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Journal Transl Androl Urol

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Testicular rupture following rubber bullet trauma case report.

Madison E Kahle, Kayla M Hamann, Aliya A Sakher, Erika A Kaske, Travis Pagliara, Joseph J Pariser,

Following civil unrest during 2020, physicians began to notice a variety of injuries resulting from crowd control weapons. While prior research emphasized ocular trauma, genitourinary complications of injuries have yet to be investigated. A previously healthy 27-year-old male presented to the emergency department due to sudden onset of severe left ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3529-3531]

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A systematic review and meta-analysis of radical cystectomy in the treatment of muscular invasive bladder cancer (MIBC).

Juan Zhao, Li Zhou, Yan Pan, Lan Chen,

<h4>Background</h4>A meta-analysis was conducted to evaluate the curative effect of radical cystectomy in the treatment of muscular invasive bladder cancer (MIBC).<h4>Methods</h4>Chinese and English databases were searched using free combinations of the terms "bladder cancer," "radical cystectomy," "muscle invasive bladder cancer," and "bladder preservation." Review Manager 5.3 software was used for ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3476-3485]

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A randomized placebo-controlled study: Phellodendron Bawei tablets combined with standard management can improve storage symptoms, sleep quality, and medication compliance in patients with benign prostatic hyperplasia compared to placebo with standard management.

Yu-Chen Gong, Xiang Chen, Qing-Tian Song, Yu Gan, Bo Zhang, Bing-Sheng Li, Zhi Chen, Yao He,

<h4>Background</h4>Benign prostatic hyperplasia (BPH) is a common micturition disorder in middle-aged and elderly males, and it is one of the most common urology-related diseases worldwide. However, standard therapeutic drugs (α1-receptor blockers + 5α reductase inhibitors) do not provide anti-inflammatory or anti-infective effects. The Phellodendron Bawei tablet is a proprietary Chinese ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3423-3431]

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Young age increases the risk of lymph node positivity but improves prognosis in patients with bladder cancer treated via cystectomy: a population-based study.

Tianming Ma, Zijian Tian, Lingfeng Meng, Wei Zhang, Jiawen Wang, Xiaodong Liu, Xiaonan Wang, Yaoguang Zhang,

<h4>Background</h4>Age and lymph node positivity are significant prognostic indicators in patients with bladder cancer. This study aimed to investigate the impact of age on lymph node positivity and bladder cancer outcomes.<h4>Methods</h4>Patients with bladder cancer who underwent cystectomy with at least one lymph node examined between 2004 and 2015 were identified ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3375-3385]

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Terminal augmented ureteroplasty with bladder onlay flap technique for recurrent distal ureteral stricture after ureteroneocystostomy: an initial case series.

Yucai Wu, Weijie Zhu, Kunlin Yang, Shubo Fan, Bao Guan, Bingwei Huang, Jie Wang, Jianxin Wang, Zhihua Li, Hua Guan, Yanbo Huang, Zhe Li, Peng Zhang, Xuesong Li, Liqun Zhou,

<h4>Background</h4>Bladder flap has been shown to be a feasible treatment for distal ureteral stenosis; this technique has been improved such that it can be used to address complex urinary tract obstructions. The purpose of the present study was to describe a surgical technique of ureteroplasty with a bladder onlay flap, ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3332-3339]

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High TNFSF13B expression as a predictor of poor prognosis in adrenocortical carcinoma.

Yongxin Mao, Parehe Alimu, Chenghe Wang, Wenming Ma, Ran Zhuo, Fukang Sun,

<h4>Background</h4>Adrenocortical carcinoma (ACC) is an extremely rare malignant tumor with poor prognosis. Existing treatment options have limited effects, and new therapeutic targets urgently need to be discovered. TNFSF13B has been reported to be associated with the prognosis of clear cell renal cell carcinoma, but it has not been studied in ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3275-3285]

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Retrograde intrarenal surgery for a staghorn renal calculus in a patient with solitary kidney and urinary tract deformity: a case report.

Yuancheng Xu, Zhengquan Lu, Yulong Lan, Dan Wu, Lin Xiong,

Staghorn renal calculi are large, branched stones in the kidney that partially or completely fill the renal pelvis and renal calyces. Percutaneous nephrolithotomy (PCNL) is the gold standard treatment for staghorn calculi. However, we report a retrograde intrarenal surgery (RIRS) performed to treat a staghorn calculus in a patient with ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3532-3539]

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CYR61, regulated by miR-22-3p and MALAT1, promotes autophagy in HK-2 cell inflammatory model.

Pengwei Guo, Yanfei Ma, Gao Deng, Lingling Li, Yunxia Gong, Fafen Yang, Yanwu You,

<h4>Background</h4>Renal tubular epithelial cells play an important role in renal function and are a major site of injury from inflammation. Emerging evidence suggests that CYR61 is involved in the regulation of autophagy. However, there are few studies on CYR61 in nephropathy and associated inflammation. This study aimed to clarify how ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3486-3500]

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Combination therapy with curcumin plus tamsulosin and finasteride in the treatment of men with benign prostatic hyperplasia: a single center, randomized control study.

Jing Qiao, Yu Gan, Yuchen Gong, Qingtian Song, Bo Zhang, Bingsheng Li, Feng Ru, Yang Li, Yao He,

<h4>Background</h4>To perform a prospective, randomized, single center study to investigate the efficacy of combined use of curcumin, an anti-inflammatory agent, with the best standard management (BSM, tamsulosin and finasteride) in benign prostatic hyperplasia (BPH) patients.<h4>Methods</h4>One hundred and twenty-two consecutive patients were randomized to receive tamsulosin 0.2 mg, finasteride 5 mg, ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3432-3439]

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Holographic reconstruction technology used for intraoperative real-time navigation in robot-assisted partial nephrectomy in patients with renal tumors: a single center study.

Shaohua Zeng, Yu Zhou, Min Wang, Hui Bao, Yanqun Na, Tiejun Pan,

<h4>Background</h4>To explore the efficacy and advantages of real-time navigation using holographic reconstruction (HR) technology combined with da VinciTM robotic system for partial nephrectomy (PN) in patients with renal tumor.<h4>Methods</h4>The clinical data of 41 patients with totally intrarenal tumors receiving robot-assisted partial nephrectomy (RAPN) from April 2018 to October 2020 in ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3386-3394]

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Neuroinflammatory gene expression in chronic prostatitis/chronic pelvic pain syndrome patients: insights into etiology and phenotype biology.

Daniel A Shoskes, Karen S Keslar, Paige Gotwald, Ryan Berglund, Sarah Vij,

<h4>Background</h4>Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has diverse clinical phenotypes and its etiology is multifactorial. Studies to date of gene expression in humans have been limited to small numbers of target genes. NanoString can simultaneously measure hundreds of genes. We wished to study gene expression in blood and urine of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3340-3347]

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Comparison of in situ preservation techniques for kidneys from donors after circulatory death: a systematic review and meta-analysis.

Alberto Artiles Medina, Francisco Javier Burgos Revilla, Marta Álvarez Nadal, Alfonso Muriel García, Noelia Álvarez Díaz, Victoria Gómez Dos Santos,

<h4>Background</h4>Several techniques have been developed to reduce the warm ischaemic injury of donation after circulatory death (DCD) organs before procurement. There are scarce data about the <i>in situ</i> preservation techniques for kidney graft outcomes. The aim of this systematic review was to evaluate the best <i>in situ</i> preservation method for ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3286-3299]

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Bilateral ileal ureter substitution for patients with ureteral strictures secondary to gynecological tumors radiotherapy: a multi-center retrospective study.

Xinfei Li, Weijie Zhu, Zhen Zeng, Qian Wang, Dong Fang, Zhihua Li, Hua Guan, Yanbo Huang, Peng Zhang, Hongjian Zhu, Xuesong Li, Liqun Zhou,

<h4>Background</h4>The selection of treatment for bilateral ureteral strictures caused by radiotherapy in patients with gynecological tumors often brings great challenges to urologists. This study was designed to analyze the characteristics of radiation-induced ureteral strictures and summarize the surgical experience of bilateral ileal ureter substitution.<h4>Methods</h4>We retrospectively collected the medical records of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3226-3238]

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Bioinformatics analysis reveals biomarkers with cancer stem cell characteristics in kidney renal clear cell carcinoma.

Zan Zhang, Xueyang Xiong, Rufeng Zhang, Guoliang Xiong, Changyuan Yu, Lida Xu,

<h4>Background</h4>Kidney renal clear cell carcinoma (KIRC) is a renal cortical tumor. KIRC is the most common subtype of kidney cancer, accounting for 70%-80% of kidney cancer. Early identification of the risk of KIRC patients can facilitate more accurate clinical treatment, but there is a lack of effective prognostic markers. We ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3501-3514]

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Bioinformatics analysis based on immune-autophagy-related lncRNAs combined with immune infiltration in bladder cancer.

Guobin Tan, Aiming Wu, Zhiqin Li, Guangming Chen, Yonglu Wu, Shuitong Huang, Xianxi Chen, Guanjun Li,

<h4>Background</h4>To construct a prognostic model based on immune-autophagy-related long noncoding RNA (IArlncRNAs), mainly to predict the overall survival rate (OS) of bladder cancer patients and investigate its possible mechanisms.<h4>Methods</h4>Transcriptome and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. We identified the IArlncRNA by co-expression analysis, differential expression ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3440-3455]

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Combination of transurethral resection of the prostate and flexible and rigid ureteroscopy for benign prostatic hyperplasia and ureteral calculus.

Kunlun He, Yan Liu, Dong Li, Qian Yu,

<h4>Background</h4>Combination of transurethral resection of the prostate (TURP) and flexible and rigid ureteroscopy (URS/RIRS) is a successful approach for patients with benign prostatic hyperplasia (BPH) and ureteral calculus (UC), and the sequence is URS/RIRS followed by TURP. This research aims to compare TURP followed by URS/RIRS with URS/RIRS followed by ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3395-3401]

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Increased phosphorylated CREB1 protein correlates with poor prognosis in clear cell renal cell carcinoma.

Zhongyuan Zhang, Bao Guan, Yifan Li, Qun He, Xuesong Li, Liqun Zhou,

<h4>Background</h4>This study aims to investigate the level of cAMP response element-binding protein 1 (phospho S133) (p-CREB1) protein in clear cell renal cell carcinoma (ccRCC) and evaluates its prognosis significance.<h4>Methods</h4>Immunohistochemistry (IHC) method was performed to detect p-CREB1 staining in 233 ccRCC patients. Three or more high-power fields per tissue section were ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3348-3357]

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Identification of novel biomarkers of prostate cancer through integrated analysis.

Pu Zhang, Bei Qian, Zijian Liu, Decai Wang, Fang Lv, Yifei Xing, Yajun Xiao,

<h4>Background</h4>The current methods adopted to screen for prostate cancer (PCa) can sometimes be misleading and inaccurate. Moreover, for advanced stages of PCa, the current effect of treatment is not satisfactory for some patients. Accordingly, we aimed to identify new biomarkers for the diagnosis and prognosis of PCa.<h4>Methods</h4>A series of bioinformatic ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3239-3254]

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Effects of L-carnitine combined with pancreatic kininogenase on thioredoxin 2, thioredoxin reductase 1, and sperm quality in patients with oligoasthenospermia.

Yang Wang, Rui Zhang, Weijun Pan, Zhe Xu, Huan Yang, Qi Luo, Xiping Ye, Xianfeng Cheng,

<h4>Background</h4>To study the effects of L-carnitine (LC) combined with pancreatic kininogenase on thioredoxin 2 (Trx 2), thioredoxin reductase 1 (TrxR 1), and sperm quality in patients with oligoasthenospermia.<h4>Methods</h4>A total of 300 male infertility patients with oligoasthenospermia who were treated in the andrology clinic of our hospital from December 2019 to ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3515-3523]

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Female chronic posterior urethritis is underestimated in patients with lower urinary tract symptoms.

Juanjuan Xie, Xin Li, Yufang Lü, Caisheng Huang, Xinyang Long, Yong Liu, Huaxiang Lu, Jianhua Long, Bo Chen, Zhigang Luo, Zengnan Mo,

<h4>Background</h4>As one of the causes of urethral symptoms, female chronic posterior urethritis is a common and distressing disease; however, it is often neglected and misdiagnosed as overactive bladder (OAB) or interstitial cystitis/bladder pain syndrome (IC/BPS). Currently, little is known about the urothelium and lamina propria of the bladder neck and ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3456-3464]

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Discovery of bladder cancer biomarkers in paired pre- and postoperative urine samples.

Xuechao Li, Chuanxi Huang, Xueli Zhang, Tao Yang, Shidong Zuo, Chengwei Fu, Yongjie Zhang, Chunyuan Yang, Lijun Chen,

<h4>Background</h4>Bladder cancer (BC), a common cancer of the urinary system, has a low mortality but an extremely high recurrence rate. Patients who have undergone initial surgical treatment often undergo frequent prognostic examinations with a substantial burden of discomfort and costs. Urine samples can reflect early disease processes in the urinary ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3402-3414]

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Efficacy and safety of aildenafil citrate in Chinese men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled crossover trial.

Wan-Shou Cui, Rui-Li Guan, Hong-En Lei, Ji-Hong Liu, Tao Wang, Sai-Nan Zhu, Chen Yao, Jiang Wang, Yu-Hong Feng, Long Tian, Zhong-Cheng Xin,

<h4>Background</h4>To evaluate the efficacy and safety of aildenafil citrate in the treatment of erectile dysfunction (ED) in Chinese population.<h4>Methods</h4>A multicenter, randomized, double-blind, placebo-controlled, double-cycle crossover trial was conducted in three medical centers. Male patients with mild to moderate ED were randomized into two groups and received either aildenafil citrate or ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3358-3367]

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Barriers to receiving testosterone replacement therapy in the community during COVID-19 pandemic.

Victoria L Troesch, Denise Juhr, Amy Pearlman,

<h4>Background</h4>While the etiology for the upsurge in testosterone testing and prescriptions is likely multifactorial, increased direct-to-consumer marketing and the expansion of clinical care centers devoted to testosterone treatment likely play a role. Many of these centers require patients to report, in-person, on a regular basis for their injectable therapy and/or ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3312-3316]

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Whether histologic subtyping affect the oncological outcomes of patients with papillary renal cell carcinoma: evidence from a systematic review and meta-analysis.

Shengwei Xiong, Weijie Zhu, Xinfei Li, Yanfei Yu, Kunlin Yang, Lei Zhang, Yue Mi, Xuesong Li, Liqun Zhou,

<h4>Background</h4>Whether the histologic subtype (type 1 and type 2) of papillary renal cell carcinoma (pRCC) is a tool to predict the prognosis is of great debate. This study is aimed to evaluate the prognostic significance of histologic subtype in patients with pRCC after surgery through a systematic review and meta-analysis.<h4>Methods</h4>We ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3255-3266]

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Hidden penis: a rare case of delayed complication after a pelvic blunt trauma.

Erika Palagonia, Daniele Castellani, Piero Ronchi, Lucio Dell'Atti, Andrea B Galosi,

Penile dislocation following a traumatic pubic bone fracture is a very rare condition. Only a few cases are reported in the literature and the presentation mechanism is still not completely understood. The impact energy on the pelvis usually causes a displaced fracture with concomitant withdrawal of the pubic bone. The ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(8):3524-3528]

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