Full Text Journal Articles in
Journal Thorax

Advertisement

Find full text journal articles






Parkin, an E3 ubiquitin ligase, enhances airway mitochondrial DNA release and inflammation.

Kris Genelyn Dimasuay, Niccolette Schaunaman, Richard J Martin, Nicole Pavelka, Christena Kolakowski, Roberta A Gottlieb, Fernando Holguin, Hong Wei Chu,

INTRODUCTION:Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent evidence suggests the involvement of Parkin in promoting inflammation. In the present study, we determined if Parkin regulates airway mitochondrial DNA (mtDNA) release and inflammatory responses to type 2 ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.

Michaela R Anderson, Imaani Easthausen, Grace Gallagher, Jayaram Udupa, Yubing Tong, Drew Torigian, Joshua Matthew Diamond, Mary Katherine Porteous, Scott M Palmer, Laurie D Snyder, Luke Benvenuto, Meghan Aversa, Selim Arcasoy, John R Greenland, Steven R Hays, Jasleen Kukreja, Edward Cantu, John Shinn Kim, Dympna Gallagher, Matthew R Baldwin, R Graham Barr, David J Lederer, Jason D Christie, Jonathan Paul Singer,

CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study.

Michelle Marks, Chad Steele, Wendy C Moore, Deborah A Meyers, Brian Rector, Elizabeth Ampleford, Eugene R Bleecker, Annette T Hastie,

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Pneumothorax and the biology of Birt-Hogg-Dubé syndrome.

Stefan J Marciniak, Simon R Johnson,

Thorax (Thorax)
[2020, 75(6):442-443]

Cited: 0 times

View full text PDF listing >>



Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in lymphangioleiomyomatosis.

Leonardo Bottolo, Suzanne Miller, Simon R Johnson,

BACKGROUND:Lymphangioleiomyomatosis (LAM) is a rare multisystem disease almost exclusively affecting women which causes loss of lung function, lymphatic abnormalities and angiomyolipomas. LAM occurs sporadically and in people with tuberous sclerosis complex (TSC). Loss of TSC gene function leads to dysregulated mechanistic target of rapamycin (mTOR) signalling. As mTOR is a ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Increasing incidence of asbestosis worldwide, 1990-2017: results from the Global Burden of Disease study 2017.

Meng Yang, Dongming Wang, Shiming Gan, Lieyang Fan, Man Cheng, Linling Yu, Bin Wang, Wei Li, Jixuan Ma, Min Zhou, Weihong Chen,

Global incidence and temporal trends of asbestosis are rarely explored. Using the detailed information on asbestosis from the Global Burden of Disease (GBD) 2017, we described the age-standardised incidence rate (ASIR) and its average annual percentage change. A Joinpoint Regression model was applied to identify varying temporal trends over time. ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



COVID-19: in the footsteps of Ernest Shackleton.

Alvin J Ing, Christine Cocks, Jeffery Peter Green,

We describe what we believe is the first instance of complete COVID-19 testing of all passengers and crew on an isolated cruise ship during the current COVID-19 pandemic. Of the 217 passengers and crew on board, 128 tested positive for COVID-19 on reverse transcription-PCR (59%). Of the COVID-19-positive patients, 19% ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



SARS-CoV-2 pandemic: clinical picture of COVID-19 and implications for research.

Marc Lipman, Rachel Clare Chambers, Mervyn Singer, Jeremy Stuart Brown,

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Spirometry performed as part of the Manchester community-based lung cancer screening programme detects a high prevalence of airflow obstruction in individuals without a prior diagnosis of COPD.

Haval Balata, Jonathan Harvey, Phil V Barber, Denis Colligan, Rebecca Duerden, Peter Elton, Matthew Evison, Melanie Greaves, John Howells, Klaus Irion, Devinda Karunaratne, Stuart Mellor, Tom Newton, Richard Sawyer, Anna Sharman, Elaine Smith, Ben Taylor, Sarah Taylor, Janet Tonge, Anna Walsham, James Whittaker, Joergen Vestbo, Richard Booton, Phil A Crosbie,

BACKGROUND:COPD is a major cause of morbidity and mortality in populations eligible for lung cancer screening. We investigated the role of spirometry in a community-based lung cancer screening programme. METHODS:Ever smokers, age 55-74, resident in three deprived areas of Manchester were invited to a 'Lung Health Check' (LHC) based in ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study.

Rajendra Prasad Janapatla, Mei-Hua Hsu, Chyi-Liang Chen, Sung-Hsi Wei, Ming-Jia Yu, Lin-Hui Su, Tzou-Yien Lin, Cheng-Hsun Chiu,

In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 µg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Coexistent COVID-19 pneumonia and pulmonary embolism: challenges in identifying dual pathology.

Katrina Abernethy, Parthipan Sivakumar, Tanya Patrick, Hastie Robbie, Jimstan Periselneris,

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Psychological well-being, physical health and social prescribing in the context of social research.

Susan Nunn,

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Balance impairment in individuals with COPD: a systematic review with meta-analysis.

Kirsti Jane Loughran, Greg Atkinson, Marla K Beauchamp, John Dixon, Denis Martin, Shaera Rahim, Samantha Louise Harrison,

BACKGROUND:People with chronic obstructive pulmonary disease (COPD) are four times more likely to fall than healthy peers, leading to increased morbidity and mortality. Poor balance is a major risk factor for falls. This review aims to quantify the extent of balance impairment in COPD, and establish contributing clinical factors, which ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis.

Anitha Vijayasingam, Emily Frost, Julie Wilkins, Lise Gillen, Presanna Premachandra, Kate Mclaren, Desmond Gilmartin, Lorenzo Picinali, Alberto Vidal-Diez, Simone Borsci, Melody Zhifang Ni, Wai Y Tang, Deborah Morris-Rosendahl, Jonny Harcourt, Caroline Elston, N J Simmonds, Anand Shah,

INTRODUCTION:Individuals with chronic lung disease (eg, cystic fibrosis (CF)) often receive antimicrobial therapy including aminoglycosides resulting in ototoxicity. Extended high-frequency audiometry has increased sensitivity for ototoxicity detection, but diagnostic audiometry in a sound-booth is costly, time-consuming and requires a trained audiologist. This cross-sectional study analysed tablet-based audiometry (Shoebox MD) performed ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Man with chest wall mass and hypotension.

Che-Yu Guan, Cheng-Hsuan Ho, Yi-Jhih Huang, Hong-Hau Wang, Ying-Yi Chen, Chia-Hsin Liu,

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Vaping-associated lung injury.

Orla O'Carroll, Keshav Sharma, Aurelie Fabre, David J Murphy, Michael P Keane, Cormac McCarthy,

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Pulmonary rehabilitation at a time of social distancing: prime time for tele-rehabilitation?

Linzy Houchen-Wolloff, Michael C Steiner,

Thorax (Thorax)
[2020, 75(6):446-447]

Cited: 0 times

View full text PDF listing >>



Applications of artificial intelligence and machine learning in respiratory medicine.

Sherif Gonem, Wim Janssens, Nilakash Das, Marko Topalovic,

The past 5 years have seen an explosion of interest in the use of artificial intelligence (AI) and machine learning techniques in medicine. This has been driven by the development of deep neural networks (DNNs)-complex networks residing in silico but loosely modelled on the human brain-that can process complex input data ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Tuberculosis associated with Triplet therapy for lung cancer.

Danielle Crawley, Ronan A Breen, Paul T Elkington, Eleni Karapanagiotou,

We report the first case of TB associated with triplet therapy (chemotherapy and immunotherapy concurrently) for lung cancer, developing just 44 days after treatment initiation. We feel that several important learning points arise from the discussion that are likely to be very relevant to the broad readership of Thorax, and ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Ultrasound for identifying pleural effusion aetiology: have you checked the ribs?

Maged Hassan, Helen McDill, John P Corcoran, Cyrus Daneshvar,

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.

Aida Venado, Nicholas A Kolaitis, Chiung-Yu Huang, Ying Gao, David V Glidden, Allison Soong, Nicole Sutter, Patricia P Katz, John R Greenland, Daniel R Calabrese, Steven R Hays, Jeffrey A Golden, Rupal J Shah, Lorriana E Leard, Jasleen Kukreja, Tobias Deuse, Paul J Wolters, Kenneth Covinsky, Paul D Blanc, Jonathan P Singer,

BACKGROUND:Lung transplantation and related medications are associated with pathobiological changes that can induce frailty, a state of decreased physiological reserve. Causes of persistent or emergent frailty after lung transplantation, and whether such transplant-related frailty is associated with key outcomes, are unknown. METHODS:Frailty and health-related quality of life (HRQL) were prospectively ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Oral nitrate supplementation to enhance pulmonary rehabilitation in COPD: ON-EPIC a multicentre, double-blind, placebo-controlled, randomised parallel group study.

Matthew J Pavitt, Rebecca Jayne Tanner, Adam Lewis, Sara Buttery, Bhavin Mehta, Helen Jefford, Katrina J Curtis, Winston A S Banya, Syed Husain, Karnan Satkunam, Dinesh Shrikrishna, William Man, Michael I Polkey, Nicholas S Hopkinson,

RATIONALE:Dietary nitrate supplementation has been proposed as a strategy to improve exercise performance, both in healthy individuals and in people with COPD. We aimed to assess whether it could enhance the effect of pulmonary rehabilitation (PR) in COPD. METHODS:This double-blind, placebo-controlled, parallel group, randomised controlled study performed at four UK ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Occupational exposure to inhaled pollutants and risk of airflow obstruction: a large UK population-based UK Biobank cohort.

Steven S Sadhra, Nuredin Mohammed, Om P Kurmi, David Fishwick, Sara De Matteis, Sally Hutchings, Debbie Jarvis, Jon G Ayres, Lesley Rushton,

BACKGROUND:Although around 10% to 15% of COPD burden can be attributed to workplace exposures, little is known about the role of different airborne occupational pollutants (AOP). The main aim of the study was to assess the effect size of the relationship between various AOP, their level and duration of exposure ... Read more >>

Thorax (Thorax)
[2020, 75(6):468-475]

Cited: 0 times

View full text PDF listing >>



Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis Molecular Bacterial Load Assay.

Wilber Sabiiti, Khalide Azam, Eoghan Charles William Farmer, Davis Kuchaka, Bariki Mtafya, Ruth Bowness, Katarina Oravcova, Isobella Honeyborne, Dimitrios Evangelopoulos, Timothy Daniel McHugh, Celso Khosa, Andrea Rachow, Norbert Heinrich, Elizabeth Kampira, Geraint Davies, Nilesh Bhatt, Elias N Ntinginya, Sofia Viegas, Ilesh Jani, Mercy Kamdolozi, Aaron Mdolo, Margaret Khonga, Martin J Boeree, Patrick P J Phillips, Derek Sloan, Michael Hoelscher, Gibson Kibiki, Stephen H Gillespie,

In this comparative biomarker study, we analysed 1768 serial sputum samples from 178 patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load Assay (TB-MBLA) reduces time-to-TB-bacillary-load-result from days/weeks by culture to hours and detects early patient treatment response. By day 14 of treatment, 5% of ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Pulmonary complications for women with sickle cell disease in pregnancy: systematic review and meta-analysis.

Sivarajini Inparaj, Mickey Buckingham, Laura Oakley, Paul T Seed, Sebastian Lucas, Eugene Oteng-Ntim,

BACKGROUND:Sickle cell disease (SCD) is a multisystem disease characterised by vaso-occlusive crisis, chronic anaemia and a shorter lifespan. More patients with SCD are living till reproductive age and contemplating pregnancy. Pulmonary complications in pregnancy are significant causes of maternal morbidity and mortality but yet this has not been systematically quantified. ... Read more >>

Thorax (Thorax)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9978 s