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Correction: From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression.

Alexios-Fotios A Mentis, Efthimios Dardiotis, Eleni Katsouni, George P Chrousos,

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):488]

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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia.

Agnieszka Kalinowski, Joanna Liliental, Lauren A Anker, Omer Linkovski, Collin Culbertson, Jacob N Hall, Reenal Pattni, Chiara Sabatti, Douglas Noordsy, Joachim F Hallmayer, Elizabeth D Mellins, Jacob S Ballon, Ruth O'Hara, Douglas F Levinson, Alexander E Urban,

Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression. C4-anaphylatoxin (C4-ana) is a C4 protein fragment released upon C4 protein activation that has the potential to change the blood-brain barrier ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):486]

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Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study.

Shi-Dong Chen, Jia-Ying Lu, Hong-Qi Li, Yu-Xiang Yang, Jie-Hui Jiang, Mei Cui, Chuan-Tao Zuo, Lan Tan, Qiang Dong, Jin-Tai Yu, ,

A biological research framework to define Alzheimer' disease with dichotomized biomarker measurement was proposed by National Institute on Aging-Alzheimer's Association (NIA-AA). However, it cannot characterize the hierarchy spreading pattern of tau pathology. To reflect in vivo tau progression using biomarker, we constructed a refined topographic <sup>18</sup>F-AV-1451 tau PET staging scheme ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):483]

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Efficacy and safety of clozapine in psychotic disorders-a systematic quantitative meta-review.

Elias Wagner, Spyridon Siafis, Piyumi Fernando, Peter Falkai, William G Honer, Astrid Röh, Dan Siskind, Stefan Leucht, Alkomiet Hasan,

A recent increase in the literature regarding the evidence base for clozapine has made it increasingly difficult for clinicians to judge "best evidence" for clozapine use. As such, we aimed at elucidating the state-of-the-art for clozapine with regard to efficacy, effectiveness, tolerability, and management of clozapine and clozapine-related adverse events ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):487]

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CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells.

Lang He, Shang Wang, Linliu Peng, Huifang Zhao, Shuai Li, Xiaobo Han, Jean de Dieu Habimana, Zhao Chen, Chunrong Wang, Yun Peng, Huirong Peng, Yue Xie, Lijing Lei, Qi Deng, Linlin Wan, Na Wan, Hongyu Yuan, Yiqing Gong, Guangdong Zou, Zhiyuan Li, Beisha Tang, Hong Jiang,

Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is a progressive autosomal dominant neurodegenerative disease caused by abnormal CAG repeats in the exon 10 of ATXN3. The accumulation of the mutant ataxin-3 proteins carrying expanded polyglutamine (polyQ) leads to selective degeneration of neurons. Since the pathogenesis of SCA3 has not been fully ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):479]

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Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum.

Klara Danielsson, Rosita Stomberg, Louise Adermark, Mia Ericson, Bo Söderpalm,

Schizophrenia is associated with three main categories of symptoms; positive, negative and cognitive. Of these, only the positive symptoms respond well to treatment with antipsychotics. Due to the lack of effect of antipsychotics on negative symptoms, it has been suggested that while the positive symptoms are related to a hyperdopaminergic ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):472]

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Who benefits most from expectancy effects? A combined neuroimaging and antidepressant trial in depressed older adults.

Sigal Zilcha-Mano, Meredith L Wallace, Patrick J Brown, Joel Sneed, Steven P Roose, Bret R Rutherford,

Depressed patients' expectations of improvement drive placebo effects in antidepressant clinical trials, yet there is considerable heterogeneity in the magnitude of expectancy effects. The present study seeks to identify those individuals who benefit most from expectancy effects using baseline neuroimaging and cognitive measures. Older adult outpatients diagnosed with major depressive ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):475]

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Prevalence and correlates of suicidal ideation and suicide attempts in preadolescent children: A US population-based study.

Hannah R Lawrence, Taylor A Burke, Ana E Sheehan, Brianna Pastro, Rachel Y Levin, Rachel F L Walsh, Alexandra H Bettis, Richard T Liu,

The present study evaluated sociodemographic and diagnostic predictors of suicidal ideation and attempts in a nationally representative sample of preadolescent youth enrolled in the Adolescent Brain Cognitive Development Study. Rates and predictors of psychiatric treatment utilization among suicidal youth also were examined. Eleven thousand eight hundred and seventy-five 9- and ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):489]

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A dismantling study on imaginal retraining in overweight or obese women.

Janina Wirtz, Leonie Ascone, Josefine Gehlenborg, Steffen Moritz, Simone Kühn,

Imaginal retraining is a variant of approach bias modification and transfers the method into one's own mind. As the technique contains multiple elements, this pilot study aimed to dismantle which of its components is most efficient in reducing craving for high-calorie food. A total of 113 women were randomly allocated ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):481]

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Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms.

James F Cavanagh, David Gregg, Gregory A Light, Sarah L Olguin, Richard F Sharp, Andrew W Bismark, Savita G Bhakta, Neal R Swerdlow, Jonathan L Brigman, Jared W Young,

There has been a fundamental failure to translate preclinically supported research into clinically efficacious treatments for psychiatric disorders. One of the greatest impediments toward improving this species gap has been the difficulty of identifying translatable neurophysiological signals that are related to specific behavioral constructs. Here, we present evidence from three ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):482]

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Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.

Pavol Mikolas, Kyra Bröckel, Christoph Vogelbacher, Dirk K Müller, Michael Marxen, Christina Berndt, Cathrin Sauer, Stine Jung, Juliane Hilde Fröhner, Andreas J Fallgatter, Thomas Ethofer, Anne Rau, Tilo Kircher, Irina Falkenberg, Martin Lambert, Vivien Kraft, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Thomas Stamm, Felix Bermpohl, Jana Fiebig, Georg Juckel, Vera Flasbeck, Christoph U Correll, Philipp Ritter, Michael Bauer, Andreas Jansen, Andrea Pfennig,

In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):485]

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Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits.

Elaine Tierney, Alan T Remaley, Audrey Thurm, Leah R Jager, Christopher A Wassif, Lisa E Kratz, Joan E Bailey-Wilson, Irena Bukelis, Geeta Sarphare, Eun Sol Jung, Boudewien Brand, Kelly K Noah, Forbes D Porter,

An improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with ≥2 children with ASD participating with the Autism Genetic Resource Exchange (AGRE), as well as ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):471]

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DNA methylation of the glucocorticoid receptor gene predicts substance use in adolescence: longitudinal data from over 1000 young individuals.

Elena Raffetti, Philippe Anastasios Melas, Anton Jonatan Landgren, Filip Andersson, Yvonne Forsell, Catharina Lavebratt, Maria Rosaria Galanti,

Early life stress has been linked to increased methylation of the Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1) gene, which codes for the glucocorticoid receptor. Moreover, early life stress has been associated with substance use initiation at a younger age, a risk factor for developing substance use disorders. ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):477]

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Cortical structure and the risk for Alzheimer's disease: a bidirectional Mendelian randomization study.

Bang-Sheng Wu, Ya-Ru Zhang, Hong-Qi Li, Kevin Kuo, Shi-Dong Chen, Qiang Dong, Yong Liu, Jin-Tai Yu,

Progressive loss of neurons in a specific brain area is one of the manifestations of Alzheimer's disease (AD). Much effort has been devoted to investigating brain atrophy and AD. However, the causal relationship between cortical structure and AD is not clear. We conducted a bidirectional two-sample Mendelian randomization analysis to ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):476]

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Machine-learning-based diagnosis of drug-naive adult patients with attention-deficit hyperactivity disorder using mismatch negativity.

Sungkean Kim, Ji Hyun Baek, Young Joon Kwon, Hwa Young Lee, Jae Hyun Yoo, Se-Hoon Shim, Ji Sun Kim,

Relatively little is investigated regarding the neurophysiology of adult attention-deficit/hyperactivity disorder (ADHD). Mismatch negativity (MMN) is an event-related potential component representing pre-attentive auditory processing, which is closely associated with cognitive status. We investigated MMN features as biomarkers to classify drug-naive adult patients with ADHD and healthy controls (HCs). Sensor-level features ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):484]

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Absence of covert face valuation in Autism.

Fabien Vinckier, Mathias Pessiglione, Baudouin Forgeot d'Arc,

Autism is a neurodevelopmental condition defined on clinical criteria related to diminished social reciprocity and stereotyped behavior. An influential view explains autism as a social motivation disorder characterized by less attention paid to the social environment and less pleasure experienced with social rewards. However, experimental attempts to validate this theory, ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):463]

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Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares.

Gwenn S Smith, Clifford I Workman, Hillary Protas, Yi Su, Alena Savonenko, Hiroto Kuwabara, Neda F Gould, Michael Kraut, Jin Hui Joo, Ayon Nandi, Dimitri Avramopoulos, Eric M Reiman, Kewei Chen,

Depression in late-life is associated with increased risk of cognitive decline and development of all-cause dementia. The neurobiology of late-life depression (LLD) may involve both neurochemical and neurodegenerative mechanisms that are common to depression and dementia. Transgenic amyloid mouse models show evidence of early degeneration of monoamine systems. Informed by ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):473]

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Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway.

Shira Mencer, Maryam Kartawy, Felix Lendenfeld, Huda Soluh, Manish Kumar Tripathi, Igor Khaliulin, Haitham Amal,

Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological disorders that share common clinical features, such as language impairment, executive functions, and motor problems. A genetic convergence has been proposed as well. However, the molecular mechanisms of these pathologies are still not well understood. Protein S-nitrosylation (SNO), ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):480]

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Beneficial effects of running exercise on hippocampal microglia and neuroinflammation in chronic unpredictable stress-induced depression model rats.

Kai Xiao, Yanmin Luo, Xin Liang, Jing Tang, Jin Wang, Qian Xiao, Yingqiang Qi, Yue Li, Peilin Zhu, Hao Yang, Yuhan Xie, Hong Wu, Yong Tang,

Running exercise has been shown to relieve symptoms of depression, but the mechanisms underlying the antidepressant effects are unclear. Microglia and concomitant dysregulated neuroinflammation play a pivotal role in the pathogenesis of depression. However, the effects of running exercise on hippocampal neuroinflammation and the number and activation of microglia in ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):461]

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Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies.

Yujie Xu, Linan Zeng, Kun Zou, Shufang Shan, Xiaoyu Wang, Jingyuan Xiong, Li Zhao, Lingli Zhang, Guo Cheng,

The role of diet in depression is becoming increasingly acknowledged. This umbrella review aimed to summarize comprehensively the current evidence reporting the effects of dietary factors on the prevention and treatment of depression. PubMed, Embase, and the Cochrane Library were searched up to June 2021 to identify relevant meta-analyses of ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):478]

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Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression.

Xiangchuan Chen, Diana J Beltran, Valeriya D Tsygankova, Bobbi J Woolwine, Trusharth Patel, Wendy Baer, Jennifer C Felger, Andrew H Miller, Ebrahim Haroon,

Inflammation is associated with the development of anhedonia in major depression (MD), but the pathway by which inflammatory molecules gain access to the brain and lead to anhedonia is not clear. Molecules of the kynurenine pathway (KP), which is activated by inflammation, readily influx into the brain and generate end ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):456]

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Network analysis of depressive symptoms in Hong Kong residents during the COVID-19 pandemic.

Teris Cheung, Yu Jin, Simon Lam, Zhaohui Su, Brian J Hall, Yu-Tao Xiang, ,

In network theory depression is conceptualized as a complex network of individual symptoms that influence each other, and central symptoms in the network have the greatest impact on other symptoms. Clinical features of depression are largely determined by sociocultural context. No previous study examined the network structure of depressive symptoms ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):460]

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Ca2+ channel blockade reduces cocaine's vasoconstriction and neurotoxicity in the prefrontal cortex.

Congwu Du, Kicheon Park, Craig P Allen, Xiu-Ti Hu, Nora D Volkow, Yingtain Pan,

Cocaine profoundly affects both cerebral blood vessels and neuronal activity in the brain. The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca<sup>2+</sup>]<sub>i</sub> accumulation are likely to jeopardize neuronal tissue that in the prefrontal cortex (PFC) could contribute to impaired self-regulation and compulsive cocaine consumption. Here we used ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):459]

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Neural correlates of emotional reactivity and regulation in traumatized North Korean refugees.

Kyung Hwa Lee, Ha Young Lee, Inkyung Park, Yu Jin Lee, Nambeom Kim, Sehyun Jeon, Soohyun Kim, Jeong Eun Jeon, Seog Ju Kim,

Refugees often report heightened emotional reactivity and emotion regulation difficulties and are at high risk for mental health problems. Given that refugees are repeatedly exposed to traumatic events that may cause changes in the brain, the present study examined neural correlates of emotional reactivity and regulation and their associations with ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):452]

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Facilitating improvements in young people's social relationships to prevent or treat depression: there's an app for that.

Bridianne O'Dea,

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):470]

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