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Journal Phytother Res

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Fucoidan mitigated diabetic nephropathy through the downregulation of PKC and modulation of NF-κB signaling pathway: in vitro and in vivo investigations.

Jingge Xu, Yan Wang, Zhen Wang, Lanping Guo, Xinpeng Li,

The persistence of hyperglycemia and oxidative stress in diabetic patients ultimately leads to diabetic nephropathy (DN). In this study, we investigated the effect of sulfated polysaccharides (SPS) extracted from Laminaria japonica in relieving DN symptoms. To induce the diabetic model, normal rats were kept on a high-sugar, high-fat diet, then ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma through modulating c-Myc-TFR1 axis.

Hongbao Yang, Abdullahi Mohamed Said, Huimin Huang, Akuetteh Percy David Papa, Guihua Jin, Shijia Wu, Nengfang Ma, Linhua Lan, Fugen Shangguan, Qiyu Zhang,

Pancreatic ductal adenocarcinoma (PDAC) is severe malignant tumor in human, the outcomes of PDAC is extremely poor. Here, we evaluated the potential anti-tumor activity of chlorogenic Acid (CA) in PDAC. Here, we found CA was effective to suppress PDAC cell growth in vitro and in vivo. Importantly, we found overall ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Purpurin: A natural anthraquinone with multifaceted pharmacological activities.

Jyoti Singh, Yusuf Hussain, Suaib Luqman, Abha Meena,

Purpurin is a naturally occurring anthraquinone isolated from the roots of Rubia cordifolia. Historically, it has been used as a red dye. However, its photosensitizing property and biological effects have deciphered its novel application. Purpurin shows antigenotoxic, anticancer, neuromodulatory, and antimicrobial potential associated with antioxidant action in in vivo and ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Identification of protocatechuic acid as a novel blocker of epithelial-to-mesenchymal transition in lung tumor cells.

Min Hee Yang, Seung Ho Baek, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kwang Seok Ahn,

Protocatechuic acid (PA) is widely distributed and commonly occurring natural compound that can exert antioxidant, anti-inflammatory, as well as anti-cancer effects. Epithelial-to-mesenchymal transition (EMT) is important cellular process that can control tumor invasion and metastasis. Here, we investigated whether PA can modulate the EMT process in basal and transforming growth ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured Vero cells.

Minghui Yang, Jinli Wei, Ting Huang, Luping Lei, Chenguang Shen, Jinzhi Lai, Min Yang, Lei Liu, Yang Yang, Guoshi Liu, Yingxia Liu,

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Ethical considerations and challenges in herbal drug trials with the focus on scientific validity and risk assessment.

Nut Koonrungsesomboon, Nimit Morakote, Juntra Karbwang,

Scientific validity and risk assessment are two main ethical issues which raise specific challenges and are unique to clinical trials investigating crude extracts/fractions from herbal materials. There are considerable challenges for both clinical investigators and ethics committee members in dealing with such issues, many of them remain unresolved, resulting in ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Inhibitory effect of flavonoid xanthomicrol on triple-negative breast tumor via regulation of cancer-associated microRNAs.

Farnoosh Attari, Faezeh Keighobadi, Mohammad Abdollahi, Ehsan Arefian, Reza Lotfizadeh, Houri Sepehri, Mahdi Moridi Farimani,

Breast cancer is the leading cause of cancer death in women worldwide. Due to the side effects of current chemo-reagents on healthy tissues, it is essential to search for alternative compounds with less toxicity and better efficacy. In the present study, we have investigated the anticancer effects of flavonoid xanthomicrol ... Read more >>

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[2020, :]

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Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: A double blind, placebo-controlled, randomized clinical trial.

Fereshteh Dehghani, Seyed Hashem Sezavar Seyedi Jandaghi, Leila Janani, Mohammadtaghi Sarebanhassanabadi, Hadi Emamat, Mohammadreza Vafa,

Myocardial infarction (MI) is one of the leading causes of death in the world. Epidemiological studies have shown that dietary flavonoids are inversely related to cardiovascular morbidity and mortality. The study aimed to determine whether quercetin supplementation can improve inflammatory factors, total antioxidant capacity (TAC) and quality of life (QOL) ... Read more >>

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[2020, :]

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Apple polyphenols extract alleviated dextran sulfate sodium-induced ulcerative colitis in C57BL/6 male mice by restoring bile acid metabolism disorder and gut microbiota dysbiosis.

Fang Liu, Xinjing Wang, Deming Li, Yuan Cui, Xinli Li,

To investigate and compare the preventive effects of apple polyphenols extract (APE) with phloretin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC), 60 male mice were treated with 125 or 500 mg/(kg bw d) APE or 100 mg/(kg bw d) phloretin, the single-ingredient of APE, for continuous 3 weeks by intragastric administration, meanwhile, mice were provided with ... Read more >>

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[2020, :]

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The effect of Alpha-lipoic acid supplementation on endothelial function: A systematic review and meta-analysis.

Yahya Jalilpiran, Maryam Hajishafiee, Masoud Khorshidi, Hamid Rezvani, Mohsen Mohammadi-Sartang, Jamal Rahmani, Seyed Mohammad Mousavi,

There is evidence that alpha-lipoic acid (ALA) supplementation plays an important role in preventing cardiovascular diseases. However, its effect, specifically, on endothelial function (EF) is unclear. Therefore, this systematic review and meta-analysis aimed to evaluate the effects of ALA supplementation on EF. Databases including PubMed/Medline, Scopus, and ISI Web of ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Total saponin extract, ginsenoside Rb1, and compound K alleviate peripheral and central neuropathic pain through estrogen receptors on rats.

Jee Youn Lee, Hae Young Choi, Chan Sol Park, Dong Hyun Kim, Tae Young Yune,

In this study, we investigated whether total saponin extract (TSE), ginsenoside Rb1, and Rb1 metabolite compound K, which are isolated from red ginseng, have antinociceptive effects on peripheral and central neuropathic pain (PNP and CNP, respectively). PNP and CNP were induced by tail nerve injury (TNI) at S1 and by ... Read more >>

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[2020, :]

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Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats.

Fatma Z Sakhri, Naoki Adachi, Sakina Zerizer, Yusuke Ohashi, Hideshi Ikemoto, Mana Tsukada, Zahia Kabouche, Tadashi Hisamitsu, Masataka Sunagawa,

It is known that chronic stress is a contributing factor to several physical and mental diseases. In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field test (OFT), sucrose preference test ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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An approach of fatty acids and resveratrol in the prevention of COVID-19 severity.

Tung Hoang,

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll-like receptor-4 via NF-κB pathway.

Long-Fei Li, Grace G-L Yue, Ben C-L Chan, Qiang Zeng, Quan-Bin Han, Ping-Chung Leung, Kwok-Pui Fung, Ji-Kai Liu, Clara B-S Lau,

The biological activities of water-soluble components of edible mushroom Rubinoboletus ballouii (RB) were seldom reported. Polysaccharides of RB (RBP) were prepared and well-characterized using chemical analyses. The immunomodulatory properties of RBP were investigated using human monocyte-derived dendritic cells (moDC) in vitro, and cyclophosphamide (CTX)-induced immunosuppressive mouse model. Results showed that ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Effects of pine pollen wall on gut microbiota and biomarkers in mice with dyslipidemia.

Xiao Song, Yali Wang, Rui Guan, Ning Ma, Lei Yin, Micun Zhong, Tong Wang, Lihua Shi, Yue Geng,

Pinus yunnanensis pollen is rich in various physiological functions. However, whether the pine pollen wall (PW) plays a beneficial role in the body has not been studied. In this work, we have analyzed its effects on the metabolism and gut microbiota of mouse models of dyslipidemia. We found that the ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.

Mehrdad Mokhtari, Reza Razzaghi, Mansooreh Momen-Heravi,

This study was conducted to determine the effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients with grade 3 DFU. Participants were randomly allocated into two groups (30 participants each group), ... Read more >>

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[2020, :]

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Therapeutic effect of curcumin on oral diseases: A literature review.

Weilong Tang, Minquan Du, Shuang Zhang, Han Jiang,

Curcumin (diferuloylmethane) is a polyphenol compound extracted from the rhizome of the plant Curcuma longa. It has the feature of being a yellow or orange pigment with a variety of biological properties, including anti-inflammation, antioxidation, anti-tumor, anti-bacteria, anti-fungus, and wound healing. Previous studies have reported the role of curcumin in ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Potential of algal metabolites for the development of broad-spectrum antiviral therapeutics: Possible implications in COVID-19 therapy.

Rimjhim Sangtani, Atreyee Ghosh, Hem C Jha, Hamendra Singh Parmar, Kiran Bala,

Covid-19 pandemic severely affected human health worldwide. Till October 19, 2020, total confirmed patients of COVID-19 are 39,944,882, whereas 1,111,998 people died across the globe. Till to date, we do not have any specific medicine and/or vaccine to treat COVID-19; however, research is still going on at war footing. So ... Read more >>

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[2020, :]

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Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial.

Jestin V Thomas, Thozhuthum Parambil Smina, Aman Khanna, Ajaikumar B Kunnumakkara, Balu Maliakel, Ratheesh Mohanan, Illathu Madhavamenon Krishnakumar,

A 6-week, randomized, open-label, active-controlled clinical trial was conducted to evaluate the influence of a low-dose curcumagalactomannosides (CGM) (400 mg once daily) in OA subjects. The treatment was compared with a standard combination of 500 mg glucosamine hydrochloride (GLN) and 415 mg chondroitin sulphate (CHN), supplied as a single oral dose twice a ... Read more >>

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[2020, :]

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Bergamot phytosome improved visceral fat and plasma lipid profiles in overweight and obese class I subject with mild hypercholesterolemia: A randomized placebo controlled trial.

Mariangela Rondanelli, Gabriella Peroni, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Teresa Fazia, Luisa Bernardinelli, Maurizio Naso, Milena Anna Faliva, Alice Tartara, Clara Gasparri, Vittoria Infantino, Simone Perna,

Bergamot has been traditionally used for the relief of diseases related to oxidative stress. Our aim was to investigate the effect of bergamot phytosome on visceral adipose tissue (VAT) and on metabolic profile, in overweight and obese subjects with mild hypercholesterolemia. A total of 64 participants were randomized into two ... Read more >>

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[2020, :]

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Alisma genus: Phytochemical constituents, biosynthesis, and biological activities.

Lei Feng, Tian-Tian Liu, Xiao-Kui Huo, Xiang-Ge Tian, Chao Wang, Xia Lv, Jing Ning, Wen-Yu Zhao, Bao-Jing Zhang, Cheng-Peng Sun, Xiao-Chi Ma,

The genus Alisma contains 11 species distributed worldwide, of which at least two species (A. orientale [Sam.] Juzep. and A. plantago-aquatica Linn.) have been used as common herbal medicines. Secondary metabolites obtained from the genus Alisma are considered to be the material basis for the various biological functions and medicinal ... Read more >>

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[2020, :]

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Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia.

Maryam Mohammadlou, Maryam Abdollahi, Maral Hemati, Rasoul Baharlou, Ehsan Manouchehri Doulabi, Mehrnoosh Pashaei, Farahnaz Ghahremanfard, Mohammad Faranoush, Parviz Kokhaei,

Berberine is a natural isoquinoline alkaloid that has been shown to inhibit the proliferation and induce apoptosis in a wide variety of tumor cells. However, the action mechanism of berberine in CLL cells is unknown. The previous study has shown that berberine leads to reduced viability and elevated levels of ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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The effect of curcumin supplementation on recovery following exercise-induced muscle damage and delayed-onset muscle soreness: A systematic review and meta-analysis of randomized controlled trials.

Wang Fang, Yasaman Nasir,

BACKGROUND:curcumin consumption may have a protective effect against exercise-induced muscle damage (EIMD) through stabilization of the cell membrane via inhibition of free radical formation. Evidence supporting a protective role of curcumin after physical activity induced muscle injury in humans, however, it is inconsistent. METHODS:Medline, Scopus, and Google scholar were systematically ... Read more >>

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[2020, :]

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Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: A randomized clinical trial.

Davood Soleimani, Mitra Rezaie, Farnood Rajabzadeh, Jamshid Gholizadeh Navashenaq, Mohammadreza Abbaspour, Mahsa Miryan, Farkhondeh Razmpour, Golnaz Ranjbar, Reza Rezvani, Lida Jarahi, Seyed Isaac Hashemy, Ladan Goshayeshi, Mohsen Nematy,

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, while no drugs have been approved for its treatment. The pieces of evidence indicate that propolis as a novel anti-inflammatory agent might be a promising candidate to treat NAFLD. We aimed to evaluate the efficacy of propolis on ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Santalum album extract exhibits neuroprotective effect against the TLR3-mediated neuroinflammatory response in human SH-SY5Y neuroblastoma cells.

Kanmani Suganya, Quan Feng Liu, Byung-Soo Koo,

Neuroinflammation is an inflammatory response in the nervous system that is associated with various neurological diseases including Alzheimer's diseases and others. Many studies evaluated the anti-inflammatory potential of Santalum album (S. album) extract, but none of them analyzed its effects against neuroinflammatory response in vitro. In addition, the precise mechanism ... Read more >>

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[2020, :]

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