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All-optical, an ultra-thin endoscopic photoacoustic sensor using multi-mode fiber.

Nadav Shabairou, Benjamin Lengenfelder, Martin Hohmann, Florian Klämpfl, Michael Schmidt, Zeev Zalevsky,

Photoacoustic endoscopy (PAE) is a method of in-vivo imaging that uses tissue absorption properties. In PAE, the main tools used to detect the acoustic signal are mechanical ultrasound transducers, which require direct contact and which are difficult to miniaturize. All-optic photoacoustic sensors can challenge this issue as they can provide ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9142]

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Water is a biomarker of changes in the cellular environment in live animals.

Pratibha Siwach, Evgeniya Levy, Leonid Livshits, Yuri Feldman, Daniel Kaganovich,

The biological processes that are associated with the physiological fitness state of a cell comprise a diverse set of molecular events. Reactive oxygen species (ROS), mitochondrial dysfunction, telomere shortening, genomic instability, epigenetic changes, protein aggregation, and down-regulation of quality control mechanisms are all hallmarks of cellular decline. Stress-related and decline-related ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9095]

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The microbial biogeography of the gastrointestinal tract of preterm and term lambs.

Clara Yieh Lin Chong, Tommi Vatanen, Mark Oliver, Frank H Bloomfield, Justin M O'Sullivan,

Nutritional supplementation is a common clinical intervention to support the growth of preterm infants. There is little information on how nutritional supplementation interacts with the developing microbiome of the small intestine, the major site for nutrient metabolism and absorption. We investigated the effect of preterm birth and nutritional supplementation on ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9113]

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Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential.

Nelson G J Oliveira, Marlon H Cardoso, Nadya Velikova, Marcel Giesbers, Jerry M Wells, Taia M B Rezende, Renko de Vries, Octávio L Franco,

The spread of multi-drug resistance and the slow pace at which antibiotics come onto the market are undermining our ability to treat human infections, leading to high mortality rates. Aiming to overcome this global crisis, antimicrobial peptides are considered promising alternatives to counter bacterial infections with multi-drug resistant bacteria. The ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9127]

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De novo RNA sequencing analysis of Aeluropus littoralis halophyte plant under salinity stress.

Elham Younesi-Melerdi, Ghorban-Ali Nematzadeh, Ali Pakdin-Parizi, Mohammad Reza Bakhtiarizadeh, Seyed Abolfazl Motahari,

The study of salt tolerance mechanisms in halophyte plants can provide valuable information for crop breeding and plant engineering programs. The aim of the present study was to investigate whole transcriptome analysis of Aeluropus littoralis in response to salinity stress (200 and 400 mM NaCl) by de novo RNA-sequencing. To assemble ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9148]

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Association Between Cerebrospinal Fluid Biomarkers and Age-related Brain Changes in Patients with Normal Pressure Hydrocephalus.

Foad Taghdiri, Melisa Gumus, Musleh Algarni, Alfonso Fasano, David Tang-Wai, Maria Carmela Tartaglia,

Our study aimed to: 1)investigate the diagnostic utility of CSF Aβ42, t-tau, and p-tau to differentiate normal-pressure-hydrocephalus(NPH) from Alzheimer's-disease(AD) and normal-controls; and 2)investigate if age and ventricular size affect the levels of CSF biomarkers in NPH patients. We recruited 131 participants: (a)Suspected-NPH: 72 with ventriculomegaly and clinical symptoms of NPH. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9106]

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Cellular Fibronectin Containing Extra Domain A Causes Insulin Resistance via Toll-like Receptor 4.

Sangam Rajak, Yusuf Hussain, Khushboo Singh, Swasti Tiwari, Basir Ahmad, Sachi Bharti, Prem Prakash,

We determined the role of cellular fibronectin (CFN) containing the alternatively spliced extra domain A (FN-EDA) in causing insulin resistance (IR) through toll-like receptor 4 (TLR4). Circulating FN-EDA level was evaluated in mouse and rat IR models. Specific anti-FN-EDA antibody and TLR4 inhibitor were used to study its role in ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9102]

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Identification of two aptamers binding to Legionella pneumophila with high affinity and specificity.

Mariam Saad, Deanna Chinerman, Maryam Tabrizian, Sebastien P Faucher,

Legionella pneumophila (Lp) is a water borne bacterium causing Legionnaires' Disease (LD) in humans. Rapid detection of Lp in water system is essential to reduce the risk of LD outbreaks. The methods currently available require expert skills and are time intensive, thus delaying intervention. In situ detection of Lp by ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9145]

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Subjective versus objective, polymer bur-based selective carious tissue removal: 1-year interim analysis of a randomized clinical trial.

Marta Gomes Marques, Leandro Augusto Hilgert, Larissa Ribeiro Silva, Karine Medeiros Demarchi, Patrícia Magno Dos Santos Matias, Ana Paula Dias Ribeiro, Soraya Coelho Leal, Sebastian Paris, Falk Schwendicke,

We aimed to compare subjective (S) vs. objective (O) selective carious tissue removal using hand-excavation versus a self-limiting polymer bur, respectively. A community-based single-blind cluster-randomized controlled superiority trial was performed. This is a 1-year-interim analysis. 115 children (age 7-8 years) with ≥1 vital primary molar with a deep dentin lesion ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9130]

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Thiol Groups as a Biomarker for the Diagnosis and Prognosis of Prostate Cancer.

Alexsandro Koike, Brunna Emanuella França Robles, Ana Gabriela da Silva Bonacini, Camila Cataldi de Alcantara, Edna Maria Vissoci Reiche, Isaias Dichi, Michael Maes, Rubens Cecchini, Andréa Name Colado Simão,

Oxidative stress (OS) is associated with the onset of prostate cancer (PCa). The aims of this study are to examine whether OS biomarkers may be employed as external validating criteria for the diagnosis PCa. This case-control study recruited 204 subjects, 73 patients with PCa, 67 patients with benign prostate hyperplasia ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9093]

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Wideband Magnetic Excitation System for Atomic Force Microscopy Cantilevers with Megahertz-Order Resonance Frequency.

Kaito Hirata, Takumi Igarashi, Keita Suzuki, Keisuke Miyazawa, Takeshi Fukuma,

Small cantilevers with a megahertz-order resonance frequency provide excellent sensitivity and speed in liquid-environment atomic force microscopy (AFM). However, stable and accurate oscillation control of a small cantilever requires the photothermal excitation, which has hindered their applications to the studies on photo-sensitive materials. Here, we develop a magnetic excitation system ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9133]

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Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.

Christian M Garrido, Karen M Henkels, Kristen M Rehl, Hong Liang, Yong Zhou, Jordan U Gutterman, Kwang-Jin Cho,

K-Ras must interact primarily with the plasma membrane (PM) for its biological activity. Therefore, disrupting K-Ras PM interaction is a tractable approach to block oncogenic K-Ras activity. Here, we found that avicin G, a family of natural plant-derived triterpenoid saponins from Acacia victoriae, mislocalizes K-Ras from the PM and disrupts ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9120]

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Spontaneous MEG activity of the cerebral cortex during eyes closed and open discriminates Alzheimer's disease from cognitively normal older adults.

Yoshihisa Ikeda, Mitsuru Kikuchi, Moeko Noguchi-Shinohara, Kazuo Iwasa, Masafumi Kameya, Tetsu Hirosawa, Mitsuhiro Yoshita, Kenjiro Ono, Miharu Samuraki-Yokohama, Masahito Yamada,

This study aimed to examine whether magnetoencephalography (MEG) is useful to detect early stage Alzheimer's disease (AD). We analyzed MEG data from the early stage AD group (n = 20; 6 with mild cognitive impairment due to AD and 14 with AD dementia) and cognitively normal control group (NC, n = 27). MEG was ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9132]

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Publisher Correction: Surface Modification and Charge Injection in a Nanocomposite Of Metal Nanoparticles and Semiconductor Oxide Nanostructures.

Bo Xiao, Gugu N Rutherford, Amrit P Sharma, Sangram K Pradhan, Carl E Bonner, Messaoud J Bahoura,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9346]

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Author Correction: Non-professional phagocytosis: a general feature of normal tissue cells.

Jacob C Seeberg, Monika Loibl, Fabian Moser, Manuela Schwegler, Maike Büttner-Herold, Christoph Daniel, Felix B Engel, Arndt Hartmann, Ursula Schlötzer-Schrehardt, Margarete Goppelt-Struebe, Vera Schellerer, Elisabeth Naschberger, Ingo Ganzleben, Lucie Heinzerling, Rainer Fietkau, Luitpold V Distel,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9345]

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Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors.

Vanessa Vezzi, Caterina Ambrosio, Maria Cristina Grò, Paola Molinari, Gökçe Süral, Tommaso Costa, H Ongun Onaran, Susanna Cotecchia,

Vasopressin receptor 2 (V2R) mutations causing the nephrogenic syndrome of inappropriate antidiuresis (NSIAD) can generate two constitutively active receptor phenotypes. One type results from residue substitutions in several V2R domains and is sensitive to vaptan inverse agonists. The other is only caused by Arg 137 replacements and is vaptan resistant. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9111]

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Short microsecond pulses achieve homogeneous electroporation of elongated biological cells irrespective of their orientation in electric field.

Janja Dermol-Černe, Tina Batista Napotnik, Matej Reberšek, Damijan Miklavčič,

In gene electrotransfer and cardiac ablation with irreversible electroporation, treated muscle cells are typically of elongated shape and their orientation may vary. Orientation of cells in electric field has been reported to affect electroporation, and hence electrodes placement and pulse parameters choice in treatments for achieving homogeneous effect in tissue ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9149]

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Integrative description of a new Dactylobiotus (Eutardigrada: Parachela) from Antarctica that reveals an intraspecific variation in tardigrade egg morphology.

Ji-Hoon Kihm, Sanghee Kim, Sandra J McInnes, Krzysztof Zawierucha, Hyun Soo Rho, Pilmo Kang, Tae-Yoon S Park,

Tardigrades constitute one of the most important group in the challenging Antarctic terrestrial ecosystem. Living in various habitats, tardigrades play major roles as consumers and decomposers in the trophic networks of Antarctic terrestrial and freshwater environments; yet we still know little about their biodiversity. The Eutardigrada is a species rich ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9122]

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Novel approach using serum progesterone as a triage to guide management of patients with threatened miscarriage: a prospective cohort study.

Thiam Chye Tan, Chee Wai Ku, Lee Koon Kwek, Kai Wei Lee, Xiaoxuan Zhang, John C Allen, Valencia Ru-Yan Zhang, Nguan Soon Tan,

Threatened miscarriage is a common gynaecological emergency, with up to 25% of women eventually progressing to spontaneous miscarriage. The uncertainty of pregnancy outcomes results in significant anxiety. However, there is currently no acceptable framework for triaging patients presenting with threatened miscarriage. We aim to evaluate the efficacy and safety of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9153]

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Profile distribution of soil moisture response to precipitation on the Pisha sandstone hillslopes of China.

Pan Zhang, Peiqing Xiao, Wenyi Yao, Guobin Liu, Weiying Sun,

The Pisha sandstone area in China is located on the upper and middle reaches of the Yellow River, which is a region with some of the most severe soil erosion in both the Loess Plateau and in the world. Soil moisture is an important link between rainfall, surface water, and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9136]

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Inequalities by education and marital status in the co-occurrence of cardiovascular risk factors in Finland persisted between 1997-2017.

Laura Paalanen, Tommi Härkänen, Jukka Kontto, Hanna Tolonen,

Understanding on sociodemographic variation of the co-occurrence of cardiovascular disease risk factors is crucial for planning future prevention strategies. We aimed at examining (1) the co-occurrence of smoking, obesity, hypertension and elevated serum cholesterol by education and marital status, and (2) its trends in different sociodemographic groups in Finland. We ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9123]

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Incidence of Cervical, Ovarian and Uterine Cancer in Eritrea: Data from the National Health Laboratory, 2011-2017.

Lidia Biniam Medhin, Lia Alem Tekle, Oliver Okoth Achila, Salih Said,

The main objective of this study was to investigate the incidence of cervical (C53), ovarian (C56) and uterine (C54-55) cancers in pathology department of the National Health Laboratory of Eritrea between 2011 and 2017. All tumour positive cases from cervix, ovary and uterus diagnosed between 2011 and 2017 were analyzed, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9099]

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Plastome Structural Conservation and Evolution in the Clusioid Clade of Malpighiales.

Dong-Min Jin, Jian-Jun Jin, Ting-Shuang Yi,

The clusioid clade of Malpighiales is comprised of five families: Bonnetiaceae, Calophyllaceae, Clusiaceae, Hypericaceae and Podostemaceae. Recent studies have found the plastome structure of Garcinia mangostana L. from Clusiaceae was conserved, while plastomes of five riverweed species from Podostemaceae showed significant structural variations. The diversification pattern of plastome structure of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9091]

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Sentinel optical and SAR data highlights multi-segment faulting during the 2018 Palu-Sulawesi earthquake (Mw 7.5).

Guillaume Bacques, Marcello de Michele, Michael Foumelis, Daniel Raucoules, Anne Lemoine, Pierre Briole,

The main active tectonic structure in the western part of Central Sulawesi (Indonesia) is the left-lateral Palu-Koro strike-slip fault. Its offshore section was thought not to have broken during the Mw 7.5 Palu Earthquake on 28 September 2018, challenging the established knowledge of the tectonic setting at this location. Here, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9103]

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Sagittal en bloc resection of primary tumors in the thoracic and lumbar spine: feasibility, safety and outcome.

Lei Dang, Zhongjun Liu, Xiaoguang Liu, Liang Jiang, Miao Yu, Fengliang Wu, Feng Wei,

This study is to test feasibility, safety and the outcome of sagittal en bloc resection of paravertebral primary tumors in the thoracic and the lumbar spine. Sagittal en bloc resection was planned based on WBB classification and performed via combined anterior-posterior or anterior-posterior-lateral approach in 9 consecutive patients with aggressive ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9108]

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