotra, David J Kennedy, Christopher J Cooper, Steven T Haller,

Background Renal artery stenosis is a common cause of renal ischemia, contributing to the development of chronic kidney disease. To investigate the role of local CD40 expression in renal artery stenosis, Goldblatt 2-kidney 1-clip surgery was performed on hypertensive Dahl salt-sensitive rats (S rats) and genetically modified S rats in ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(7):e014072]

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Immunological cross-reactions with paramyxovirus nucleoproteins may explain sporadic apparent ebolavirus seropositivity in European populations.

Lisa Bishop, Marcell Mullner, Amalie Bjurhult-Kennedy, Robert Lauder, Derek Gatherer,

Although confirmed outbreaks of Ebola Virus Disease (EVD) have been confined to central and west Africa, seropositivity to Zaire ebolavirus (EBOV) has been reported in other parts of Africa and even in one study from the early 1990s in Germany. The possible reasons for the discrepancy between serological studies and ... Read more >>

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Lysosomal storage disease spectrum in nonimmune hydrops fetalis: a retrospective case control study.

Huda B Al-Kouatly, Laura Felder, Mona M Makhamreh, Stephanie L Kass, Neeta L Vora, Vincenzo Berghella, Seth Berger, David A Wenger, Paola Luzi,

OBJECTIVES:Nonimmune hydrops fetalis (NIHF) accounts for 90% of hydrops fetalis cases. About 15% to 29% of unexplained NIHF cases are caused by lysosomal storage diseases (LSD). We review the spectrum of LSD and associated clinical findings in NIHF in a cohort of patients referred to our institution. METHODS:We present a ... Read more >>

Prenat. Diagn. (Prenatal diagnosis)
[2020, :]

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Grip Strength in Adults and Children with Cystinosis

Julien Hogan, Helina Iyob-Tessema, Chia-Shi Wang, Sabina Kennedy, Loretta Reyes, Stella Shin, Larry Greenbaum,

<title>Abstract</title> <p> Background: Chronic kidney disease (CKD) is associated with impaired muscle strength. Cystinosis patients have increased risk for impaired muscle strength due to early development of CKD and cystinosis-induced myopathy. This study assesses muscle strength in cystinosis patients and investigates risk factors of decreased muscle strength. Methods: ... Read more >>

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Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain.

Ranjie Xu, Xiaoxi Li, Andrew J Boreland, Anthony Posyton, Kelvin Kwan, Ronald P Hart, Peng Jiang,

Microglia, the brain-resident macrophages, exhibit highly dynamic functions in neurodevelopment and neurodegeneration. Human microglia possess unique features as compared to mouse microglia, but our understanding of human microglial functions is largely limited by an inability to obtain human microglia under homeostatic states. Here, we develop a human pluripotent stem cell ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1577]

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Associations among patient care workers' schedule control, sleep, job satisfaction and turnover intentions.

Rebecca M Brossoit, Tori L Crain, Leslie B Hammer, Soomi Lee, Todd E Bodner, Orfeu M Buxton,

Healthcare is the fastest growing occupational sector in America, yet patient care workers experience low job satisfaction, high turnover, and susceptibility to poor sleep compared to workers in other jobs and industries. Increasing schedule control may be one way to help mitigate these issues. Drawing from conservation of resources theory, ... Read more >>

Stress Health (Stress and health : journal of the International Society for the Investigation of Stress)
[2020, :]

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Type II Alexander disease caused by splicing errors and aberrant overexpression of an uncharacterized GFAP isoform.

Guy Helman, Asako Takanohashi, Tracy L Hagemann, Ming D Perng, Marzena Walkiewicz, Sarah Woidill, Sunetra Sase, Zachary Cross, Yangzhu Du, Ling Zhao, Amy Waldman, Bret C Haake, Ali Fatemi, Michael Brenner, Omar Sherbini, Albee Messing, Adeline Vanderver, Cas Simons,

Alexander disease results from gain-of-function mutations in the gene encoding glial fibrillary acidic protein (GFAP). At least eight GFAP isoforms have been described, however, the predominant alpha isoform accounts for ∼90% of GFAP protein. We describe exonic variants identified in three unrelated families with Type II Alexander disease that alter ... Read more >>

Hum. Mutat. (Human mutation)
[2020, :]

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Physician and Hospital Utilization of P2Y12 Inhibitors in ST-Segment-Elevation Myocardial Infarction in the United States: A Study From the National Cardiovascular Data Registry's Research to Practice Initiative.

Kamil F Faridi, Kirk N Garratt, Kevin F Kennedy, Thomas M Maddox, Eric A Secemsky, Neel M Butala, Robert W Yeh,

Background Ticagrelor and prasugrel are potent P2Y12 inhibitors with superior efficacy compared with clopidogrel among patients with ST-segment-elevation myocardial infarction (STEMI), though use in recent practice is not well described. In this retrospective study, we assessed trends, predictors, and variation in use of P2Y12 inhibitors in patients with STEMI in ... Read more >>

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2020, 13(3):e006275]

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The Respiratory Phenotype of Pompe Disease Mouse Models.

Anna F Fusco, Angela L McCall, Justin S Dhindsa, Lucy Zheng, Aidan Bailey, Amanda F Kahn, Mai K ElMallah,

Pompe disease is a glycogen storage disease caused by a deficiency in acid α-glucosidase (GAA), a hydrolase necessary for the degradation of lysosomal glycogen. This deficiency in GAA results in muscle and neuronal glycogen accumulation, which causes respiratory insufficiency. Pompe disease mouse models provide a means of assessing respiratory pathology ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

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Adding Epidemiologically Important Meteorological Data to Peanut Rx, the Risk Assessment Framework for Spotted Wilt of Peanut.

Thomas M Chappell, Clarence B Codod, Blake W Williams, Robert C Kemerait, Albert K Culbreath, George G Kennedy,

Management of disease affecting peanut in the southeastern United States has benefited from extensive field research identifying disease-associated risk factors since the 1990s. An assessment of risk factors associated with the tomato spotted wilt (TSW) disease, caused by Tomato spotted wilt virus and spread exclusively by thrips, is available to ... Read more >>

Phytopathology (Phytopathology)
[2020, :]

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Giant Pituitary Adenoma Presenting with Foster-Kennedy Syndrome in a 21-Year Old Ethiopian Patient: A Rarely Reported Phenomenon: A Case Report.

Biniyam Ayele, Abenet Mengesha, Abdi Wotiye, Yodit Alemayehu,

Background:Disorders of the pituitary gland and the sellar region present a wide spectrum of clinical problems. A variety of lesions in this area tend to present with similar problems; namely, headache, hormonal disorders, and loss of vision. Benign adenomas of the pituitary gland are by far the most common disorders ... Read more >>

Ethiop J Health Sci (Ethiopian journal of health sciences)
[2020, 30(2):311-314]

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A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain.

Elle C Roberson, Ngan K Tran, Mia J Konjikusic, Rebecca D Fitch, Ryan S Gray, John B Wallingford,

BACKGROUND:In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, ... Read more >>

Dev. Dyn. (Developmental dynamics : an official publication of the American Association of Anatomists)
[2020, :]

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Impact of Intravenous Fluid Therapy on Survival Among Patients With Ebola Virus Disease: An International Multisite Retrospective Cohort Study.

Adam R Aluisio, Derrick Yam, Jillian L Peters, Daniel K Cho, Shiromi M Perera, Stephen B Kennedy, Moses Massaquoi, Foday Sahr, Michael A Smit, Tao Liu, Adam C Levine,

BACKGROUND:Intravenous fluid (IVF) is a frequently recommended intervention in Ebola virus disease (EVD), yet its impact on patient outcomes remains unclear. METHODS:This retrospective cohort study evaluated patients with EVD admitted to 5 Ebola treatment units (ETUs) in West Africa. The primary outcome was the difference in 28-day survival between cases ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(6):1038-1047]

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BK polyomavirus diversity-Why viral variation matters.

Jason T Blackard, Stella M Davies, Benjamin L Laskin,

BK polyomavirus (BKPyV or BKV) is a non-enveloped, circular double-stranded DNA virus that may exceed 80% seroprevalence in adults. BKV infection typically occurs during childhood, and the majority of adults are latently infected. While BKV infection is rarely associated with clinical disease in most individuals, in immunosuppressed individuals, reactivation may ... Read more >>

Rev. Med. Virol. (Reviews in medical virology)
[2020, :e2102]

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Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.

Wei Wang, Bailey A Allard, Tana S Pottorf, Henry H Wang, Jay L Vivian, Pamela V Tran,

Primary cilia are sensory organelles that are essential for eukaryotic development and health. These antenna-like structures are synthesized by intraflagellar transport protein complexes, IFT-B and IFT-A, which mediate bidirectional protein trafficking along the ciliary axoneme. Here using mouse embryonic fibroblasts (MEF), we investigate the ciliary roles of two mammalian orthologues ... Read more >>

FASEB J. (The FASEB Journal)
[2020, :]

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Operative and nonoperative management of anterior cruciate ligament injury: Differences in gait biomechanics at 5 years.

Elizabeth Wellsandt, Ashutosh Khandha, Jacob Capin, Thomas S Buchanan, Lynn Snyder-Mackler,

Gait biomechanics after anterior cruciate ligament (ACL) injury are associated with functional outcomes and the development of posttraumatic knee osteoarthritis. However, biomechanical outcomes between patients treated nonoperatively compared with operatively are not well understood. The primary purpose of this study was to compare knee joint contact forces, angles, and moments ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2020, :]

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Impact of elective on students' perceptions of treating patients with a substance use disorder.

Ally Jarvi, Phillip Hughes, J Greene Shepherd, M Lindsey Hedgepeth Kennedy, Courtenay Gilmore Wilson,

OBJECTIVE:To evaluate the impact of a substance use disorder (SUD) elective curriculum on students' perceptions of treating patients with SUDs using the Drug and Drug Problems Perceptions Questionnaire (DDPPQ). METHODS:In 2017, a third-year pharmacy elective, conceptualizing SUD as a chronic, relapsing brain disease with psychosocial and societal influencers, was introduced. ... Read more >>

J Am Pharm Assoc (2003) (Journal of the American Pharmacists Association : JAPhA)
[2020, :]

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Assessment of loss-of-control eating in healthy youth by interview and questionnaire.

Deborah R Altman, Marian Tanofsky-Kraff, Lisa M Shank, Taylor N Swanson, Eliana Ramirez, Nia A Moore, Sarah G Rubin, Meghan E Byrne, Sarah LeMay-Russell, Natasha A Schvey, Nichole R Kelly, Megan N Parker, Sriram Gubbi, Sheila M Brady, Susan Z Yanovski, Jack A Yanovski,

OBJECTIVE:The aim of this study is to evaluate two questionnaires, an updated youth version of the questionnaire on eating and weight patterns (Questionnaire on Eating and Weight Patterns-5 Children/Adolescent [QEWP-C-5]) and the Loss-of-Control (LOC) Eating Disorder Questionnaire (LOC-ED-Q), against the Eating Disorder Examination (EDE) interview to assess the presence of ... Read more >>

Int J Eat Disord (The International journal of eating disorders)
[2020, :]

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Predictors of Distant Metastases in Triple-Negative Breast Cancer Without Pathologic Complete Response After Neoadjuvant Chemotherapy.

William R Kennedy, Christopher Tricarico, Prashant Gabani, Ashley A Weiner, Michael B Altman, Laura L Ochoa, Maria A Thomas, Julie A Margenthaler, Souzan Sanati, Lindsay L Peterson, Cynthia X Ma, Foluso O Ademuyiwa, Imran Zoberi,

BACKGROUND:Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC) predicts decreased distant metastasis. However, most patients do not experience pCR, and other risk factors for distant metastasis after NAC are poorly characterized. This study investigated factors predictive of distant metastasis in TNBC without pCR after NAC. ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2020, 18(3):288-296]

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Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice.

Clinton M Hasenour, Arion J Kennedy, Tomasz Bednarski, Irina A Trenary, Brandon J Eudy, Robin P DaSilva, Kelli L Boyd, Jamey D Young,

Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control progression from simple steatosis to NASH are not fully known. Here, we tested the hypothesis that dietary vitamin ... Read more >>

J. Lipid Res. (Journal of lipid research)
[2020, :]

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Association of peripheral artery disease with life-space mobility restriction and mortality in community-dwelling older adults.

Shipra Arya, Anjali Khakharia, Kara A Rothenberg, Theodore M Johnson, Patricia Sawyer, Richard E Kennedy, Cynthia J Brown, C Barrett Bowling,

OBJECTIVE:Symptomatic peripheral artery disease (PAD) impairs walking, but data on the impact of PAD on community mobility is limited. Life-space mobility measures the distance, frequency, and assistance needed as older adults move through geographic areas extending from their bedroom (life-space mobility score: 0) to beyond their town (life-space mobility score: ... Read more >>

J. Vasc. Surg. (Journal of vascular surgery)
[2020, :]

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Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease.

Jonathan A Hollander, Deborah A Cory-Slechta, Felice N Jacka, Steven T Szabo, Tomás R Guilarte, Staci D Bilbo, Carolyn J Mattingly, Sheryl S Moy, Ebrahim Haroon, Mady Hornig, Edward D Levin, Mikhail V Pletnikov, Julia L Zehr, Kimberly A McAllister, Anika L Dzierlenga, Amanda E Garton, Cindy P Lawler, Christine Ladd-Acosta,

The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, :]

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