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Journal Regen Med

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A scoping review of patient and public perspectives on cell and gene therapies.

Karen Macpherson, Olalekan Lee Aiyegbusi, Lauren Elston, Susan Myles, Jennifer Washington, Nisha Sungum, Mark Briggs, Philip Newsome, Melanie Calvert,

<b>Aim:</b> The development and introduction of cell and gene therapies presents complex social and economic issues. Fully addressing these challenges requires engagement with patients and the public. <b>Materials & methods:</b> A systematically conducted scoping review was undertaken to gauge current patient and public knowledge and perspectives, and as such inform ... Read more >>

Regen Med (Regenerative medicine)
[2021, :]

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The presence of sensational language describing stem cell therapies in news articles: a cross-sectional analysis.

Vivian Pham, Madison Slawson, Savannah Nicks, Ryan Ottwell, Benjamin Greiner, Matt Vassar,

<b>Aim:</b> News articles and their use of sensational language have the potential to influence health behaviors and decisions, thus the purpose of this study was to evaluate the use of sensational language (i.e., superlatives) describing stem cell therapies in public news articles. <b>Materials & methods:</b> In this study, we conducted ... Read more >>

Regen Med (Regenerative medicine)
[2021, :]

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Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes.

Nafiisha Genet, Karen K Hirschi,

The use of neural stem cell (NSC) therapy for the treatment of stroke patients is successfully paving its way into advanced phases of large-scale clinical trials. To understand how to optimize NSC therapeutic approaches, it is fundamental to decipher the crosstalk between NSC and other cells that comprise the NSC ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(9):861-870]

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Neuroprotective effect of bone marrow derived mesenchymal stem cell secretome in 6-OHDA-induced Parkinson's disease.

Dhruv Mahendru, Ashish Jain, Seema Bansal, Deepti Malik, Neha Dhir, Amit Raj Sharma, Phulen Sarma, Ajay Prakash, Uma Nahar, Alka Bhatia, Shalmoli Bhattacharyya, Bikash Medhi,

<b>Aim:</b> The aim of the study was to evaluate the neuroprotective effect of bone marrow stem cell secretome in the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. <b>Materials & methods:</b> Secretome prepared from mesenchymal stem cells of 3-month-old rats was injected daily for 7 days between days 7 and 14 after 6-OHDA administration. After ... Read more >>

Regen Med (Regenerative medicine)
[2021, :]

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A new model of chronic peripheral nerve compression for basic research and pharmaceutical drug testing.

Lucas Degrugillier, Katharina M Prautsch, Dirk J Schaefer, Raphael Guzman, Stefan Schären, Daniel F Kalbermatten, Srinivas Madduri,

<b>Aim:</b> To develop a consistent model to standardize research in the field of chronic peripheral nerve neuropathy. <b>Methods:</b> The left sciatic nerve of 8-week-old Sprague-Dawley rats was compressed using a customized instrument leaving a defined post injury nerve lumen (400 μm, 250 μm, 100 μm, 0 μm) for 6 weeks. Sensory and motor outcomes were measured ... Read more >>

Regen Med (Regenerative medicine)
[2021, :]

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Extracellular matrix extraction techniques and applications in biomedical engineering.

Kirthanashri S Vasanthan, Varadharajan Srinivasan, Deepti Pandita,

The concept of tissue engineering involves regeneration and repair of damaged tissue and organs using various combinations of cells, growth factors and scaffolds. The extracellular matrix (ECM) forms the integral part of the scaffold to induce cell proliferation thereby leading to new tissue formation. Decellularization technique provides decellularized ECM (dECM), free ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(8):775-802]

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Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: a pilot study.

Prathap Jayaram, Gu Eon Kang, Brett L Heldt, Olumide Sokunbi, Bo Song, Peter C Yeh, Max Epstein, Theodore B Shybut, Brendan H Lee, Bijan Najafi,

<b>Background:</b> Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. <b>Aim:</b> To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). <b>Materials & methods:</b> ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(9):823-832]

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Industry updates from the field of stem cell research and regenerative medicine in June 2021.

Dusko Ilic, Mirjana Liovic,

The latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in June 2021. ... Read more >>

Regen Med (Regenerative medicine)
[2021, :]

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CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells.

Qiannan Niu, Shuning Shen, Jiaojiao He, Lei Wang,

<b>Background:</b> Osteogenesis greatly depends on the differentiation of bone marrow mesenchymal stem cells (BMSCs). CKIP-1 is considered to be a negative regulator of BMSCs. <b>Methods:</b> We established a <i>CKIP-1</i> knockout mouse model, then isolated and cultured BMSCs from wild-type and knockout groups. <b>Results:</b> Our data demonstrated that <i>CKIP-1</i> knockout significantly increased bone ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(9):847-859]

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Partnership agreements for regenerative medicines: a database analysis and implications for future innovation.

Tingting Qiu, Yitong Wang, Shuyao Liang, Ru Han, Mondher Toumi,

<b>Aim:</b> Partnerships have been leveraged to advance the regenerative medicines (RMs) development. This study analyzed the evolution of partnership landscape for regenerative medicines (RMs). <b>Methods:</b> Partnership agreements publicly announced from January 2014 - June 2020 were described. <b>Results:</b> 1169 partnership agreements with total amount of US$63,496 million were identified. Most agreements concerned RMs ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(8):733-755]

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Decellularized human-sized pulmonary scaffolds for lung tissue engineering: a comprehensive review.

Seyed Hossein Mahfouzi, Seyed Hamid Safiabadi Tali, Ghassem Amoabediny,

The ultimate goal of lung bioengineering is to produce transplantable lungs for human beings. Therefore, large-scale studies are of high importance. In this paper, we review the investigations on decellularization and recellularization of human-sized lung scaffolds. First, studies that introduce new ways to enhance the decellularization of large-scale lungs are ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(8):757-774]

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Identification of regeneration-involved growth factors in cartilage engineering procedure promotes its reconstruction.

Mahmoud Azami, Nima Beheshtizadeh,

<b>Aim:</b> To fabricate mature cartilage for implantation, developmental biological processes and proteins should be understood and employed. <b>Methods:</b> A systems biology study of all protein-coding genes participating in cartilage regeneration resulted in a network graph with 11 nodes and 28 edges. Gene ontology and centrality analysis were performed based on ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(8):719-731]

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Comparability: what we can learn from the review of advanced therapy medicinal products.

Alexis Cockroft, Alison Wilson,

Publicly available summaries from Marketing Authorization Applications for gene and cell therapy products (advanced therapies) were evaluated to explore data expectations for product characteristics pre and post changes (comparability). Public assessment reports were used to analyze trends in information requests from regulators concerning comparability from current commercial advanced therapies. In ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(7):655-667]

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Challenges in corneal endothelial cell culture.

Rintra Wongvisavavit, Mohit Parekh, Sajjad Ahmad, Julie T Daniels,

Corneal endothelial cells (CECs) facilitate the function of maintaining the transparency of the cornea. Damage or dysfunction of CECs can lead to blindness, and the primary treatment is corneal transplantation. However, the shortage of cornea donors is a significant problem worldwide. Thus, cultured CEC therapy has been proposed and found ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(9):871-891]

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Mesenchymal stem cell-derived exosomes: therapeutic implications for rotator cuff injury.

Jinbing He, Shuai Ping, Fangyang Yu, Xi Yuan, Jiang Wang, Jun Qi,

Rotator cuff injuries are a common clinical condition of the shoulder joint. Surgery that involves reattaching the torn tendon to its humeral head bony attachment has a somewhat lower success rate. The scar tissue formed during healing of the rotator cuff leads to poor tendon-related mechanical properties. To promote healing, ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(8):803-815]

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Adipose tissue versus stem cell-derived small extracellular vesicles to enhance the healing of acute burns.

Jalil Rohani Ivari, Elahe Mahdipour,

<b>Aim:</b> Proper healing of extensive burns remains a healthcare challenge. In the present study, we proposed a distinct therapeutic application of adipose tissue and small extracellular vesicles isolated from human menstrual blood-derived mesenchymal stem cells (MenSC) small extracellular vesicles (sEVs) to enhance the repair of third-degree burn injury. <b>Materials & methods:</b> ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(7):629-641]

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Urine-based regenerative RNA biomarkers for urinary bladder wound healing.

Chanzhen Liu, Juan Zhou, You Li, Yulei Lu, Haoyuan Lu, Wei Wei, Mingsong Wu, Xianlin Yi,

<b>Background:</b> This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair. <b>Materials & methods:</b> Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors and cholinergic signals were detected. <b>Results:</b> HIF-1α, ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(8):709-718]

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Mechanisms underlying the therapeutic potential of mesenchymal stem cells in atherosclerosis.

Thomas Kirwin, Ana Gomes, Ravi Amin, Annam Sufi, Sahil Goswami, Brian Wang,

Atherosclerosis is a chronic inflammatory condition resulting in the formation of fibrofatty plaques within the intimal layer of arterial walls. The identification of resident stem cells in the vascular wall has led to significant investigation into their contributions to health and disease, as well as their therapeutic potential. Of these, ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(7):669-682]

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Industry updates from the field of stem cell research and regenerative medicine in May 2021.

Dusko Ilic, Mirjana Liovic,

The latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in May 2021. ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(9):814-821]

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Technology digest: the importance of reagent consistency in culturing organoids.

Freya Leask,

Regen Med (Regenerative medicine)
[2021, 16(7):615-617]

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Vascularization strategies for tissue engineering for tracheal reconstruction.

Fei Sun, Yi Lu, Zhihao Wang, Hongcan Shi,

Tissue engineering technology provides effective alternative treatments for tracheal reconstruction. The formation of a functional microvascular network is essential to support cell metabolism and ensure the long-term survival of grafts. Although several tracheal replacement therapy strategies have been developed in the past, the critical significance of the formation of microvascular ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(6):549-566]

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Biomimicry in 3D printing design: implications for peripheral nerve regeneration.

Zhiwen Yan, Yun Qian, Cunyi Fan,

Nerve guide conduits (NGCs) connect dissected nerve stumps and effectively repair short-range peripheral nerve defects. However, for long-range defects, autografts show better therapeutic effects, despite intrinsic limitations. Recent evidence shows that biomimetic design is essential for high-performance NGCs, and 3D printing is a promising fabricating technique. The current work includes a brief review ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(7):683-701]

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LncRNA X inactive-specific transcript promotes osteoclast differentiation through Tgif2 by acting as a ceRNA of miR-590-3p in a murine model.

Yuefeng Shao, Xinya Hu, Xuejian Wu,

<b>Aim:</b> This study aims to investigate whether <i>long noncoding RNA (lncRNA)  X-inactive specific transcript (Xist)</i> can regulate osteoclast differentiation in osteoporosis and the mechanism. <b>Materials & methods:</b> The mouse model of osteoporosis was established by ovariectomy surgery. Osteoclast differentiation from RAW264.7 cells was induced <i>in vitro</i>. The relationships between associated genes were ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(7):643-653]

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Recombinant human FGF-2 for the treatment of early-stage osteonecrosis of the femoral head: TRION, a single-arm, multicenter, Phase II trial.

Yutaka Kuroda, Takeyuki Tanaka, Takaki Miyagawa, Hidetoshi Hamada, Hiroyasu Abe, Toshiko Ito-Ihara, Ryuta Asada, Yusuke Fujimoto, Daisuke Takahashi, Tomonori Tetsunaga, Ayumi Kaneuji, Michiaki Takagi, Yutaka Inaba, Satoshi Morita, Nobuhiko Sugano, Sakae Tanaka, Shuichi Matsuda, Haruhiko Akiyama, ,

<b>Aim:</b> This study aimed to evaluate the 2-year outcomes from a clinical trial of recombinant human FGF-2 (rhFGF-2) for osteonecrosis of the femoral head (ONFH). <b>Patients & methods:</b> Sixty-four patients with nontraumatic, precollapse and large ONFHs were percutaneously administered with 800 μg rhFGF-2 contained in gelatin hydrogel. Setting the end point ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(6):535-548]

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Industry updates from the field of stem cell research and regenerative medicine in April 2021.

Dusko Ilic, Mirjana Liovic,

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in April 2021. ... Read more >>

Regen Med (Regenerative medicine)
[2021, 16(8):703-707]

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