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The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

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Depression among predictors of intermittent claudication: A cross-sectional study.

Gergely Tóth-Vajna, Zsombor Tóth-Vajna, Barna Konkoly Thege, Piroska Balog,

The aim of the present cross-sectional study was to investigate the relationship between depression and intermittent claudication (IC), independently of traditional risk factors. The sample consisted of 300 individuals (M age = 65.3 ± 8.7 years, 61.0% female) recruited from the offices of 33 general practitioners. Participants' medical history and ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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The use of near-infrared spectroscopy for the evaluation of a 4-week rehabilitation program in patients with COPD.

Botond Szucs, Mate Petrekanits, Monika Fekete, Janos T Varga,

Near-infrared spectroscopy (NIRS) technology can evaluate muscle metabolism and oxygenation. NIRS-based oximeters can measure skeletal muscle oxygen delivery and utilization during static and dynamic work non-invasively. Our goal was to assess the value and usability of NIRS technology in chronic obstructive pulmonary disease (COPD) rehabilitation program. Forty patients with COPD ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Aerobic interval training improves irisin and chemerin levels of both liver and visceral adipose tissues and circulating asprosin in rats with metabolic syndrome.

Fereshteh Ahmadabadi, Hossein Nakhaei, Mehdi Mogharnasi, Chun-Jung Huang,

The perturbation of adipokinetic hormones, such as irisin, chemerin, and asprosin has been reported to participate in pathological conditions (e.g., insulin resistance) and chronic inflammation. However, exercise training has been long established as an effective intervention for prevention and treatment of these chronic and metabolic diseases. This study was to ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Ferulic acid attenuates osteoporosis induced by glucocorticoid through regulating the GSK-3β/Lrp-5/ERK signalling pathways.

Wei Zhou, Bo Chen, Jingbo Shang, Renbo Li,

<h4>Objective</h4>To evaluate in-vivo and in-vitro effects of ferulic acid (FA) on glucocorticoid-induced osteoarthritis (GIO) to establish its possible underlying mechanisms.<h4>Methods</h4>The effects of FA on cell proliferation, cell viability (MTT assay), ALP activity, and mineralization assay, and oxidative stress markers (ROS, SOD, GSH LDH and MDA levels) were investigated by MC3T3-E1 ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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The influence of external load variables on creatine kinase change during preseason training period.

Dániel Csala, Bence Márk Kovács, Péter Bali, Gábor Reha, Gergely Pánics,

<h4>Objective</h4>The aim of the present study was to analyse the relationships between creatine kinase (CK) concentration, an indirect marker of muscle damage, and global positioning system (GPS)-derived metrics of a continuous two-week-long preseason training period in elite football.<h4>Design</h4>Twenty-one elite male professional soccer players were assessed during a 14-day preseason preparatory ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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The "GG" genotype of rs26802 variant in the ghrelin gene is a potential protective factor against nonalcoholic fatty liver disease.

Gholamreza Rezamand, Touraj Mahmoudi, Seidamir Pasha Tabaeian, Hamid Farahani, Fatemeh Shahinmehr, Hossein Nobakht, Reza Dabiri, Asadollah Asadi, Fariborz Mansour-Ghanaei, Mohammad Reza Zali,

<h4>Background</h4>Nonalcoholic fatty liver disease (NAFLD) is an emerging global chronic liver disease worldwide. Considering the powerful association between NAFLD, insulin resistance (IR) and obesity, as well as the key role of ghrelin in these metabolic disorders, we hypothesized that some single nucleotide polymorphisms (SNPs) of the ghrelin (GHRL) and ghrelin ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Perturbation-based balance assessment: Examining reactive balance control in older adults with mild cognitive impairments.

Lakshmi N Kannan, Tanvi S Bhatt,

<h4>Background</h4>Older adults with mild cognitive impairment (OAwMCI) present subtle balance and gait deficits along with subjective memory decline. Although these presentations might not affect activities of daily living (ADLs), they attribute to a two-folded increase in falls. While changes occurring in volitional balance control during ADLs have been extensively examined ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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The effect of strength-endurance training on serum and urine metabolic profiles of female adolescent volleyball athletes.

W Zhou, G Zeng, C Lyu, F Kou, S Zhang, H Wei,

<h4>Aim</h4>Limited investigations on metabolic responses to exercise training in female adolescent volleyball athletes exist. The aim of this study was to obtain serum and urine metabolite markers in female adolescent volleyball athletes within 2-week strength-endurance training using a metabolomics approach coupled with biochemical analysis, which would be potential biomarkers for ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Effect of malnutrition and body composition on the quality of life of COPD patients.

M Fekete, V Fazekas-Pongor, P Balazs, S Tarantini, G Szollosi, J Pako, A N Nemeth, J T Varga,

<h4>Background</h4>Pathological alterations in nutritional status may develop in Chronic Obstructive Pulmonary Disease (COPD) patients through production of inflammatory cytokines and inadequate diet.<h4>Objective</h4>The aim of our study was to determine the correlation between nutritional status and quality of life of COPD patients.<h4>Methods</h4>We evaluated the nutritional status of COPD patients of Hungarian ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Heart rate dynamics and lactate following high-intensity race-pace continuous vs interval workouts in highly trained athletes.

I Martinez-Navarro, A Montoya, M Mateo-March, C Blasco-Lafarga,

<h4>Purpose</h4>The present study aimed to compare the physiological responses of high-intensity race-pace continuous vs. interval workouts commonly used in middle-distance athletics, by means of analyzing post-exercise cardiac autonomic regulation and lactate.<h4>Methods</h4>Nineteen highly-trained 800-m male runners were asked to run a 600-m race-pace continuous workout and a 2 × 4 × ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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ORAI3 contributes to hypoxia-inducible factor 1/2α-sensitive colon cell migration.

D Zhu, R He, W Yu, C Li, H Cheng, B Zhu, J Yan,

<h4>Background</h4>Hypoxia is a pivotal initiator of tumor angiogenesis and growth through the stabilization of hypoxia-inducible factors (HIFs). This study set out to examine the involvement of HIF-1α and HIF-2α in colon cancer and ascertained whether ORAI3 was involved in the pathway.<h4>Materials and methods</h4>Patients and murine models as well as human ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Neonatal hyperbilirubinemia: Background and recent literature updates on the diagnosis and treatment.

H Nawaz, M Aslam, T Rehman,

Hyperbilirubinemia or jaundice has been studied by many researchers because of its diverse causes and potential for toxicity especially in the neonate but to a lesser extent beyond the neonate as well. Several studies have been performed on the normal metabolism and metabolic disorders of bilirubin in last decades of ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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The shear resistance of a member without shear reinforcement according to Eurocode 2; the error of the calculated value and the mechanical explanation of the problem.

Béla Bogdándy,

In this paper the shear resistance of a member without shear reinforcement according to Eurocode 2 is investigated. This expression, as most expressions of design codes typically used to estimate the nominal shear resistance, has been created based on experimental investigations. It will be verified that in case of non-prestressed ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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An autophagy-related long non-coding RNA signature for patients with colorectal cancer.

Dongyan Zhao, Xizhen Sun, Sidan Long, Shukun Yao,

<h4>Aim</h4>Long non-coding RNAs (lncRNAs) have been identified to regulate cancers by controlling the process of autophagy and by mediating the post-transcriptional and transcriptional regulation of autophagy-related genes. This study aimed to investigate the potential prognostic role of autophagy-associated lncRNAs in colorectal cancer (CRC) patients.<h4>Methods</h4>LncRNA expression profiles and the corresponding clinical ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Luteolin, an aryl hydrocarbon receptor antagonist, alleviates diabetic retinopathy by regulating the NLRP/NOX4 signalling pathway: Experimental and molecular docking study.

Y Yang, M Zhou, H Liu,

<h4>Objective</h4>The present report evaluates the protective effects of luteolin against diabetic retinopathy (DR).<h4>Materials and methods</h4>Diabetes was induced in rats by i.p. administration of 60 mg/kg of streptozotocin (STZ), followed by treatment with luteolin for 4 weeks. The effects of luteolin were determined based on the blood glucose and cytokine levels, ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Beneficial impact of Nesfatin-1 on reproductive dysfunction induced by nicotine in male rats: Possible modulation of autophagy and pyroptosis signaling pathways.

N M Madi, R E Abo El Gheit, R A Barhoma, A El Saadany, G M Alghazaly, K Marea, M H El-Saka,

This study was conducted to explore the beneficial impact of nesfatin-1 on reproductive dysfunction induced by nicotine (NT) in male rats with possible modulation of autophagy and pyroptosis signaling pathways. This research was performed on 40 Wistar male rats. They were distributed into four groups: control, normal+nesfatin-1, NT, and NT+nesfatin-1. ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Level of kisspeptin-10 in patients with multiple sclerosis and the association between third ventricle diameter size and vitamin D level.

T Akdag, A U Uca, M Altas, F O Odabas, F Aktas,

<h4>Objective</h4>Multiple sclerosis (MS) is a chronic and progressive neurological disease affecting the central nervous system (CNS). Some studies report an association between MS pathogenesis and cytokines. Here, we aimed to determine and evaluate serum kisspeptin-10 level in MS patients and its related clinic parameters.<h4>Materials and methods</h4>A total of 92 participants, ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Gene expression level of renalase in the skeletal muscles is increased with high-intensity exercise training in mice on a high-fat diet.

Katsuyuki Tokinoya, Seiko Ono, Kai Aoki, Koki Yanazawa, Yasuhiro Shishikura, Takehito Sugasawa, Kazuhiro Takekoshi,

<h4>Introduction</h4>Exercise training is beneficial for reducing obesity. In particular, exercise training can lower the catecholamine concentration in circulation. Renalase, whose expression was first confirmed in the kidneys, is a physiologically active substance that decomposes circulating catecholamines; additionally, it has been reported to be present in the skeletal muscles. The aim ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Health-related quality of life of COPD patients aged over 40 years.

V Fazekas-Pongor, M Fekete, P Balazs, D Árva, M Pénzes, S Tarantini, R Urbán, J T Varga,

<h4>Background</h4>Chronic obstructive pulmonary disease (COPD) is the fourth most frequent disease globally, and its worldwide prevalence is projected to increase in the following decades. Health-related quality of life (HRQOL) of COPD patients depends on multiple factors.<h4>Objective</h4>The aim of this study was to identify the most important risk factors affecting HRQOL ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Blind spot in sepsis management - Tissue level changes in microcirculation.

G Xantus, P Allen, P Kanizsai,

In sepsis cytokine-mediated inflammation, clotting cascade activation and glycocalyx shedding impair both function and structure of the microcirculation, compromising adequate tissue oxygenation/perfusion. Such mismatch results in "dysoxia", an imbalance in mitochondrial respiration.Microvessel injuries can be grouped into four types: cytotoxic oedema, micro-vessel heterogeneity, sluggish/absent flow, and focal anaemia. Recognition of ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Effects of aging on proteasomal-ubiquitin system, oxidative stress balance and calcium homeostasis in middle-aged female rat colon.

N Almási, Z Murlasits, A Al-Awar, Á Csonka, S Dvorácskó, C Tömböly, S Török, D Bester, A Pósa, C Varga, K Kupai,

Aging is a multifactorial process, which is considered as a decline over time. It is increasingly clear that there is a gender difference in aging and in the prevalence of age-related diseases as well. We aimed to examine the effects of the aging process in the colonic tissue of female ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Treatment-induced tumor cell apoptosis following high-intensity interval training and saffron aqueous extract in mice with breast cancer.

F Ahmadabadi, M Saghebjoo, M Hedayati, R Hoshyar, C-J Huang,

This study was to investigate whether high-intensity interval training (HIIT) and saffron aqueous extract (SAE) would provide a synergistic effect to improve tumor volume reduction and also modulate pro- and anti-apoptotic protein expression in tumor tissue of 4T1 breast cancer-bearing mice. Female mice following induction of breast cancer through injection ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Lactoferrin for the treatment of age-associated inflammation - A pilot study.

T Laskow, J Langdon, P Abadir, Q-L Xue, J Walston,

<h4>Background</h4>Chronic inflammation (CI) is a common trait of aging associated with adverse outcomes including mortality. We hypothesized that recombinant human Lactoferrin (rhLf) would reduce chronic inflammation of aging.<h4>Methods</h4>Thirty-six community dwelling older adults were randomly assigned to rhLf or placebo treatment in 1:1 ratio for 3 months. IL-6, sTNFR1, Comprehensive Metabolic ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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Subthreshold membrane potential dynamics of posterior parietal cortical neurons coupled with hippocampal ripples.

Y Sato, H Mizuno, N Matsumoto, Y Ikegaya,

During behavioral states of immobility, sleep, and anesthesia, the hippocampus generates high-frequency oscillations called ripples. Ripples occur simultaneously with synchronous neuronal activity in the neocortex, known as slow waves, and contribute to memory consolidation. During these ripples, various neocortical regions exhibit modulations in spike rates and local field activity irrespective ... Read more >>

Physiol Int (Physiology international)
[2021, :]

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