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Journal Reprod. Toxicol.

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Corrigendum to "Inhibitory effects of cigarette smoke extracts on neural differentiation of mouse embryonic stem cells" [Reprod. Toxicol. 95 (2020) 75-85].

Cho-Won Kim, Sung-Moo Lee, Eul-Bee Ko, Ryeo-Eun Go, Eui-Bae Jeung, Min-Seok Kim, Kyung-Chul Choi,

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.

Jerrold J Heindel, Scott Belcher, Jodi A Flaws, Gail S Prins, Shuk-Mei Ho, Jiude Mao, Heather B Patisaul, William Ricke, Cheryl S Rosenfeld, Ana M Soto, Frederick S Vom Saal, R Thomas Zoeller,

"Consortium Linking Academic and Regulatory Insights on BPA Toxicity" (CLARITY-BPA) was a comprehensive "industry-standard" Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. The investigator-initiated studies were focused on integrating disease-associated, molecular, and physiological endpoints previously found by ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2018 and 2019.

Paul Barrow, Nicole Clemann,

Details of embryo-fetal development (EFD) studies were compiled for all FDA drug approvals in 2018-19. EFD studies were performed for 82 % of approvals (84 % of small molecules and 70 % of biopharmaceuticals). Rats and rabbits were used for 84 % of small molecule (SM) drugs for which EFD ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8 activation.

Yanxi Wang, Fangfang Zhu, Yingxuan Zhang, Chunlin Chen, Yuling Lai, Jianhua Sun, Si Chen, Pin Qiu, Jie Gao, Gaopi Deng,

Unruptured ectopic pregnancy (UEP) is a common cause of morbidity and, occasionally, of mortality in women of reproductive age. Pharmacological intervention is a common therapeutic approach for early-stage UEP. Herein, we investigated the cytotoxic effect and novel mechanism of shikonin, a natural naphthoquinone pigment purified from Lithospermum erythrorhizon, in human ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:104-112]

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Inhibitory effects of cigarette smoke extracts on neural differentiation of mouse embryonic stem cells.

Cho-Won Kim, Sung-Moo Lee, Eul-Bee Ko, Ryeo-Eun Go, Eui-Bae Jeung, Min-Seok Kim, Kyung-Chul Choi,

Maternal smoking during the perinatal period is linked to adverse neonatal outcomes such as low birth weight and birth defects. Numerous studies have shown that cigarette smoke or nicotine exposure has a widespread effect on fetal nerve development. However, there exists a lack of understanding of what specific changes occur ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:75-85]

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Obesity-induced testicular oxidative stress, inflammation and apoptosis: Protective and therapeutic effects of orlistat.

Joseph Bagi Suleiman, Victor Udo Nna, Zaida Zakaria, Zaidatul Akmal Othman, Ainul Bahiyah Abu Bakar, Mahaneem Mohamed,

Obesity has been reported to induce oxidative stress, inflammation and apoptosis in the testis. The objective of this study was to determine the effects of the anti-obesity drug orlistat, on testicular oxidative stress, inflammation and apoptosis in high-fat diet (HFD)-fed rats. Twenty-four adult male Sprague Dawley rats weighing 250-300 g were ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:113-122]

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The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study.

Zhaoyan Nie, Lei Zhang, Wei Chen, Yanan Zhang, Rui Hua, Wei Wang, Tiantian Zhang, Haifeng Wu,

Cyclophosphamide (Cy), a chemotherapeutic agent, is widely used to treat tumoursand is also associated with premature ovarian insufficiency. 4-Hydroperoxycyclophosphamide (4-HC), an active metabolite of Cy, was used for in vitro experiments. Granulosa cells (GCs) are crucial for maintaining follicle development and are also used in reproductive toxicity research in vitro. ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:66-74]

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Role of Cbp, p300 and Akt in valproic acid induced neural tube defects in CD-1 mouse embryos.

Sidra Shafique, Louise M Winn,

Valproic acid (VPA), an antiepileptic and mood-stabilizing drug, is prescribed to women of reproductive age. VPA is associated with a 1-2% increase in neural tube defects in offspring following gestational exposure and results in epigenetic modifications induced by perturbations in transcription cofactors. Cbp and p300, two transcription cofactors, play key ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:86-94]

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Dissimilar effects of curcumin on human granulosa cells: Beyond its anti-oxidative role.

Beatriz Moreira-Pinto, Lia Costa, Bruno M Fonseca, Irene Rebelo,

Global infertility prevalence has been increasing in recent decades, mainly due to advanced reproductive age. Concerned women look for dietary supplements with antioxidant properties advertised as a natural way to increase fertility. Curcumin (CUR) is a polyphenol with antioxidant and anti-inflammatory properties. CUR elicits apoptotic cell death as evidenced in ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:51-58]

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In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice.

Karina F Rodriguez, Namya Mellouk, Erica K Ungewitter, Barbara Nicol, Chang Liu, Paula R Brown, Cynthia J Willson, Humphrey H-C Yao,

In utero exposure to arsenite (iAs) is known to increase disease risks later in life. We investigated the effect of in utero exposure to iAs in the drinking water on metabolic and reproductive parameters in male mouse offspring at postnatal and adult stages. Pregnant CD-1 mice were exposed to iAs ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:95-103]

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Machine learning on drug-specific data to predict small molecule teratogenicity.

Anup P Challa, Andrew L Beam, Min Shen, Tyler Peryea, Robert R Lavieri, Ethan S Lippmann, David M Aronoff,

Pregnant women are an especially vulnerable population, given the sensitivity of a developing fetus to chemical exposures. However, prescribing behavior for the gravid patient is guided on limited human data and conflicting cases of adverse outcomes due to the exclusion of pregnant populations from randomized, controlled trials. These factors increase ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:148-158]

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Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats.

Sabrina L Roberti, Romina Higa, Hugo Sato, Dalmiro Gomez Ribot, Evangelina Capobianco, Alicia Jawerbaum,

Maternal diabetes induces fetal programming of cardiovascular diseases. Diabetes induced-cardiac fibrosis is a process that may start in utero and may be related to the prooxidant/proinflammatory environment. The aim of this study was to investigate the effect of a maternal diet enriched in olive oil on the levels of components ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:137-147]

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Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model.

J K Akintunde, T E Akintola, F H Aliu, M O Fajoye, S O Adimchi,

This study investigated the effect of naringin (NRG) on extracellular metabolism of ATP through the NOS/cGMP/PKG signaling pathway induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) on exposure to Bisphenol-A (BPA) in penis. Fifty-six adult male albino rats were randomly distributed into eight (n = 7) groups. Group I: control animals, ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:123-136]

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Pregnancy outcomes in patients treated with leflunomide, the parent compound of the multiple sclerosis drug teriflunomide.

Lily J Henson, Salman Afsar, Lynn Davenport, Annie Purvis, Elizabeth M Poole, Philippe Truffinet,

Leflunomide is contraindicated in pregnant women, yet human data from leflunomide-exposed pregnancies do not indicate an embryofetal toxicity signal. The objective of the present analysis was to report pregnancy outcomes for leflunomide-exposed pregnancies in clinical trials and in the post-marketing setting. Pregnancy outcomes are summarized from leflunomide clinical trials and ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:45-50]

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Developmental Exposure to Tetrabromobisphenol A Has Minimal Impact on Male Rat Reproductive Health.

Paula R Brown, Sagi Enicole A Gillera, Suzanne E Fenton, Humphrey Hung-Chang Yao,

The flame retardant and plasticizer, tetrabromobisphenol-A (TBBPA) has rapidly become a common component in the manufacture of circuit boards and plastics worldwide. It is also an analog of bisphenol A (BPA), an endocrine disrupting chemical identified by the Endocrine Society. As such, TBBPA needs to be investigated for similar potential ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:59-65]

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Enhanced normograms and pregnancy outcome analysis in nonhuman primate developmental toxicity studies.

Heiko Grossmann, Gerhard F Weinbauer, Ann Baker, Antje Fuchs, C Marc Luetjens,

The incidence of spontaneous pregnancy/infant losses is highly variable in long-tailed macaques (cynomolgus monkey), making it potentially difficult to ascertain test item-related effects in developmental toxicity studies. Therefore, pregnancy normograms had been developed by Jarvis et al. [1] to aid in the distinction of normal (e.g. test facility background) versus ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:29-36]

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"Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines.

Eliza Drwal, Agnieszka Rak, Wacław Tworzydło, Ewa Łucja Gregoraszczuk,

Using JEG-3 and BeWo cells, we examined the effect of "real life" mixtures of polycyclic aromatic hydrocarbons (PAHs), at doses reported in maternal blood (Mix I) and in placental tissue (Mix II), on human chorionic gonadotropin (hCG), placental lactogen (hPL) and placental growth factor (hPLGF) secretion, protein expression and immunolocalization. ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:1-10]

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Vascular and inflammatory effects of estrogen and anti-androgen therapy in the testis and epididymis of male to female transgender adults.

Cristina Peña Barreno, Pilar Gonzalez-Peramato, Manuel Nistal,

The volume of ubiquitous chemicals with estrogenic properties is on the rise and some reports relate the increase in hormonal diseases to these compounds. A morphological and immunohistochemical analysis has been performed on 42 bilateral orchiectomy specimens from adult individuals who underwent gender reassignment surgery after receiving crossed-sex hormone therapy ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:37-44]

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Prenatal exposure to phthalates and male reproductive system development: Results from a Canadian pregnancy cohort study.

Rodrigo L P Romao, Linda Dodds, Jillian Ashley-Martin, Patricia Monnier, Tye E Arbuckle,

Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:11-18]

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Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression.

Samantha Adams, Kimberly Wiersielis, Ali Yasrebi, Kristie Conde, Laura Armstrong, Grace L Guo, Troy A Roepke,

After the phase-out of polybrominated diphenyl ethers, their replacement compounds, organophosphate flame retardants (OPFRs) became ubiquitous in home and work environments. OPFRs, which may act as endocrine disruptors, are detectable in human urine, breast milk, and blood samples collected from pregnant women. However, the effects of perinatal OPFR exposure on ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 94:65-74]

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Computational approach for collection and prediction of molecular initiating events in developmental toxicity.

Xabier Cendoya, Celia Quevedo, Maitane Ipiñazar, Francisco J Planes,

Developmental toxicity is defined as the occurrence of adverse effects on the developing organism as a result from exposure to a toxic agent. These alterations can have long-term acute effects. Current in vitro models present important limitations and the evaluation of toxicity is not entirely objective. In silico methods have ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 94:55-64]

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Associations of exposure to phthalates and environmental phenols with gynecological disorders.

Jangwoo Lee, Yunsun Jeong, Sori Mok, Kyungho Choi, Jeongim Park, Hyo-Bang Moon, Gyuyeon Choi, Hai-Joong Kim, Su Young Kim, Soo Ran Choi, Sungkyoon Kim,

Phthalates and environmental phenols might be associated with some benign diseases that have been found to be hormone-sensitive. Current knowledge on adverse effects of these chemicals among reproductive women is limited and often controversial. Therefore, the purpose of this study was to investigate the association between the urinary concentration of ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:19-28]

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Prenatal ethanol exposure induced disorder of hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programming alteration and dysfunction of glucose and lipid metabolism in 40-week-old female offspring rats.

Liping Xia, Zhexiao Jiao, Linguo Pei, Chao Yuan, Yanjuan Zhao, Yu Guo, Hui Wang,

This study was designed to demonstrate disorder of hypothalamic-pituitary-adrenal (HPA) axis-associated neuroendocrine metabolic programming alteration and dysfunction of glucose and lipid metabolism induced by prenatal ethanol exposure (PEE) in postnatal week 40 (PW40) female offspring rats. Pregnant Wistar rats were administrated 4  g/kg·d ethanol intragastrically from gestational day 11 until ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 94:48-54]

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The aryl hydrocarbon receptor mediates sex ratio distortion in the embryos sired by TCDD-exposed male mice.

Kristin M Bircsak, Latresa T Copes, Sara King, Andrew M Prantner, Wei-Ting Hwang, George L Gerton,

Many reports describe an association between preconceptional paternal exposure to environmental chemicals, including the persistent organic pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with an increased number of female offspring. We chronically treated wild-type C57BL/6 male mice with TCDD to investigate a role for the aryl hydrocarbon receptor (AHR) transcription factor. These mice had ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 94:75-83]

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Gestational vitamin D deficiency impairs fetal lung development through suppressing type II pneumocyte differentiation.

Peng Wang, Zhu-Xia Tan, Lin Fu, Yi-Jun Fan, Biao Luo, Zhi-Hui Zhang, Shen Xu, Yuan-Hua Chen, Hui Zhao, De-Xiang Xu,

Gestational vitamin D deficiency is associated with pulmonary diseases. This study aimed to investigate the effect of gestational vitamin D deficiency on fetal lung development in mice. Absolute and relative weights of fetal lungs were reduced in vitamin D deficient (VDD) group. Incrassate mesenchyme, measured by septal wall thickness, accompanied ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, 94:40-47]

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