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Journal Proc Natl Acad Sci U S A

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Correction for Langer and Le, Scaling confirmation of the thermodynamic dislocation theory.

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(2):]

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Looks can be deceiving: Bacterial enzymes work through unanticipated mechanism.

Joshua D Shirley, Erin E Carlson,

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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Citizens from 13 countries share similar preferences for COVID-19 vaccine allocation priorities.

Raymond Duch, Laurence S J Roope, Mara Violato, Matias Fuentes Becerra, Thomas S Robinson, Jean-Francois Bonnefon, Jorge Friedman, Peter John Loewen, Pavan Mamidi, Alessia Melegaro, Mariana Blanco, Juan Vargas, Julia Seither, Paolo Candio, Ana Gibertoni Cruz, Xinyang Hua, Adrian Barnett, Philip M Clarke,

How does the public want a COVID-19 vaccine to be allocated? We conducted a conjoint experiment asking 15,536 adults in 13 countries to evaluate 248,576 profiles of potential vaccine recipients who varied randomly on five attributes. Our sample includes diverse countries from all continents. The results suggest that in addition ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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Genuine divalent magnesium-ion storage and fast diffusion kinetics in metal oxides at room temperature.

Jinlin Yang, Jibiao Li, Wenbin Gong, Fengxia Geng,

Rechargeable magnesium batteries represent a viable alternative to lithium-ion technology that can potentially overcome its safety, cost, and energy density limitations. Nevertheless, the development of a competitive room temperature magnesium battery has been hindered by the sluggish dissociation of electrolyte complexes and the low mobility of Mg<sup>2+</sup> ions in solids, ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis.

Chenlu Zhang, Mahendran Chinnappan, Courtney A Prestwood, Marshall Edwards, Methinee Artami, Bonne M Thompson, Kaitlyn M Eckert, Goncalo Vale, Christos C Zouboulis, Jeffrey G McDonald, Tamia A Harris-Tryon,

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of the immune cytokines IL-4 and IL-13. These cytokines lead to skin barrier disruption and lipid abnormalities in AD, yet the underlying mechanisms are unclear. Sebaceous ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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Cognitive maps of social features enable flexible inference in social networks.

Jae-Young Son, Apoorva Bhandari, Oriel FeldmanHall,

In order to navigate a complex web of relationships, an individual must learn and represent the connections between people in a social network. However, the sheer size and complexity of the social world makes it impossible to acquire firsthand knowledge of all relations within a network, suggesting that people must ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(39):]

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Bluefin tuna reveal global patterns of mercury pollution and bioavailability in the world's oceans.

Chun-Mao Tseng, Shin-Jing Ang, Yi-Sheng Chen, Jen-Chieh Shiao, Carl H Lamborg, Xiaoshuai He, John R Reinfelder,

Bluefin tuna (BFT), highly prized among consumers, accumulate high levels of mercury (Hg) as neurotoxic methylmercury (MeHg). However, how Hg bioaccumulation varies among globally distributed BFT populations is not understood. Here, we show mercury accumulation rates (MARs) in BFT are highest in the Mediterranean Sea and decrease as North Pacific ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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Machine learning potentials for complex aqueous systems made simple.

Christoph Schran, Fabian L Thiemann, Patrick Rowe, Erich A Müller, Ondrej Marsalek, Angelos Michaelides,

Simulation techniques based on accurate and efficient representations of potential energy surfaces are urgently needed for the understanding of complex systems such as solid-liquid interfaces. Here we present a machine learning framework that enables the efficient development and validation of models for complex aqueous systems. Instead of trying to deliver ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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North Atlantic jet stream projections in the context of the past 1,250 years.

Matthew B Osman, Sloan Coats, Sarah B Das, Joseph R McConnell, Nathan Chellman,

Reconstruction of the North Atlantic jet stream (NAJ) presents a critical, albeit largely unconstrained, paleoclimatic target. Models suggest northward migration and changing variance of the NAJ under 21st-century warming scenarios, but assessing the significance of such projections is hindered by a lack of long-term observations. Here, we incorporate insights from ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.

Fabian A Fischer, Linda F M Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Benjamin Demarco, Michael Ohlmeyer, Michelle Sue Jann Lee, Cevayir Coban, Jonathan C Kagan, Elena Di Daniel, Jelena S Bezbradica,

NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation is beneficial during infection and vaccination but, when uncontrolled, is detrimental and contributes to inflammation-driven pathologies. Hence, discovering endogenous mechanisms that regulate NLRP3 activation is important for disease interventions. Activation of NLRP3 is regulated at the transcriptional level and by ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

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Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics.

Dhiraj Kumar, Akhilesh Mishra, Ala Lisok, Rakeeb Kureshi, Sagar Shelake, Donika Plyku, Rupashree Sen, Michele Doucet, Ravindra A De Silva, Ronnie C Mease, Patrick M Forde, Elizabeth M Jaffee, Prashant Desai, Sudipto Ganguly, Edward Gabrielson, Dhananjay Vaidya, Jamie B Spangler, Sridhar Nimmagadda,

Macromolecules such as monoclonal antibodies (mAbs) are likely to experience poor tumor penetration because of their large size, and thus low drug exposure of target cells within a tumor could contribute to suboptimal responses. Given the challenge of inadequate quantitative tools to assess mAb activity within tumors, we hypothesized that ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Norms of assertion in the United States, Germany, and Japan.

Markus Kneer,

The recent controversy about misinformation has moved a question into the focus of the public eye that has occupied philosophers for decades: Under what conditions is it appropriate to assert a certain claim? When asserting a claim that <i>x</i>, must one know that <i>x</i>? Must <i>x</i> be true? Might it ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.

Rachel-Ann A Garibsingh, Elias Ndaru, Alisa A Garaeva, Yueyue Shi, Laura Zielewicz, Paul Zakrepine, Massimiliano Bonomi, Dirk J Slotboom, Cristina Paulino, Christof Grewer, Avner Schlessinger,

ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates intracellular glutamine levels, fueling cell proliferation. Nutrient deprivation via ASCT2 inhibition provides a potential strategy for cancer therapy. Here, we rationally designed stereospecific inhibitors exploiting ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.

Martijn Schonewille, Allison E Girasole, Philippe Rostaing, Caroline Mailhes-Hamon, Annick Ayon, Alexandra B Nelson, Antoine Triller, Mariano Casado, Chris I De Zeeuw, Guy Bouvier,

Long-term synaptic plasticity is believed to be the cellular substrate of learning and memory. Synaptic plasticity rules are defined by the specific complement of receptors at the synapse and the associated downstream signaling mechanisms. In young rodents, at the cerebellar synapse between granule cells (GC) and Purkinje cells (PC), bidirectional ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.

Hsuan-Wen Lin, Chun-Chao Chen, J Steven de Belle, Tim Tully, Ann-Shyn Chiang,

Episodic events are frequently consolidated into labile memory but are not necessarily transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM formation are poorly understood, however, especially at the resolution of identified neurons. Here, we demonstrate enhanced LTM following aversive olfactory conditioning in <i>Drosophila</i> when the transcription factor ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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A second S4 movement opens hyperpolarization-activated HCN channels.

Xiaoan Wu, Rosamary Ramentol, Marta E Perez, Sergei Yu Noskov, H Peter Larsson,

Rhythmic activity in pacemaker cells, as in the sino-atrial node in the heart, depends on the activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. As in depolarization-activated K<sup>+</sup> channels, the fourth transmembrane segment S4 functions as the voltage sensor in hyperpolarization-activated HCN channels. But how the inward movement of S4 in ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Intrinsic physicochemical profile of marketed antibody-based biotherapeutics.

Lucky Ahmed, Priyanka Gupta, Kyle P Martin, Justin M Scheer, Andrew E Nixon, Sandeep Kumar,

Feeding biopharma pipelines with biotherapeutic candidates that possess desirable developability profiles can help improve the productivity of biologic drug discovery and development. Here, we have derived an in silico profile by analyzing computed physicochemical descriptors for the variable regions (Fv) found in 77 marketed antibody-based biotherapeutics. Fv regions of these ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Bacterial endosymbionts protect beneficial soil fungus from nematode attack.

Hannah Büttner, Sarah P Niehs, Koen Vandelannoote, Zoltán Cseresnyés, Benjamin Dose, Ingrid Richter, Ruman Gerst, Marc Thilo Figge, Timothy P Stinear, Sacha J Pidot, Christian Hertweck,

Fungi of the genus <i>Mortierella</i> occur ubiquitously in soils where they play pivotal roles in carbon cycling, xenobiont degradation, and promoting plant growth. These important fungi are, however, threatened by micropredators such as fungivorous nematodes, and yet little is known about their protective tactics. We report that <i>Mortierella verticillata</i> NRRL ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Climate variability and density-dependent population dynamics: Lessons from a simple High Arctic ecosystem.

Dominique Fauteux, Audun Stien, Nigel G Yoccoz, Eva Fuglei, Rolf A Ims,

Ecologists are still puzzled by the diverse population dynamics of herbivorous small mammals that range from high-amplitude, multiannual cycles to stable dynamics. Theory predicts that this diversity results from combinations of climatic seasonality, weather stochasticity, and density-dependent food web interactions. The almost ubiquitous 3- to 5-y cycles in boreal and ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Fast and nonuniform dynamics of perisaccadic vision in the central fovea.

Janis Intoy, Naghmeh Mostofi, Michele Rucci,

Humans use rapid eye movements (saccades) to inspect stimuli with the foveola, the region of the retina where receptors are most densely packed. It is well established that visual sensitivity is generally attenuated during these movements, a phenomenon known as saccadic suppression. This effect is commonly studied with large, often ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Correction for Huidobro et al., Fresnel drag in space-time-modulated metamaterials.

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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p62 condensates are a hub for proteasome-mediated protein turnover in the nucleus.

Pia Erdbrügger, Florian Wilfling,

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Relative mobility of screw versus edge dislocations controls the ductile-to-brittle transition in metals.

Yan Lu, Yu-Heng Zhang, En Ma, Wei-Zhong Han,

Body-centered cubic metals including steels and refractory metals suffer from an abrupt ductile-to-brittle transition (DBT) at a critical temperature, hampering their performance and applications. Temperature-dependent dislocation mobility and dislocation nucleation have been proposed as the potential factors responsible for the DBT. However, the origin of this sudden switch from toughness ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Hydrodynamic nonlinear response of interacting integrable systems.

Michele Fava, Sounak Biswas, Sarang Gopalakrishnan, Romain Vasseur, S A Parameswaran,

We develop a formalism for computing the nonlinear response of interacting integrable systems. Our results are asymptotically exact in the hydrodynamic limit where perturbing fields vary sufficiently slowly in space and time. We show that spatially resolved nonlinear response distinguishes interacting integrable systems from noninteracting ones, exemplifying this for the ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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Inherent stochasticity during insulator-metal transition in VO2.

Shaobo Cheng, Min-Han Lee, Richard Tran, Yin Shi, Xing Li, Henry Navarro, Coline Adda, Qingping Meng, Long-Qing Chen, R C Dynes, Shyue Ping Ong, Ivan K Schuller, Yimei Zhu,

Vanadium dioxide (VO<sub>2</sub>), which exhibits a near-room-temperature insulator-metal transition, has great potential in applications of neuromorphic computing devices. Although its volatile switching property, which could emulate neuron spiking, has been studied widely, nanoscale studies of the structural stochasticity across the phase transition are still lacking. In this study, using in ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

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