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Early bilingual experience is associated with change detection ability in adults.

Dean D'Souza, Daniel Brady, Jennifer X Haensel, Hana D'Souza,

To adapt to their more varied and unpredictable (language) environments, infants from bilingual homes may gather more information (sample more of their environment) by shifting their visual attention more frequently. However, it is not known whether this early adaptation is age-specific or lasts into adulthood. If the latter, we would ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2068]

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Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system.

Kaoru Hattori, Natsuki Nakama, Jumpei Takada, Gohki Nishimura, Ryo Moriwaki, Eita Kawasaki, Michinobu Nagao, Yasuhiro Goto, Hiroshi Niinami, Kiyotaka Iwasaki,

The characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve models. A magnetic resonance imaging-compatible pulsatile flow circulation system was ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2066]

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The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells.

Yurie Nagai, Naoya Mimura, Ola Rizq, Yusuke Isshiki, Motohiko Oshima, Mohamed Rizk, Atsunori Saraya, Shuhei Koide, Yaeko Nakajima-Takagi, Makiko Miyota, Tetsuhiro Chiba, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Shio Mitsukawa, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Tohru Iseki, Chiaki Nakaseko, William Lennox, Josephine Sheedy, Marla Weetall, Koutaro Yokote, Atsushi Iwama, Emiko Sakaida,

The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and in combination with proteasome inhibitors in the treatment of multiple myeloma (MM). PTC596 inhibited the proliferation of MM cell lines as ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2074]

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Fabrication of copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2-2-aminobenzohydrazide and investigation of its catalytic application in the synthesis of 1,2,3-triazole compounds.

H Rajabi-Moghaddam, M R Naimi-Jamal, M Tajbakhsh,

In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> modified by isatoic anhydride. The structure of the catalyst has been determined by XRD, FE-SEM, TGA, VSM, ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2073]

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Insect derived extra oral GH32 plays a role in susceptibility of wheat to Hessian fly.

Subhashree Subramanyam, Jill A Nemacheck, Victor Bernal-Crespo, Nagesh Sardesai,

The Hessian fly is an obligate parasite of wheat causing significant economic damage, and triggers either a resistant or susceptible reaction. However, the molecular mechanisms of susceptibility leading to the establishment of the larvae are unknown. Larval survival on the plant requires the establishment of a steady source of readily ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2081]

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Partridge and embryonated partridge egg as new preclinical models for candidiasis.

Hadi Tavakkoli, Ahmad Khosravi, Iraj Sharifi, Zohreh Salari, Ehsan Salarkia, Reza Kheirandish, Kazem Dehghantalebi, Maziar Jajarmi, Seyedeh Saedeh Mosallanejad, Shahriar Dabiri, Alireza Keyhani,

Candida albicans (C. albicans) is the most common cause of candidiasis in humans and animals. This study was established to a new experimental infection model for systemic candidiasis using partridge and embryonated partridge egg. First, we tested the induction of systemic candidiasis in partridge and embryonated partridge egg. Finally, interaction ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2072]

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The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson's disease.

F Konrad Schumacher, Lena V Schumacher, Florian Amtage, Andreas Horn, Karl Egger, Tobias Piroth, Cornelius Weiller, Björn O Schelter, Volker A Coenen, Christoph P Kaller,

Deep brain stimulation of the subthalamic nucleus (STN-DBS) alleviates motor symptoms in Parkinson's disease (PD) but also affects the prefrontal cortex (PFC), potentially leading to cognitive side effects. The present study tested alterations within the rostro-caudal hierarchy of neural processing in the PFC induced by STN-DBS in PD. Granger-causality analyses ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2138]

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Detection and characterization of ESBL-producing Enterobacteriaceae from the gut of subsistence farmers, their livestock, and the surrounding environment in rural Nepal.

Supram Hosuru Subramanya, Indira Bairy, Yang Metok, Bharat Prasad Baral, Dipendra Gautam, Niranjan Nayak,

The increasing trend of gut colonization by extended-spectrum β-lactamase (ESBL) producing Enterobacterales has been observed in conventional farm animals and their owners. Still, such colonization among domesticated organically fed livestock has not been well studied. This study aimed to determine the gut colonization rate of ESBL-producing Enterobacteriaceae and carbapenemase-producing Enterobacteriaceae ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2091]

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Detecting operons in bacterial genomes via visual representation learning.

Rida Assaf, Fangfang Xia, Rick Stevens,

Contiguous genes in prokaryotes are often arranged into operons. Detecting operons plays a critical role in inferring gene functionality and regulatory networks. Human experts annotate operons by visually inspecting gene neighborhoods across pileups of related genomes. These visual representations capture the inter-genic distance, strand direction, gene size, functional relatedness, and ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2124]

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A directional 3D neurite outgrowth model for studying motor axon biology and disease.

Xandor M Spijkers, Svetlana Pasteuning-Vuhman, Jennifa C Dorleijn, Paul Vulto, Nienke R Wevers, R Jeroen Pasterkamp,

We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel, whereas dendrites and soma remain predominantly in the somal compartment, ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2080]

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Headache and musculoskeletal pain in school children are associated with uncorrected vision problems and need for glasses: a case-control study.

Hanne-Mari Schiøtz Thorud, Rakel Aurjord, Helle K Falkenberg,

Musculoskeletal pain and headache are leading causes of years lived with disability, and an escalating problem in school children. Children spend increasingly more time reading and using digital screens, and increased near tasks intensify the workload on the precise coordination of the visual and head-stabilizing systems. Even minor vision problems ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2093]

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Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

Ting-Bi Hua, Cheng-Xiong Liu, Wei-Min Hu, Long Wang, Qing-Qing Yang,

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields. ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2078]

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Biomechanical characterization of human temporal muscle fascia in uniaxial tensile tests for graft purposes in duraplasty.

Johann Zwirner, Benjamin Ondruschka, Mario Scholze, Gundula Schulze-Tanzil, Niels Hammer,

The human temporal muscle fascia (TMF) is used frequently as a graft material for duraplasty. Encompassing biomechanical analyses of TMF are lacking, impeding a well-grounded biomechanical comparison of the TMF to other graft materials used for duraplasty, including the dura mater itself. In this study, we investigated the biomechanical properties ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2127]

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Septohippocampal transmission from parvalbumin-positive neurons features rapid recovery from synaptic depression.

Feng Yi, Tavita Garrett, Karl Deisseroth, Heikki Haario, Emily Stone, J Josh Lawrence,

Parvalbumin-containing projection neurons of the medial-septum-diagonal band of Broca ([Formula: see text]) are essential for hippocampal rhythms and learning operations yet are poorly understood at cellular and synaptic levels. We combined electrophysiological, optogenetic, and modeling approaches to investigate [Formula: see text] neuronal properties. [Formula: see text] neurons had intrinsic membrane ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2117]

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Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.

Tania S Darphorn, Keshia Bel, Belinda B Koenders-van Sint Anneland, Stanley Brul, Benno H Ter Kuile,

Resistance plasmids play a crucial role in the transfer of antimicrobial resistance from the veterinary sector to human healthcare. In this study plasmids from foodborne Escherichia coli isolates with a known (ES)BL or tetracycline resistance were sequenced entirely with short- and long-read technologies to obtain insight into their composition and ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2136]

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The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass.

Joao Pedro Werneck-de-Castro, Flavia Leticia Martins Peçanha, Diego Henrique Silvestre, Ernesto Bernal-Mizrachi,

Mechanistic target of rapamycin complex 1 (mTORC1) deficiency or chronic hyperactivation in pancreatic β-cells leads to diabetes. mTORC1 complexes with La-related protein 1 (LARP1) to specifically regulate the expression of 5' terminal oligopyrimidine tract (5'TOP) mRNAs which encode proteins of the translation machinery and ribosome biogenesis. Here we show that ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2079]

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Developmental stages of peach, plum, and apple fruit influence development and fecundity of Grapholita molesta (Lepidoptera: Tortricidae).

Souvic Sarker, Young Ha Woo, Un Taek Lim,

Host plant attributes are essential factors determining the population dynamics of herbivorous insects. The developmental stage of host plants, in particular, may affect the biology of Grapholita molesta (Busck), a possibility that has rarely been examined. Here we assessed the effect of developmental stage of plum, peach, and apple fruits ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2105]

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Ultrahigh sensitive refractive index nanosensors based on nanoshells, nanocages and nanoframes: effects of plasmon hybridization and restoring force.

MirKazem Omrani, Hamidreza Mohammadi, Hamidreza Fallah,

In this study, the effect of the plasmon hybridization mechanism on the performance and refractive index (RI) sensitivity of nanoshell, nanocage and nanoframe structures is investigated using the finite-difference time-domain simulation. To create nanocage structure, we textured the cubic nanoshell surfaces and examined the impact of its key parameters (such ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2065]

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Re-expression of REG family and DUOXs genes in CRC organoids by co-culturing with CAFs.

Mie Naruse, Masako Ochiai, Shigeki Sekine, Hirokazu Taniguchi, Teruhiko Yoshida, Hitoshi Ichikawa, Hiromi Sakamoto, Takashi Kubo, Kenji Matsumoto, Atsushi Ochiai, Toshio Imai,

Organoids derived from epithelial tumors have recently been utilized as a preclinical model in basic and translational studies. This model is considered to represent the original tumor in terms of 3D structure, genetic and cellular heterogeneity, but not tumor microenvironment. In this study, we established organoids and paired cancer-associated fibroblasts ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2077]

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Structural insights into vesicle amine transport-1 (VAT-1) as a member of the NADPH-dependent quinone oxidoreductase family.

Sun-Yong Kim, Tomoyuki Mori, Min Fey Chek, Shunji Furuya, Ken Matsumoto, Taisei Yajima, Toshihiko Ogura, Toshio Hakoshima,

Vesicle amine transport protein-1 (VAT-1) has been implicated in the regulation of vesicular transport, mitochondrial fusion, phospholipid transport and cell migration, and is a potential target of anticancer drugs. Little is known about the molecular function of VAT-1. The amino acid sequence indicates that VAT-1 belongs to the quinone oxidoreductase ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2120]

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Esophageal metal stent for malignant obstruction after prior radiotherapy.

Hiroyoshi Iwagami, Ryu Ishihara, Sachiko Yamamoto, Noriko Matsuura, Ayaka Shoji, Katsunori Matsueda, Takahiro Inoue, Muneaki Miyake, Kotaro Waki, Hiromu Fukuda, Yusaku Shimamoto, Mitsuhiro Kono, Hiroko Nakahira, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Yoji Takeuchi, Koji Higashino, Noriya Uedo,

The association between severe adverse events (SAEs) and prior radiotherapy or stent type remains controversial. Patients with esophageal or esophagogastric junctional cancer who underwent stent placement (2005-2019) were enrolled in this retrospective study conducted at a tertiary cancer institute in Japan. The exclusion criteria were follow-up period of < 1 month and insufficient ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2134]

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Development and large volume production of extremely high current density YBa2Cu3O7 superconducting wires for fusion.

A Molodyk, S Samoilenkov, A Markelov, P Degtyarenko, S Lee, V Petrykin, M Gaifullin, A Mankevich, A Vavilov, B Sorbom, J Cheng, S Garberg, L Kesler, Z Hartwig, S Gavrilkin, A Tsvetkov, T Okada, S Awaji, D Abraimov, A Francis, G Bradford, D Larbalestier, C Senatore, M Bonura, A E Pantoja, S C Wimbush, N M Strickland, A Vasiliev,

The fusion power density produced in a tokamak is proportional to its magnetic field strength to the fourth power. Second-generation high temperature superconductor (2G HTS) wires demonstrate remarkable engineering current density (averaged over the full wire), J<sub>E</sub>, at very high magnetic fields, driving progress in fusion and other applications. The ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2084]

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Author Correction: Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts.

Thanuja D K Herath, Richard P Darveau, Chaminda J Seneviratne, Cun-Yu Wang, Yu Wang, Lijian Jin,

Sci Rep (Scientific reports)
[2021, 11(1):2337]

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Diabetes among tuberculosis patients and its impact on tuberculosis treatment in South Asia: a systematic review and meta-analysis.

Sanju Gautam, Nipun Shrestha, Sweta Mahato, Tuan P A Nguyen, Shiva Raj Mishra, Gabriele Berg-Beckhoff,

The escalating burden of diabetes is increasing the risk of contracting tuberculosis (TB) and has a pervasive impact on TB treatment outcomes. Therefore, we conducted this systematic review and meta-analysis to examine the burden of diabetes among TB patients and assess its impact on TB treatment in South Asia (Afghanistan, ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2113]

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Identifying the true number of specimens of the extinct blue antelope (Hippotragus leucophaeus).

Elisabeth Hempel, Faysal Bibi, J Tyler Faith, James S Brink, Daniela C Kalthoff, Pepijn Kamminga, Johanna L A Paijmans, Michael V Westbury, Michael Hofreiter, Frank E Zachos,

Native to southern Africa, the blue antelope (Hippotragus leucophaeus) is the only large African mammal species known to have become extinct in historical times. However, it was poorly documented prior to its extinction ~ 1800 AD, and many of the small number of museum specimens attributed to it are taxonomically contentious. This ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2100]

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