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Journal Toxicology

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Zinc oxide nanoparticles attenuate prepubertal exposure to cisplatin- induced testicular toxicity and spermatogenesis impairment in rats.

Eman T Hamam, Amira Awadalla, Ahmed A Shokeir, Amoura M Aboul-Naga,

Cisplatin exposure represents a significant fertility problem for childhood cancer. In this study we examined the possible therapeutic role of Zinc oxide nanoparticles (ZnO-NPs) on Cisplatin (Cis) induced impairment in the spermatogenesis initiation during puberty. Seventy-two male rats aged 30 days were distributed into four equal groups: Control group; ZnO-NPs ... Read more >>

Toxicology (Toxicology)
[2022, :153102]

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Alginic acid induces oxidative stress-mediated hormone secretion disorder, apoptosis and autophagy in mouse granulosa cells and ovaries.

Jieyu Cui, Yankun Li, Wenqiang Zhang, Hongrun Qian, Zhiying Zhang, Kun Xu,

Alginic acid (AA) is a kind of polysaccharide extracted from brown seaweeds and has been widely used in food industry. Certain positive effects of AA, such as anti-inflammation and anti-allergy, have been reported. Nevertheless, as a potential chemical contaminant of the environment, its impact on female reproductive system remains to ... Read more >>

Toxicology (Toxicology)
[2022, 467:153099]

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Kupffer cells play a crucial role in monocrotaline-induced liver injury by producing TNF-α.

Yuhan Cao, Meng Liu, Shouyan Wu, Junjiu Xu, Wenjie Wang, Xinming Qi, Jin Ren, Jianhua Sun, Jing Chen, Likun Gong,

Monocrotaline (MCT), an unsaturated pyrrolizidine alkaloid (PA) in plants, is mainly toxic to the lung and liver of mammals. As a commonly used tool for liver injury model, the mechanism of MCT hepatoxicity has still not been fully clarified. Kupffer cells (KCs) are the liver-resident macrophages and have various responses ... Read more >>

Toxicology (Toxicology)
[2022, :153101]

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Pulmonary toxicity, genotoxicity, and carcinogenicity evaluation of molybdenum, lithium, and tungsten: A review.

Niels Hadrup, Jorid B Sørli, Anoop K Sharma,

Molybdenum, lithium, and tungsten are constituents of many products, and exposure to these elements potentially occurs at work. Therefore it is important to determine at what levels they are toxic, and thus we set out to review their pulmonary toxicity, genotoxicity, and carcinogenicity. After pulmonary exposure, molybdenum and tungsten are ... Read more >>

Toxicology (Toxicology)
[2022, 467:153098]

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Enantioselective toxic effects of mefentrifluconazole in the liver of adult zebrafish (Danio rerio) based on transcription level and metabolomic profile.

Yanhong Li, Hongwu Liang, Bo Ren, Tingting Zhao, Haiyue Chen, Yuexing Zhao, Hanlin Liang,

Mefentrifluconazole, a new type of chiral triazole fungicide, is widely applied to control a variety of fungal diseases in crops. However, the toxicological effects of mefentrifluconazole on aquatic organisms are unknown, especially at the enantiomer level. In the present study, zebrafish were selected as a typical model for mefentrifluconazole enantiomer ... Read more >>

Toxicology (Toxicology)
[2022, 467:153095]

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O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway.

Juan-Juan Li, Xin-Yi Lu, Pengcheng Jia, Lin Zhu, Ao Wang, Fang-Tian Bu, Yi-Long Zhang, Cheng Huang, Jun Li,

Alcoholic liver injury (ALI) is a major risk factor for alcoholic liver disease, characterized by excessive inflammatory response and abnormal liver dysfunction. Previous studies have indicated that O-alkyl and o-benzyl hesperetin derivative-1 L (HD-1 L) has anti-inflammatory and hepato-protective effects in CCl<sub>4</sub>-induced liver injury. However, its effect on ALI and ... Read more >>

Toxicology (Toxicology)
[2022, 466:153087]

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Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice.

Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang,

Elemicin (Ele) is a constituent of natural alkenylbenzene present in many foods and herbs. Ele exposure could induce hepatomegaly and hepatosteatosis. However, the role of gut microbiota in Ele-induced hepatotoxicity remains unclear. Here, the mice were treated with 200 mg/kg/day of Ele for 4 weeks with or without depletion of ... Read more >>

Toxicology (Toxicology)
[2022, 467:153088]

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Regulating of LncRNA2264/miR-20b-5p/IL17RD axis on hydrogen sulfide exposure-induced inflammation in broiler thymus by activating MYD88/NF-κB pathway.

Yu Wang, Yujiao He, Xueyuan Hu, Qianru Chi, Bing Zhao, Jingying Ye, Shu Li,

Hydrogen sulfide (H<sub>2</sub>S) is an environmental pollutant. Chronic exposure to H<sub>2</sub>S can damage the immune system of birds, but the detailed mechanisms of H<sub>2</sub>S-induced thymus toxicity have not been determined. Competitive endogenous RNA (ceRNA) mechanism participates in many pathophysiological processes by regulating gene expression, including environmental pollutant-induced injury. Therefore, we ... Read more >>

Toxicology (Toxicology)
[2021, 467:153086]

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Toxicity mechanism of acrolein on DNA damage and apoptosis in BEAS-2B cells: Insights from cell biology and molecular docking analyses.

Dan Liu, Ye Cheng, Zhipeng Tang, Xueying Mei, Xiangyu Cao, Jianli Liu,

Acrolein is a hazardous air pollutant for humans and is responsible for many pulmonary diseases, but the underlying mechanisms have not been completely elucidated. This work is focused on the genotoxicity effects of human bronchial epithelial (BEAS-2B) cells induced by acrolein (20, 40, 80 μM). The molecular mechanism was investigated base ... Read more >>

Toxicology (Toxicology)
[2022, 466:153083]

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Ovarian Toxicity Induced by Aluminum Chloride: Alteration of Cyp19a1, Pcna, Puma, and Map1lc3b genes Expression.

Farima Rahimi Mansour, Mohammad Nabiuni, Elaheh Amini,

Aluminum (Al) is an abundant metal with wide application in our daily lives including medicine, industry, cosmetics, and packaging. After entrance to the body, aluminum binds to transferrin and reaches different tissues. Al is a metalloestrogen that can lead to oxidative stress (OxS) and endocrine disruption. No detailed study can ... Read more >>

Toxicology (Toxicology)
[2022, 466:153084]

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miR-21-5p and canonical Wnt signaling pathway promote osteoblast function through a feed-forward loop induced by fluoride.

Ning Guo, Yanling Yu, Yanru Chu, Qun Lou, Wei Huang, Liaowei Wu, Chenlu Fan, Mengyao Su, Meichen Zhang, Fanshuo Yin, Zhizhong Guan, Yanmei Yang, Yanhui Gao,

Long-term excessive exposure to fluoride from environmental sources can cause serious public health problems such as dental fluorosis and skeletal fluorosis. The aberrant activation of osteoblasts in the early stage is one of the critical steps during the pathogenesis of skeletal fluorosis and canonical Wnt signaling pathway participate in the ... Read more >>

Toxicology (Toxicology)
[2022, 466:153079]

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Acute cytotoxicity of mineral fibres observed by time-lapse video microscopy.

Dario Di Giuseppe, Sonia Scarfì, Andrea Alessandrini, Anna Maria Bassi, Serena Mirata, Vanessa Almonti, Gregorio Ragazzini, Andrea Mescola, Monica Filaferro, Rossella Avallone, Giovanni Vitale, Valentina Scognamiglio, Alessandro F Gualtieri,

Inhalation of mineral fibres is associated with the onset of an inflammatory activity in the lungs and the pleura responsible for the development of fatal malignancies. It is known that cell damage is a necessary step for triggering the inflammatory response. However, the mechanisms by which mineral fibres exert cytotoxic ... Read more >>

Toxicology (Toxicology)
[2022, 466:153081]

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New insights into inhibitory nature of triclosan on acetylcholinesterase activity.

Narasimha Pullaguri, Andrea R Kagoo, Anamika Bhargava,

The antimicrobial agent, triclosan, has been designated as a "contaminant of emerging concern (CEC)". Previous in vivo studies have shown that triclosan exposure can inhibit acetylcholinesterase (AChE) activity. However, mechanistic insights into AChE inhibition by triclosan are missing. Here, using in vitro activity assay with purified AChE, we show that ... Read more >>

Toxicology (Toxicology)
[2022, 466:153080]

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The role of DRP1- PINK1-Parkin-mediated mitophagy in early cadmium-induced liver damage.

Jian Sun, Fan Yu, Tao Wang, Jianchun Bian, Zongping Liu, Hui Zou,

Cadmium (Cd) is an important environmental pollutant that causes varying degrees of damage to multiple systems of the body. However, the specific mechanism of Cd-induced liver mitophagy remains unclear. In the present study, 5-week-old BALB/c mice and a mouse liver parenchyma cell line (AML12) were studied using a combination of ... Read more >>

Toxicology (Toxicology)
[2022, 466:153082]

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BDE-209 induce spermatocytes arrest at early-pachytene stage during meiotic prophase I in mice.

Jinxia Zhai, Wenfeng Geng, Taifa Zhang, Yu Wei, Huan He, Wenjing Chen,

Deca-brominated diphenyl ether (BDE-209) is a common flame retardant utilized in electronic products, textiles, furniture, and upholstery materials. Environmental BDE-209 exposure results in spermatogenesis disorder, because of the characteristics of bioaccumulation, persistence, and probably toxicity. Meiotic prophase I is a crucial phase during spermatogenesis which is a key influential factor ... Read more >>

Toxicology (Toxicology)
[2021, 467:153061]

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Molecular mechanisms of developmental toxicity induced by BBP in zebrafish embryos.

Guijin Sun, Yingqiu Li,

Butylbenzyl phthalate (BBP) has been shown to negatively affect the development of zebrafish embryos, however, its underlying mechanisms remain unclear. Therefore, our study aims to reveal the molecular mechanisms of developmental toxicity on zebrafish embryos. Zebrafish embryos were exposed to BBP (0, 0.6, and 1.2 mg/L) from 4 to 72 ... Read more >>

Toxicology (Toxicology)
[2022, 466:153078]

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Mitochondria damage and ferroptosis involved in Ni-induced hepatotoxicity in mice.

Ling Wei, Zhicai Zuo, Zhuangzhi Yang, Heng Yin, Yue Yang, Jing Fang, Hengmin Cui, Zongjun Du, Ping Ouyang, Xia Chen, Jian Chen, Yi Geng, Yanqiu Zhu, Zhengli Chen, Chao Huang, Fengyuan Wang, Hongrui Guo,

Nickel (Ni) is an environmental toxicant that can cause toxic damage to humans and animals. Although the hepatotoxicity of Ni has been confirmed, its precise mechanism is still unclear. In this study, the results showed that nickel chloride (NiCl<sub>2</sub>)-treatment could induce mice hepatotoxicity including hepatic histopathological alterations and up-regulation of ... Read more >>

Toxicology (Toxicology)
[2022, 466:153068]

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3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs.

Yanni Zhang, Le Liu, Na Li, Yihua Wang, Xuanfeng Yue,

In order to overcome the weakness of conventional approaches for cell culture, and provide cells with more in vivo-like microenvironment for studying hepatotoxicity of drugs, "multiple-in-one" strategy was adopted to fabricate a 3D scaffold of silk fibroin/hydroxyapatite/poly lacticco-glycolic acid (SF/HA/PLGA), where HepG2 cells were cultivated and the toxicity of drugs ... Read more >>

Toxicology (Toxicology)
[2022, 466:153066]

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Cx43 overexpression is involved in the hyper-proliferation effect of trichloroethylene on human embryonic stem cells.

Ying Xia, Bin Jiang, Zhongkun Teng, Tiantian Liu, Jianming Wang, Stanley Aniagu, Guoxing Zhang, Tao Chen, Yan Jiang,

Trichloroethylene (TCE) is a major environmental contaminant. Maternal exposure of TCE is linked to developmental defects, but the mechanisms remain to be elucidated. Along with a strategy of 3Rs principle, human embryonic stem cells (hESCs) are regarded as most promising in vitro models for developmental toxicity studies. TCE interfered with ... Read more >>

Toxicology (Toxicology)
[2022, 465:153065]

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Nicotine stimulates IL-8 expression via ROS/NF-κB and ROS/MAPK/AP-1 axis in human gastric cancer cells.

Sen Lian, Shinan Li, Jun Zhu, Yong Xia, Young Do Jung,

Nicotine, a major alkaloid found in tobacco, is a significant risk factor for gastric cancer. IL-8, a pleiotropic cytokine, plays a vital role in cancer cell metastasis. The role of nicotine in IL-8 expression and the underlying mechanism is currently unknown. Here, we examined the effects of nicotine on IL-8 ... Read more >>

Toxicology (Toxicology)
[2022, 466:153062]

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Evaluation of the effects produced by subacute tributyltin administration on vascular reactivity of male wistar rats.

Ana Beatriz Araújo Mendes, Nadia Alice Vieira Motta, Gabriel Ferreira Lima, Lis Jappour Autran, Stephani Correia Brazão, D'Angelo Carlo Magliano, Vinícius Sepúlveda-Fragoso, Christianne Brêtas Vieira Scaramello, Jones Bernardes Graceli, Leandro Miranda-Alves, Fernanda Carla Ferreira Brito,

Tributyltin chloride (TBT) is an organotin compound widely used in several high biocides for agroindustrial applications, such as fungicides, and marine antifouling paints leading to endocrine disrupting actions, such as imposex development in mollusks. In female rats, TBT has been shown to promote ovarian dysfunction, reduction of estrogen protective effect ... Read more >>

Toxicology (Toxicology)
[2022, 465:153067]

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Pulmonary toxicity, cytotoxicity, and genotoxicity of submicron-diameter carbon fibers with different diameters and lengths.

Katsuhide Fujita, Sawae Obara, Junko Maru,

Submicron-diameter carbon fibers (SCFs) are a type of fine-diameter fibrous carbon material that can be used in various applications. To accelerate their practical application, a hazard assessment of SCFs must be undertaken. This study demonstrated the pulmonary toxicity, cytotoxicity, and genotoxicity of three types of SCFs with different diameters and ... Read more >>

Toxicology (Toxicology)
[2022, 466:153063]

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Evaluation of lens opacity due to inhibition of cholesterol biosynthesis using rat lens explant cultures.

Taishi Miyashita, Masanori Senshu, Kanata Ibi, Hiroyuki Yamanaka, Hiroaki Nejishima, Tatsuki Fukami, Miki Nakajima,

Drug-induced lens opacity has the potential to cause blindness and is of concern in drug development. Inhibition of cholesterol biosynthesis is one of the causes of lens opacity. Lens opacity is only observed after chronic administration in in vivo nonclinical studies in drug development. Thus, to save resources (e.g., time ... Read more >>

Toxicology (Toxicology)
[2022, 465:153064]

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Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach.

Styliani Fragki, Rudolf Hoogenveen, Conny van Oostrom, Paul Schwillens, Aldert H Piersma, Marco J Zeilmaker,

With the increasing application of cell culture models as primary tools for predicting chemical safety, the quantitative extrapolation of the effective dose from in vitro to in vivo (QIVIVE) is of increasing importance. For developmental toxicity this requires scaling the in vitro observed dose-response characteristics to in vivo fetal exposure, ... Read more >>

Toxicology (Toxicology)
[2022, 465:153060]

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Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice.

Zhaolan Wei, Yunyi Wang, Shuwei Wang, Jing Xie, Qi Han, Mingqing Chen,

Microplastics (MPs) may have an impact on the reproductive development of humans and mammals. However, any effects of MPs exposure on male and female reproductive systems and fertility are still ambiguous. In this study, male and female C57BL/6 mice were exposed to saline or 0.1 mg/d polystyrene microplastics (PS-MPs) for ... Read more >>

Toxicology (Toxicology)
[2022, 465:153059]

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