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Adding carboplatin to chemotherapy regimens for metastatic castrate-resistant prostate cancer in postsecond generation hormone therapy setting: Impact on treatment response and survival outcomes.

Mohamed E Ahmed, Jack R Andrews, Jamal Alamiri, Julianna Higa, Rimki Haloi, Manaf Alom, Giovanni Motterle, Vidhu Joshi, Paras H Shah, R Jeffrey Karnes, Eugene Kwon,

The clinical course in metastatic castrate-resistant prostate cancer (mCRPC) can be complicated when patients have disease progression after prior treatment with second generation hormone therapy (second HT), such as enzalutamide or abiraterone. Currently, limited data exist regarding the optimal choice of chemotherapy for mCRPC after failing second generation hormone therapy. ... Read more >>

Prostate (The Prostate)
[2020, :]

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Increased nuclear factor I/B expression in prostate cancer correlates with AR expression.

Jagpreet S Nanda, Wisam N Awadallah, Sarah E Kohrt, Petra Popovics, Justin M M Cates, Janni Mirosevich, Peter E Clark, Giovanna A Giannico, Magdalena M Grabowska,

BACKGROUND:Most prostate cancers express androgen receptor (AR), and our previous studies have focused on identifying transcription factors that modify AR function. We have shown that nuclear factor I/B (NFIB) regulates AR activity in androgen-dependent prostate cancer cells in vitro. However, the status of NFIB in prostate cancer was unknown. METHODS:We ... Read more >>

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[2020, :]

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Identifying and treating ROBO1-ve /DOCK1+ve prostate cancer: An aggressive cancer subtype prevalent in African American patients.

Marina G Ferrari, Arsheed A Ganaie, Ashraf Shabenah, Adrian P Mansini, Li Wang, Paari Murugan, Elai Davicioni, Jinhua Wang, Yibin Deng, Luke H Hoeppner, Christopher A Warlick, Badrinath R Konety, Mohammad Saleem,

BACKGROUND:There is a need to develop novel therapies which could be beneficial to patients with prostate cancer (CaP) including those who are predisposed to poor outcome, such as African-Americans. This study investigates the role of ROBO1-pathway in predicting outcome and race-based disparity in patients with CaP. METHODS AND RESULTS:Aided by ... Read more >>

Prostate (The Prostate)
[2020, :]

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Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry.

Peggi M Angel, Laura Spruill, Melanie Jefferson, Jennifer R Bethard, Lauren E Ball, Chanita Hughes-Halbert, Richard R Drake,

BACKGROUND:The emergence of reactive stroma is a hallmark of prostate cancer (PCa) progression and a potential source for prognostic and diagnostic markers of PCa. Collagen is a main component of reactive stroma and changes systematically and quantitatively to reflect the course of PCa, yet has remained undefined due to a ... Read more >>

Prostate (The Prostate)
[2020, :]

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Tight junction protein claudin-1 is downregulated by TGF-β1 via MEK signaling in benign prostatic epithelial cells.

Ke Wang, Laura E Pascal, Feng Li, Wei Chen, Rajiv Dhir, Goundappa K Balasubramani, Donald B DeFranco, Naoki Yoshimura, Dalin He, Zhou Wang,

BACKGROUND:Benign prostatic hyperplasia (BPH) is arguably the most common disease in aging men. Although the etiology is not well understood, chronic prostatic inflammation is thought to play an important role in BPH initiation and progression. Our recent studies suggest that the prostatic epithelial barrier is compromised in glandular BPH tissues. ... Read more >>

Prostate (The Prostate)
[2020, :]

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Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.

Harsimar Kaur, Iryna Samarska, Jiayun Lu, Farzana Faisal, Benjamin L Maughan, Sanjana Murali, Kaushal Asrani, Mohamed Alshalalfa, Emmanuel S Antonarakis, Jonathan I Epstein, Corinne E Joshu, Edward M Schaeffer, Juan Miguel Mosquera, Tamara L Lotan,

BACKGROUND:Small cell neuroendocrine (NE) carcinomas of the prostate classically lose androgen receptor (AR) expression, may harbor loss of the RB1, TP53, and PTEN tumor suppressor genes, and are associated with a poor prognosis. However usual-type adenocarcinomas may also contain areas of NE differentiation, and in this context the molecular features ... Read more >>

Prostate (The Prostate)
[2020, 80(12):1012-1023]

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Differential impact of paired patient-derived BPH and normal adjacent stromal cells on benign prostatic epithelial cell growth in 3D culture.

Wei Chen, Laura E Pascal, Ke Wang, Rajiv Dhir, Alexa M Sims, Robert Campbell, Gwenyth Gasper, Donald B DeFranco, Naoki Yoshimura, Zhou Wang,

BACKGROUND:Benign prostatic hyperplasia (BPH) is an age-related disease characterized by nonmalignant abnormal growth of the prostate, which is also frequently associated with lower urinary tract symptoms. The prostate with BPH exhibits enhanced growth not only in the epithelium but also in the stroma, and stromal-epithelial interactions are thought to play ... Read more >>

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[2020, :]

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Prostate cancer-specific mortality burden by risk group among men with localized disease: Implications for research and clinical trial priorities.

Edward Christopher Dee, Michelle D Nezolosky, Fallon E Chipidza, Melaku A Arega, Santino S Butler, Sybil T Sha, Brandon A Mahal, Paul L Nguyen, David D Yang, Vinayak Muralidhar,

OBJECTIVE:To estimate contemporary population-based patterns of the relative burden of prostate cancer-specific mortality (PCSM) attributable to each N0M0 prostate cancer risk-group, that may guide prioritization in research, trial design, and clinical practice. METHODS:We categorized 2004-2015 Surveillance, Epidemiology, and End Results database patients by risk group (low, favorable intermediate, unfavorable intermediate, ... Read more >>

Prostate (The Prostate)
[2020, :]

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miR-196a-mediated downregulation of p27kip1 protein promotes prostate cancer proliferation and relates to biochemical recurrence after radical prostatectomy.

Bin Zhan, Linjin Huang, Yachun Chen, Wen Ye, Jingkun Li, Jianhui Chen, Sheng Yang, Wei Jiang,

BACKGROUND:Dysregulation of microRNAs has performed vital gene regulatory functions in the genesis, progression, and prognosis of multiple malignant tumors. This study aimed to elucidate the regulatory mechanism of miR-196a in prostate cancer (PCa) and explore its clinical significance. METHODS:Quantitative real-time polymerase chain reaction was implemented to examine miR-196a and p27kip1 ... Read more >>

Prostate (The Prostate)
[2020, 80(12):1024-1037]

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Reduced KLK2 expression is a strong and independent predictor of poor prognosis in ERG-negative prostate cancer.

Sarah Bonk, Martina Kluth, Kristina Jansen, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Doris Höflmayer, Sören Weidemann, Katharina Möller, Ria Uhlig, Franziska Büscheck, Andreas M Luebke, Eike Burandt, Till S Clauditz, Stefan Steurer, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Guido Sauter, Ronald Simon, David Dum,

BACKGROUND:Kallikrein-related peptidase 2 (KLK2)-like KLK3 (prostate-specific antigen [PSA])-belongs to the highly conserved serine proteases of the glandular kallikrein protein family (KLK family). Studies suggested that measurement of KLK2 serum levels advanced the predictive accuracy of PSA testing in prostate cancer. METHODS:To clarify the potential utility of KLK2 as a prognostic ... Read more >>

Prostate (The Prostate)
[2020, :]

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CXCL12γ induces human prostate and mammary gland development.

Younghun Jung, Jin Koo Kim, Eunsohl Lee, Frank C Cackowski, Ann M Decker, Paul H Krebsbach, Russell S Taichman,

BACKGROUND:Epithelial stem cells (ESCs) demonstrate a capacity to maintain normal tissues homeostasis and ESCs with a deregulated behavior can contribute to cancer development. The ability to reprogram normal tissue epithelial cells into prostate or mammary stem-like cells holds great promise to help understand cell of origin and lineage plasticity in ... Read more >>

Prostate (The Prostate)
[2020, :]

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PTEN and ERG expression in MRI-ultrasound guided fusion biopsy correlated with radical prostatectomy findings in men with prostate cancer.

Andrew M Erickson, Utku Lokman, Kanerva Lahdensuo, Sara Tornberg, Harri Visapaa, Robin Bergroth, Henrikki Santti, Anssi Petas, Antti S Rannikko, Tuomas Mirtti,

BACKGROUND:Conventional systematic prostate biopsies (SBx) have multiple limitations, and magnetic resonance imaging (MRI)-ultrasound fusion targeting is increasingly applied (fusion biopsies [FBx]). In our previous studies, we have shown that loss of the tumor suppressor gene phosphatase and tensin homolog (PTEN) in radical prostatectomy (RP) specimens predicts poor disease-specific survival, and in ... Read more >>

Prostate (The Prostate)
[2020, :]

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Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer.

Mierxiati Abudurexiti, Wenkai Zhu, Yuchen Wang, Jun Wang, Wenhao Xu, Yongqiang Huang, Yao Zhu, Guohai Shi, Hailiang Zhang, Yiping Zhu, Yijun Shen, Bo Dai, Fangning Wan, Guowen Lin, Dingwei Ye,

BACKGROUND:Prostate cancer is characterized by aberrant lipid metabolism, including elevated fatty acid oxidation. Carnitine palmitoyltransferase 1B (CPT1B) catalyzes the rate-limiting step of fatty acid oxidation. This study aimed to determine if CPT1B has a critical role in prostate cancer progression and to identify its regulatory mechanism. METHODS:CPT1B expression data from ... Read more >>

Prostate (The Prostate)
[2020, 80(12):950-961]

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Patterns of stemness-associated markers in the development of castration-resistant prostate cancer.

Joël R Federer-Gsponer, David C Müller, Tobias Zellweger, Maurice Eggimann, Katharina Marston, Christian Ruiz, Hans-Helge Seifert, Cyrill A Rentsch, Lukas Bubendorf, Clémentine Le Magnen,

BACKGROUND:Putative castration-resistant (CR) stem-like cells (CRSC) have been identified based on their ability to initiate and drive prostate cancer (PCa) recurrence following castration in vivo. Yet the relevance of these CRSC in the course of the human disease and particularly for the transition from hormone-naive (HN) to castration-resistance is unclear. ... Read more >>

Prostate (The Prostate)
[2020, :]

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Modulating tumor reactive stroma by extracorporeal shock waves to control prostate cancer progression.

Letizia Rinella, Benedetta Pizzo, Roberto Frairia, Luisa Delsedime, Giorgio Calleris, Paolo Gontero, Valentina Zunino, Nicoletta Fortunati, Emanuela Arvat, Maria Graziella Catalano,

BACKGROUND:Prostate cancer is the second most common cancer worldwide. Tumor microenvironment is composed of activated fibroblasts, the so called carcinoma-associated fibroblasts (CAFs). They express high levels of α-smooth muscle actin (α-SMA) and type I collagen (COL1), and support proliferation and migration of tumor epithelial cells. Extracorporeal shock waves (ESWs), acoustic ... Read more >>

Prostate (The Prostate)
[2020, :]

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Fungal prostatitis due to endemic mycoses and Cryptococcus: A multicenter case series.

David J Epstein, Lester D R Thompson, Atif Saleem, Chia-Sui Kao, Jonathan I Epstein,

BACKGROUND:Fungal prostatitis is exceedingly rare with mostly case reports. METHODS:Electronic medical records at three medical centers were searched for cases of fungal prostatitis due to endemic mycoses and Cryptococcus over the preceding 10 years. RESULTS:Seven cases were identified from 105 600 prostate biopsies within the Southern California Permanente Medical Group for ... Read more >>

Prostate (The Prostate)
[2020, 80(12):1006-1011]

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The effect of pirfenidone on rat chronic prostatitis/chronic pelvic pain syndrome and its mechanisms.

Xufeng Peng, Hailin Guo, Jun Chen, Jihong Wang, Jianwen Huang,

BACKGROUND:Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable problem of the urogenital system. The aetiopathogenesis and effective treatments for CP/CPPS are needed to be untangled. Pirfenidone is a molecule that exhibits anti-inflammatory, antifibrotic, and antioxidative stress capacities in a variety of animal experiments and clinical trials. This study was ... Read more >>

Prostate (The Prostate)
[2020, 80(12):917-925]

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Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer.

Diane Begemann, Yang Wang, Wei Yang, Natasha Kyprianou,

BACKGROUND:Disruption of the phenotypic landscape via epithelial-mesenchymal transition (EMT) enables prostate cancer cells to metastasize and acquire therapeutic resistance. Our previous studies demonstrated that cabazitaxel (CBZ) (second-generation Food and Drug Administration-approved taxane chemotherapy), used for the treatment of castration-resistant prostate cancer (CRPC), causes reversal of EMT to mesenchymal-epithelial transition (MET) ... Read more >>

Prostate (The Prostate)
[2020, 80(12):926-937]

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Promotion of epithelial hyperplasia by interleukin-8-CXCR axis in human prostate.

Diandra K Smith, Sarrah L Hasanali, Jiaojiao Wang, Georgios Kallifatidis, Daley S Morera, Andre R Jordan, Martha K Terris, Zachary Klaassen, Roni Bollag, Vinata B Lokeshwar, Bal L Lokeshwar,

BACKGROUND:The clinical manifestation of benign prostatic hyperplasia (BPH) is causally linked to the inflammatory microenvironment and proliferation of epithelial and stromal cells in the prostate transitional zone. The CXC-chemokine interleukin-8 (IL-8) contributes to inflammation. We evaluated the expression of inflammatory cytokines in clinical specimens, primary cultures, and prostatic lineage cell ... Read more >>

Prostate (The Prostate)
[2020, 80(12):938-949]

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Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells.

Kai Wang, Zhen Chen, Jian Shi, Yuehua Feng, Miaomei Yu, Yangyang Sun, Qianfeng Zhuang, Bin Liang, Guanghua Luo, Xianlin Xu, Min Fan,

BACKGROUND:Recently, resveratrol (Res) has been suggested to suppress the migration and invasion of prostate cancer (PCa). In the present study, we aimed to investigate the effects of Res on genomic DNA methylation, as well as the migration and invasion of PCa cells. METHODS:The suppression by Res of the growth of ... Read more >>

Prostate (The Prostate)
[2020, 80(12):977-985]

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Novel small-molecule LG1836 inhibits the in vivo growth of castration-resistant prostate cancer.

Yanhua Chen, Xin Li, Kenza Mamouni, Yang Yang, Alira Danaher, Joseph White, HongYan Liu, Omer Kucuk, Lajos Gera, Daqing Wu,

BACKGROUND:Androgen deprivation therapy (ADT) is the mainstay of treatment for castration-resistant prostate cancer (CRPC). Unfortunately, although ADT initially prolongs survival, most patients relapse and develop resistance. Clinical failure of these treatments in CRPC highlights the urgent need to develop novel strategies to more effectively block androgen receptor (AR) signaling and ... Read more >>

Prostate (The Prostate)
[2020, 80(12):993-1005]

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Can ultrasound irradiation be a therapeutic option for prostate cancer?

Noriaki Maeshige, Koichi Kitagawa, Saya Yamasaki, Aya Ishii, Toshiro Shirakawa, Yong-Ming Yang, Shian-Ying Sung, Kuan-Chou Chen, Zhi-Min Yuan, Katsumi Shigemura, Masato Fujisawa,

BACKGROUND:Focal therapies for prostate cancer (PC) can reduce adverse events and do not lead to androgen-independent progression. Ultrasound could be used for cancer treatments if the repetition frequency is fitted to the purpose. We investigated the possible therapeutic effect of ultrasound irradiation on PC cells. MATERIALS AND METHODS:We irradiated two ... Read more >>

Prostate (The Prostate)
[2020, 80(12):986-992]

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Selenium-binding protein 1 alters energy metabolism in prostate cancer cells.

Mostafa Elhodaky, Lenny K Hong, Shrinidhi Kadkol, Alan M Diamond,

OBJECTIVE:The broad goal of the research described in this study was to investigate the contributions of selenium-binding protein 1 (SBP1) loss in prostate cancer development and outcome. METHODS:SBP1 levels were altered in prostate cancer cell lines and the consequences on oxygen consumption, expression of proteins associated with energy metabolism, and ... Read more >>

Prostate (The Prostate)
[2020, 80(12):962-976]

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Early intervention exercise training does not delay prostate cancer progression in Pten-/- mice.

Renea A Taylor, Simon G Farrelly, Ashlee K Clark, Matthew J Watt,

BACKGROUND:There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of exercise therapy, although there is limited preclinical, and no clinical, data to directly support the notion that exercise training improves prostate cancer prognosis or outcome. The aim of this study was ... Read more >>

Prostate (The Prostate)
[2020, 80(11):906-914]

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Development and initial clinical correlation of a DNA methylation-based blood test for prostate cancer.

Jacob J K Carson, Michael A Di Lena, David M Berman, D Robert Siemens, Christopher R Mueller,

BACKGROUND:One of the principle limitations for more precise management of advanced prostate cancer is the lack of accurate biomarkers allowing estimation of tumor burden, ongoing assessment of progression, and response to treatment. Although prostate-specific antigen (PSA) performs modestly, nonsecreting cancers including those with early castrate-resistance warrant investigation of other predictive ... Read more >>

Prostate (The Prostate)
[2020, 80(12):1038-1042]

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