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Possible antiapoptotic and neuroprotective effects of magnesium sulfate on retina in a preterm hypoxic-ischemic rat model.

Serhat Imamoğlu, Ebru Yalin Imamoğlu, Serkan Erdenöz, Alev Cumbul, Ünal Uslu, Şamil Aktaş, Hüsnü Fahri Ovali,

<h4>Background</h4>The effects of systemic magnesium sulfate (MgSO4) on retina in preterm hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4 on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2) and glial fibrillary acidic ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, :]

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Central Nervous System Involvement in Patients with Acute Myeloid Leukemia.

Hatime Arzu Yaşar, Olgu Erkin Çinar, Nur Yazdali Köylü, Ibrahim Barişta, Hakan Göker, Yahya Büyükaşik,

<h4>Introduction</h4>To evaluate the incidence, clinical features, risk factors, and prognosis of central nervous system (CNS) involvement in patients with acute myeloid leukemia (AML).<h4>Methods</h4>All AML patients who were admitted to Hacettepe University hospital between 2000 and 2021 were evaluated. The medical records of 548 AML cases were retrospectively analyzed.<h4>Results</h4>The frequency of ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, :]

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Effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, steroid dependence and small airways in patients with severe eosinophilic asthma.

Insu Yilmaz, Sakine Nazik Bahçecioğlu, Murat Türk, Nuri Tutar, Gülden Paçaci Çetin, Bahar Arslan,

<h4>Background</h4>The efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce.<h4>Objective</h4>This study evaluated the effectiveness of mepolizumab therapy on ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, :]

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Acute necrotizing encephalopathy of childhood: a single-center experience

Erhan Aksoy, Ülkü Öztoprak, Halil Çelik, Fatih Mehmet Akif Özdemir, Mehbare Özkan, Hülya Kayılıoğlu, Ayşegül Danış, Özge Kucur, Selman Kesici, Mutlu Uysal Yazıcı, Ebru Azapağası, Yasemin Taşcı Yıldız, Nesrin Ceylan, Saliha Şenel, Deniz Yüksel,

<h4>Background/aim</h4>Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it.<h4>Materials and methods</h4>Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):706-715]

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Evaluation of serum anti-Müllerian hormone levels in women with Hashimoto thyroiditis in the reproductive age

İlknur Öztürk Ünsal, Sema Hepşen, Pınar Akhanlı, Murat Çalapkulu, Muhammed Erkam Sencar, Ali Yalçındağ, Erman Çakal,

<h4>Background/aim</h4>Autoimmune thyroid disease in women is associated with subfertility and early pregnancy loss, and patients with primary ovarian insufficiency have a high prevalence of thyroid autoimmune disorders. The aim of this study was to investigate the association between Hashimoto thyroiditis (HT) and ovarian reserve.<h4>Materials and methods</h4>Levels of serum thyroid stimulating ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):716-721]

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Demographic and clinical characteristics of children with autosomal dominant polycystic kidney disease: a single center experience

Belde Kasap Demir, Fatma Mutlubaş, Eren Soyaltın, Caner Alparslan, Merve Arya, Demet Alaygut, Seçil Arslansoyu Çamlar, Afig Berdeli, Önder Yavaşcan,

<h4>Background/aim</h4>In children with autosomal dominant polycystic kidney disease (ADPKD), clinical manifestations range from severe neonatal presentation to renal cysts found by chance. We aimed to evaluate demographic, clinical, laboratory findings, and genetic analysis of children with ADPKD.<h4>Materials and methods</h4>We evaluated children diagnosed with ADPKD between January 2006 and January 2019. ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):772-777]

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Evaluation of serum CXC chemokine ligand 16 (CXCL16) as a novel inflammatory bio- marker or familial Mediterranean fever disease

Taner Akyol, Tolga Düzenli, Alpaslan Tanoğlu,

<h4>Background/aim</h4>Familial Mediterranean fever (FMF) is a disease that is mainly diagnosed with clinical features. Several well- known inflammatory markers increase in FMF. However, there is still a need for diagnostic tests for specifying FMF and monitoring inflammatory activity. CXCL16 is a chemokine produced by inflammatory cells that demonstrate efficacy in ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):813-818]

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Clinical course of COVID-19 disease in immunosuppressed renal transplant patients

Hamad Dheir, Savaş Sipahi, Selçuk Yaylacı, Esma Seda Çetin, Ahmed Bilal Genç, Necattin Fırat, Mehmet Köroğlu, Gürkan Muratdağı, Yakup Tomak, Kezban Özmen, Ömer Faruk Ateş, Oğuz Karabay,

<h4>Background/aim</h4>We aimed to identify clinical settings of renal transplant patients with COVID-19.<h4>Materials and methods</h4>In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1st, 2020. Characteristics of the patients, including basal and last outpatient biochemical parameters were recorded. ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):428-434]

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Factors influencing anterior/low anterior resection syndrome after rectal or sigmoid resections

Sami Benli, Tahsin Çolak, Mehmet Özgür Türkmenoğlu,

<h4>Background/aim</h4>Sphincter-preserving surgery is one of the main goals in the treatment of rectal cancer because it improves the quality of life (QoL). However, some patients may experience disrupted symptoms called anterior or low anterior resection syndrome (LARS). This study was designed to evaluate the frequency and influencing factors of LARS ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):623-630]

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Cerebral hemodynamic alterations in patients with Covid-19

Ali Rıza Sonkaya, Bilgin Öztrk, Ömer Karadaş,

<h4>Background/aim</h4>Coronavirus 2019 disease (Covid-19) was first seen in December 2019 and afterwards it became pandemic. Several systemic involvements have been reported in Covid-19 patients. In this study, it was aimed to investigate the cerebrovascular hemodynamics in patients with Covid-19.<h4>Materials and methods</h4>The sample of this study included 20 patients hospitalized in ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):435-439]

Cited: 2 times

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Retrospective evaluation of 377 patients with penetrating foreign body injuries: a university hospital experience (a present case of missed sponge foreign body injury)

Anıl Murat Öztürk, Omar Aljasim, Gamze Şanlıdağ, Meltem Taşbakan,

<h4>Background/aim</h4>This study aimed to retrospectively analyse patients with foreign body (FB) injuries in our hospital and to present a patient with missed penetrating sponge FB injury.<h4>Materials and methods</h4>This study lasted 12 years (2008–2020) and reviewed all patients with FB injuries who were admitted to the emergency department (ED) of our ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):570-582]

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Characteristics and mortality determinants of COVID-19 patients undergoing hemodialysis

Savaş Sipahi, Hamad Dheir, Aysel Toçoğlu, Melike Bektaş, Seyyid Bilal Açıkgöz, Ahmed Cihad Genç, Fuldem Mutlu, Mehmet Köroğlu, Ali Fuat Erdem, Oğuz Karabay,

<h4>Background/aim</h4>The COVID-19 infection, which started in Wuhan City, China, in December 2019, turned into a pandemic in a very short time, affecting mainly the elderly and those with serious chronic illnesses. COVID-19 infections have been observed to have a high mortality rate, especially in patients undergoing maintenance hemodialysis.<h4>Materials and methods</h4>Forty-two ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):421-427]

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Sural nerve harvest for infants: integrated with information based on anatomical dissections

Mustafa Buyukmumcu, Anıl Didem Aydın Kabakçı, Duygu Akın Saygın, Mehmet Tuğrul Yılmaz, Muzaffer Şeker,

<h4>Background/aim</h4>The aim of the present study was to determine the course and possible variations of the sural nerve with all anatomical details in human fetal cadavers.<h4>Materials and methods</h4>This study was performed on 60 fetal cadavers. Formation type and level of the sural nerve was detected.<h4>Results</h4>According to trimesters, it was determined ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):473-482]

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Differences in corpus callosum morphology between healthy adolescents and adolescents with migraine: a case control study.

Mustafa Emre Akin, Ayşegül Neşe Çitak Kurt,

<h4>Background/aim</h4>This study objected to compare the measurements of corpus callosum substructures of adolescents with migraine and healthy adolescents.<h4>Materials and methods</h4>In a case-control design, adolescents aged 12-18 years with the diagnosis of migraine and healthy control group had brain magnetic resonance imaging examination. The CC dimensions including anteroposterior length, truncus, genu ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, :]

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Extracorporeal carbon dioxide removal (ECCO2R) therapy in COPD and ARDS patients with severe hypercapnic respiratory failure. A retrospective case-control study.

Volkan Inal, Serdar Efe,

<h4>Background/aim</h4>Treatment of severe hypercapnic respiratory failure (HRF) has some challenges in patients with chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS), especially when lung protective ventilation (LPV) strategies are required. Extracorporeal CO2 removal (ECCO2R) therapy is an emerging option to manage hypercapnia while allowing LPV in these ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, :]

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Can preoperative modified systemic inflammation score (mSIS) be used to predict malignancy in persistent nondiagnostic thyroid nodules?

Hakan Ataş, Bİrol Korukluoğlu, Bülent Çomçali, Neşe Yakşi, Barış Saylam, Mesut Tez,

<h4>Background/aim</h4>Despite the use of ultrasound guidance, a significant part of thyroid biopsies are nondiagnostic (ND). We aimed to investigate the utility of the preoperative modified systemic inflammation score (mSIS) to predict malignancies in patients with persistent ND thyroid nodules (TNs).<h4>Materials and methods</h4>Records of 924 patients underwent thyroidectomy between September 2016 ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):700-705]

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Umbilical cord levels of macrophage migration inhibitory factor in neonatal respiratory distress syndrome

Süleyman Bayraktar, Bilge Tanyeri Bayraktar, Ülkan Kılıç,

<h4>Background/aim</h4>We aimed to evaluate the association of the umbilical cord macrophage migration inhibitory factor (MIF) with the respiratory distress syndrome (RDS) in preterm infants.<h4>Materials and methods</h4>A total of eighty six preterm infants (38 with RDS and 48 without RDS) were involved in the study. ELISA is the technique assaying MIF values.<h4>Results</h4>The ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):722-726]

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Inflammatory complications of vocal fold injection with hyaluronic acid: a multiinstitutional study

Necati Enver, Elad Azizli, Sevtap Akbulut, Emel Çadallı Tatar, Muhammed Kürşad Yelken, Kayhan Öztürk, Hakan Coşkun, Ahmet Hakan Birkent, Zahide Çiler Büyükatalay, Ozan Bağış Özgürsoy, Haldun Oğuz,

<h4>Background/aim</h4>This study aimed to assess the inflammatory adverse reactions of vocal fold injection laryngoplasty with hyaluronic acid.<h4>Materials and methods</h4>This study was a retrospective chart review of patients who underwent vocal fold injection augmentation with HA injection from January 2005 to September 2016 in nine different institutions. Demographic data, indication for ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):819-825]

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Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism

Güven Yenmiş, Nail Beşli, Elif Yaprak Saraç, Fatma Sinem Hocaoğlu Emre, Kazım Şenol, Gönül Kanıgür,

<h4>Background/aim</h4>In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs).<h4>Materials and methods</h4>PBCCs were treated with two doses of metformin (0 mM, 25 mM). Proliferation was determined by BrdU as- say. ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):826-834]

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Evaluation of the relationship between shear wave elastography measurements with laboratory and Doppler US parameters in patients with adult Hashimoto’s thyroiditis

Nurten Andaç Baltacıoğlu, Ferhan Mantar, Efe Soydemir,

<h4>Background/aim</h4>Hashimoto thyroiditis (HT) is an autoimmune disease that leads to tissue stiffening secondary to lymphocyte infiltration of the thyroid gland. Gray-scale ultrasound (US) is widely used in its diagnosis. Numerous studies have been conducted comparing elastography findings of HT with tissue stiffness and immunoreactivity levels. This study aims to reveal ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):778-786]

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Evaluation of the results of patients who applied to the Çukurova University, Medical Genetics Department for prenatal diagnosis and determination of genetic counseling principles

Sevcan Tuğ Bozdoğan, Selim Büyükkurt, Sinem Özer, Atıl Bişgin,

<h4>Background/aim</h4>The aim of this study was to summarize the experiences of a single medical center for genetic diagnosis and treatment of prenatal patients.<h4>Materials and methods</h4>This study includes a retrospective data analysis of 2843 prenatally investigated cases using invasive methods during a 6-year period (2013–2019) at a single tertiary care center.<h4>Results</h4>Chromosomal ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):657-660]

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Characteristics and outcomes of critically ill patients with covid-19 in Sakarya, Turkey: a single centre cohort study

Havva Kocayiğit, Kezban Özmen Süner, Yakup Tomak, Gürkan Demir, İbrahim Kocayiğit, Selçuk Yaylacı, Yusuf Aydemir, Mehmet Köroğlu, Oğuz Karabay, Mehmet Halil Öztürk, Ali Fuat Erdem,

<h4>Background/aim</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Turkey on March 10, 2020 and the number of the patients are increasing day by day. Coronavirus disease 2019 (Covid-19) has high mortality rates in intensive care units (ICUs). We aimed to describe the demographic characteristics, comorbidities, treatment protocols, ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):440-447]

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Basal and pentagastrin-stimulated calcitonin cut-off values in diagnosis of preoperative medullary thyroid cancer

Emine Kartal Baykan, Mehmet Erdoğan,

<h4>Background/aim</h4>Medullary thyroid cancer (MTC) originates from parafollicular cells (C cell) and produces calcitonin (CT). Basal serum CT was used in the diagnosis and treatment of MTC. If basal CT level is 100 pg/mL or higher, it is likely to have MTC, but if basal CT level is below 10 pg/mL, ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):650-656]

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Nonsteroidal antiinflammatory drugs alter antibiotic susceptibility and expression of virulence-related genes and protein A of Staphylococcus aureus

İsmail Öztürk, Yasemin Eraç, Petek Ballar Kırmızibayrak, Şafak Ermertcan,

<h4>Background/aim</h4>Nonsteroidal antiinflammatory drugs (NSAIDs) including diclofenac, naproxen, ibuprofen, acetylsalicylic acid, and acetaminophen have been shown to have antimicrobial effects on various microorganisms. The aim of this study was to investigate the antibacterial effects of NSAIDs on Staphylococcus aureus.<h4>Materials and methods</h4>Susceptibilities of S. aureus strains to NSAIDs with or without antimicrobials ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):835-847]

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A comparison of rates and severity of chronic kidney disease in deceased-donor and living-donor liver transplant recipients: times matter

Yücel Yankol, Emily Bugeaud, Tiffany Zens, Michael Rizzari, Nesimi Mecit, Glen E Leverson, David Foley, Joshua D Mezrich, Turan Kanmaz, Oya Münevver Andaçoğlu, Anthony M D'Alessandro, Koray Sadık Acarlı, Münci Kalayoğlu, Luis A Fernandez,

<h4>Background/aim</h4>The progression of chronic kidney disease (CKD) in recipients of living-donor liver transplant (LDLT) compared to deceased-donor liver transplant (DDLT) has not been studied in the literature. We hypothesize that CKD stage progression in LDLT recipients is reduced compared to that of their DDLT counterparts.<h4>Materials and methods</h4>A retrospective study was ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):610-622]

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