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Evaluation of the contribution of fine-needle non-aspiration cytology to diagnosis in cases with pulmonary malignant lesions.

Şenay Yilmaz, Güntülü Ak, Selma Metintaş, Emine Dündar, Muzaffer Metintaş,

<h4>Background/aim</h4>Fine-needle non-aspiration cytology (FNNAC) is an easy-to-apply, minimally invasive diagnostic method that contributes to the diagnosis and staging of lung cancer. FNNAC can be performed from peripheral lymph nodes as well as in peripheral lung lesions. Study aimed to evaluate the contribution of FNNAC performed from peripheral lesions or lymph ... Read more >>

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[2021, :]

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Three-Dimensional Assessment of Pharyngeal Airway in Individuals with Myotonic Dystrophy Type 1.

Burcu Evlice, Ayşe Filiz Koç, Hazal Duyan, Damla Soydan Çabuk,

<h4>Background</h4>The objectives of this study were to assess pharyngeal airway volume (PAV) in patients with myotonic dystrophy type 1 (DM1) by cone-beam computerized tomography (CBCT) and to evaluate the impact of diaphragm thickness and pulmonary function tests on PAV.<h4>Materials and methods</h4>Thirty DM1 patients (10 female and 20 male; mean age ... Read more >>

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Circular RNA circPRMT5 is Upregulated in Breast Cancer and is Required for Cell Proliferation and Migration.

Xiaofeng Li, Dairong Zhang, Zuxi Feng, Xiangjing Xu, Jihong Zhang, Aiping Yu, Li Zhu, Jie Xiao, Junhua Du, Min Chen,

<h4>Objective</h4>To evaluate the role of cyclic protein arginine methyltransferase 5 (circPRMT5) in the occurrence and development of breast cancer (BC).<h4>Methods</h4>A total of 90 BC patients who underwent radical mastectomy and 40 age-matched healthy female controls were recruited in the Second People's Hospital of China Three Gorges University, Yichang Second People's ... Read more >>

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Non-pharmaceutical interventions in Turkey and worldwide during COVID-19 pandemic.

Mustafa Necmi Ilhan, Hakan Tüzün, Rahmi Kiliç, Nuran Yildirim,

Non-pharmaceutical interventions (NPIs) are actions apart from getting vaccinated and medications, in order to promote deceleration of the spread of illness among people and communities during pandemic. In this article, we aim to examine NPIs applied in Turkey and worldwide due to the COVID-19 pandemic. Some of the NPIs such ... Read more >>

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[2021, :]

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HEART RATE TURBULENCE MEASUREMENTS IN PATIENTS WITH DIPPER AND NONDIPPER HYPERTENSION: THE EFFECTS OF AUTONOMIC FUNCTIONS.

Çağlar Alp, Mehmet Tolga Doğru, Vahit Demir,

OBJECTIVE Hypertensive patients have shown autonomic dysfunction that is closely associated with the measurements of heart rate variability (HRV) and heart rate turbulence (HRT). We aimed to show the alterations of HRV and HRT measurements in patients with both dipper and non-dipper hypertension. MATERIALS AND METHODS This was a retrospective ... Read more >>

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Germline variant screening with targeted next generation sequencing in prostate cancer: phenotype-genotype correlation.

Ali Yavuz Çakir, Kuyaş Hekimler Öztürk, Alper Özorak,

<h4>Background/aim</h4>Next generation sequencing provides new information about the molecular pathogenesis of cancer. We used a targeted NGS-based multiple gene panel comprising prostate cancer (PCa) predisposing genes to assess the prevalence of germline mutations in PCa patients.<h4>Material and methods</h4>In a cohort of twenty one PCa patients with a family history of ... Read more >>

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Comparison of Different Neuromuscular Facilitation Techniques and Conventional Physiotherapy in Knee Osteoarthritis.

Ayşenur Gökşen, Filiz Can, Seval Yilmaz, Feza Korkusuz,

<h4>Background/aim</h4>This study was conducted to compare the effects of two different `Proprioceptive Neuromuscular Facilitation (PNF)? techniques on knee muscle strength, knee muscular endurance, and proprioception in knee osteoarthritis (KOA) and conventional physiotherapy.<h4>Materials and methods</h4>The study included 35 patients aged 47-62 years and diagnosed with stage 1?2 KOA. Using a block ... Read more >>

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Serum Chitotriosidase and YKL-40 in Acute Pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers.

Ece Ünal Çetin, Fatih Kamiş, Adil Uğur Çetin, Yavuz Beyazit, Murat Kekilli,

<h4>Background</h4>Chitotriosidase and YKL-40, also called chitinase 3-like protein 1, are homologs of family 18 glycosyl hydrolases, secreted by human macrophages and granulocytes under inflammatory conditions. Although increased levels of chitotriosidase and YKL-40 are linked with several inflammatory diseases, the physiological utility of these two enzymes is still not fully characterized. ... Read more >>

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Effects of Pulmonary Rehabilitation on Diaphragm Thickness and Contractility in Patients with Chronic Obstructive Pulmonary Disease.

Seçilay Güneş, Aysun Genç, Yeşim Kurtaiş, Fatma Çiftci, Serhat Hayme, Akin Kaya,

<h4>Background</h4>Studies are showing that pulmonary rehabilitation (PR) increases diaphragmatic excursion by decreasing hyperinflation in patients with chronic obstructive pulmonary disease (COPD). However, there is a lack of knowledge about its effects on the diaphragm thickness(dt) and contractility. This study aims to evaluate the dt and contractility before and after PR ... Read more >>

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Conservative management of patients with endometrial intraepithelial neoplasia (EIN): Factors that could affect response and pregnancy rates.

Christos Iavazzo, Ioannis Gkegkes,

N/A. ... Read more >>

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A newly described imaging finding for Idiopathic Normal Pressure Hydrocephalus: Can Hummingbird sign contribute to the diagnosis?

Başak Atalay, Umut Perçem Orhan Söylemez, Hüseyin Yildiz,

Background/aim In this study, we aimed to evaluate whether morphological changes in the mesencephalon which were previously described as a diagnostic tool for progressive supranuclear palsy could be associated also with idiopathic normal pressure hydrocephalus. Materials and Methods Consecutive 52 patients with a possible diagnosis of idiopathic normal pressure hydrocephalus ... Read more >>

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BILIARY STENTS ARE FORGOTTEN MORE FREQUENTLY IN ELDERLY PATIENTS.

Ali Erkan Duman, Hasan Yilmaz, Sadettin Hülagü,

<h4>Background/aim</h4>Plastic biliary stents that remain in situ for more than 12 months, termed forgotten biliary stents (FBSs), can cause complications such as cholangitis, stent migration, stent occlusion and perforation. We evaluated the incidence, complications, and management of FBSs in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).<h4>Materials and methods</h4>The medical records of ... Read more >>

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Presentation characteristics and clinical outcome of patients with giant cell arteritis followed by a single center.

Mert Öztaş, Hamit Özgül, Emire Seyahi, Serdal Uğurlu,

<h4>Background/aim</h4>Giant cell arteritis (GCA) is a large vessel vasculitis that may cause significant morbidity in the elderly population. We aimed to evaluate presentation characteristics, treatment, and outcome in a cohort of patients with GCA diagnosed and followed in a single center.<h4>Materials and methods</h4>A retrospective chart review revealed 84 (41 M/43 ... Read more >>

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[2021, :]

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Assessment of Takayasu arteritis in routine practice with PETVAS, an 18F-FDG PET quantitative scoring tool.

Sema Kaymaz Tahra, Salih Özgüven, Ali Uğur Ünal, Fatma Alibaz Öner, Tunç Öneş, Tanju Yusuf Erdil, Rafi Haner Direskeneli,

<h4>Background/aim</h4>The aim of this study was to evaluate the value of PET Vascular Activity Score (PETVAS) during the follow-up of patients with Takayasu arteritis.<h4>Materials and methods</h4>Takayasu arteritis patients who underwent 18F-Fluorodeoxyglucose (FDG) PET imaging were evaluated retrospectively. In 8 patients both 1 and 2-hour imagings were also performed prospectively. For ... Read more >>

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[2021, :]

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Could computed tomography histogram analysis add value to the diagnosis of cholesteatoma.

Nursel Yurttutan, Nagihan Bilal, Betül Kizildağ, Adem Doğaner,

<h4>Background/aim</h4>To investigate the potential role of computed tomography (CT) histogram analysis in differentiating cholesteatoma (CHS) and non-cholesteatoma (NCHS).<h4>Materials and methods</h4>We evaluated 77 temporal bone CT images (from November 2016 to February 2020) that were obtained pre-operatively (mean age, 37.10±17.27 years in CHS; 36.72±16.08 years in NCHS group). Histogram analyses of ... Read more >>

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[2021, :]

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Evaluation of efficacy and safety of pirfenidone 200 mg tablets in patients with idiopathic pulmonary fibrosis in a real-life setting.

Necmiye Funda Coşkun, Aykut Çilli, Ismail Hanta, Can Sevinç, Ayşe Ödemiş, Ahmet Ursavaş,

<h4>Background/aim</h4>Phase III trials have demonstrated a significant efficacy and an acceptable safety for pirfenidone in patients having mild to moderate idiopathic pulmonary fibrosis (IPF). Real-life data on the use of pirfenidone 200 mg tablets are limited. This study aimed to investigate the efficacy and safety of pirfenidone 200 mg tablets ... Read more >>

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Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status.

Mhd Boshr Alesh, Didem Barlak Keti, Ayşenur Paç Kisaarslan, Sabahattin Muhtaroğlu, Sema Nur Taşkin,

<h4>Background/aim</h4>Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investigate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an ... Read more >>

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[2021, :]

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Pregnancy and COVID-19: Prevention, Vaccination, Therapy and Beyond.

Dilek Şahin, Atakan Tanaçan, Sophia Ne Webster, Özlem Moraloğlu Tekin,

Coronavirus disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized by significant changes in cardiovascular, respiratory, endocrine and immunological systems, there are concerns on issues like the course of disease in pregnant women, safety of ... Read more >>

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[2021, :]

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DEVELOPING THE NAUSEA AND VOMITING THERMOMETER SCALE IN CHILDREN WITH CANCER.

Asli Akdeniz Kudubeş, Murat Bektaş,

<h4>Background/aim</h4>This study aimed to develop the Nausea and Vomiting Thermometer Scale (NVTS) in children with cancer.<h4>Materials and methods</h4>This methodological study was conducted on 250 children with cancer at the research and training university hospital in Turkey between September 2019 and January 2020. The t-test, the ROC analysis, the Diagnostic index, ... Read more >>

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The Evaluation of Breast Findings Detected Through Different Visualisation Techniques in Acromegaly Patients- A Retrospective Study.

Pinar Akhanli, Sema Hepşen, Bekir Uçan, Hakan Düğer, Hayri Bostan, Muhammed Kizilgül, Muhammed Erkam Sencar, Erman Çakal,

<h4>Background/aim</h4>It is known that the increased growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have mitogenic and antiapoptotic properties in breast cells in acromegaly. Our study aims to evaluate breast findings in patients with acromegaly by comparing them to the control group.<h4>Materials and methods</h4>Sixty-one patients followed with acromegaly diagnosis and ... Read more >>

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Calcitonin levels in washout samples vs. cytology in detection of malignant lymph node metastasis in recurrent medullary thyroid cancer.

Asena Gökçay Canpolat, Mustafa Şahin, Koray Ceyhan, Serpil Sak, Özgür Demir, Rifat Emral, Murat Faik Erdoğan, Sevim Güllü, Demet Çorapçioğlu,

<h4>Background</h4>Calcitonin level in fine-needle aspirate washout fluid (Ct-FNA) was extensively studied for thyroid nodules and lymph nodes (LN). However, the data was scarce for neck recurrences/metastases of medullary thyroid cancer (MTC). Thus, the diagnostic accuracy of Ct-FNA and cytology in detection of neck LN metastases of recurrent MTC cases were ... Read more >>

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Evaluation of Atrial Fibrosis in Atrial Fibrillation Patients with Three Different Methods.

Cem Çöteli, Tuncay Hazirolan, Kudret Aytemir, Ahmet Gürkan Erdemir, Emine Nilay Bakir, Uğur Canpolat, Hikmet Yorgun, Ahmet Hakan Ateş, Ergün Bariş Kaya, Zeliha Günnur Dikmen, Necla Özer,

Background The presence of atrial fibrosis has already been known as a risk factor for atrial fibrillation (AF) development. Objective We aimed to evaluate atrial fibrosis with previously defined three different methods, which were cardiac magnetic resonance imaging (C-MRI), echocardiographic strain imaging, and biomarkers, and show the relationship between these ... Read more >>

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INVESTIGATION OF THE EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS ON ANEMIA IN PATIENTS WITH NORMAL OR MILDLY LOW GLOMERULAR FILTRATION RATE.

Betül Ergün, Aysun Aybal Kutlugün, Mustafa Cagri Ergun, Galip Aktürk, Esin Beyan,

<h4>Background</h4>The relationship between the activation of the renin-angiotensin system and the increase in erythropoiesis has been shown in many studies. In addition, the use of angiotensin converting enzyme inhibitors or angiotensin-receptor blockers has been reported to reduce hemoglobin levels in various patient groups at risk for secondary erythrocytosis/polycythemia.<h4>Aims</h4>To investigate whether ... Read more >>

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[2021, :]

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Distal Spread and Tumor Regression Patterns Following Preoperative Chemoradiotherapy in Rectal Cancer Patients.

Ilter Özer, Neslihan Inci Zengin, Haci Murat Çayci, Adem Yüksel, Tahsin Dalgiç, Murat Ulaş, Erdal Birol Bostanci, Musa Akoğlu,

<h4>Background/aim</h4>This study aimed to evaluate the regression pattern with the distal intramural spread (DIS) of rectum cancer after preoperative chemoradiation.<h4>Patients and methods</h4>Specimens from 56 patients who underwent radical resection after preoperative chemoradiation for rectal cancer were examined. The regression pattern (total, fragmented) of the tumor was recorded. DIS status was ... Read more >>

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Clinicopathological features of mammary Paget's Disease: A single center experience in Turkey.

Haldun Kar, Sultan Deniz Altindağ, Demet Etit, Seyran Yiğit, Nihan Acar, Mustafa Agah Tekindal, Emine Özlem Gür, Betül Bolat Küçükzeybek, Özgün Akgül, Murat Kemal Atahan,

<h4>Background/aim</h4>Paget?s disease (PD) of the breast is a very rare presentation of breast malignancy, accounting for 1?3% of all primary breast tumors. We aimed to evaluate and compare the clinicopathological featuresand clinical outcome of PD accompanied by in situ carcinoma and invasive cancer.<h4>Materials and methods</h4>We used the archive of our ... Read more >>

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