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Author Correction: Impact of KRAS mutation status on the efficacy of immunotherapy in lung cancer brain metastases.

Adam Lauko, Rupesh Kotecha, Addison Barnett, Hong Li, Vineeth Tatineni, Assad Ali, Pradnya Patil, Alireza M Mohammadi, Samuel T Chao, Erin S Murphy, Lilyana Angelov, John H Suh, Gene H Barnett, Nathan A Pennell, Manmeet S Ahluwalia,

Sci Rep (Scientific reports)
[2022, 12(1):1147]

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Objective evaluation of deep uncertainty predictions for COVID-19 detection.

Hamzeh Asgharnezhad, Afshar Shamsi, Roohallah Alizadehsani, Abbas Khosravi, Saeid Nahavandi, Zahra Alizadeh Sani, Dipti Srinivasan, Sheikh Mohammed Shariful Islam,

Deep neural networks (DNNs) have been widely applied for detecting COVID-19 in medical images. Existing studies mainly apply transfer learning and other data representation strategies to generate accurate point estimates. The generalization power of these networks is always questionable due to being developed using small datasets and failing to report ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):815]

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Superior frontal regions reflect the dynamics of task engagement and theta band-related control processes in time-on task effects.

Shijing Yu, Moritz Mückschel, Christian Beste,

Impairment of cognitive performance is often observed in time-on tasks. Theoretical considerations suggest that especially prefrontal cortex cognitive control functions is affected by time-on-task effects, but the role of effort/task engagement is not understood. We examine time-on-task effects in cognitive control on a neurophysiological level using a working-memory modulated response ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):846]

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Quadriceps physiological response during the 1-min sit-to-stand test in people with severe COPD and healthy controls.

Sarah Gephine, Patrick Mucci, Mathieu Bielmann, Mickael Martin, Laurent Bouyer, Didier Saey, François Maltais,

We compared quadriceps oxygenation and surface electromyography (sEMG) responses during the 1-min sit-to-stand (1STS) in 14 people with severe COPD and 12 controls, in whom cardiorespiratory response, near-infrared spectroscopy signals (oxy [Hb-Mb], deoxy [Hb-Mb], total [Hb-Mb], and SmO<sub>2</sub>) and sEMG signals of the quadriceps were recorded. Time duration of each ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):794]

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Rapid design and implementation of a UVC decontamination room.

Andrew Hummel, Awatef Ergai, LeeAnna Spiva, Sharlene Toney, Austin Crawford,

With the recent COVID-19 pandemic that has swept the world and the nation, hospitals around the country have experienced shortages in Personal Protective Equipment, specifically N95 filter face-mask respirators (FFRs). This has created the need for facilities to develop sterilization processes to enable reuse of face masks by the health ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):835]

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Impacts of offshore wind farms on the atmospheric environment over Taiwan Strait during an extreme weather typhoon event.

Tsung-Yu Lee, Yu-Ting Wu, Mien-Tze Kueh, Chuan-Yao Lin, Yi-Ying Lin, Yang-Fan Sheng,

Wind is one of the cleanest renewable energy resources. Through the "Thousand Wind Turbines Project", Taiwan is planning to increase the proportion of power generation from renewable energy and has set a target of 5.7 GW for offshore wind by 2025. The effects of future offshore wind farms (OWFs) over ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):823]

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Frequency dependence prediction and parameter identification of rubber bushing.

Guang Li, Liguang Wu, Shuyu Zhang, Fang Liu,

Affected by frequency, amplitude and some other factors, the dynamic mechanical properties of rubber bushing are nonlinear. In order to study the frequency dependence of the rubber bushing, a BP neural network optimized by genetic algorithm (GA-BP neural network) is applied to predict the dynamic stiffness and loss factor under ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):863]

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Design specification management with automated decision-making for reliable optimization of miniaturized microwave components.

Slawomir Koziel, Anna Pietrenko-Dabrowska, Piotr Plotka,

The employment of numerical optimization techniques for parameter tuning of microwave components has nowadays become a commonplace. In pursuit of reliability, it is most often carried out at the level of full-wave electromagnetic (EM) simulation models, incurring considerable computational expenses. In the case of miniaturized microstrip circuits, densely arranged layouts ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):829]

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Binding behavior of spike protein and receptor binding domain of the SARS-CoV-2 virus at different environmental conditions.

Meiyi Zhang, Haoqi Wang, Emma R Foster, Zivko L Nikolov, Sandun D Fernando, Maria D King,

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of the COVID-19 pandemic that originated in China in December 2019. Although extensive research has been performed on SARS-CoV-2, the binding behavior of spike (S) protein and receptor binding domain (RBD) of SARS-CoV-2 at different ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):789]

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Methylation statuses of NCOR2, PARK2, and ZSCAN12 signify densities of tumor-infiltrating lymphocytes in gastric carcinoma.

Xianyu Wen, Hye-Yeong Jin, Meihui Li, Younghoon Kim, Nam-Yun Cho, Yoonjin Kwak, Jeong Mo Bae, Hye Seung Lee, Gyeong Hoon Kang,

Individual cell types of human tissues have their own CpG site methylation profiles, which might be utilized for the development of methylation markers to denote tumor-infiltrating lymphocytes (TILs). We aimed to develop DNA methylation markers that recapitulate the densities of TILs in gastric carcinoma (GC). Through genome-wide methylation profiling, NCOR2, ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):862]

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Modeling risk of Sclerotinia sclerotiorum-induced disease development on canola and dry bean using machine learning algorithms.

F Shahoveisi, M Riahi Manesh, L E Del Río Mendoza,

Diseases caused by the fungus Sclerotinia sclerotiorum are managed mainly through fungicide applications in canola and dry bean. Accurate estimation of the risk of disease development on these crops could help farmers make spraying decisions. Five machine learning (ML) models were evaluated in classification and regression modes for predicting disease ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):864]

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Bioinspired antifouling Fe-based amorphous coating via killing-resisting dual surface modifications.

Yu Li, Ling-Yu Zhang, Cheng Zhang, Zhan-Rong Zhang, Lin Liu,

Fe-based amorphous coatings with outstanding corrosion resistance are promise for marine applications. However, these coatings encounter a great challenge of biofouling in marine environments. Inspired by the unique micro-nano hierarchical structure of shark skin with excellent antifouling properties, in this paper, we construct a bioinspired Fe-based amorphous coating with killing-resisting ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):819]

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Joint analysis of the intention to vaccinate and to use contact tracing app during the COVID-19 pandemic.

Marta Caserotti, Paolo Girardi, Alessandra Tasso, Enrico Rubaltelli, Lorella Lotto, Teresa Gavaruzzi,

Pharmacological and non-pharmacological measures will overlap for a period after the onset of the pandemic, playing a strong role in virus containment. We explored which factors influence the likelihood to adopt two different preventive measures against the COVID-19 pandemic. An online snowball sampling (May-June 2020) collected a total of 448 ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):793]

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Anti-Pseudomonas aeruginosa activity of a C16-terpene dilactone isolated from the endophytic fungus Neofusicoccum luteum of Kigelia africana (Lam.).

Olusola Bodede, Mamokoena Kuali, Gerhard Prinsloo, Roshila Moodley, Roshini Govinden,

Fungal endophytes have the capacity to biosynthesize secondary metabolites that are produced by their host plants. In this study, a dilactone terpenoid of C<sub>16</sub> architecture was isolated from the fungal endophytes of Kigelia africana, in our attempt to identify anti-Pseudomonas aeruginosa metabolites. Thirty-eight fungal isolates were cultured for biomolecule production ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):780]

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AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.

Runa Izutsu, Mitsuhiko Osaki, Hideyuki Nemoto, Maho Jingu, Ryo Sasaki, Yusuke Yoshioka, Takahiro Ochiya, Futoshi Okada,

Adhesion of cancer cells to vascular endothelial cells in target organs is an initial step in cancer metastasis. Our previous studies revealed that amphoterin-induced gene and open reading frame 2 (AMIGO2) promotes the adhesion of tumor cells to liver endothelial cells, followed by the formation of liver metastasis in a ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):792]

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Low-invasive 5D visualization of mitotic progression by two-photon excitation spinning-disk confocal microscopy.

Takafumi Kamada, Kohei Otomo, Takashi Murata, Kaito Nakata, Shota Hiruma, Ryota Uehara, Mitsuyasu Hasebe, Tomomi Nemoto,

Non-linear microscopy, such as multi-photon excitation microscopy, offers spatial localities of excitations, thereby achieving 3D cross-sectional imaging with low phototoxicity even in thick biological specimens. We had developed a multi-point scanning two-photon excitation microscopy system using a spinning-disk confocal scanning unit. However, its severe color cross-talk has precluded multi-color simultaneous ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):809]

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Comparative transcriptome analysis of two contrasting resistant and susceptible Aegilops tauschii accessions to wheat leaf rust (Puccinia triticina) using RNA-sequencing.

Saeideh Dorostkar, Ali Dadkhodaie, Esmaeil Ebrahimie, Bahram Heidari, Mahmood Ahmadi-Kordshooli,

Leaf rust, caused by Puccinia triticina Eriks., is the most common rust disease of wheat (Triticum aestivum L.) worldwide. Owing to the rapid evolution of virulent pathotypes, new and effective leaf rust resistance sources must be found. Aegilops tauschii, an excellent source of resistance genes to a wide range of ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):821]

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Intestinal ion regulation exhibits a daily rhythm in Gymnocypris przewalskii exposed to high saline and alkaline water.

Fei Wang, Lin Zhu, Yuxing Wei, Pengcheng Gao, Yimeng Liu, Kai Zhou, Zhen Sun, Qifang Lai, Zongli Yao,

Naked carp (Gymnocypris przewalskii), endemic to the saline-alkaline Lake Qinghai, have the capacity to tolerate combinations of high salinity and alkalinity, but migrate to spawn in freshwater rivers each year. In this study, we measured the drinking rate over a 24 h period for naked carp exposed to saline-alkaline lake waters ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):807]

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Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament.

Hiroaki Nakashima, Shiro Imagama, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, Kazuo Kusano, Yukihiro Nakagawa, Takashi Hirai, Kanichiro Wada, Keiichi Katsumi, Kengo Fujii, Atsushi Kimura, Takeo Furuya, Tsukasa Kanchiku, Yukitaka Nagamoto, Yasushi Oshima, Narihito Nagoshi, Kei Ando, Masahiko Takahata, Kanji Mori, Hideaki Nakajima, Kazuma Murata, Shunji Matsunaga, Takashi Kaito, Kei Yamada, Sho Kobayashi, Satoshi Kato, Tetsuro Ohba, Satoshi Inami, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Yuanying Li, Hiroshi Yatsuya, Masao Koda, Yoshiharu Kawaguchi, Katsushi Takeshita, Morio Matsumoto, Masashi Yamazaki, Atsushi Okawa, ,

This prospective multicenter study, established by the Japanese Ministry of Health, Labour and Welfare and involving 27 institutions, aimed to compare postoperative outcomes between laminoplasty (LM) and posterior fusion (PF) for cervical ossification of the posterior longitudinal ligament (OPLL), in order to address the controversy surrounding the role of instrumented ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):748]

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Controlling polarization direction in epitaxial Pb(Zr0.2Ti0.8)O3 films through Nb (n-type) and Fe (p-type) doping.

Cristina Florentina Chirila, Viorica Stancu, Georgia Andra Boni, Iuliana Pasuk, Lucian Trupina, Lucian Dragos Filip, Cristian Radu, Ioana Pintilie, Lucian Pintilie,

Fe (acceptor) and Nb (donor) doped epitaxial Pb(Zr<sub>0.2</sub>Ti<sub>0.8</sub>)O<sub>3</sub> (PZT) films were grown on single crystal SrTiO<sub>3</sub> substrates and their electric properties were compared to those of un-doped PZT layers deposited in similar conditions. All the films were grown from targets produced from high purity precursor oxides and the doping was ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):755]

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Feasibility study of immersive virtual prism adaptation therapy with depth-sensing camera using functional near-infrared spectroscopy in healthy adults.

Sungmin Cho, Won Kee Chang, Jihong Park, Seung Hyun Lee, Jongseung Lee, Cheol E Han, Nam-Jong Paik, Won-Seok Kim,

Prism Adaptation (PA) is used to alleviate spatial neglect. We combined immersive virtual reality with a depth-sensing camera to develop virtual prism adaptation therapy (VPAT), which block external visual cues and easily quantify and monitor errors than conventional PA. We conducted a feasibility study to investigate whether VPAT can induce ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):767]

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Oscillatory dynamics underlying noun and verb production in highly proficient bilinguals.

Shuang Geng, Nicola Molinaro, Polina Timofeeva, Ileana Quiñones, Manuel Carreiras, Lucia Amoruso,

Words representing objects (nouns) and words representing actions (verbs) are essential components of speech across languages. While there is evidence regarding the organizational principles governing neural representation of nouns and verbs in monolingual speakers, little is known about how this knowledge is represented in the bilingual brain. To address this ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):764]

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Effect of electron and X-ray irradiation on microbiological and chemical parameters of chilled turkey.

Ulyana Bliznyuk, Valentina Avdyukhina, Polina Borshchegovskaya, Timofey Bolotnik, Victoria Ipatova, Zoya Nikitina, Alexander Nikitchenko, Igor Rodin, Felix Studenikin, Alexander Chernyaev, Dmitry Yurov,

The purpose of this work was to compare the effect of electron and X-ray irradiation on microbiological content and volatile organic compounds in chilled turkey meat. Dose ranges which significantly suppress the pathogenic microflora while maintaining the organoleptic properties of the turkey meat are different for electron and X-ray irradiation. ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):750]

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Use of the proteomic tool MALDI-TOF MS in termite identification.

Bouthaina Hasnaoui, Adama Zan Diarra, Jean-Michel Berenger, Hacène Medkour, Ahmed Benakhla, Oleg Mediannikov, Philippe Parola,

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) has proved effective for the identification of many arthropods. A total of 432 termite specimens were collected in Mali, Cote d'Ivoire, Togo, Senegal, Switzerland and France. Morphologically, 22 species were identified, including Ancistrotermes cavithorax, Amitermes evuncifer, Cryptotermes brevis, Cubitermes orthognathus, Kalotermes flavicollis, Macrotermes ... Read more >>

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[2022, 12(1):718]

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Mining for novel cyclomaltodextrin glucanotransferases unravels the carbohydrate metabolism pathway via cyclodextrins in Thermoanaerobacterales.

Sara Centeno-Leija, Laura Espinosa-Barrera, Beatriz Velazquez-Cruz, Yair Cárdenas-Conejo, Raúl Virgen-Ortíz, Georgina Valencia-Cruz, Roberto A Saenz, Yerli Marín-Tovar, Saúl Gómez-Manzo, Beatriz Hernández-Ochoa, Luz María Rocha-Ramirez, Rocío Zataraín-Palacios, Juan A Osuna-Castro, Agustín López-Munguía, Hugo Serrano-Posada,

Carbohydrate metabolism via cyclodextrins (CM-CD) is an uncommon starch-converting pathway that thoroughly depends on extracellular cyclomaltodextrin glucanotransferases (CGTases) to transform the surrounding starch substrate to α-(1,4)-linked oligosaccharides and cyclodextrins (CDs). The CM-CD pathway has emerged as a convenient microbial adaptation to thrive under extreme temperatures, as CDs are functional amphipathic ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):730]

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