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Journal Ther Drug Monit


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Longitudinal Monitoring of Hair Cortisol Using Liquid Chromatography-Mass Spectrometry to Prevent Hypercortisolism in Patients Undergoing Glucocorticoid Replacement Therapy.

Katarína Kostolanská, Helena Šiprová, Elis Bartečků, Jan Juřica, Ivan Řiháček, Eva Táborská, Miroslav Souček, Ondřej Peš,

<h4>Objective</h4>Currently available methods for endogenous cortisol monitoring in patients with hormonal insufficiency rely on measurements of plasma levels only at a single time point; thus, any kind of chronic exposure to cortisol is challenging to evaluate because it requires collecting samples at different time points. Hair cortisol levels acquired longitudinally ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2022, 44(3):438-447]

Cited: 0 times

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Development of a Sensitive and High-Throughput Assay for Simultaneous Quantification of 5 Tyrosine Kinase Inhibitors and 2 Active Metabolites in Human Plasma Using Ultra-high Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry.

Takahiro Sumimoto, Ryosuke Nakahara, Yosuke Suzuki, Ryota Tanaka, Natsumi Yoshida, Masao Ogata, Hiroki Itoh,

<h4>Background</h4>Breakpoint cluster region-Abelson (BCR-ABL) tyrosine kinase inhibitors (TKIs) demonstrate improved therapeutic efficacy in chronic myeloid leukemia (CML). However, drug-drug interactions, nonadherence, and host-related factors may influence plasma concentrations. Therefore, therapeutic drug monitoring may be necessary for patients presenting inadequate treatment responses or adverse events. Herein, the authors aimed to develop ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2022, 44(3):419-429]

Cited: 1 time

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