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Journal Transfusion

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Leukapheresis for the management of hyperleukocytosis in acute myeloid leukemia-A systematic review and meta-analysis.

Jan P Bewersdorf, Smith Giri, Martin S Tallman, Amer M Zeidan, Maximilian Stahl,

BACKGROUND:Up to 20% of patients with acute myeloid leukemia (AML) present with hyperleukocytosis, usually defined as a white blood cell (WBC) count greater than 100 × 109 /L. Given the high early mortality rate, emergent cytoreduction with either leukapheresis, hydroxyurea, or chemotherapy is indicated, but the optimal strategy is unknown. STUDY DESIGN ... Read more >>

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[2020, :]

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Red blood cell alloimmunization prevalence and hemolytic disease of the fetus and newborn in Israel: A retrospective study.

Naomi Rahimi-Levene, Judith Chezar, Vered Yahalom, ,

Hemolytic disease of the fetus and newborn (HDFN) is a severe form of anemia caused by maternal antibodies against fetal red blood cells (RBC) that can cause intrauterine and perinatal morbidity and mortality. The prevalence and specificities of alloantibodies among Israeli pregnant women and clinical outcomes for their fetuses and ... Read more >>

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[2020, :]

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Naturally occurring point mutation Cys460Trp located in the I-EGF1 domain of integrin β3 alters the binding of some anti-HPA-1a antibodies.

Sarah Theresa Holzwarth, Behnaz Bayat, Jieqing Zhu, Roongaroon Phuangtham, Lars Fischer, Doris Boeckelmann, Lida Röder, Heike Berghöfer, Silke Schmidt, Gregor Bein, Sentot Santoso,

BACKGROUND:Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by the destruction of platelets in the fetus or newborn by maternal platelet alloantibodies, mostly against human platelet antigen (HPA)-1a. Recent studies indicate that two anti-HPA subtypes exist: Type I reacts with epitopes residing on the plexin-semaphorin-integrin (PSI) and type II with ... Read more >>

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[2020, :]

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Warming blood products for transfusion to neonates: In vitro assessments.

Whitley Hulse, Timothy M Bahr, Lauren Fredrickson, Christy M Canfield, Kim Friddle, Theodore J Pysher, Sarah J Ilstrup, Robin K Ohls, Robert D Christensen,

BACKGROUND:Blood products may be transfused into neonates at temperatures at or below room temperature. The benefits and risks of warming blood to 37°C are not defined in this population or with the equipment used in neonates. Physiologic warming might enhance product effectiveness or decrease transfusion-associated hypothermia. STUDY DESIGN AND METHODS:We ... Read more >>

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[2020, :]

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Tools for rapid analysis of blood usage and inventory during the COVID-19 pandemic.

Colin Murphy, Bryon Jackson, Magali Fontaine,

BACKGROUND:The COVID-19 pandemic caused downtrends in both blood collections and blood usage. Rapidly visualizing the impact of the pandemic and newly implemented hospital policies on usage could potentially inform blood ordering practices to help avoid wastage. STUDY DESIGN AND METHODS:Blood usage data were obtained from the laboratory information system. An ... Read more >>

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[2020, :]

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Hemolysis in the plasma of a specimen? Add a drop to clarify it.

Piñeyroa Juan, Gomez-Hernando Marta, Rodriguez-Aliberas Marta, Cid Joan, Molina Angel, Lozano Miquel,

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[2020, :]

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Barriers to blood donation on social media: An analysis of Facebook and Twitter posts.

Steven Ramondt, Melissa Zijlstra, Peter Kerkhof, Eva-Maria Merz,

BACKGROUND:To better understand donor behavior and ensure a safe and sufficient blood supply, various observational studies have examined barriers to blood donation. This study used Facebook and Twitter data to enhance existing research on donation barriers and associated emotions communicated on social media by both donors and non-donors. STUDY DESIGN ... Read more >>

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[2020, :]

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Discarded plasma obtained after cord blood volume reduction as an alternative for fetal calf serum in mesenchymal stromal cells cultures.

Marija Vlaski-Lafarge, Jean Chevaleyre, Julie Cohen, Zoran Ivanovic, Xavier Lafarge,

BACKGROUND:Utilization of the fetal calf serum (FCS) carries a potential health risk and raises growing economic and ethical problems. Umbilical cord blood volume reduction, required for banking, provides clinical-grade umbilical cord blood plasma (UCBP) discarded as a waste. The aim of this study was to test whether serum derived from ... Read more >>

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[2020, :]

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Validation of a SCID mouse model for transfusion by concurrent comparison of circulation kinetics of human platelets, stored under various temperature conditions, between human volunteers and mice.

Monique P Gelderman, Chunrong Cheng, Fei Xu, Andrey Skripchenko, Johannah Ryan, Ying Li, Pamela Whitley, Stephen J Wagner, Jaroslav G Vostal,

BACKGROUND:Initial evaluation of new platelet (PLT) products for transfusion includes a clinical study to determine in vivo recovery and survival of autologous radiolabeled PLTs in healthy volunteers. These studies are expensive and do not always produce the desired results. A validated animal model of human PLTs in vivo survival and ... Read more >>

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[2020, :]

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Residual bacterial detection rates after primary culture as determined by secondary culture and rapid testing in platelet components: A systematic review and meta-analysis.

Brandon S Walker, Sandra K White, Robert L Schmidt, Ryan A Metcalf,

BACKGROUND:Primary culture alone was a bacterial risk control strategy intended to facilitate interdiction of contaminated platelets (PLTs). A September 2019 FDA guidance includes secondary testing options to enhance safety. Our objective was to use meta-analysis to determine residual contamination risk after primary culture using secondary culture and rapid testing. STUDY ... Read more >>

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[2020, :]

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Pathogenic and likely pathogenic variants in at least five genes account for approximately 3% of mild isolated nonsyndromic thrombocytopenia.

Paul Guéguen, Arnaud Dupuis, Jean-Yves Py, Aurore Desprès, Emmanuelle Masson, Cédric Le Marechal, David N Cooper, Christian Gachet, Jian-Min Chen, Claude Férec,

BACKGROUND:Thrombocytopenia has a variety of different etiologies, both acquired and hereditary. Inherited thrombocytopenia may be associated with other symptoms (syndromic forms) or may be strictly isolated. To date, only about half of all the familial forms of thrombocytopenia have been accounted for in terms of well-defined genetic abnormalities. However, data ... Read more >>

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[2020, :]

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Diagnostic accuracy of the PLASMIC score in patients with suspected thrombotic thrombocytopenic purpura: A systematic review and meta-analysis.

Koosha Paydary, Emma Banwell, Jiayi Tong, Yong Chen, Adam Cuker,

BACKGROUND:The PLASMIC score was developed to identify patients with thrombotic microangiopathy who are most likely to have immune thrombotic thrombocytopenic purpura (TTP) and benefit from therapeutic plasma exchange (TPE). PLASMIC scores of 0-4, 5, and 6-7 are said to correspond to low, intermediate, and high probability of TTP, respectively. STUDY ... Read more >>

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[2020, :]

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Differential red blood cell age fractionation and Band 3 phosphorylation distinguish two different subtypes of warm autoimmune hemolytic anemia.

Evgenia M Bloch, Haley A Branch, Darinka Sakac, Regina M Leger, Donald R Branch,

Warm autoimmune hemolytic anemia (wAIHA) is a blood disorder characterized by the increased destruction of autologous red blood cells (RBCs) due to the presence of opsonizing pathogenic autoantibodies. Preliminary reports published more than three decades ago proposed the presence of two wAIHA subtypes: Type I, in which autoantibodies preferentially recognize the ... Read more >>

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[2020, :]

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Dynamics of shape recovery by stored red blood cells during washing at the single cell level.

Madeleine Lu, Sergey S Shevkoplyas,

BACKGROUND:Hypothermic storage transforms red blood cells (RBC) from smooth biconcave discocytes into increasingly spherical spiculated echinocytes and, ultimately, fragile spherocytes (S). Individual cells undergo this transformation at different rates, producing a heterogeneous mixture of RBCs at all stages of echinocytosis in each unit of stored blood. Here we investigated how ... Read more >>

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[2020, :]

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Entrustable professional activities for apheresis medicine education.

Monica B Pagano, Angela Treml, Laura D Stephens, Sarita Joshi, Yanhua Li, Ileana Lopez-Plaza, Srivaths Poyyapakkam, Joseph Schwartz, Yvette Tanhehco, Nicole D Zantek,

BACKGROUND:Entrustable professional activities (EPAs) are well-defined, executable, observable, and measurable activities that are performed by a trainee and can be performed independently as training progresses. The purpose of this study is to develop EPAs specific for the practice of apheresis medicine (AM). METHODS:Members of the American Society for Apheresis Graduate ... Read more >>

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[2020, :]

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Lessons learned from early compassionate use of convalescent plasma on critically ill patients with Covid-19.

Miao Liu, Zhen Chen, Meng-Yuan Dai, Jun-Hui Yang, Xiao-Bing Chen, Di Chen, Hua You, Xin Guo, Yan Leng, Li Yu, Meng-Li Zhang, Xian Wu, Junyu Yang, Chong Gao, Daniel G Tenen, Li Chai, Fen Ai,

BACKGROUND:The management of critically ill patients with coronavirus disease 2019 (COVID-19), caused by a new human virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is challenging. Recently, there have been several reports with inconsistent results after treatment with convalescent plasma (CP) on critically ill patients with COVID-19, which was produced ... Read more >>

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[2020, :]

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Performance profile of an updated safety measure rapid assay for bacteria in platelets.

Remo P Vallejo, Lisa Shinefeld, David LaVerda, Nancy Best, Gregory Lawrence, Adam Lousararian, Nancy Hornbaker, Patricia Rasmusson, Paul D Mintz,

BACKGROUND:The Verax PGD rapid test for bacteria in platelets (PLTs) has been updated to simplify workflow and improve specificity and sensitivity by employing a novel sequential format. The performance of this updated version, called PGDprime, was evaluated to determine its suitability for use as an FDA-cleared "safety measure" to supplant ... Read more >>

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[2020, :]

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Blood group-related antigen Ley on human platelets and its involvement in platelet aggregation via a possible interaction with CD61.

Huijun Zhu, Qinqin Ma, Ruishu Li, Min Fu, Ping Lu,

BACKGROUND:The Ley antigen is a carbohydrate chain belonging to the ABH-Lewis blood group family. Ley has been reported to be present on red blood cells (RBCs) and granulocytes, but its distribution and function in platelets remain unknown. There are a variety of glycoproteins on platelets, which may carry the Ley ... Read more >>

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[2020, :]

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Secondary bacterial culture of platelets to mitigate transfusion-associated sepsis: A 3-year analysis at a large academic institution.

Alexander J Fenwick, Eric A Gehrie, Christi E Marshall, Aaron A R Tobian, Ruchee Shrestha, Seema Kacker, Patricia A R Brunker, Lisa Shifflett, Karen C Carroll, Donna Gozelanczyk, Ruchika Goel, Paul M Ness, Evan M Bloch,

BACKGROUND:In 2019, the United States Food and Drug Administration published its final recommendations to mitigate bacterial contamination of platelets. We sought to evaluate our secondary bacterial culture (SBC) strategy in light of those recommendations. STUDY DESIGN AND METHODS:A retrospective analysis was conducted of SBC data (October 2016-2019) at our institution. ... Read more >>

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[2020, :]

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Use of a rapid electronic survey methodology to estimate blood donors' potential exposure to emerging infectious diseases: Application of a statistically representative sampling methodology to assess risk in US blood centers.

Barbee I Whitaker, Mark Walderhaug, Susan Hinkins, Whitney R Steele, Brian Custer, Debra Kessler, German Leparc, Jerome L Gottschall, Walter Bialkowski, Susan L Stramer, Roger Y Dodd, Lauren Crowder, Farnaz Vahidnia, Beth H Shaz, Hany Kamel, Mark Rebosa, Michael Stern, Steven A Anderson,

Risk assessments of transfusion-transmitted emerging infectious diseases (EIDs) are complicated by the fact that blood donors' demographics and behaviors can be different from the general population. Therefore, when assessing potential blood donor exposure to EIDs, the use of general population characteristics, such as U.S. travel statistics, may invoke uncertainties that ... Read more >>

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[2020, :]

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Red blood cell and platelet transfusion support in the first 30 and 100 days after allogeneic hematopoietic cell transplant.

Shan Yuan, Dongyun Yang, Ryotaro Nakamura, Lefan Zhuang, Monzr M Al Malki, Chatchada Karanes, Shirong Wang,

BACKGROUND:Allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients often require substantial but variable transfusion support. STUDY DESIGN AND METHODS:This single-center, retrospective study evaluated the red blood cell (RBC) and platelet (PLT) transfusion data of first-time allo-HSCT recipients transplanted in 2011 to 2017. Multivariate analyses were performed to assess the associations between ... Read more >>

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[2020, :]

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Short-Term exposure of umbilical cord blood CD34+ cells to human platelet lysate and cytokines enhances engraftment.

Marie-Ève Rhéaume, Pascal Rouleau, Tony Tremblay, Isabelle Paré, Lionel Loubaki,

BACKGROUND:Intra bone marrow (IBM) injection has been proposed as a strategy to bypass homing inefficiencies associated with intravenous (IV) hematopoietic progenitor stem cell (HSPC) transplantation and thus increases the number of HSPC that engraft. Despite physical delivery into the bone marrow cavity, many donor cells are rapidly redistributed by vascular ... Read more >>

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[2020, :]

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Preoperative identification of cardiac surgery patients at risk of receiving a platelet transfusion: The Australian Cardiac Surgery Platelet Transfusion (ACSePT) risk prediction tool.

Andrew W J Flint, Michael Bailey, Christopher M Reid, Julian A Smith, Lavinia Tran, Erica M Wood, Zoe K McQuilten, Michael C Reade,

Platelet (PLT) transfusions are limited and costly resources. Accurately predicting clinical demand while limiting product wastage remains difficult. A PLT transfusion prediction score was developed for use in cardiac surgery patients who commonly require PLT transfusions. STUDY DESIGN AND METHODS:Using the Australian and New Zealand Society of Cardiac and Thoracic ... Read more >>

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[2020, :]

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Preliminary characterization of the properties of cold-stored apheresis platelets suspended in PAS-III with and without an 8-hour room temperature hold.

Stephen J Wagner, Todd M Getz, Dedeene Thompson-Montgomery, Annette Turgeon,

BACKGROUND:Use of extended cold storage of platelets promises to increase PLT availability and the bacterial safety of bleeding patients. No information is currently available on the preservation of apheresis PLT in vitro quality parameters when PLTs are held at room temperature early in the storage period prior to transfer to ... Read more >>

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[2020, :]

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Sepsis from an apheresis platelet contaminated with Acinetobacter calcoaceticus/baumannii complex bacteria and Staphylococcus saprophyticus after pathogen reduction.

Joy L Fridey, Susan L Stramer, Ashok Nambiar, Morvarid Moayeri, Sonia Bakkour, Charles Langelier, Emily Crawford, Thea Lu, Marion C Lanteri, Jack Kamm, Steve Miller, Stephen J Wagner, Richard J Benjamin, Michael P Busch,

BACKGROUND:Strategies to reduce platelet (PLT) bacterial contamination include donor screening, skin disinfection, sample diversion, bacterial culture, pathogen reduction (PR), and day-of-transfusion tests. We report bacterial sepsis following a pathogen-reduced PLT transfusion. CASE REPORT:An adult male with relapsed acute lymphoblastic leukemia was successfully treated for central catheter-associated Staphylococcus aureus bacteremia. A ... Read more >>

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[2020, :]

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