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Journal Thyroid Res

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Can we safely reduce the administration of 131-iodine in patients with differentiated thyroid cancer? - experience of the Brugmann hospital in Brussels.

Laura Iconaru, Felicia Baleanu, Georgiana Taujan, Ruth Duttmann, Linda Spinato, Rafik Karmali, Pierre Bergmann, Anne-Sophie Hambye,

Background:131-iodine (131I) administration after surgery remains a standard practice in differentiated thyroid cancer (DTC). In 2014, the American Thyroid Association presented new guidelines for the staging and management of DTC, including no systematic 131I in patients at low-risk of recurrence and a reduced 131I activity in intermediate risk.The present study ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:15]

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Total T4 rise in pregnancy: a relook?

Subhodip Pramanik, Pradip Mukhopadhyay, Sujoy Ghosh,

Background:Total T4 (TT4) measurement is preferred to free T4 (FT4) especially in last part of pregnancy. Guidelines by American Thyroid Association, European Thyroid Association and Endocrine Society state that TT4 increases 1.5 times pre-pregnant levels after week 16 of pregnancy. However, this is based on a small study conducted 40 years ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:14]

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Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate.

Minoru Kihara, Akira Miyauchi, Hiroo Masuoka, Takuya Higashiyama, Yasuhiro Ito, Akihiro Miya,

Background:Our previous kinetic analyses of changes in the tumor volume (TV) of papillary thyroid microcarcinomas during active surveillance revealed that the tumors' growth varied over time from rather rapid growth to shrinkage and that the hypothetical TV-doubling rates (DRs) before the patients' presentation were much larger than their observed TV-DRs, ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:13]

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Teprotumumab: a disease modifying treatment for graves' orbitopathy.

Michelle Ting, Daniel G Ezra,

Background:On 21st January 2020, the FDA approved Tepezza (teprotumumab-trbw) for the treatment of active Graves' orbitopathy (GO) in adults. This approval was based on positive results from two multinational randomised double-blind placebo-controlled clinical trials. Discussion:This article discusses the outcomes of those trials and the potential role of teprotumumab in altering ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:12]

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Antithyroid drugs and birth defects.

Stine Linding Andersen, Stig Andersen,

Antithyroid drugs (ATDs) are preferred for the treatment of hyperthyroidism caused by Graves' disease in pregnant women. The drugs have been a recognized treatment for decades, and a general risk of side effects is known. For the use of ATDs in pregnancy, a concern about teratogenic side effects has been ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:11]

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Macrofollicular variant of papillary thyroid carcinoma with metastasis to femur.

Fernando Candanedo-Gonzalez, Diana Rodriguez-Orihuela, Julian Arista-Nasr,

Background:Macrofollicular variant of papillary thyroid carcinoma (MFV-PTC) is a rare subtype with histological features and an indolent clinical course that can be confused with nodular goiter or follicular adenoma. However, on rare occasions it may show more aggressive biological behavior. Only two cases of MFV-PTC with bone metastases have been ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:10]

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Elevated serum TSH concentrations are associated with higher BMI Z-scores in southern Iranian children and adolescents.

Ashkan Habib, Mohadeseh Molayemat, Asadollah Habib,

Background:Subclinical hypothyroidism is defined as elevated TSH levels while T4 or FT4 levels are normal. Elevated TSH levels are linked with obesity in adults. In a recent meta-analysis in Iran, 6.1% of children below 18 had obesity. Due to the low number of studies on the subject in children we, ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:9]

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Thyroid cancer among patients with thyroid nodules in Yemen: a three-year retrospective study in a tertiary center and a specialty clinic.

Butheinah A Al-Sharafi, Jamila A AlSanabani, Ibraheem M Alboany, Amani M Shamsher,

Background:The prevalence of thyroid cancer is increasing worldwide. No previous data are available on the prevalence of thyroid cancer in Yemen. We performed this study to determine the prevalence of thyroid cancer among patients with thyroid nodules in Yemen. Methods:A retrospective chart review was performed for 550 patients with thyroid ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:8]

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Nice guideline on thyroid disease: where does it take us with liothyronine?

Graham P Leese,

The new NICE guidelines on thyroid disease and its management do not recommend the routine use of liothyronine, but do not completely rule it out either. Guidelines from the British and European Thyroid Associations are open to a "trial of liothyronine" on an individual basis. Some patients do not feel ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:7]

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Adequate timing and constant supervision are the keys for successful implementation of levothyroxine or levothyroxine/paracetamol absorption test.

Krzysztof C Lewandowski, Katarzyna Dąbrowska, Magdalena Basińska-Lewandowska, Marek Bolanowski, Marek Ruchała, Andrzej Lewiński,

Background:Levothyroxine (LT4) pseudomalabsorption due to medication non-adherence results in significant costs for Health Service. High dose LT4 or LT4/paracetamol absorption test is used in such cases. Hence, establishment of an optimal test protocol and timing of sample collection is of utmost importance. Case presentation:A 34-year old woman was admitted to ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:5]

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The effectiveness of cognitive- behavioral therapy on quality of life in women with hypothyroidism in the reproductive age: a randomized controlled trial.

Sohaila Rezaei, Parvin Abedi, Elham Maraghi, Najmeh Hamid, Homaira Rashidi,

Background:Worldwide, hypothyroidism affects 3.7% of the population, and is associated with impaired quality of life. This study aimed to evaluate the effect of cognitive- behavioral therapy (CBT) on the quality of life in women with hypothyroidism. Methods:96 women with hypothyroidism randomly allocated into two groups: CBT group (n = 48) and control ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:6]

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Time-dependent changes in FT4 and FT3 levels measured using mass spectrometry after an acute ingestion of excess levothyroxine in a case with hypothyroidism.

Yuko Ito, Satoru Suzuki, Yoshiko Matsumoto, Chiyo Ohkouchi, Satoshi Suzuki, Manabu Iwadate, Sanae Midorikawa, Susumu Yokoya, Shinichi Suzuki, Hiroki Shimura,

Background:Thyrotoxicosis is common disorder among endocrine dysfunctions. It is not rare that the free thyroid hormone level exceeds the measurement range of immunoassay. Such extreme high concentration of free thyroid hormone is generally considered to be impossible to measure correctly because of changes in the balance between free hormones and ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:4]

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Should radioiodine now be first line treatment for Graves' disease?

Onyebuchi E Okosieme, Peter N Taylor, Colin M Dayan,

Background:Radioiodine represents a cost-effective treatment option for Graves' disease. In the UK, it is traditionally reserved for patients who relapse after initial thionamide therapy. In a change from current practice, the new guidelines of the National Institute for Health and Care Excellence (NICE) recommends that radioiodine should now be first ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:3]

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Falsely undetectable TSH in a euthyroid patient.

Monireh Rahimkhani, Kiana Kazemian, Rashid Ramezani Daryasari,

Background:Measuring thyroid hormone levels is essential and helpful in the diagnosis of thyroid diseases. Case presentation:We had a patient with undetectable serum TSH level by the Siemens immunoassay, whereas by ELISA and Roche-Abott immunoassay, serum level of TSH was in the normal range. Conclusion:If the result of TSH level revealed ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:2]

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Cross-sectional and prospective study on anti-Müllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer.

Miranda Mittica, Andrea Dotto, Martina Comina, Marsida Teliti, Eleonora Monti, Massimo Giusti,

Background:Anti-Müllerian hormone (AMH) decreases acutely after post-surgical radioactive iodine (RAI) ablation in females with differentiated thyroid cancer (DTC). Aim:We performed a cross-sectional and prospective study on AMH levels in pre-menopausal females with a history of DTC. Methods:Fifty-nine females after surgery and RAI (group 1) and 30 females after surgery alone ... Read more >>

Thyroid Res (Thyroid research)
[2020, 13:1]

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Meeting Abstracts from the 67th Annual British Thyroid Association Meeting.

Thyroid Res (Thyroid Research)
[2019, 12(Suppl 1):]

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Pre-sternal thyroid swellings: a case of rare aberrant site recurrence and review of literature.

Lovenish Bains, Sushant Bhatia, Rohit Kaushik, Sudhir Kumar Jain, Chandra Bhushan Singh, Shramana Mandal, Daljit Kaur,

Background:Thyroid swellings enlarge caudally into the mediastinum behind the sternum. Pre-sternal swelling of thyroid origin is very rare. We present our case of pre-sternal thyroid swelling which was albeit a surprisingly rare site of papillary thyroid carcinoma recurrence and review of pre-sternal thyroid swellings reported till date. Case summary:A 60 year ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:12]

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The surgical management of locally advanced well-differentiated thyroid carcinoma: changes over the years according to the AJCC 8th edition Cancer Staging Manual.

Alessio Metere, Valerio Aceti, Laura Giacomelli,

Background:Well-differentiated thyroid carcinoma is defined as locally advanced in the presence of an extra thyroid extension, e.g., when the surrounding structures such as the trachea, larynx, esophagus and main blood vessels are invaded by cancer. The 8th edition AJCC Cancer Staging Manual states that this is the main characteristic to ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:10]

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Painless destructive thyroiditis in a patient with resistance to thyroid hormone: a case report.

Tomoko Nagamine, Jaeduk Yoshimura Noh, Naoya Emoto, Takahito Kogai, Akira Hishinuma, Fumitaka Okajima, Hitoshi Sugihara,

Background:Resistance to thyroid hormone (RTH) usually features a syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH) without suppression of the typical high thyroid hormone levels. However, some patients with RTH show thyroid-stimulating hormone (TSH) suppression due to thyrotoxicosis. We report a case of painless thyroiditis in a patient with RTH ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:8]

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Association of thyroid hormones with resting energy expenditure and complement C3 in normal weight high body fat women.

Maryam Karkhaneh, Mostafa Qorbani, Asal Ataie-Jafari, Mohamad Reza Mohajeri-Tehrani, Hamid Asayesh, Saeed Hosseini,

Background:A high body fat percentage has a specific effect on activation of the hypothalamic-pituitary-thyroid axis. On the other hand, a slight change in thyroid hormones can affect metabolism and body composition as well as immune function. This study aims to examine the relationship between adiposity, thyroid hormone levels and immunity ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:9]

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Genomic test ends a long diagnostic odyssey in a patient with resistance to thyroid hormones.

Todor Arsov, Chengmei Xie, Nan Shen, Dan Andrews, Carola G Vinuesa, Olivija Vaskova,

Background:Resistance to thyroid hormones is a very rare condition, which is often misdiagnosed and mistreated. The cases where there is a concomitant autoimmune thyroid disorder are ultra-rare and particularly challenging to treat. Diagnostic and research-based genomic testing can sometimes identify pathogenic variants unrelated to the primary reason for testing (incidental ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:7]

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Levothyroxine before conception in women with thyroid antibodies: a step forward in the management of thyroid disease in pregnancy.

Roberto Negro,

Studies suggesting an association between thyroid autoimmunity and pregnancy-related adverse outcomes, particularly miscarriage and preterm delivery, date to nineties. The postulated causes for these associations were attributed to a direct or indirect effect of autoimmunity and/or to a mild thyroid impairment. Since then, small trials and several meta-analyses confirmed a ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:5]

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Association of antithyroglobulin antibody with iodine nutrition and thyroid dysfunction in Nepalese children.

Binaya Tamang, Saroj Khatiwada, Basanta Gelal, Shrijana Shrestha, Kishun Deo Mehta, Nirmal Baral, Gauri Shankar Shah, Madhab Lamsal,

Background:Aberrant iodine intake and thyroid autoimmunity affect thyroid function. Deficiencies of iodine including thyroid disorders have serious impact on child physical and mental development. This study was conducted to investigate iodine nutrition, thyroid function and thyroid autoimmunity in the Nepalese children, and explore the association of thyroidal autoimmunity with iodine ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:6]

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Semi-quantitative assessment of diffuse hepatic uptake seen in I-131 scans - an indicator of functioning thyroid tissue and disease burden in differentiated thyroid cancer.

Prasanta K Pradhan, Suruchi Jain, Madhusudhanan Ponnuswamy, Amitabh Arya, Manish Ora,

Background:To semi-quantitatively analyze liver uptake of I-131 in diagnostic and post-therapy scans by calculating hepatic to thigh ratios (HTR) and evaluate its clinical significance in management of differentiated thyroid cancer. Method:Two hundred forty-nine patients were included in the study. Hepatic to thigh ratio (HTR) of counts were calculated for 249 ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:4]

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Normalization of thyroid function tests among thyrotoxicosis patients attending a University Hospital in North-West Ethiopia.

Eyob Alemayehu Gebreyohannes, Emneteab Mesfin Ayele, Soliana Alemayehu Tesfaye, Mohammed Assen Seid,

Background:Thyrotoxicosis is a clinical state that results from inappropriately high thyroid hormone action in tissues. Although it is one of the common endocrine disorders, there is scarcity of data on the management of thyrotoxicosis in Africa, particularly in Ethiopia. The aim of this study was to investigate treatment outcomes and ... Read more >>

Thyroid Res (Thyroid research)
[2019, 12:3]

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