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Journal Turk J Med Sci

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Evaluation of The Results of Patients who Applied to the Cukurova University Medical Genetics Department for Prenatal Diagnosis and Determination of Genetic Counseling Principles.

Sevcan TuĞ BozdoĞan, Selİm BÜyÜkkurt, Sİnem Özer, Atil BİŞgİn,

INTRODUCTION:The aim of this study was to summarize the experiences of a single medical center for genetic diagnosis and treatment of prenatal patients. MATERIALS AND METHODS:This study includes a retrospective data analysis of 2843 prenatally investigated cases using invasive methods during a 6-year period (2013-2019) at a single tertiary care ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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THE IMPORTANCE OF QUALITY AND ACCREDITATION IN HEALTH CARE SERVICES IN THE PROCESS OF STRUGGLE AGAINST COVID-19.

Demet GÖkmen Kavak, AyŞe Sİbel ÖksÜz, Canan Cengİz, İbrahİm Halİl Kayral, Fİgen Çİzmecİ Şenel,

BACKGROUND/AIM:The aim of this research is to evaluate the relationship between the quality of health and accreditation standards with the Covid-19 process and to reveal the importance of quality and accreditation in health care in the process of combating coronavirus. MATERIALS AND METHODS:The relationship between Turkish Healthcare Quality and Accreditation ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Characteristics and Outcomes of Critically Ill Patients with Covid-19 in Sakarya, Turkey: A Single Center Cohort Study.

Havva KocayİĞİt, Kezban Özmen SÜner, Yakup Tomak, GÜrkan Demİr, İbrahİm KocayİĞİt, SelÇuk Yaylaci, Yusuf Aydemİr, Mehmet KÖroĞlu, OĞuz Karabay, Mehmet Halİl ÖztÜrk, Alİ Fuat Erdem,

BACKGROUND/AIM:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Turkey on March 10, 2020 and the number of the patients are increasing day by day. Coronavirus disease 2019 (Covid-19) has high mortality rates in the intensive care unit (ICU). We aimed to describe the demographic characteristics, co-morbidities, treatment ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Clinical course of COVID-19 disease in immunosuppressed renal transplant patients.

Hamad Dheİr, SavaŞ Sİpahİ, SelÇuk Yaylaci, Esma Seda Çetİn, Ahmed Bİlal GenÇ, Necattİn Firat, Mehmet KÖroĞlu, GÜrkan MuratdaĞi, Yakup Tomak, Kezban Özmen SÜner, Ömer Faruk AteŞ, OĞuz Karabay,

BACKGROUND/AIM:We aimed to identified clinical settings of renal transplant patients with COVID-19 Material and methods: In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1, 2020. Characteristics of the patients, basal and last outpatient biochemical parameters of ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Continuous renal replacement therapy in critically ill children: single-center experience.

GÜl Hatİce Erkol Tuncer, Mesİha Ekİm, Emel Okulu, Begum Atasay, Tanil Kendİrlİ,

BACKGROUND AND AIM:Continuous renal replacement therapy (CRRT) has significant benefits in the treatment of critically ill children. The objective of this study is to describe the treatment indications, methods, demographics and outcome of the patients, who received CRRT in our pediatric intensive care unit and neonatal care unit and according ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Effects of sitagliptin on ß-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta.

Ayhanim Elİf MÜderrİsoĞlu, BetÜl Rabİa ErdoĞan, Zeynep Elİf YeŞİlyurt, Ceren Uyar BoztaŞ, İrem KaraÖmerlİoĞlu, Vecdİ Melİh Altan, Ebru ArioĞlu İnan,

BACKGROUND/AIM:Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic and vasodilatory effects. ß2-adrenoceptors (ß2-ARs) mediate the vasorelaxation in the aorta. However, ß3-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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The effect of comorbidity on mortality in elderly patients undergoing emergency abdominal surgery: a systematic review and meta-analysis.

Fadİme Çinar, GÖknur Parlak, Fatma Etİ Aslan,

BACKGROUND/AIM:With the increase in the elderly population, the elderly proportion needing emergency surgery is also increasing. Despite medical advances in surgery and anesthesia, negative postoperative outcomes and high mortality rates are still present in elderly patients undergoing emergency surgery. Comorbidities are described as the main determining factors in poor outcomes. ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Is there any difference between oral preemptive pregabalin vs placebo administration on response to EBUS-TBNA under sedation?

Semİh Aydemİr, Alİ AlagÖz, Fatma Ulus, Mehtap TunÇ, Hİlal Sazak, NİlgÜn Yilmaz Demİrcİ,

BACKGROUND/AIM:The aim of this study is to evaluate the effects of preemptive oral pregabalin on hemodynamic response, anxiety, sedation, and recovery in patients who underwent Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS ? TBNA) under sedation with intravenous ketamine-propofol combination. MATERIALS AND METHODS:Sixty patients were included in this study, and patients ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Correlation between serum vitamin d level and dichotomous distribution of hematological parameters in a cohort of 12709 patients.

Oktay OlmuŞÇelİk, ÖmÜr GÖkmen Sevİndİk,

Background/aim Recent evidence suggest that Vitamin D deficiency may be associated with a varying degrees of peripheral blood cytopenia(s). However, the effect of Vitamin D on hematopoiesis is largely unknown. According to pre-defined inclusion criteria, here we analyzed the correlation between serum Vitamin D level and hematological parameters. Materials and ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Imaging modalities used in diagnosis and follow-up of patients with Takayasu's arteritis.

AyŞe Bahar KeleŞoĞlu DİnÇer, Levent KiliÇ, Abdulsamet Erden, Umut Kalyoncu, Tuncay Hazirolan, Sedat Kİraz, Ömer KaradaĞ,

INTRODUCTION:Takayasu's arteritis (TA) is a rare, large-vessel vasculitis of unknown etiology, affecting aortic arch and its main branches. Non-invasive imaging methods are frequently used in diagnosis and follow up in Takayasu?s arteritis. Studies investigating optimal timing of follow up imaging are rare. This study is aimed to investigate the radiologic ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Does Fludrocortisone Treatment Cause Hypomagnesemia in Children with Primary Adrenal Insufficiency?

İbrahİm Mert ErbaŞ, Selda AyÇa Altincik, GÖnÜl Çatli, Tolga ÜnÜvar, Bayram Özhan, Ayhan Abaci, Ahmet Anik,

BACKGROUND:Aldosterone is a mineralocorticoid that secreted from adrenal glands and a known factor to increase magnesium excretion by direct and indirect effects on renal tubular cells. Although the frequency of hypomagnesemia was found to be approximately 5% in adult studies, there is no study in the literature investigating the frequency ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Assessment and Prevalence of Concomitant Chemo-Radiotherapy-Induced Oral Mucositis in Patients with Oral Squamous Cell Carcinoma.

Sadia Minhas, Aneequa Sajjad, Rabia Chaudhry, Hamza Zahid, Azfar Shahid, Muhammad Kashif,

Background Quantification of oral mucositis that progresses during concomitant chemo-radiotherapy (CCRT) is essential for its management. It is important to determine the methods that are simple, reliable and beneficial in foreseeing mucositis at earlier stages of treatment. Materials and Methods A prospective study was conducted on 100 oral cancer patients ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Thalamocortical network interruption: A fresh view for migraine symptoms

Hayrunnisa Bolay,

Migraine is a multifaceted brain disorder where multisensory disturbances are associated with headache. Yet sensory symptoms are conventionally justified by dysfunctions confined to the cerebral cortex, a perspective through the complex interplay of thalamocortical network would provide the entire picture, more pertinent to the central sensory processing. It is important ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1651-1654]

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Molecular subtyping bladder cancer: Is it ready for clinical practice?

Funda Vakar Lopez,

Bladder cancer, one of the more common cancers, is a heterogeneous disease, both morphologically and clinically. Although histological classification and extent of the disease (staging) guide treatment options, the heterogeneity in responses to therapy highlights the need for better stratification of patients for the appropriate therapy in order to achieve ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1677-1678]

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BMP and TGFβ use and release in bone regeneration

Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz,

A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1707-1722]

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Decreasing incidence and severity of Behçet’s disease: a changing trend in epidemiological spectrum possibly associated with oral health

Gonca Mumcu, Fatma Alibaz Öner, Tülin Ergun, Rafi Haner Direskeneli,

Behçet’s disease (BD) is a systemic and inflammatory disorder that is mainly present along the ancient Silk Road, from the Mediterranean Sea to East Asia. A wide range of prevalence figures (0.1–420/100,000) have been reported for BD, also among Turkish populations of similar genetic background living in different countries. Recently, ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1587-1590]

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Update on liver transplantation-newer aspects

Olga Metin, Cem Şimşek, Ahmet Gürakar,

Liver transplantation (LT) remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF), as well as for certain early-stage liver tumors. Currently, the greatest challenge facing LT is the simple fact that there are not enough adequate livers for all the ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1642-1650]

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Graft-versus-cancereffect and innovative approaches in thetreatment of refractory solid tumors

Uğur Şahin, Taner Demirer,

Background/aim:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been used for the treatment of various refractory solid tumors during the last two decades. After the demonstration of graft-versus-leukemia (GvL) effect in a leukemic murine model following allo-HSCT from other strains of mice, graft-versus-tumor (GvT) effect in a solid tumor after allo-HSCT ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1697-1706]

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The negative effects of dry eye disease on quality of life and visual function

Lee W Guo OD, Esen Akpek,

In recent years, dry eye has become a hot topic within ophthalmology and optometry, especially in regards to new frontiers in treatment modalities which include novel devices, procedures, and medications. However, some of the more understudied areas in dry eye involve its impact on quality of life. Although ocular discomfort ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1611-1615]

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Ankaferd hemostat: from molecules to medicine

Rafiye Çiftçiler, İbrahim Celalettin Haznedaroglu,

Ankaferd hemostat (ABS; Ankaferd Blood Stopper®, İstanbul, Turkey) is a hemostatic agent having an impact on red blood cell– fibrinogen interactions. The hemostatic effect of ABS depends upon the quick promotion of a protein network, particularly fibrinogen gamma, in relation to the erythrocyte aggregation. The entire physiological process involves ABS-induced ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1739-1750]

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The importance of histological patterns on PD-L1 staining heterogeneity: Should we use pattern-based approach for selecting tumor samples for PD-L1 testing in lung adenocarcinomas?

Pinar Bulutay, Pinar Firat, Emİne Handan Zeren, Suat Erus, Serhan Tanju, Mustafa ŞÜkrÜ Dİlege,

BACKGROUND/AIM:Programmed death ligand-1 (PD-L1) is a predictive marker for immunotherapeutic agents. However, heterogeneous staining of PD-L1 can cause false-negative results. The aim of this study is to evaluate the importance of histological patterns on PD-L1 staining heterogeneity in lung adenocarcinomas (LAC). MATERIALS AND METHODS:PD-L1 immunohistochemistry (IHC) stain was performed to ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Family-Centeredness of Services for Young Children with Down Syndrome: An Observational Study from Turkey.

Emİne Bahar BİngÖler Pekcİcİ, Ezgİ Özalp Akin, Funda Akpinar, Gamze Hayran, Cansu KeleŞ, BetÜl YaĞbasan, Nazmİye KurŞun, İlgİ Ertem,

BACKGROUND/AIM:Physicians require information on the family centeredness of services for children with Down syndrome, one of the most frequently encountered disabilities in childhood. We aimed to determine the family-centeredness of services for young children with Down syndrome and using a bioecological theory framework we hypothesized that child, family and service-related ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Non-traumatic coma in the pediatric intensive care unit: etiology, clinical characteristics and outcome.

Muhterem Duyu, Zeynep Karakaya Altun, Selİn Yildiz,

BACKGROUND/AIM:The purpose of this study was to evaluate the etiology, clinical characteristics and outcome of non-traumatic coma (NTC) among children admitted to a Pediatric Intensive Care Unit (PICU). MATERIALS AND METHODS:A total of 159 children with NTC were included in the study. The Modified Glasgow Coma Scale (GCS) was used ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Behçet Syndrome as a Construct

Hasan Yazici,

We still do not know the cause(s) of Behçet syndrome. Most probably several, separate disease mechanisms are involved. I, like some others, propose we call it not a disease but a syndrome, a construct with a list of strong and weak elements. I like to think that this frank admission ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1585-1586]

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Immune gene therapy of cancer

Hakan Akbulut,

Cancer gene therapy emerged as a promising treatment modality 3 decades ago. However, the failure of the first gene therapy trials in cancer treatment has decreased its popularity. Likewise, immunotherapy has followed a similar course. While it was a popular and promising treatment with IL-2 and interferon and cancer vaccines ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(SI-2):1679-1690]

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