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Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.

Linlin Wang, Li Cheng, Li Ma, Ammad Ahmad Farooqi, Gan Qiao, Yuxi Zhang, Hanlin Ye, Minghua Liu, Jianlin Huang, Xiaohui Yang, Xiukun Lin, Shousong Cao,

Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL-7402 cells. However, the underlying mechanisms associated with its anticancer activity remain unknown. In the present study, we evaluated the anticancer effect of alnustone against several human cancers focused on HCC and the possible associated mechanisms. The results ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Efficacy and safety of therapeutic use of cannabis derivatives and their synthetic analogs: Overview of systematic reviews.

Rachel Riera, Rafael Leite Pacheco, Ângela Maria Bagattini, Ana Luiza Cabrera Martimbianco,

The debate on the use of cannabinoids for therapeutic purposes is constantly on the rise. This overview aimed to map the evidence on the therapeutic effects of cannabis derivatives and their synthetic analogs. Systematic reviews (SRs) of randomized trials were identified through a comprehensive search in several databases, and their ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Efficacy of herbal treatments for functional dyspepsia: A systematic review and meta-analysis of randomized clinical trials.

Alireza Heiran, Kamran Bagheri Lankarani, Ryan Bradley, Alireza Simab, Mehdi Pasalar,

Functional dyspepsia (FD) is a very common condition globally. Relevant keywords were searched for in title and abstract of selected databases, that is, Medline/PubMed, Scopus, Embase, Web of knowledge, and Google Scholar. Placebo and active-control trials on herbal remedies amongst adults who were diagnosed with FD were included. Dichotomous outcomes ... Read more >>

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[2021, :]

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Polyphenols: Potential anti-inflammatory agents for treatment of metabolic disorders.

Fahimeh Zamani-Garmsiri, Solaleh Emamgholipour, Soheil Rahmani Fard, Ghasem Ghasempour, Roya Jahangard Ahvazi, Reza Meshkani,

Ample evidence highlights the potential benefits of polyphenols in health status especially in obesity-related metabolic disorders such as insulin resistance, type 2 diabetes, and cardiovascular diseases. Mechanistically, due to the key role of "Metainflammation" in the pathomechanism of metabolic disorders, recently much focus has been placed on the properties of ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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The effect of almond intake on glycemic control: A systematic review and dose-response meta-analysis of randomized controlled trials.

Omid Asbaghi, Vihan Moodi, Azadeh Neisi, Mina Shirinbakhshmasoleh, Sajjad Abedi, Fatemeh Hosseini Oskouie, Elham Eslampour, Ehsan Ghaedi, Maryam Miraghajani,

Number trials have evaluated the effect of almond intake on glycemic control in adults; however, the results remain equivocal. Therefore, the present meta-analysis aims to examine the effectiveness of almond intake on glycemic parameters. Online databases including PubMed, Scopus, ISI web of science, Embase, and Cochrane Library were searched up ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches.

Bin Zeng, Ailing Wei, Qiang Zhou, Minghao Yuan, Kelu Lei, Yushi Liu, Jiawen Song, Li Guo, Qiang Ye,

Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and fever, sore throat, sore tongue, snake bite with its excellent functions of clearing heat and toxin, cooling blood and detumescence from times immemorial. ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Promotion of osteogenesis by Sweroside via BMP2-involved signaling in postmenopausal osteoporosis.

La Yoon Choi, Mi Hye Kim, Woong Mo Yang,

Phlomis umbrosa has been traditionally used for bone diseases in traditional Korean Medicine. Sweroside (SOS), marker compounds of P. umbrosa, has been known to promote osteoblast differentiation. In this study, ameliorative effects of SOS on osteoporosis and potential target pathway were investigated. Ovariectomized mice were administered three doses of SOS ... Read more >>

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[2021, :]

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Role of herbal medicine for prevention and treatment of migraine.

Yulong Chen, Shengpeng Wang, Yitao Wang,

Migraine is a disabling neurovascular disease with unilateral or bilateral pulsatile headache, which intensively affects human health and quality of life due to high morbidity worldwide. Migraine is commonly accompanied by abnormal pain sensitization, neuroinflammatory response, and vasomotor dysfunction. Owing to the management dilemmas of migraine, there is an urgent ... Read more >>

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[2021, :]

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Esculetin: A review of its pharmacology and pharmacokinetics.

Linlin Zhang, Qingxuan Xie, Xiaofang Li,

Esculetin is a natural dihydroxy coumarin; it is mainly extracted from twig skin and the trunk bark of the Chinese herbal medicine Fraxinus rhynchophylla Hance. Emerging evidence suggests that esculetin has a wide range of pharmacological activities. Based on its fundamental properties, including antioxidant, antiinflammatory, antiapoptotic, anticancer, antidiabetic, neuroprotective, and ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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An updated review on the potential antineoplastic actions of oleuropein.

Yudong Zheng, Zhenzhen Liu, Xiulan Yang, Lian Liu, Kwang Seok Ahn,

Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4-dihydroxyphenylethanol). It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Neuroprotective properties of ethanolic extract of Citrus unshiu Markovich peel through NADPH oxidase 2 inhibition in chemotherapy-induced neuropathic pain animal model.

Aelee Jang, Go-Eun Choi, Yoo-Jeong Kim, Gil-Hyun Lee, Kyung-Yae Hyun,

The present study aimed to determine the antioxidant effect of Citrus unshiu Markovich (CUM) extract in neuronal cell lines under oxidative stress and to investigate the effect of chemotherapy-induced peripheral neuropathy (CIPN) on the nociceptive response in a preclinical mice model. We tested the inhibition of H<sub>2</sub> O<sub>2</sub> in Neuro2A ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Efficacy of Cuminum Cyminum supplementation on lipid profile and anthropometric parameters: A systematic review and meta-analysis of randomized controlled clinical trials.

Omid Mohammad Tavakoli-Rouzbehani, Amir Hossein Faghfouri, Maryam Anbari, Omid Nikpayam, Hadi PourMirzaei Olyaei, Mohammad Alizadeh,

We aimed to evaluate the effect of Cuminum Cyminum (CC) supplementation on lipid profile and selected anthropometric parameters. PubMed, Scopus, Web of Science, and Embase databases were systematically searched until May 2021. The random-effect model was used to study the effect sizes. The sources of heterogeneity were assessed using subgroup ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials.

Mojgan Shavakhi, Amirhossein Sahebkar, Farinaz Shirban, Mohammad Bagherniya,

This systematic review was undertaken with the main aim of assessing the therapeutic effects of herbal medicines in recurrent aphthous stomatitis (RAS). A comprehensive search was performed in PubMed, Scopus, ISI Web of Science, and Google Scholar up to July 2021 to identify randomized clinical trials investigated the effects of ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Evaluating the effect of black myrobalan on cognitive, positive, and negative symptoms in patients with chronic schizophrenia: A randomized, double-blind, placebo-controlled trial.

Mohammad Banazadeh, Mitra Mehrabani, Nabi Banazadeh, Fatemeh Dabaghzadeh, Farzad Shahabi,

Schizophrenia, as a chronic and disabling mental disorder, causes a wide range of symptoms, including cognitive impairments, positive, negative, and mood symptoms. There are no effective treatments for cognitive symptoms. Black myrobalan (Terminalia chebula Retz.), a medicinal plant of the Combretaceae family, exerts antioxidant, antiacetylcholinesterase, and anti-inflammatory effects. These effects ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Antitumor effect of acanthoic acid against primary effusion lymphoma via inhibition of c-FLIP.

Gunya Sittithumcharee, Ryusho Kariya, Teerapich Kasemsuk, Rungnapha Saeeng, Seiji Okada,

Acanthoic acid (AA) is an active substance that is extracted from Croton oblongifolius Roxb., a traditional plant in Thailand. The antiinflammatory effect of AA on NF-κB pathway has been exclusively reported, however, its anticancer effect is still lacking. PEL is a B cell lymphoma that is mostly found in HIV ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Abscisic acid inhibited reactive oxygen species-mediated endoplasmic reticulum stress by regulating the PPAR-γ signaling pathway in ARDS mice.

Lixia Wang, Hongyun Zou, Xueying Xiao, Huimei Wu, Yan Zhu, Jun Li, Xuesheng Liu, Qiying Shen,

Acute respiratory distress syndrome (ARDS) is a life-threatening form of a respiratory disorder, and there are few effective therapies. Abscisic acid (ABA) has been proven to be effective in influenza and asthma. Herein, we explored the protective effect of ABA on the resolution of ARDS and the underlying mechanism. Mice ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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An exploratory double-blind, randomized, placebo-controlled study to assess the efficacy of CitruSlim on body composition and lipid parameters in obese individuals.

Juan Hancke, Shalini Srivastava, Dante D Caceres, Rafael A Burgos, Pablo Alarcon,

The prevalence of obesity in developing and developed countries has been well recognized, and the worldwide obesity rates have nearly tripled since 1975, according to the World Health Organization. CitruSlim, a standardized product containing a blend of Citrus bergamia and Eurycoma longifolia, can reduce cortisol, cholesterol, triglycerides, and hyperglycemia. These ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Curcumol simultaneously induces both apoptosis and autophagy in human nasopharyngeal carcinoma cells.

Juan Wang, Guoxiang Liu, Xiaojuan Li, Mengjie Huangfu, Yisa Liu, Xumei Li, Dan Yu, Luwei Zhou, Xu Chen,

Autophagy is usually considered as a protective mechanism against cell death, and in the meantime, leads to cell injury even apoptosis. Apoptosis and autophagy are very closely connected and may cooperate, coexist, or antagonize each other on progressive occurrence of cell death triggered by natural compounds. Therefore, the interplay between ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double-blind crossover clinical trial.

Zahra Shekarriz, Seyed Afshin Shorofi, Maryam Nabati, Bizhan Shabankhani, Seyde Sedighe Yousefi,

For a long time, Melissa officinalis (M. officinalis) has been used to treat cardiovascular diseases. Therefore, this study aimed at evaluating the effects of M. officinalis on systolic and diastolic blood pressures in hypertensive patients. We conducted a double-blind, controlled, randomized crossover clinical trial on 49 patients who received either ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Corrigendum.

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[2021, :]

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Astragalin mediates the pharmacological effects of Lysimachia candida Lindl on adipogenesis via downregulating PPARG and FKBP51 signaling cascade.

Sagar Barge, Barsha Deka, Bhaswati Kashyap, Simanta Bharadwaj, Raghuram Kandimalla, Aparajita Ghosh, Partha Pratim Dutta, Suman Kumar Samanta, Prasenjit Manna, Jagat C Borah, Narayan Chandra Talukdar,

Metabolic disturbances in different tissue cells and obesity are caused by excessive calorie intake, and medicinal plants are potential sources of phytochemicals for combating these health problems. This study investigated the role of methanolic extract of the folklore medicinal plant Lysimachia candida (LCM) and its phytochemical, astragalin, in managing obesity ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review.

Elyas Nattagh-Eshtivani, Hanieh Barghchi, Naseh Pahlavani, Mehdi Barati, Yasaman Amiri, Abdulmannan Fadel, Maryam Khosravi, Saeedeh Talebi, Pishva Arzhang, Rahele Ziaei, Abed Ghavami,

Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological properties, including the potential to reduce total and low-density lipoprotein (LDL) cholesterol levels and thereby decreasing the risk of cardiovascular diseases. Other ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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(Poly)phenol toxicity in vivo following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and anthocyanin-rich extracts.

Dennis P Cladis, Connie M Weaver, Mario G Ferruzzi,

Fruit- and vegetable-derived (poly)phenols are secondary plant metabolites that may have beneficial effects on human health when consumed regularly. Recent years have seen rapid growth in both consumer demand for and research interest in (poly)phenol-rich dietary supplements, natural colorants, and functional foods. As these products continue to enter the marketplace ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Antidepressant-like effect of rosmarinic acid during LPS-induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR-γ signaling pathway.

Alexandre Augusto Barros Lataliza, Pollyana Mendonça de Assis, Larissa da Rocha Laurindo, Elaine Cristina Dalazen Gonçalves, Nádia Rezende Barbosa Raposo, Rafael Cypriano Dutra,

Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, has anti-inflammatory and neuroprotective activities. Herein, this study investigated in silico the drug-likeness and the potential molecular targets to RA. Moreover, it tested the antidepressant-like potential of RA in the lipopolysaccharide (LPS)-induced depression model. RA (MW = 360.31 g/mol) meets the ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Quercetin and its derivates as antiviral potentials: A comprehensive review.

Amalia Di Petrillo, Germano Orrù, Antonella Fais, Massimo C Fantini,

Quercetin, widely distributed in fruits and vegetables, is a flavonoid known for its antioxidant, antiviral, antimicrobial, and antiinflammatory properties. Several studies highlight the potential use of quercetin as an antiviral, due to its ability to inhibit the initial stages of virus infection, to be able to interact with proteases important ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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