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Journal Tohoku J Exp Med

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The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma.

Konomi Yashige, Tatsuki R Kataoka, Yosuke Yamada, Hirona Maeda, Marina Oji-Tsujimura, Tetsurou Yamamoto, Yusuke Takei, Koki Moriyoshi, Kazuo Ono, Yo Kaku, Tetsuya Tabata, Ichiro Murakami, Hirokazu Nakamine, Hironori Haga,

Langerhans cell neoplasms, which include Langerhans cell histiocytosis and Langerhans cell sarcoma, are tumors that originate from dendritic cells. Langerhans cell sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features and the Langerhans cell-like phenotype, and generally has a poorer prognosis and more aggressive phenotype than Langerhans ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 255(1):27-31]

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Knowledge, Experience, and Perceptions of Generic Drugs among Middle-Aged Adults and their Willingness-to-Pay: A Nationwide Online Survey in Japan.

Yuki Ito, Konan Hara, Hajime Sato, Jun Tomio,

Promoting generic drugs can reduce the financial burden on patients and improve healthcare finances. The insurers have been conducting promotional efforts, such as direct-mail campaigns, but little is known about the public's perception of generic drugs and effective message strategies for promotion. In 2018, we conducted a web-based survey of ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 255(1):9-17]

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Nephrotoxicity of Immune Checkpoint Inhibitors: A Disproportionality Analysis from 2013 to 2020.

Jiaming Qu, Yanming Ding, Kaiwen Jiang, Junxia Hao, Yuanzhi Li, Aijun Zhang, Zhaohang Li, Guanpeng Qi, Ze Xu, Xin Liu, Juman Ma, Kaishun Bi, Zuojing Li,

Nephrotoxicity occasionally occurs during treatment with immune checkpoint inhibitors (ICIs). Few related studies compare the differences between these drugs. This study aimed to systematically characterize nephrotoxicity after ICI initiation. Data were extracted from the US FDA Adverse Event Reporting System (FAERS) database. Disproportionality analysis, including information components (ICs) and reporting ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):275-282]

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Fulminant Type 1 Diabetes Mellitus Developed about Half a Year after Discontinuation of Immune Checkpoint Inhibitor Combination Therapy with Nivolumab and Ipilimumab: A Case Report.

Kazuma Yaura, Kanako Sakurai, Satsuki Niitsuma, Ryota Sato, Kazuhiro Takahashi, Zenei Arihara,

The cytotoxic T-lymphocyte antigen-4 and programmed cell death 1 pathways are novel therapeutic targets in immune checkpoint inhibitor (ICI) therapy for cancer. However, they may cause endocrine-related adverse events, including hypophysitis, autoimmune thyroiditis and type 1 diabetes mellitus (DM). Moreover, delayed immune-related adverse events (irAEs) after discontinuation of ICI therapy ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):253-256]

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Analysis of Gender Sensitivity of Turkey's Disaster Legislation to Create a Disaster-Resilient Society.

Nuket Paksoy Erbaydar, Ebru Inal Onal, Edip Kaya,

Disasters frequently occur in Turkey. Although there is comprehensive disaster legislation in Turkey, it has not been well studied in terms of gender sensitivity. This study aimed to evaluate the disaster legislation of Turkey in the context of gender equality. We investigated 17 non-technical disaster legislations to determine in what ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):261-266]

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Role of Early Mobilization on the Clinical Course of Patients who Underwent Pancreaticoduodenectomy: A Retrospective Cohort Study.

Takuya Fukushima, Tomohiko Adachi, Masatoshi Hanada, Takayuki Tanaka, Masato Oikawa, Hiroki Nagura, Susumu Eguchi, Ryo Kozu,

The length of hospital stay is an important outcome measure in patients who have undergone pancreaticoduodenectomy. Although postoperative complications are known to adversely affect the length of hospital stay (LOS), the influence of early mobilization on LOS has not been clarified yet. This study aimed to examine the impact of ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):287-294]

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Amniotic Fluid L-Type Fatty Acid-Binding Protein in Predicting Fetal Condition.

Daisuke Katsura, Shunichiro Tsuji, Kaori Hayashi, Shinsuke Tokoro, Rika Zen, Takako Hoshiyama, Fuminori Kimura, Nobuyuki Kita, Takashi Murakami,

Ultrasonography and fetal heart rate monitoring are subjective assessments of fetal condition, which warrants the need for objective markers to predict fetal condition. Urinary L-type fatty acid-binding protein (L-FABP) levels correlate with hypoperfusion. Elevated amniotic fluid L-FABP levels may represent fetal tissue hypoperfusion since the amniotic fluid contains fetal urine. ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):267-273]

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Behçet's Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment.

Ryohei Ogino, Karin Shimada, Daiki Narai, Masanori Goto, Katsuhiro Sato, Yoshihisa Katsuta, Akimasa Shiigi, Juri Ueda, Chika Oyama, Yuko Fujikawa, Isabelle Miyazawa, Takahiro Ohara, Kazuhiro Sumitomo, Shigeru Sato, Nobuo Koinuma, Atsuhiro Kanno, Katsutoshi Furukawa,

Behçet's disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet's disease who ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):283-286]

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Postinfectious Bronchiolitis Obliterans Misdiagnosed as Bronchial Asthma in a Pediatric Patient.

Yuji Fujita, Kenji Miyamoto, George Imataka, Shigemi Yoshihara,

Bronchiolitis obliterans is a chronic obstructive respiratory disease involving stenosis or occlusion of the bronchioles and smaller airways. The prognosis of bronchiolitis obliterans is poor, and the patient might require home oxygen therapy and/or lung transplantation. Bronchiolitis obliterans has various etiologies; in children, the most common causes are infections by ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):257-260]

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Regulation of Adaptive Cell Proliferation by Vagal Nerve Signals for Maintenance of Whole-Body Homeostasis: Potential Therapeutic Target for Insulin-Deficient Diabetes.

Junta Imai,

In insulin-resistant states such as obesity, pancreatic β-cells proliferate to prevent blood glucose elevations. Failure of this β-cells proliferative response leads to the development of diabetes. On the other hand, when organs are damaged, cells proliferate to repair the organs. Therefore, these proliferations are compensatory mechanisms aimed at maintaining whole-body ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(4):245-252]

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Deep Learning-Based Nuclear Lobe Count Method for Differential Count of Neutrophils.

Mayu Yabuta, Iori Nakamura, Haruhi Ida, Hiromi Masauzi, Kazunori Okada, Sanae Kaga, Keiko Miwa, Nobuo Masauzi,

Differentiating neutrophils based on the count of nuclear lobulation is useful for diagnosing various hematological disorders, including megaloblastic anemia, myelodysplastic syndrome, and sepsis. It has been reported that one-fifth of sepsis-infected patients worldwide died between 1990 and 2017. Notably, fewer nuclear-lobed and stab-formed neutrophils develop in the peripheral blood during ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):199-206]

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Microvascular Decompression for Glossopharyngeal Neuralgia in the Semi-Sitting Position: A Report of Two Cases.

Shinjitsu Nishimura, Keiichi Kubota, Sumito Okuyama, Junko Matsuyama, Ken Kazama, Masato Tomii, Tadao Matsushima, Masato Kurihara, Kazuo Watanabe,

The semi-sitting position is well known to neurosurgeons. However, there are few reports of microvascular decompression surgery for glossopharyngeal neuralgia performed using the semi-sitting position. The semi-sitting position is not widely adopted in Japan, but it is considered to be a very useful neurosurgical position. Microvascular decompression surgery for glossopharyngeal ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):183-188]

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Long Non-Coding RNA SOX2 Overlapping Transcript Aggravates H9c2 Cell Injury via the miR-215-5p/ZEB2 Axis and Promotes Ischemic Heart Failure in a Rat Model.

Jiahong Tu, Liping Ma, Mingqing Zhang, Jie Zhang,

Heart failure is a common cardiovascular disease, which has been regarded as one of the highest health care costs with high morbidity and mortality in the western countries. Long noncoding RNAs have been widely reported to regulate the initiation or progression of cardiovascular diseases. However, the specific role of SOX2 ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):221-231]

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A Single Arm Prospective Pilot Study Examining the Efficacy and Safety of Bevacizumab Single Maintenance Therapy Following Platinum-Based Chemotherapy in Patients with Advanced or Recurrent Cervical Cancer.

Masafumi Toyoshima, Muneaki Shimada, Satomi Sasaki, Masumi Ishibashi, Shogo Shigeta, Keita Tsuji, Tomoyuki Nagai, Hideki Tokunaga, Hitoshi Niikura, Nobuo Yaegashi,

Although the addition of bevacizumab to platinum-based combination chemotherapy has been recommended as a standard regimen for patients with advanced or recurrent cervical cancer, there is no clear evidence regarding the effectiveness of bevacizumab monotherapy as salvage chemotherapy. This study prospectively examined the efficacy and safety of switching from platinum-based ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):145-153]

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Intestinal Perforation in a Patient with Colon Cancer during Treatment with Regorafenib: A Case Report and Review of the Literature.

Ryusuke Ouchi, Kouji Okada, Kensuke Usui, Naoko Kurata, Shinju Suzuki, Munenori Nagao, Yoshiteru Watanabe, Kaori Koyama,

The multikinase inhibitor, regorafenib, is known to exert its antitumor effects by targeting several kinases, inhibiting interstitial intracellular signaling and suppressing tumor cell proliferation. Regorafenib causes gastrointestinal perforation and gastrointestinal fistula as adverse events, and discontinuation is recommended if these adverse events occur during administration. However, there are no prescribed ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):207-211]

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Superiority of Cystatin C over Creatinine for Early Diagnosis of Acute Kidney Injury in Pediatric Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.

Takashi Yamazoe, Shohei Akagawa, Ryosuke Matsuno, Yuko Akagawa, Sohsaku Yamanouchi, Taichi Omachi, Takahisa Kimata, Shoji Tsuji, Kazunari Kaneko,

The exact incidence of acute kidney injury (AKI) during chemotherapy for acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL) is unknown. Furthermore, childhood cancer survivors are at risk of AKI-chronic kidney disease transition. Thus, early diagnosis of AKI is crucial. This study aimed to elucidate the incidence of AKI in patients undergoing ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):163-170]

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Increased Severity of Ulcerative Colitis in the Terminal Phase of the Metabolic Syndrome.

Marina Milun Jovanovic, Milena Milenko Jurisevic, Nevena Miroslav Gajovic, Nebojsa Nikola Arsenijevic, Miodrag Vukasin Jocic, Ivan Petar Jovanovic, Natasa Dragan Zdravkovic, Aleksandar Ljubodrag Djukic, Veljko Jovo Maric, Milan Milorad Jovanovic,

Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severity of ulcerative colitis. Still, there is no evidence that ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):171-182]

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High Feasibility and Safety, but Negligible Efficacy of Acupressure for Treating Nausea in Cancer Patients Admitted to the Palliative Care Unit: A Pilot Study.

Hiroyuki Tsugita, Maho Aoyama, Noriaki Satake, Makoto Saito, Yusuke Hiratsuka, Akira Inoue, Shin Takayama, Mitsunori Miyashita,

Management of nausea is an important dimension of palliative care. The first choice for treating nausea is antiemetics, but their efficacy is inadequate. Acupressure intervention for nausea in cancer patients has been studied as a non-pharmacological therapy, and appears to have had some effect. However, such a therapy has not ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):155-161]

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Relationship between an Oral Health Risk Assessment Using a Salivary Multi-Test System and Woman's Subjective Oral Health Symptoms and Sleep Disorder.

Eun-Ha Jung, Mi-Kyoung Jun,

Saliva is used as a diagnosis and monitoring tool for various diseases because it can maintain the balance of the oral ecosystem and reflect the physiological and pathological state of the body. Because women suffer more fatigue than men because of physiological, psychological, and social factors, individual management strategies are ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):213-219]

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Circular RNA circ_0046264 Suppresses Osteosarcoma Progression via microRNA-940/Secreted Frizzled Related Protein 1 Axis.

Rui Du, Bingjin Fu, Guangchao Sun, Bingdong Ma, Mingming Deng, Xiaodong Zhu, Dehai Kong,

Circular RNAs (circRNAs) feature prominently in regulating tumor progression. The study aims to investigate the role and mechanism of circ_0046264 in osteosarcoma. In this study, dysregulated circRNAs in osteosarcoma tissues and adjacent tissues were screened out by analyzing circRNA microarray (GSE140256). The expressions of circ_0046264 in 58 osteosarcoma tissues and ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(3):189-197]

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Nomogram for Predicting Chemotherapy-Induced Nausea and Vomiting for Breast Cancer Patients.

Xin-Juan Huang, Xu-Ying Li, Jin-Hua Li, Zhe-Yu Hu, Lu Luo, Yan Tan, Hong-Yun Chen, Rong-Rong Fan, Tong-Yu Wang, Ling-Qi Meng, Tao Wei,

Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of cancer treatment. The factors influencing CINV in breast cancer patients remain unclear. In this study, we developed a nomogram for predicting the occurrence of CINV in this group using prospective clinical data. We pooled data from multiple studies which ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(2):111-121]

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Comparative Study of Oral Bacteria and Fungi Microbiota in Tibetan and Chinese Han Living at Different Altitude.

Ke Dong, Kunpeng Wu, Tianli Zheng, Ji Yue, Weipeng Wang, Ruocheng Luo, Lan You, Xun He, Jingjing Li, Zehui Hong, Haojiang Zuo, Xiaofang Pei,

Knowledge about the impact of altitude and ethnicity on human oral microbiota is currently limited. To obtain the baseline of normal salivary microbiota, we analyzed the bacteria and fungi composition in Tibetan (HY group) and Han population (CD group) living at different altitudes by using next-generation sequencing (NGS) technology combined ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(2):129-139]

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Preoperative Endovascular Embolization in an Easily Bleeding Respiratory Epithelial Adenomatoid Hamartoma of the Olfactory Cleft: A Case Report.

Jun Suzuki, Hiroki Tozuka, Tomotaka Hemmi, Hiroyuki Ikushima, Tomohiko Ishikawa, Yohei Morishita, Kazuhiro Nomura, Mitsuru Sugawara, Yukio Katori,

Respiratory epithelial adenomatoid hamartomas (REAHs) are rare tumors occurring in the nasal cavity and sinuses, and their etiology is unknown. REAH is a relatively recently established lesion and is often misdiagnosed as nasal polyposis or other tumors. Preoperative endovascular embolization for sinonasal tumors is now widely accepted as an effective ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(2):107-110]

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Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study.

Daisuke Niino, Luong Thi My Hanh, Shiro Miura, Masahiro Nakashima, Masako Iwanaga,

The development of multiple histologic types of lymphoma in a single patient has been sporadically reported as sequential or composite lymphoma. However, the incidence pattern of such patients has been rarely evaluated in a large population-based setting. We investigated the incidence of sequential or composite lymphoma based on 11,174 lymphoma ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(2):123-127]

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Impacts of Natural Environmental Factors and Prevalence of Airway Symptoms on the Local Spread of COVID-19: A Time-Series Analysis in Regional COVID-19 Epidemics.

Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Noriko Sugawara, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi,

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the world's largest public health concern in 2021. This study evaluated the associations of the prevalence of airway symptoms among the tested individuals and data regarding the natural environmental factors with the weekly number of newly ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 254(2):89-100]

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