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Journal Pharmacol Res Perspect

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The abrupt pathological deterioration of cisplatin-induced acute kidney injury: Emerging of a critical time point.

Qin Gong, Mulan Wang, Ya Jiang, Chengliang Zha, Dong Yu, Fan Lei, Yingying Luo, Yulin Feng, Shilin Yang, Jun Li, Lijun Du,

Cisplatin (CP), an anticancer drug, often causes kidney damage. However, the mechanism of CP-induced acute kidney injury (AKI) is not completely understood. AKI was induced by intravenous injection (i.v.) of cisplatin at doses of 5, 8, and 10 mg/kg. Anemoside B4 (B4) (20 mg/kg, i.m.) and dexamethasone (DXM) (0.5 mg/kg, i.v.) were used ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00895]

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Serious adverse drug reactions in sub-Saharan Africa in the era of antiretroviral treatment: A systematic review.

Johannes P Mouton, Nicole Jobanputra, Gayle Tatz, Karen Cohen,

We aimed to summarize and describe the burden of serious adverse drug reactions (ADRs) in sub-Saharan Africa (SSA) in the era of antiretroviral therapy. We searched Medline, CINAHL, Africa-Wide Information, Scopus, and Web of Science, without language restriction up to March 2021. We hand-searched reference lists, conference abstracts, and dissertation ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00875]

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Corrigendum.

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00889]

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Antiarrhythmic drug therapy after catheter ablation for atrial fibrillation-Insights from the German Ablation Registry.

Ruben Schleberger, Andreas Metzner, Karl-Heinz Kuck, Dietrich Andresen, Stephan Willems, Ellen Hoffmann, Thomas Deneke, Lars Eckardt, Johannes Brachmann, Matthias Hochadel, Jochen Senges, Andreas Rillig,

Data on the optimal treatment strategy for antiarrhythmic drug therapy (AAD) after catheter ablation for atrial fibrillation (AF) are inconsistent. The present study investigates whether postinterventional AAD leads to an improved long-term outcome. Patients from the prospective German Ablation Registry (n = 3275) discharged with or without AAD after catheter ablation for ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00880]

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Inter-ethnic differences in pharmacokinetics-is there more that unites than divides?

Olusola Olafuyi, Nikita Parekh, Jacob Wright, Jennifer Koenig,

Inter-ethnic variability in pharmacokinetics (PK) has been attributed to several factors ranging from genetic to environmental. It is not clear how current teaching in higher education (HE) reflects what published literature suggests on this subject. This study aims to gain insights into current knowledge about inter-ethnic differences in PK based ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00890]

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Spinal glial cells in itch modulation.

Miho Shiratori-Hayashi, Makoto Tsuda,

Glial cells are non-neuronal cells in the nervous system that are electrically non-excitable and outnumber neurons in humans. Glial cells have attracted attention in recent years for their active involvement in the regulation of neuronal activity, suggesting their contribution to the pathogenesis and progression of neurological diseases. Studies have shown ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00754]

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Analgesic effects of medicinal plants and phytochemicals on chemotherapy-induced neuropathic pain through glial modulation.

Ji Hwan Lee, Nari Kim, Sangwon Park, Sun Kwang Kim,

Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in cancer patients. This side effect lowers the quality of life of patients and may cause the patients to abandon chemotherapy. Several medications (e.g., duloxetine and gabapentin) are recommended as remedies to treat CIPN; however, usage of these drugs is limited because of low ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00819]

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The relationship between vancomycin AUC/MIC and trough concentration, age, dose, renal function in Chinese critically ill pediatric patients.

Jihui Chen, Xiaohui Huang, Shuhong Bu, Xiaoxiao Chen, Jia Zhou, Xinzhu Liu, Xiaowen Guo, Lixia Li, Jian Zhang,

To assess the pharmacokinetic parameters of vancomycin in Chinese critically ill pediatric patients, children treated with vancomycin, hospitalized in the intensive care unit were included. Samples to determine peak and trough serum concentrations were obtained on the third day of treatment. Half-life was significantly longer in neonates and showed a ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00885]

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Deprived social status is associated with decreased use of oral chemotherapy in patients with metastatic colorectal cancer: A retrospective cohort study on administrative databases in a French University Hospital.

Gwendoline Gautier, Mélodie Lucas, Thomas Vermeulin, Frederic Di Fiore, Veronique Merle,

Factors associated with the choice of oral versus intravenous CT are not clearly established. Our purpose was to evaluate the influence of social status and home distance to hospital on the use of oral CT in patients with metastatic colorectal cancer (mCRC). This retrospective single-center study included mCRC patients between ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00888]

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Donepezil improves vascular function in a mouse model of Alzheimer's disease.

Carolina Pellegrini, Vanessa D'Antongiovanni, Matteo Fornai, Emiliano Duranti, Filippo Baldacci, Nunzia Bernardini, Stefano Taddei, Agostino Virdis, Corrado Blandizzi, Stefano Masi, Luca Antonioli,

Cardiovascular complications in Alzheimer's disease (AD) patients can occur years to decades prior to the onset of clinical symptoms of the disease. Donepezil represents the most effective drug in the treatment of AD. However, the potential effect of donepezil on vascular function and structure remains largely unexplored. Here, we assessed ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00871]

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SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia.

Jun Takouda, Sayako Katada, Takuya Imamura, Tsukasa Sanosaka, Kinichi Nakashima,

The brain consists of three major cell types: neurons and two glial cell types (astrocytes and oligodendrocytes). Although they are generated from common multipotent neural stem/precursor cells (NS/PCs), embryonic NS/PCs cannot generate all of the cell types at the beginning of brain development. NS/PCs first undergo extensive self-renewal to expand ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00749]

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Goshajinkigan attenuates paclitaxel-induced neuropathic pain via cortical astrocytes.

Kenta Takanashi, Keisuke Shibata, Keita Mizuno, Ryohei Komatsu, Schuichi Koizumi,

The anticancer agents platinum derivatives and taxanes such as paclitaxel (PCX) often cause neuropathy known as chemotherapy-induced peripheral neuropathy with high frequency. However, the cellular and molecular mechanisms underlying such neuropathy largely remain unknown. Here, we show new findings that the effect of Goshajinkigan (GJG), a Japanese KAMPO medicine, inhibits ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00850]

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Urine volume to hydration volume ratio is associated with pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma.

Tetsuichiro Isono, Daiki Hira, Aya Morikochi, Tadateru Fukami, Satoshi Ueshima, Kazuhiko Nozaki, Tomohiro Terada, Shin-Ya Morita,

High-dose methotrexate (HD-MTX)-based chemotherapy is the first-line treatment for primary central nervous system lymphoma (PCNSL), but is associated with severe adverse effects, including myelosuppression and renal impairment. MTX is primarily excreted by the kidneys. Renal function calculated using serum creatinine (Scr) derived from muscle may be overestimated in elderly PCNSL ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00883]

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Defining and unpacking the core concepts of pharmacology education.

Marina Santiago, Elizabeth A Davis, Tina Hinton, Thomas A Angelo, Alison Shield, Anna-Marie Babey, Barbara Kemp-Harper, Gregg Maynard, Hesham S Al-Sallami, Ian F Musgrave, Lynette B Fernandes, Suong N T Ngo, Arthur Christopoulos, Paul J White,

Pharmacology education currently lacks a research-based consensus on which core concepts all graduates should know and understand, as well as a valid and reliable means to assess core conceptual learning. The Core Concepts in Pharmacology Expert Group (CC-PEG) from Australia and New Zealand recently identified a set of core concepts ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00894]

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Jadomycins: A potential chemotherapy for multi-drug resistant metastatic breast cancer.

Esther P Bonitto, Brendan T McKeown, Kerry B Goralski,

Breast cancer causes the most cancer fatalities in women worldwide. Approximately one-third of breast cancers metastasize, or spread from primary tumors to other tissues, and have a 70% 5-year mortality rate. Current breast cancer treatments like doxorubicin and paclitaxel become ineffective when breast cancer cells develop multi-drug resistance and overexpress ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00886]

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Glial pharmacology in Asia & Beyond.

Schuichi Koizumi,

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00881]

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Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology.

Hiroshi Katsuki,

This review provides an overview of researches on the NR1 and NR4 nuclear receptors involved in the regulation of microglial functions. Nuclear receptors are attractive candidates for drug targets in the therapies of the central nervous system disorders, because the activation of these receptors is expected to regulate the functions ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00766]

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In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor.

Heather Zhang, Ying C Ou, Dan Su, Fan Wang, Lai Wang, Srikumar Sahasranaman, Zhiyu Tang,

Zanubrutinib is a highly selective, potent, orally available, targeted covalent inhibitor (TCI) of Bruton's tyrosine kinase (BTK). This work investigated the in vitro drug metabolism and transport of zanubrutinib, and its potential for clinical drug-drug interactions (DDIs). Phenotyping studies indicated cytochrome P450 (CYP) 3A are the major CYP isoform responsible ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00870]

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Studies on CYP3A activity during the menstrual cycle as measured by urinary 6β-hydroxycortisol/cortisol.

Helena Bergström, Anna Lindahl, Anna Warnqvist, Ulf Diczfalusy, Lena Ekström, Linda Björkhem-Bergman,

The 6β-OH-cortisol/cortisol ratio (6β-OHC/C) in urine is an endogenous marker of drug-metabolizing enzyme cytochrome P450 3A (CYP3A). The primary aim of this single center, prospective, non-interventional cohort study, was to investigate the variability of 6β-OHC/C during the menstrual cycle. In addition, possible associations between the CYP3A activity and sex hormones, ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00884]

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Normal variation of the gut microbiota affects hepatic cytochrome P450 activity in mice.

Masao Togao, Shinnosuke Tajima, Takashi Kurakawa, Gaku Wagai, Jun Otsuka, Shoichi Kado, Koji Kawakami,

Several studies revealed that substantial artificial changes in the gut microbiota resulted in modification of hepatic cytochrome P450 3a (Cyp3a) in mice. Consequently, we hypothesized that "normal" variation of the gut microbiota might also alter hepatic Cyp activity and lead to individual differences in drug metabolism. Therefore, this study investigated ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00893]

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Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox.

Joshua C Zamora, Hudson R Smith, Elaine M Jennings, Teresa S Chavera, Varun Kotipalli, Aleasha Jay, Stephen M Husbands, Alex Disney, Kelly A Berg, William P Clarke,

Opioid overdose is a leading cause of death in the United States. The only treatment available currently is the competitive antagonist, naloxone (Narcan<sup>®</sup> ). Although naloxone is very effective and has saved many lives, as a competitive antagonist it has limitations. Due to the short half-life of naloxone, renarcotization can ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00887]

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Statin withdrawal and treating COVID-19 patients.

David S Fedson,

Most but not all observational studies of statin treatment of COVID-19 patients suggest that treatment improves outcomes. However, almost all of these studies fail to consider that withdrawing statins after hospital admission may have detrimental effects, a finding which cardiovascular investigators have known for 15-20 years. Continuing or starting statin treatment ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00861]

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Did our pharmacological strategy for COVID-19 fail?

Jennifer H Martin, Michelle Baddeley, Richard Head,

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00866]

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Dynamics of the QTc interval over a 24-h dose interval after start of intravenous ciprofloxacin or low-dose erythromycin administration in ICU patients.

Florine A Berger, Willem van Weteringen, Heleen van der Sijs, Nicole G M Hunfeld, Jeroen J H Bunge, Natasja M S de Groot, Patricia M L A van den Bemt, Teun van Gelder,

QTc interval prolongation is an adverse effect associated with the use of fluoroquinolones and macrolides. Ciprofloxacin and erythromycin are both frequently prescribed QTc-prolonging drugs in critically ill patients. Critically ill patients may be more vulnerable to developing QTc prolongation, as several risk factors can be present at the same time. ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00865]

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Chemogenetic stimulation of the Gi pathway in astrocytes suppresses neuroinflammation.

Jae-Hong Kim, Md Habibur Rahman, Won Ha Lee, Kyoungho Suk,

Engineered G protein-coupled receptors (GPCRs) are commonly used in chemogenetics as designer receptors exclusively activated by designer drugs (DREADDs). Although several GPCRs have been studied in astrocytes using a chemogenetic approach, the functional role of the astrocytic G<sub>i</sub> pathway is not clear, as the literature is conflicting depending on the ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00822]

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