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Journal Reprod Toxicol

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A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes.

Thoin F Begum, Victor Y Fujimoto, Roy Gerona, Alexandra McGough, Nikolaus Lenhart, Rebecca Wong, Evelyn Mok-Lin, Jonathan Melamed, Celeste D Butts, Michael S Bloom,

Phthalates are reproductive toxicants in experimental animal studies and exposure has been associated with infertility in human populations, although the results have been inconsistent. To help to address the data gap, we conducted a hypothesis-generating investigation of associations between urinary phthalate metabolites and reproductive outcomes among women (n = 56) and their ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models.

Sarah M Hutchison, Louise C Mâsse, Jodi L Pawluski, Tim F Oberlander,

The developmental impact of selective serotonin reuptake inhibitor (SSRI) and other antidepressant treatments during gestation and postpartum on anxiety and depression behaviors in offspring is unclear. This review focuses on how perinatal exposure to SSRI and other antidepressant may have long term consequences for these affective behaviors during early childhood ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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SARS-COV-2 (Covid-19) and Male Fertility: where are we?

Temidayo S Omolaoye, Adeloye A Adeniji, Walter D Cardona Maya, Stefan S du Plessis,

Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), a single-stranded RNA virus, was found to be the causal agent of the disease called coronavirus disease. During December 2019, China informed the World Health Organization (WHO) of an outbreak of cases of pneumonia of unknown etiology, which caused severe-acute respiratory distress. The ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Prenatal developmental toxicity studies on fumes from bitumen in the rat.

Peter J Boogaard, Jochen Buschmann, Rainer Fuhst, Katharina Blümlein, Katharina Schwarz, Dirk Schaudien, Wolfgang Koch, Christine McAlinden, Lize Deferme, Mathieu Vaissiere, Hans B Ketelslegers, Anna Steneholm,

The prenatal developmental toxicity of bitumen fume was tested by nose-only inhalation in the rat. The fumes for exposure were collected from the headspace of a storage tank filled with a bitumen corresponding in composition to an anticipated worst-case occupational exposure. The composition of these fumes was compared to actual ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 99:15-26]

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SARS-COV-2 (Covid-19) and Male Fertility: where are we?

Temidayo S Omolaoye, Adeloye A Adeniji, Walter D. Cardona Maya, Stefan S du Plessis,

Highlights • There is altered semen parameters.• Patients experienced testicular injury and inflammatory infiltration.• Viral orchitis may occur, as patients experienced scrotal discomfort.• The number of spermatozoa with DNA fragmentation is increased.• Infection with SARS-COV-2 may lead to potential fertility issues. Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), a single-stranded ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Recognized trophoblast-like cells conversion from human embryonic stem cells by BMP4 based on convolutional neural network.

Yajun Liu, Zhang Yi, Jinquan Cui,

The use of models of stem cell differentiation to trophoblastic cells provides an effective perspective for understanding the early molecular events in the establishment and maintenance of human pregnancy. In combination with the newly developed deep learning technology, the automated identification of this process can greatly accelerate the contribution to ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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No Obviously Adverse Pregnancy Complications and Outcomes of the Recovered Pregnant Women from COVID-19.

Cuifang Fan, Yuping Guo, Peng Qu, Suqing Wang, Ming Wang, Jingping Yuan, Chunyan Li, Likun Gao, Yiming Pang, Zhiwen Li, Bin Wang,

The effects of SARS-COV-2 infection on the pregnant women and their fetus growth have attracted worldwide concern. Our case study aimed to investigate the neonatal clinical outcomes of the recovered pregnant women from COVID-19 in China, expecting to provide the clinical references of urgent need for other countries. Our study ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs.

Joel Hernández-Rodríguez, Ana Laura López, Sergio Montes, Herlinda Bonilla-Jaime, Ivis Morales, Ofelia Limón-Morales, Camilo Ríos, Marisela Hernández-González, Rosa María Vigueras-Villaseñor, Marcela Arteaga-Silva,

Puberty is a transitional period from juvenile stage to adulthood, followed by the functional maturation of gonads and reproductive organs. This period is sensitive to environmental pollutants like cadmium (Cd), a heavy metal that represents a serious health risk. Cd is an endocrine disruptor that interferes with reproduction by causing ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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No Obviously Adverse Pregnancy Complications and Outcomes of the Recovered Pregnant Women from COVID-19

Cuifang Fan, Yuping Guo, Peng Qu, Suqing Wang, Ming Wang, Jingping Yuan, Chunyan Li, Likun Gao, Yiming Pang, Zhiwen Li, Bin Wang,

The effects of SARS-COV-2 infection on the pregnant women and their fetus growth have attracted worldwide concern. Our case study aimed to investigate the neonatal clinical outcomes of the recovered pregnant women from COVID-19 in China, expecting to provide the clinical references of urgent need for other countries. Our study ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency.

Alessandra Ferramosca, Stefano Lorenzetti, Mariangela Di Giacomo, Francesco Murrieri, Lamberto Coppola, Vincenzo Zara,

The widespread cultivation of genetically modified organisms (GMOs) led to a widespread use of selective herbicides to which GMOs are resistant, thus increasing the concern about human exposure to them. Glyphosate (GLY) and glufosinate ammonium (GA), the active principles of the main formulations, have been investigated for their effects on ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Different Effects of an N-Phenylimide Herbicide on Heme Biosynthesis between Human and Rat Erythroid Cells.

Satoshi Kawamura, Mitsuhiro Otani, Taiki Miyamoto, Jun Abe, Ryo Ihara, Kunifumi Inawaka, Alan G Fantel,

Rat developmental toxicity including embryolethality and teratogenicity (mainly ventricular septal defects and wavy ribs) were produced by S-53482, an N-phenylimide herbicide that inhibits protoporphyrinogen oxidase (PPO) common to chlorophyll and heme biosynthesis. The sequence of key biological events in the mode of action has been elucidated as follows: inhibition of ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Pregnancy outcome following in-utero exposure to ondansetron: A prospective comparative observational study.

Razan Sakran, Svetlana Shechtman, Judy Arnon, Orna Diav-Citrin,

The objective of the study was to evaluate the rate of major congenital anomalies after first trimester exposure to ondansetron for nausea and vomiting of pregnancy (NVP). The design is a prospective, comparative, observational cohort study, performed at the Israeli Teratology Information Service between 2010 and 2014. Follow-up was obtained ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 99:9-14]

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Retinoid Signaling in Skeletal Development: Scoping the System for Predictive Toxicology.

Thomas B Knudsen, Jocylin D Pierro, Nancy C Baker,

All-trans retinoic acid (ATRA), the biologically active form of vitamin A, is instrumental in regulating the patterning and specification of the vertebrate embryo. Various animal models demonstrate adverse developmental phenotypes following experimental retinoid depletion or excess during pregnancy. Windows of vulnerability for altered skeletal patterning coincide with early specification of ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway.

Haining Qi, Cuiyun Yao, Jianhong Xing, Ying Qin,

Pre-eclampsia (PE), a common pregnancy-systemic syndrome, is characterized by proteinuria and hypertension and is the leading cause of maternal and fetal mortality. Thus, we aim to investigate the role of G-Protein Coupled Receptor 4 (GPR4) in PE and the underlying molecular mechanism. In this study, GSE66273 microarray data were obtained ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 99:1-8]

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Editorial.

Alan M Hoberman,

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Corrigendum to "Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs" [Reprod. Toxicol. 93 (2020) 219⬜229].

Ségolène Siméon, Katharina Brotzmann, Ciarán Fisher, Iain Gardner, Steve Silvester, Richard Maclennan, Paul Walker, Thomas Braunbeck, Frederic Y Bois,

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Valproic acid alters nitric oxide status in neurulating mouse embryos.

Gian Mario Tiboni, Adalisa Ponzano, Alessio Ferrone, Sara Franceschelli, Lorenza Speranza, Antonia Patruno,

The molecular bases of the teratogenic effects elicited by valproic acid (VPA) are not fully defined. It was previously shown that inhibition of nitric oxide (NO) synthesis is associated with an enhancement of the teratogenic effects of VPA, while amplification of NO signal by sildenafil prompted a dose-dependent reduction of ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing.

Manuela Jaklin, Jitao David Zhang, Paul Barrow, Martin Ebeling, Nicole Clemann, Marcel Leist, Stefan Kustermann,

Human induced pluripotent stem cells (hiPSC) were used to develop an assay format that may deliver information on teratogenicity of drugs. A human pluripotent stem cell scorecard panel was used to monitor the expression of 96 marker genes that are indicative of the stem cell state or differentiation into the ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast.

Angela Pham, Jun Zhang, Liping Feng,

Poly- and per-fluoroalkyl substances (PFAS) have attracted widespread attention in recent years due to their bioaccumulation, toxicity, and ubiquitous nature. We and others have reported that maternal exposure to PFAS is associated with adverse birth outcomes due to altered placental functions. In this study, we investigated the effects of two ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Cell-free mitochondrial DNA increases granulosa cell apoptosis and reduces aged oocyte blastocyst development in the mouse.

Yu Liu, Qiuzi Shen, Huiying Li, Wenpei Xiang, Ling Zhang,

Cell-free mitochondrial DNA (cf-mtDNA) released into the extracellular environment can cause cellular inflammatory responses and damage. Here, we investigated the effects of cf-mtDNA on mouse ovarian granulosa cell function and on the developmental competence of oocytes matured in vitro. Granulosa cells in the cf-mtDNA treatment group had a lower ATP ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.

Emily Brehm, Changqing Zhou, Liying Gao, Jodi A Flaws,

Phthalates are known endocrine-disrupting chemicals that are found in many consumer products. Our laboratory previously developed a relevant phthalate mixture consisting of six phthalates and found that it disrupted female fertility in mice. However, it is unknown if prenatal exposure to phthalate mixtures can accelerate reproductive aging and if this ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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MDR-1 function protects oocyte mitochondria against the transgenerational effects of nitrogen mustard exposure.

Haley Clark, Barbara Pereira Vera, Zijing Zhang, Lynae M Brayboy,

Oocytes are vulnerable to alkylating agents like nitrogen mustard (NM), which can cause mitochondrial dysfunction associated with increased oxidative stress. Because mitochondria are maternally inherited, NM exposure affects oocyte mitochondrial physiology and compromises future progeny. Multidrug resistance transporters (MDRs) are transmembrane proteins that efflux such cytotoxic substances; MDR-1 is expressed ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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The optimal compound reference genes for qRT-PCR analysis in the developing rat long bones under physiological conditions and prenatal dexamethasone exposure model.

Hui Han, Liang Liu, Ming Chen, Yi Liu, Hui Wang, Liaobin Chen,

Quantitative real-time polymerase chain reaction (qRT-PCR) is a powerful tool for evaluating gene expression, but its accuracy is affected by the stability of the reference genes used for normalization. The Minimum Information for Publication of Quantitative Real-time PCR Experiments (MIQE) guidelines indicated that it was important to use multiple stable ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice.

Shuxian Wang, Qiwei Chen, Yu Zhang, Feng Zheng, Tongmin Xue, Xie Ge, Rujun Ma, Xiaoyan Li, Ronghua Wu, Kuan Liang, Zhang Qian, Yifeng Ge, Jinzhao Ma, Bing Yao,

Hydrogen sulfide (H2S), a gaseous intracellular signal transducer, participates in multiple physiological and pathological conditions, including reproductive conditions, and disrupts spermatogenesis. The blood-testis barrier (BTB) plays a vital role in spermatogenesis. However, the effect of H2S on the BTB and the underlying mechanism remain unclear. Herein, we examined the effect ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Knockout mouse models are predictive of malformations or embryo-fetal death in drug safety evaluations.

Natasha R Catlin, Christine Stethem, Christopher J Bowman, Sarah N Campion, William S Nowland, Gregg D Cappon,

Traditionally, understanding potential developmental toxicity from pharmaceutical exposures has been based on the results of ICH guideline studies in two species. However, support is growing for the use of weight of evidence approaches when communicating the risk of developmental toxicity, where the intended pharmacologic mode of action affects fundamental pathways ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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