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Journal Pregnancy Hypertens

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Pregnancy hypertension: An international journal of women's cardiovascular health.

Mohamed Rezk,

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:86]

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Increased oxidative stress and endothelial activation in umbilical veins from pregnancies diagnosed with preeclampsia.

Tamara Sáez, Camille Wiley, Anita Quon, Floor Spaans, Sandra T Davidge,

Vascular dysfunction is a hallmark of cardiovascular disease (CVD). Offspring from preeclamptic pregnancies are at risk of CVD later in life. Whether fetal vasculature from preeclamptic pregnancies displays signs of vascular dysfunction (i.e., oxidative/nitrosative stress, endothelial activation) associated with increased expression of lectin-like oxidized LDL receptor-1 (LOX-1) and angiotensin-II type-1 ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:87-90]

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Preeclampsia and high blood pressure in early pregnancy as risk factors of severe maternal cardiovascular disease during 50-years of follow-up.

Shantanu Sharma, Julia Skog, Simon Timpka, Claes Ignell,

<h4>Objectives</h4>Studies suggest preeclampsia as a risk factor for long term cardiovascular diseases (CVD), while evidence is limited regarding the risk of high blood pressures (BP) in early pregnancy.<h4>Study design</h4>A register-based follow-up of 2434 mothers in the Helsingborg Birth Cohort. Associations of high BP in early pregnancy (>95th percentile systolic [SBP], ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:79-85]

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Uterine artery Doppler for the prediction of outcome in pregnancies complicated by hypertensive disorders of pregnancy.

Chiara Loardi, Nicola Fratelli, Giorgia Mazzoni, Rossana Orabona, Adriana Valcamonico, Anna Fichera, Enrico Sartori, Federico Prefumo,

<h4>Objectives</h4>To evaluate, in pregnancies complicated by hypertensive disorders of pregnancy (HDP), the predictive role of uterine artery (UtA) Doppler for pregnancy outcome compared to the definition of preeclampsia (PE) established by ISSHP recommendations.<h4>Study design</h4>Retrospective cohort study including singleton pregnancies diagnosed with HDP, who underwent UtA Doppler assessment at admission in ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:69-74]

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Hypertension at delivery hospitalization - United States, 2016-2017.

Carla L DeSisto, Cheryl L Robbins, Matthew D Ritchey, Alexander C Ewing, Jean Y Ko, Elena V Kuklina,

In this study, hospital discharge data from the 2016-2017 Healthcare Cost and Utilization Project were analyzed to describe national and, where data were available, state-specific prevalences of chronic hypertension and pregnancy-associated hypertension at delivery hospitalization. In 2016-2017, the prevalence of chronic hypertension was 216 per 10,000 delivery hospitalizations nationwide, ranging ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:65-68]

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Low-dose aspirin increases 15-epi-lipoxins A4 in pregnancies at high-risk for developing preeclampsia.

Veronica M Gonzalez-Brown, Marwan Ma'ayeh, Douglas A Kniss, Michael Cackovic, Mark B Landon, Kara M Rood,

<h4>Background</h4>LDA triggers biosynthesis of endogenous anti-inflammatory molecules, aspirin-triggered 15-epi-lipoxin A<sub>4</sub> (15-epi-LXA<sub>4</sub>), which may counteract inflammatory process of preeclampsia (PE), and play role in LDA's mechanism of action in PE prevention in high-risk patients.<h4>Objective</h4>Investigate the effects of daily LDA on levels of 15-epi-LXA<sub>4</sub> in pregnancies at high-risk for developing PE.<h4>Materials and ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:75-78]

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Maternal haemodynamic profile in pregnancy after assisted reproductive technology: A pilot study.

Laura Sarno, Salvatore Tagliaferri, Annunziata Carlea, Farid Talhami, Sonia Migliorini, Giuseppe Maria Maruotti, Marta Campanile, Maurizio Guida,

Singleton pregnancies obtained by assisted reproductive technology (ART) are at increased risk of adverse pregnancy outcome. Aim of this pilot study was to compare maternal hemodynamic profile in ART and spontaneous singleton pregnancies. Patients were enrollered during a third trimester routine obstetric examination. Maternal haemodynamic assessment was carried out by ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:62-64]

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Changes to management of hypertension in pregnancy, and attitudes to self-management: An online survey of obstetricians, before and following the first wave of the COVID-19 pandemic.

B Fletcher, L C Chappell, L Lavallee, H M Wilson, R Stevens, L Mackillop, R J McManus, K L Tucker,

<h4>Objective</h4>This study aimed to understand the views and practice of obstetricians regarding self-monitoring for hypertensive disorders of pregnancy (blood pressure (BP) and proteinuria), the potential for self-management (including actions taken on self-monitored parameters) and to understand the impact of the COVID-19 pandemic on such views.<h4>Design</h4>Cross-sectional online survey pre- and post- ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:54-61]

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Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan.

Takafumi Ushida, Tomomi Kotani, Kenji Imai, Tomoko Nakano-Kobayashi, Yukako Iitani, Noriyuki Nakamura, Yoshinori Moriyama, Shigeru Yoshida, Mamoru Yamashita, Hiroaki Kajiyama,

<h4>Objectives</h4>To investigate the prevalence and risk factors of labor-onset hypertension (LOH), defined as hypertension first detected during labor among women without hypertension prior to admission for labor.<h4>Study design</h4>In this multicenter retrospective study, clinical data of women who delivered vaginally at term between 2012 and 2018 were collected from 12 primary ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:48-53]

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P-084. Symptomatic SARS-COV-2 infected pregnant patients and preeclampsia: worse outcome?

Lina R Marins, Erika, V Paniz, Maria LR Oppermann, Laiza SG Quadro, Janete Vetorazzi, Sérgio HM Costa, José GL Ramos,

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:e56-e56]

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P-106. COVID-19 and pre-eclampsia: a literature review

Heloísa T.B. Moreira, Ana P. Oyan, Gabriel Martines, Gabriel Vigna, Marcela G.D. Crivelaro, Patrícia G. Pereira, Claudia R.A. Starnini, Thais M.P. Souza, Eder V. Souza, Maria R.N.L. Paltronieri, Francisco L.P. Sousa,

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:e63-e64]

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Welcome Message by Congress Chair of ISSHP 2021

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:e1-e1]

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Y-013. The effect of COVID-19 on placental function: a population level and case-control study

Michael Wilkinson, Edward Johnstone, Jenny Myers,

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:e21-e21]

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Pregnancy outcomes in women with hyponatraemia and preeclampsia: Case series and literature review.

Adam Morton, Matthew Lumchee, Sailesh Kumar, Elizabeth Jarvis,

<h4>Objectives</h4>To determine the prevalence, clinical course, complications and management of preeclampsia complicated by hyponatraemia.<h4>Study design</h4>A ten year retrospective audit of women delivering at a tertiary referral hospital with preeclampsia complicated by hyponatraemia (defined as serum sodium < 130 mmol/L).<h4>Main outcome measures</h4>The prevalence, time to delivery, complications, treatment and time to recovery of hyponatraemia ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:38-41]

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Genetic predisposition to COVID-19 may increase the risk of hypertension disorders in pregnancy: A two-sample Mendelian randomization study.

Jiang-Shan Tan, Ning-Ning Liu, Ting-Ting Guo, Song Hu, Lu Hua,

<h4>Aims</h4>The aim of this study was to apply the Mendelian randomization (MR) design to explore the potential causal association between COVID-19 and the risk of hypertension disorders in pregnancy.<h4>Methods</h4>Our primary genetic instrument comprised 8 single-nucleotide polymorphisms (SNPs) associated with COVID-19 at genome-wide significance. Data on the associations between the SNPs ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:17-23]

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Cerebral hemodynamics and vasoconstriction in preeclampsia: From diagnosis to resolution.

Marta M Martínez-Martínez, Jorge Fernández-Travieso, Nieves Gómez Muñoz, Beatriz Varela Mezquita, Maria Luisa Almarcha-Menargues, Ambrosio Miralles Martínez,

<h4>Objectives</h4>To evaluate maternal cerebral hemodynamics in patients with preeclampsia (PE) from diagnosis to clinical resolution using transcranial Doppler (TCD) and compare these findings with those of healthy pregnant women. Furthermore, we sought to describe the prevalence of vasoconstriction (VC) and related clinical parameters in PE.<h4>Study design</h4>Case-control study including consecutive patients ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:42-47]

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Good performance of bioimpedance in early pregnancy to predict preeclampsia.

Célia R Trindade, Maria Regina Torloni, Rosiane Mattar, Sue Y Sun,

<h4>Introduction</h4>Preeclampsia (PE) affects 2-8% of pregnancies and is one of the main causes of maternal morbidity and mortality worldwide. Early identification of pregnant women at higher risk for PE would allow the use of interventions to reduce adverse maternal and perinatal outcomes.<h4>Objective</h4>To assess the ability of bioelectrical impedance analysis (BIA) ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:24-30]

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Enhancing the value of the sFlt-1/PlGF ratio for the prediction of preeclampsia: Cost analysis from the Belgian healthcare payers' perspective.

Frederic Chantraine, Kristel Van Calsteren, Roland Devlieger, Damien Gruson, Joachim Van Keirsbilck, Ana Dubon Garcia, Katleen Vandeweyer, Leonardo Gucciardo,

<h4>Objective</h4>To evaluate the economic impact of introducing the soluble fms-like tyrosine kinase (sFlt-1) to placental growth factor (PlGF) ratio test into clinical practice in Belgium for the prediction of preeclampsia (PE).<h4>Study design</h4>We developed a one-year time-horizon decision tree model to evaluate the short-term costs associated with the introduction of the ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:31-37]

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Corrigendum to "Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis" [Pregnancy Hypertens. 21 (2020) 14-22].

Yanfang Peng, Dan Liu, Zhenyu Diao, Zhiyin Wang, Hailin Ding, Bin Cai, Yali Hu, Guangfeng Zhao, Mingming Zheng,

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:1]

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Diagnosis of placental insufficiency independently of clinical presentations using sFlt-1/PLGF ratio, including SGA patients.

Sebastian Kwiatkowski, Magdalena Bednarek-Jędrzejek, Ewa Kwiatkowska, Aneta Cymbaluk-Płoska, Andrzej Torbè,

<h4>Introduction</h4>Angiogenic markers (sFLt1 and PlGF) are altered in preeclampsia and related placental insufficiency syndromes. The utility of these markers in various types of placental insufficiency is still not well known.<h4>Aims</h4>We analyzed blood specimens from 918 women with suspected or confirmed preeclampsia, HELLP syndrome, abruptio placenta, SGA, gestational hypertension for angiogenic ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:244-248]

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Blood pressure as a risk factor for eclampsia and pulmonary oedema in pre-eclampsia.

Pauli Van Heerden, Catherine A Cluver, Karl Bergman, Lina Bergman,

<h4>Objective</h4>We evaluated whether blood pressure and change in blood pressure measurements during pregnancy were associated with eclampsia or pulmonary oedema among women with pre-eclampsia.<h4>Study design</h4>Observational study of women with eclampsia, pre-eclampsia complicated by pulmonary oedema and pre-eclampsia without end-organ complications (pre-eclampsia controls) at a large referral center in Cape Town, ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:2-7]

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LOX-1 expression is reduced in placenta from pregnancies complicated by preeclampsia and in hypoxic cytotrophoblast.

Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie M Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Stephen Tong, Natalie J Hannan,

<h4>Objectives</h4>The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in the maternal vasculature in preeclampsia, and contributes to oxidative stress and endothelial dysfunction. However, its function in the placenta is unclear. This paper investigated LOX-1 expression in models of placental dysfunction and preeclampsia, and whether candidate therapeutics for preeclampsia could ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:255-261]

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Who said differentiating preeclampsia from COVID-19 infection was easy?

Aswathi Jayaram, Irina A Buhimschi, Hayfaa Aldasoqi, Julie Hartwig, Thomas Owens, Gloria L Elam, Catalin S Buhimschi,

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:8-10]

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Association of pre-pregnancy subclinical insulin resistance with cardiac dysfunction in healthy nulliparous women.

Rachel B C Psoinos, Erin A Morris, Carole A McBride, Ira M Bernstein,

<h4>Objectives</h4>To investigate the association between pre-pregnancy subclinical insulin resistance and cardiovascular dysfunction in healthy nulliparous women, and with hypertension in subsequent pregnancy.<h4>Study design</h4>Secondary analysis of a single center prospective observational study conducted November 2011-June 2014. Healthy nulliparous women underwent detailed cardiovascular and metabolic assessment. Insulin resistance was determined by homeostasis ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 26:11-16]

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Association between maternal hypertensive disorders, fetal growth and childhood learning outcomes.

Nina K Ayala, Lauren E Schlichting, Marga Kempner, Melissa A Clark, Patrick M Vivier, Samara I Viner-Brown, Erika F Werner,

<h4>Objective</h4>Both small for gestational age (SGA) birthweight and pregnancies complicated by maternal hypertension (HTN) are independently associated with poorer childhood learning outcomes, however the relative contribution of each remains unknown.<h4>Study design</h4>A retrospective cohort was created in which 2014-2017 third grade Rhode Island Department of Education data were linked to Rhode ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:249-254]

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