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The Difference in Potential Harms between Whole Blood and Component Blood Transfusion in major Bleeding: A Rapid Systematic Review and Meta-Analysis of RCTs.

Louise J Geneen, Susan J Brunskill, Carolyn Doree, Lise J Estcourt, Laura Green,

Our aim was to assess whether there is a difference in outcomes of potential "all-cause" harm in the transfusion of whole blood (WB) compared to blood components (BC) for any bleeding patient regardless of age or clinical condition. We searched multiple electronic databases using a pre-defined search strategy from inception ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, :]

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Blood Donation and Monetary Incentives: A Meta-Analysis of Cost-Effectiveness.

Stijn Bruers,

The effectiveness of monetary incentives to increase altruistic behavior is in dispute. Paying blood donors might be ineffective, as it could decrease altruistic motivations of voluntary donors (motivational crowding-out) or decrease blood quality (increase transmittable infectious disease risks). In a meta-analysis, including observational studies, natural experiments and field experiments, the ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, :]

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Epidemiology of Massive Transfusion - A Common Intervention in Need of a Definition.

Zoe K McQuilten, Andrew Wj Flint, Laura Green, Brenton Sanderson, James Winearls, Erica M Wood,

While massive transfusion (MT) recipients account for a small proportion of all transfused patients, they account for approximately 10% of blood products issued. Furthermore, MT events pose organizational and logistical challenges for health care providers, laboratory and transfusion services. Overall, the majority of MT events are to support major bleeding ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):73-79]

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Blood Donation Narratives on Social Media: A Topic Modeling Study.

Steven Ramondt, Peter Kerkhof, Eva-Maria Merz,

Social media have shown great potential for producing significant changes in behavior and have become the cornerstone for many public health and agency efforts. The nonprofit sector -including blood collection agencies- has adopted social media to aid their cause and reach their goals. However, despite the tremendous impact of social ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, :]

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New-Onset Methemoglobinemia After Receiving Ozone Autohemotherapy and High-Dose Vitamin C Injection.

Hao-Jen Chen, Kun-Te Lin, Chu-Chung Chou, Yan-Ren Lin,

Transfus Med Rev (Transfusion medicine reviews)
[2021, :]

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Regional Oxygenation and Perfusion Monitoring to Optimize Neonatal Packed Red Blood Cell Transfusion Practices: A Systematic Review.

Pranav Jani, Kiran Balegarvirupakshappa, James E Moore, Nadia Badawi, Mark Tracy,

Contemporary packed red blood cell transfusion practices in anaemic preterm infants are primarily based on measurement of hemoglobin or haematocrit. In neonatal intensive care units, most preterm infants receive at least 1 packed red cell transfusion as standard treatment for anaemia of prematurity. Clinicians are faced with a common question ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, :]

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The Paradox of Choice in Hemostatic Resuscitation: Still More Options Than Evidence, But a Good Start.

Simon Stanworth, Jeannie Callum,

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):71-72]

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Prehospital Tranexamic Acid (TXA) in Patients with Traumatic Brain Injury (TBI).

Marc Maegele,

Traumatic brain injury (TBI) remains a significant medical and socioeconomic challenge. The initial injury may be complicated by haemostatic derangements leading to exacerbation of lesions and haemorrhagic progression. The results from the CRASH-3 trial have promoted the implementation of the antifibrinolytic tranexamic acid (TXA) into prehospital Emergency Medical Services (EMS) ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):87-90]

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The Role of Plasma Transfusion in Pre-Hospital Haemostatic Resuscitation.

Harriet Tucker, Ross Davenport, Laura Green,

Traumatic haemorrhage remains a major cause of preventable death and early haemostatic resuscitation is now a mainstay of treatment internationally. Recently, 2 randomized control trials (RCTs) - PAMPer (Prehospital Air Medical Plasma) and COMBAT (Control of Major Bleeding After Trauma), evaluating the effect of pre-hospital use of plasma on mortality ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):91-95]

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Roles of Four-Factor Prothrombin Complex Concentrate in the Management of Critical Bleeding.

Kenichi A Tanaka, Shashank Shettar, Kofi Vandyck, Susan M Shea, Ezeldeen Abuelkasem,

Four-factor prothrombin complex concentrate (4F-PCC) is the term used to describe a pathogen-reduced, lyophilized concentrate that contains therapeutic amounts of at least 4 coagulation factors: Factor II (FII), Factor VII (FVII), Factor IX (FIX), and Factor X (FX). 4F-PCC has proven to be an effective hemostatic agent compared to plasma ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):96-103]

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Viscoelastic Testing in Traumatic Brain Injury: Key Research Insights.

Taylor N Anderson, Martin A Schreiber, Susan E Rowell,

The role of viscoelastic testing in the evaluation and management of traumatic brain injury (TBI) remains a subject of ongoing exploration. This review highlights four key publications that provide significant insights into this subject. Holcomb et al. provided early evidence of the relationship between thromboelastography (TEG) and conventional coagulation tests (CCTs). ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):108-112]

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Pathophysiology of Trauma-Induced Coagulopathy.

Patricia Duque, Alberto Calvo, Christopher Lockie, Herbert Schöchl,

There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be defined as an abnormal hemostatic response secondary to trauma. The terms "early TIC" and "late TIC" have been recently suggested. "Early TIC" would refer to the inability to achieve effective hemostasis exacerbating an uncontrolled bleeding in a ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):80-86]

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Hemostatic Resuscitation in Children.

Rafael G Ramos-Jimenez, Christine Leeper,

Trauma is a major source of morbidity and mortality for children worldwide; life-threatening hemorrhage is a primary cause of preventable death. Essential interventions in children with life-threatening hemorrhage include hemostatic resuscitation and mechanical control of bleeding. Herein we review pediatric hemostatic resuscitation, a strategy that addresses both hemorrhagic shock and ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):113-117]

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Fibrinogen Replacement in Haemostatic Resuscitation: Dose, Laboratory Targets and Product Choice.

Nicola Curry,

Fibrinogen is a key coagulation protein that is necessary for the formation of stable clots. Fibrinogen levels have been reported to be one of the first to fall during major haemorrhage reflecting consumption, dilution and fibrinogenolysis. Its role in acquired major haemorrhage, both in relation to the contribution it plays ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):104-107]

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Risk of ABO-Incompatible Plasma From Non-ABO-Identical Components.

Kristen N Ruby, Sarah K Harm, Nancy M Dunbar,

The last several decades have seen significant changes in the approach to resuscitation of bleeding patients. These include the adoption of ABO-incompatible plasma transfusion in the form of group A plasma and/or low titer group O whole blood for trauma patients of unknown ABO group. Studies to date have examined ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):118-122]

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Progression and Predictors of SARS-CoV-2 Antibody Seroreactivity In US Blood Donors.

Ralph R Vassallo, Larry J Dumont, Marjorie D Bravo, Kelsey Hazegh, Hany Kamel,

The second largest US blood center began testing for antibodies to SARS-CoV-2, the etiologic agent of Coronavirus Disease-2019 (COVID-19) to identify potential COVID-19 Convalescent Plasma (CCP) donors and encourage blood donation. We report the non-vaccine seroprevalence of total immunoglobulin directed against the S1 spike protein of SARS-CoV-2 in our donors. ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):8-15]

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A Platelet Inventory Management Assessment: Is a Pathogen Reduced Only Inventory Financially Feasible?

Louise Helander, Susan Potterveld, Mary Berg,

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):60-61]

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Red Cell Exchange as Adjunctive Therapy for Babesiosis: Is it Really Effective?

Toufic Tannous, Tracey A Cheves, Joseph D Sweeney,

Human babesiosis is a parasitic disease prevalent in the Northeastern and Midwestern United States (US). Treatment with antibiotics is the standard of care but red cell exchange (RCE) has been used as an adjunctive treatment in more severe disease. Data for the efficacy of RCE in the treatment of babesiosis ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):16-21]

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Neonatal Platelet Transfusions: Starting Again.

Carmel Maria Moore, Anna E Curley,

Preterm neonates with severe thrombocytopenia are frequently prescribed prophylactic platelet transfusions despite no evidence of benefit. Neonatal platelet transfusion practice varies, both nationally and internationally. Volumes and rates of transfusion in neonatology are based on historic precedent and lack an evidence base. The etiology of harm from platelet transfusions is ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):29-35]

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Anemia-Induced Bleeding in Patients with Platelet Disorders.

Swarni Thakar, Nadia Gabarin, Akash Gupta, Michael Radford, Theodore E Warkentin, Donald M Arnold,

Anemia is not only a consequence of bleeding, but also a modifiable risk factor for bleeding in patients with thrombocytopenia or platelet function defects. In this review we outline the mechanism of anemia-induced bleeding in patients with platelet disorders, which involves a disturbance in normal red blood cell (RBC) rheology ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):22-28]

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Daratumumab: Beyond Multiple Myeloma.

Kiran Ejaz, John D Roback, Sean R Stowell, Harold C Sullivan,

Daratumumab (DARA) is the biological name of an Immunoglobulin G1k human monoclonal antibody. DARA the first-in-class therapy targeting CD38 expressing- plasma cells (PC) and plasma blasts. It has been approved for the treatment of multiple myeloma. It is also being examined in the setting of other hematologic malignancies. As DARA ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):36-43]

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Increased Nucleated RBCs in Cord Blood: Not an Exclusion Criterion but a Quality Indicator for Hematopoietic Progenitor Cell Transplantation.

Sue Shin, Hye Ryun Lee, Jong Hyun Yoon, Byoung Jae Kim, Namhee Kim, Hyunwoong Park, Eun Youn Roh,

Increased nucleated red blood cell (NRBC) counts have been reported to be associated with adverse fetal outcomes, and cord blood units (CBUs) with increased NRBC counts require a 2<sup>nd</sup> questionnaire to determine their suitability for transplantation. However, a recent study demonstrated a positive correlation of NRBCs with CD34<sup>+</sup> cells and ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):53-59]

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Platelet Component False Positive Detection Rate in Aerobic and Anaerobic Primary Culture: A Systematic Review and Meta-Analysis.

Jessica Corean, Sandra K White, Robert L Schmidt, Brandon S Walker, Mark A Fisher, Ryan A Metcalf,

Septic reactions from platelet transfusions are one of the leading causes of transfusion-associated mortality. The FDA guidance for platelet bacterial risk control includes bacterial culture using both aerobic and anaerobic bottles. Several studies have reported false positive rates (FPR) of culture, but these data have not been summarized or influencing ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(3):44-52]

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Hospital Medicine Providers' Transfusion Knowledge: A Survey Study.

Brittne Halford, Adlin Pinheiro, Richard L Haspel,

Blood transfusion is one of the most common procedures performed in the inpatient setting. Although ordering a transfusion is a component of routine practice for most hospitalists, prior literature has shown that non-transfusion medicine physicians have poor to intermediate transfusion medicine knowledge (TMK). No recent study has evaluated TMK among ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(2):140-145]

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Blood Group Databases-Creating Order Out of Chaos?

Jill R Storry,

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(2):67-69]

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