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Journal Stroke Vasc Neurol

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Quantitative angiographic haemodynamic evaluation of bypasses for complex aneurysms: a preliminary study.

Junlin Lu, Chao Xue, Xulin Hu, Yuanli Zhao, Dong Zhang, Xiaolin Chen, Ji Zong Zhao,

<h4>Objective</h4>Open microsurgery, often with bypass techniques, is indispensable for complex aneurysms. To date, it remains unknown whether arterial anatomy or quantitative blood flow measurements can predict insufficient flow-related stroke (IRS). The present study aimed to evaluate the risk factors for IRS in patients treated with open microsurgery with bypass procedures ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Safety of endovascular therapy for symptomatic intracranial artery stenosis: a national prospective registry.

Yabing Wang, Tao Wang, Adam Andrew Dmytriw, Kun Yang, Liqun Jiao, Huaizhang Shi, Jie Lu, Tianxiao Li, Yujie Huang, Zhenwei Zhao, Wei Wu, Jieqing Wan, Qinjian Sun, Bo Hong, Yongli Li, Liyong Zhang, Jianfeng Chu, Qiong Cheng, Yiling Cai, Pengfei Wang, Qi Luo, Hua Yang, Baijing Dong, Yang Zhang, Jun Zhao, Zuoquan Chen, Wei Li, Xiaoxin Bai, Weiwen He, Xueli Cai, Maimai Ti, Osama O Zaidat,

<h4>Introduction</h4>The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown. The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis (CRTICAS) was a prospective, multicentre, real-world registry designed to assess these outcomes and the impact of centre experience.<h4>Methods</h4>1140 severe, ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage.

Zhiyuan Vera Zheng, Junfan Chen, Hao Lyu, Sin Yu Erica Lam, Gang Lu, Wai Yee Chan, George K C Wong,

<h4>Background and purpose</h4>Signal transducer and activator of transcription 3 (STAT3) may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses. Thus, this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage (SAH).<h4>Methods</h4>The SAH model ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Call for emergency action to limit global temperature increases, restore biodiversity and protect health.

Lukoye Atwoli, Abdullah H Baqui, Thomas Benfield, Raffaella Bosurgi, Fiona Godlee, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Carlos Augusto Monteiro, Ian Norman, Kirsten Patrick, Nigel Praities, Marcel Gm Olde Rikkert, Eric J Rubin, Peush Sahni, Richard Smith, Nicholas J Talley, Sue Turale, Damián Vázquez,

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, 6(3):321-323]

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Safety and efficacy of tenecteplase versus alteplase in patients with acute ischaemic stroke (TRACE): a multicentre, randomised, open label, blinded-endpoint (PROBE) controlled phase II study.

Shuya Li, Yuesong Pan, Ziran Wang, Zhigang Liang, Huisheng Chen, Dong Wang, Yi Sui, Xingquan Zhao, Yilong Wang, WanLiang Du, Huaguang Zheng, Yongjun Wang,

<h4>Background</h4>Tenecteplase (TNK) possesses several pharmacological characteristics superior to conventional alteplase (rt-PA), with well-established safety and efficacy profile in Caucasians. There exists controversy over the optimal dose of intravenous rt-PA for East Asians with acute ischaemic stroke (AIS). Current study aimed to determine the safety dose range of recombinant human TNK ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-II (TRACE II): rationale and design.

Shuya Li, Bruce C V Campbell, Lee H Schwamm, Marc Fisher, Mark Parsons, Hao Li, Yuesong Pan, Yongjun Wang, ,

<h4>Background and purpose</h4>Tenecteplase (TNK) is a promising agent for treatment of acute ischaemic stroke (AIS). We hypothesised that recombinant human TNK tissue-type plasminogen activator (rhTNK-tPA) is non-inferior to rt-PA in achieving excellent functional outcome at 90 days, when administered within 4.5 hours of ischaemic stroke onset.<h4>Methods and design</h4>Tenecteplase Reperfusion therapy ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis.

Linda Ld Zhong, Ya Zheng, Alexander Y Lau, Norman Wong, Liang Yao, Xingyao Wu, Tengteng Shao, Zhenxing Lu, Huijuan Li, Chun Sum Yuen, Jianwen Guo, Suzanne Lo, Janita Chau, Kam Wa Chan, Bacon Fung Leung Ng, Zhaoxiang Bian, Edwin Chau-Leung Yu,

<h4>Background</h4>Stroke is a major cause of death or long-term disability worldwide. Many patients with stroke receive integrative therapy consisting of Western medicine (WM) and routine rehabilitation in conjunction with Chinese medicine (CM), such as acupuncture and Chinese herbal medicine. However, there is no available evidence on the effectiveness of the ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Pertussis toxin-induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice.

Ming Zou, Yan Feng, Yuwhen Xiu, Yan Li, Ying Zhang, Junwan Fan, Haowen Li, Jingli Cao, Wenyan He, Wei-Na Jin,

<h4>Background</h4>Stroke is a devastating disease, including intracerebral haemorrhage (ICH) and ischaemic stroke. Emerging evidences indicate that systemic inflammatory cascades after stroke contribute to brain damage. However, the direct effects and features of systemic inflammation on brain injury, especially comparing between ischaemic and haemorrhagic stroke, are still obscure.<h4>Methods</h4>Pertussis toxin (PT) was ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Prominent juxtacortical white matter lesion hallmarks NOTCH3-related intracerebral haemorrhage.

Chih-Hao Chen, Hao-Chia Hsu, Yu-Wen Cheng, Ya-Fang Chen, Sung-Chun Tang, Jiann-Shing Jeng,

<h4>Background and purpose</h4><i>NOTCH3</i> p.R544C mutation accounts for 5% of spontaneous intracerebral haemorrhage (ICH) in East Asian patients. We investigated whether certain CT features are associated with <i>NOTCH3</i>-related ICH.<h4>Methods</h4>Patients with spontaneous ICH from a prospective stroke registry were screened for <i>NOTCH3</i> p.R544C mutation. The neuroimaging features on the initial non-contrast CT ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Efficacy and safety of bridging thrombolysis initiated before transfer in a drip-and-ship stroke service.

Jan Christoph Purrucker, Miriam Heyse, Simon Nagel, Christoph Gumbinger, Fatih Seker, Markus Möhlenbruch, Peter Arthur Ringleb,

<h4>Objective</h4>Data regarding the efficacy and safety of bridging thrombolysis (BT) initiated before transfer for evaluation of endovascular therapy is heterogeneous. We, therefore, analyse efficacy and safety of BT in patients treated within a drip-and-ship stroke service.<h4>Methods</h4>Consecutive adult patients suffering from acute ischaemic stroke and large-vessel occlusions (LVO) transferred to our ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli.

Waleed Brinjikji, Oana Madalina Mereuta, Daying Dai, David F Kallmes, Luis Savastano, Yang Liu, Shahid M Nimjee, Raul G Nogueira, Mehdi Abbasi, Ramanathan Kadirvel,

There has been growing interest and insight into the histological composition of retrieved stroke emboli. One of the main focuses of the stroke clot analysis literature has been the implications of clot composition on mechanical thrombectomy procedures. However, the holy grail of clot analysis may not be in the field ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Advances in mechanical thrombectomy for acute ischaemic stroke from large vessel occlusions.

Xu Guo, Zhongrong Miao,

Advances in endovascular treatment of acute ischaemic stroke from intracranial large vessel occlusions have continued in the past decade. Here, we performed a detailed review of all the new trials and studies that had the highest evidence, the guidelines for mechanical thrombectomy, the selection of the particular population outside the ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke.

Shina Kim, Joon-Tae Kim, Ji Sung Lee, Beom Joon Kim, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Sung-Il Sohn, Jeong-Ho Hong, Man-Seok Park, Kang-Ho Choi, Ki-Hyun Cho, Juneyoung Lee, Hee-Joon Bae,

<h4>Background</h4>No study has thoroughly compared the effectiveness of combined antiplatelet treatments (other than clopidogrel-aspirin) versus clopidogrel-aspirin or aspirin alone for early secondary prevention in acute ischaemic stroke.<h4>Methods</h4>We identified patients with acute, minor, non-cardiogenic ischaemic stroke treated with aspirin alone, clopidogrel-aspirin or other combination treatment. Propensity scores considering the inverse probability ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis.

Anthony Larson, Valentina Nardi, Waleed Brinjikji, John Benson, Giuseppe Lanzino, Luis Savastano,

<h4>Objective</h4>To systematically analyse prior reports of carotid endarterectomy (CEA) performed in cases of ≤50% carotid stenosis in order to understand patient tolerance and potential benefit.<h4>Methods</h4>A systematic review and descriptive analysis was performed in concordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. An English-language search was performed ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Successful management of vaccine-induced immune thrombotic thrombocytopenia-related cerebral sinus venous thrombosis after ChAdOx1 nCov-19 vaccination.

Thomas Gattringer, Paul Gressenberger, Thomas Gary, Albert Wölfler, Markus Kneihsl, Reinhard Bernd Raggam,

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan.

Benno Ikenberg, Antonia Franziska Demleitner, Thomas Thiele, Benedikt Wiestler, Katharina Götze, Georg Mößmer, Paul Lingor,

Vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) have been recently described as rare complications following vaccination against SARS-CoV-2 with vector vaccines. We report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19 (AstraZeneca). While the initial ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Off-hour effect is not significant in endovascular treatment for anterior circulation large vessel occlusion in a multicentre registry.

Mingming Zha, Qingwen Yang, Shuo Liu, Kangmo Huang, Xiaohao Zhang, Min Wu, Haodi Cai, Qiushi Lv, Rui Liu, Dong Yang, Xinfeng Liu,

<h4>Background and purpose</h4>Whether the off-hour effect has an impact on workflow and outcomes of endovascular treatment (EVT) for anterior circulation large vessel occlusion (AC-LVO) remains uncertain. This study aimed to compare the characteristics and outcomes of patients who presented or were treated during off-hour versus on-hour in a multi-center registry.<h4>Methods</h4>AC-LVO ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Clinical imaging factors of excellent outcome after thrombolysis in large-vessel stroke: a THRACE subgroup analysis.

Nolwenn Riou-Comte, Benjamin Gory, Marc Soudant, François Zhu, Yu Xie, Lisa Humbertjean, Gioia Mione, Catherine Oppenheim, Francis Guillemin, Serge Bracard, Sébastien Richard, ,

<h4>Background</h4>For patients with stroke with large-vessel occlusion (LVO), study of factors predicting response to intravenous thrombolysis (IVT) would allow identifying subgroups with high expected gain, and those for whom it could be considered as futile, and even detrimental. From patients included in the Mechanical Thrombectomy After Intravenous Alteplase vs Alteplase ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Effects and safety of aspirin use in patients after cerebrovascular bypass procedures.

Junlin Lu, Guangchao Shi, Yuanli Zhao, Rong Wang, Dong Zhang, Xiaolin Chen, Hao Wang, Ji Zong Zhao,

<h4>Object</h4>Superficial temporal artery to middle cerebral artery (STA-MCA) bypass is the most effective treatment for Moyamoya disease (MMD). In this study, we aimed to assess whether aspirin improves STA-MCA bypass patency and is safe in patients with MMD.<h4>Methods</h4>We performed a retrospective medical record review of patients with ischaemic-onset MMD who ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial.

Yongjun Wang, Claiborne Johnston, Philip M Bath, Xia Meng, Jing Jing, Xuewei Xie, Anxin Wang, Yuesong Pan, Anding Xu, Qiang Dong, Yilong Wang, Xingquan Zhao, Zixiao Li, Hao Li, ,

<h4>Background</h4>In patients with a minor ischaemic stroke or transient ischaemic attack (TIA), separate trials have shown that dual antiplatelet therapy with clopidogrel plus aspirin (clopidogrel-aspirin) or ticagrelor plus aspirin (ticagrelor-aspirin) are more effective than aspirin alone in stroke secondary prevention. However, these two sets of combination have not been directly ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, 6(2):280-285]

Cited: 2 times

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Incidence and prevalence of moyamoya disease in urban China: a nationwide retrospective cohort study.

Yixin Sun, Guoyu Zhou, Jingnan Feng, Lu Chen, Guozhen Liu, Jinxi Wang, Qingliang Wang, Junyou Yu, Xiwang Yang, Zheng Yang, Pei Gao, Shengfeng Wang, Siyan Zhan,

<h4>Background and objective</h4>Moyamoya disease (MMD) is an increasingly recognised cause of stroke, mainly described in East Asia. China is the largest nation in Asia, but few studies reported the epidemiology of MMD, especially at a national level. We aimed to estimate the incidence and prevalence of MMD in China.<h4>Methods</h4>We performed ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Is more evidence needed for thrombectomy in basilar artery occlusion? The BASICS and BEST meta-analytical approaches.

Davi J Fontoura Solla, Felipe Coelho Argolo, Karol P Budohoski, Angelos G Kolias, José Guilherme M P Caldas, Jamary Oliveira-Filho,

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Analytical validation of GMEX rapid point-of-care CYP2C19 genotyping system for the CHANCE-2 trial.

Xia Meng, Anxin Wang, Guojun Zhang, Siying Niu, Wei Li, Sifei Han, Fang Fang, Xingquan Zhao, Kehui Dong, Zening Jin, Huaguang Zheng, Kelin Chen, Hao Li, Chengyuan Yang, Yongjun Wang,

<h4>Background and purpose</h4>Rapid genotyping is useful for guiding early antiplatelet therapy in patients with high-risk nondisabling ischaemic cerebrovascular events (HR-NICE). Conventional genetic testing methods used in <i>CYP2C19</i> genotype-guided antiplatelet therapy for patients with HR-NICE did not satisfy the needs of the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, 6(2):274-279]

Cited: 1 time

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Treating acute large vessel occlusion stroke: to bridge or not to bridge?

Yunyun Xiong, Yuesong Pan, Raul G Nogueira, Zeguang Ren, Tudor G Jovin, Yongjun Wang,

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, 6(3):324-327]

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Effectiveness of intravenous r-tPA versus UK for acute ischaemic stroke: a nationwide prospective Chinese registry study.

Xinhong Wang, Xiaoqiu Li, Yuming Xu, Runhui Li, Qingcheng Yang, Yong Zhao, Fengyun Wang, Baoying Sheng, Runqing Wang, Shaoyuan Chen, Lihua Wang, Liying Shen, Xiaowen Hou, Yu Cui, Duolao Wang, Bin Peng, Craig S Anderson, Huisheng Chen, ,

<h4>Background</h4>Intravenous recombinant tissue plasminogen activator (r-tPA) and urokinase (UK) are both recommended for the treatment of acute ischaemic stroke (AIS) in China, but with few comparative outcome data being available. We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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