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Journal Pharmacol. Res.

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Edaravone: a potential treatment for the COVID-19-induced inflammatory syndrome?

Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby,

Pharmacol. Res. (Pharmacological Research)
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Enhancing PPARγ  by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice.

Qi Gao, Ai Wei, Fang Chen, Xingren Chen, Wenwen Ding, Zhiquan Ding, Zhiwei Wu, Ronghui Du, Wangsen Cao,

Atherosclerosis (AS) is a risky cardiovascular disease with limited treatment options. Various pan or type-selective histone deacetylase (HDAC) inhibitors are reportedly atheroprotective against atherosclerosis (AS); however, the key effectors and the main cellular processes that mediate the protective effects remain poorly defined. Here, we report that PPARγ (Peroxisome proliferator-activated receptor ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, :105059]

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Effect of Statin Use on Cardiovascular Events and All-Cause Mortality and in Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-Analysis involving 148,722 Participants.

Wenhui Xie, Hong Huang, Shiyu Xiao, Xinlei Yang, Zhuoli Zhang,

BACKGROUND:Immune-mediated inflammatory diseases (IMIDs) are associated with an increased risk of premature cardiovascular disease and all-cause mortality. Given lipid-lowering and anti-inflammatory properties, statins theoretically provide greater survival benefits for patients with IMIDs. OBJECTIVE:We aimed to evaluate the impact of statin on all-cause mortality and cardiovascular risk in patients with IMIDs, ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, :105057]

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Mortality in COVID-19 patients treated with ACEIs/ARBs: re-estimated meta-analysis results following the Mehra et al. retraction.

Ahmad Alamer, Ivo Abraham,

Highlights•A meta-analysis included a retracted study for Covid-19 patients on ACEI/ARBs.•Re-estimation of that meta-analysis confirms there is no increase in mortality.•As more studies accrue, a “living systematic review” is needed to update risk estimates. ... Read more >>

Pharmacol. Res. (Pharmacological Research)
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Edaravone: a potential treatment for the COVID-19-induced inflammatory syndrome?

Sandra E Reznik, Amit K Tiwari, Charles R Ashby,

Pharmacol. Res. (Pharmacological research)
[2020, :105055]

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Myo-inositol and D-chiro-inositol oral supplementation ameliorate cardiac dysfunction and remodeling in a mouse model of diet-induced obesity.

Serena L'Abbate, Giuseppina Nicolini, Francesca Forini, Sabrina Marchetti, Nicole Di Lascio, Francesco Faita, Claudia Kusmic,

Obesity is an independent risk factor to develop cardiac functional and structural impairments. Here, we investigated the effects of supplementation of inositols on the electrical, structural, and functional cardiac alterations in the mouse model of high fat diet (HFD) induced obesity. Three groups of C57BL6 mice (n = 16 each) were studied: ... Read more >>

Pharmacol. Res. (Pharmacological Research)
[2020, :105047]

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The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia.

Hélène Losson, Sruthi Reddy Gajulapalli, Manon Lernoux, Jin-Young Lee, Aloran Mazumder, Déborah Gérard, Carole Seidel, Hyunggu Hahn, Christo Christov, Mario Dicato, Gilbert Kirsch, Byung Woo Han, Michael Schnekenburger, Marc Diederich,

Despite the discovery of tyrosine kinase inhibitors (TKIs) for the treatment of breakpoint cluster region-Abelson (BCR-ABL)+ cancer types, patients with chronic myeloid leukemia (CML) treated with TKIs develop resistance and severe adverse effects. Combination treatment, especially with a histone deacetylase (HDAC) 6 inhibitor (HDAC6i), appears to be an attractive option ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, :105058]

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Tumor-Derived Extracellular Vesicles: Regulators of Tumor Microenvironment and the Enlightenment in Tumor Therapy.

Jiming Chen, Xuefeng Fei, Jianli Wang, Zhijian Cai,

In recent decades, extracellular vesicles (EVs) have been proven to establish an important bridge of communication between cells or cells and their microenvironment. It is well known that EVs play crucial roles in many human diseases, especially in tumors. Tumor-derived EVs (TEVs) are not only involved in epithelial-mesenchymal transition and ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, :105041]

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Artemisinin protects motoneurons against axotomy-induced apoptosis through activation of the PKA-Akt signaling pathway and promotes Neural stem/progenitor cells differentiation into NeuN+ neurons.

Linlin Liu, Xia Zhao, Marta Silva, Shuai Li, Xingan Xing, Wenhua Zheng,

Brachial plexus axotomy is a common peripheral nerve trauma. Artemisinin, an FDA-approved antimalarial drug, has been described to possess neuroprotective properties. However, the specific mechanisms by which artemisinin protects neurons from axotomy-induced neurotoxicity remain to be elucidated. In this study, we assessed the neuroprotective effects of artemisinin on an experimental ... Read more >>

Pharmacol. Res. (Pharmacological Research)
[2020, :105049]

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The role of semaphorins in small vessels of the eye and brain.

Chun-Lin Zhang, Can-Dong Hong, Hai-Ling Wang, An-Qi Chen, Yi-Fan Zhou, Yan Wan, Ya-Nan Li, Bo Hu,

Small vessel diseases, such as ischemic retinopathy and cerebral small vessel disease (CSVD), are increasingly recognized in patients with diabetes, dementia and cerebrovascular disease. The mechanisms of small vessel diseases are poorly understood, but the latest studies suggest a role for semaphorins. Initially identified as axon guidance cues, semaphorins are ... Read more >>

Pharmacol. Res. (Pharmacological Research)
[2020, :105044]

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Mortality in COVID-19 patients treated with ACEIs/ARBs: re-estimated meta-analysis results following the Mehra et al. retraction.

Ahmad Alamer, Ivo Abraham,

Pharmacol. Res. (Pharmacological research)
[2020, :105053]

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Controlling leukocyte trafficking in IBD.

Marisol Veny, Agnès Fernández-Clotet, Julián Panés,

Inflammatory bowel disease (IBD) is characterized by the accumulation of immune cells, myeloid cells and lymphocytes in the inflamed intestine. The presence and persistence of these cells, together with the production of pro-inflammatory mediators, perpetuate intestinal inflammation in both ulcerative colitis and Crohn's disease. Thus, blockade of leukocyte migration to ... Read more >>

Pharmacol. Res. (Pharmacological Research)
[2020, :105050]

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Targeting T cells in inflammatory bowel disease.

Paolo Giuffrida, Antonio Di Sabatino,

T cells play a pivotal role in the immune response underlying inflammatory bowel disease (IBD) pathogenesis. On this basis, over the past 25 years several drugs have assessed to target T cells in IBD patients. Amongst anti-CD3 antibodies, visilizumab and foralumab did not show clinical efficacy in ulcerative colitis (UC) ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, :105040]

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Ephrin-Eph signaling usage by a variety of viruses.

Esther C W de Boer, Janine M van Gils, Marit J van Gils,

Ephrin-Eph signaling is a receptor tyrosine kinase signaling pathway involved in a variety of cellular mechanisms, of which many are related to the adhesion or migration of cells. Both the Eph receptor and ephrin ligand are abundantly present on a wide variety of cell types, and strongly evolutionary conserved. This ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:105038]

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MicroRNAs in Chronic Airway Diseases: Clinical Correlation and Translational Applications.

Bryce W Q Tan, Wei Liang Sim, Jit Kong Cheong, Win Sen Kuan, Thai Tran, Hui Fang Lim,

MicroRNAs (miRNAs) are short single-stranded RNAs that have pivotal roles in disease pathophysiology through transcriptional and translational modulation of important genes. It has been implicated in the development of many diseases, such as stroke, cardiovascular conditions, cancers and inflammatory airway diseases. There is recent evidence that miRNAs play important roles ... Read more >>

Pharmacol. Res. (Pharmacological Research)
[2020, :105045]

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Corrigendum to "The role of the LTB4-BLT1 axis in health and disease" [Pharmacol. Res. 158 (2020) 104857].

Rui He, Yu Chen, Qian Cai,

Pharmacol. Res. (Pharmacological research)
[2020, :105011]

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SVCT2-Dependent plasma and mitochondrial membrane transport of ascorbic acid in differentiating myoblasts.

Mara Fiorani, Maddalena Scotti, Andrea Guidarelli, Sabrina Burattini, Elisabetta Falcieri, Orazio Cantoni,

The Na+-dependent Vitamin C transporter 2 (SVCT2) is expressed in the plasma and mitochondrial membranes of various cell types. This notion was also established in proliferating C2C12 myoblasts (Mb), in which the transporter was characterised by a high and low affinity in the plasma and mitochondrial membranes, respectively. In addition, ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:105042]

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The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases: From molecular mechanisms to clinical applications.

Bang-Yue Luo, Jia-Li Jiang, Yi-Fan Fang, Fang Yang, Meng-Die Yin, Bing-Chen Zhang, Rui-Rui Zhao, Jing-Wei Shao,

Thrombosis initiated by abnormal platelet aggregation is a pivotal pathological event that precedes most cases of cardiovascular diseases (CVD). Recently, growing evidence indicates that platelet could be a potential target for CVD prevention. However, as the conventional antithrombotic management strategy, applications of current antiplatelet agents are somewhat limited by their ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:105031]

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Efficacy and safety of HIF prolyl-hydroxylase inhibitor vs epoetin and darbepoetin for anemia in chronic kidney disease patients not undergoing dialysis: A network meta-analysis.

Qiyan Zheng, Huisheng Yang, Luying Sun, Ruojun Wei, Xinwen Fu, Yahui Wang, Yishan Huang, Yu Ning Liu, Wei Jing Liu,

Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of oral medicines being developed for the treatment of anemia in chronic kidney disease (CKD) patients. This study aimed to compare the efficacy and safety of HIF-PHI vs epoetin and darbepoetin in CKD patients with anemia not undergoing dialysis. The ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:105020]

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The database-based strategy may overstate the potential effects of traditional Chinese medicine against COVID-19.

Yu-Xi Huang, Wen-Xiao Wang, Sai Zhang, Yu-Ping Tang, Shi-Jun Yue,

Pharmacol. Res. (Pharmacological research)
[2020, :105046]

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Clinical efficacy and predictors of response to dulaglutide in type-2 diabetes.

C C Berra, V Resi, M Mirani, L Folini, A Rossi, S B Solerte, P Fiorina,

Aim of this retrospective multicenter observational study was to evaluate the efficacy and safety of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) dulaglutide in a type-2 diabetic real-world population and to determine the factors predicting the response in terms of glycated haemoglobin (HbA1c) and other relevant clinical outcomes. Data for ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:104996]

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Exploring the mechanism of TCM formulae in the treatment of different types of coronary heart disease by network pharmacology and machining learning.

Jian Yang, Saisai Tian, Jing Zhao, Weidong Zhang,

Traditional Chinese medicine (TCM) has long been used in the clinical treatment of coronary heart disease (CHD). TCM is characterized by syndrome-based medication, which is, using different TCM formulae for different syndromes. However, the underlying mode of action remains unclear. In this work, we utilized network pharmacology and machine learning ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:105034]

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Blame the signaling: Role of cAMP for the resolution of inflammation.

Luciana P Tavares, Graziele L Negreiros-Lima, Kátia M Lima, Patrícia M R E Silva, Vanessa Pinho, Mauro M Teixeira, Lirlândia P Sousa,

A complex intracellular signaling governs different cellular responses in inflammation. Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular network of messengers converting the first signal into a proper response: production of specific mediators, cell activation, survival, or death. Several overlapping pathways are coordinated to ensure specific and ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:105030]

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Effect of combination antiviral therapy on hematological profiles in 151 adults hospitalized with severe coronavirus disease 2019.

Xin Li, Yi Yang, Lancong Liu, Xuefeng Yang, Xiaobo Zhao, Yan Li, Yanyan Ge, Yuxin Shi, Ping Lv, Jianchu Zhang, Tao Bai, Hua Zhou, Pei Luo, Shilong Huang,

OBJECTIVES:The current diagnosis and medicines approach in coronavirus disease 2019 (COVID-19) does not reflect the heterogeneous characteristics of this disease. This study aims to find a new antiviral combination regimen by investigating the frequency of clinically relevant and objectively identified comorbidities, and the clustering of these clinical syndromes and varying ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, :105036]

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Promising targets based on pattern recognition receptors for cancer immunotherapy.

Ling Bai, Wenqian Li, Weijia Zheng, Dongsheng Xu, Naifei Chen, Jiuwei Cui,

Pattern recognition receptors (PRRs) recognize pathogen-associated as well as endogenous damage-associated molecular patterns. Once ligand binding occurs, signaling cascades develop within the cells to activate effector molecules. Thus, PRRs play key roles in immune surveillance and immune tolerance. Due to their differences in cell localization, stage of action, and ligand ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 159:105017]

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