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Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles.

Shun-Bin Luo, Er-Min Gu, Yu-Ao Chen, Shi-Chen Zhou, Chen Fan, Ren-Ai Xu,

As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food. However, it is still unknown whether quercetin and selexipag interact. The study investigated the effect of quercetin on the pharmacokinetics of ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):1-8]

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Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling.

Haoyang Lu, Hui Xiao, Manyu Dai, Yangcheng Xue, Ren Zhao,

Ferroptosis was described as an important contributor to the myocardial ischaemia/reperfusion (MIR) injury, and britanin (Bri) was reported to exert antitumor and anti-inflammatory activities. Our study explores the effect and mechanism of Bri on MIR damage. The rat model of MIR was established by ligation of the left anterior descending ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):38-45]

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The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review.

Xiaojiang Qin, Xinrong Xu, Xiaomin Hou, Ruifeng Liang, Liangjing Chen, Yuxuan Hao, Anqi Gao, Xufeng Du, Liangyuan Zhao, Yiwei Shi, Qingshan Li,

<h4>Context</h4>Farrerol, a typical natural flavanone isolated from the traditional Chinese herb 'Man-shan-hong' [<i>Rhododendron dauricum</i> L. (Ericaceae)] with phlegm-reducing and cough-relieving properties, is widely used in China for treating bronchitis and asthma.<h4>Objective</h4>To present the anti-inflammatory, antioxidant, vasoactive, antitumor, and antimicrobial effects of farrerol and its underlying molecular mechanisms.<h4>Methods</h4>The literature was reviewed ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):9-16]

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Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response.

Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han,

<h4>Context</h4>Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs). Aspirin could prevent cardiomyocyte damage by inducing heat shock response.<h4>Objective</h4>This study investigates the effect of aspirin on alleviating VSMC calcification.<h4>Materials and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):17-24]

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Protective effect of Qingre Huoxue decoction against myocardial infarction via PI3K/Akt autophagy pathway based on UPLC-MS, network pharmacology, and in vivo evidence.

Zheng Jin, Wenbo Zhang, Yuan Luo, Xiushen Li, Lijin Qing, Qiang Zuo, Junfeng Fang, Wei Wu,

<h4>Context</h4>Qingre Huoxue (QRHX) decoction, a traditional Chinese medicine, has been widely used to prevent and treat myocardial infarction (MI).<h4>Objective</h4>This study elucidates the possible mechanisms of QRHX in preventing or treating MI in a rat model.<h4>Materials and methods</h4>The chemical constituents of QRHX were identified by UPLC-MS. Sprague-Dawley rats were randomly divided ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1607-1618]

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Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis.

Yuan Zhou, Rong Wu, Fei-Fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun, Shi-Bing Su,

<h4>Context</h4>Xiaoyaosan decoction (XYS), a classical Traditional Chinese Medicine (TCM) formula is used to treat liver fibrosis in clinics.<h4>Objective</h4>This study explores defined compound combinations from XYS decoction to treat liver fibrosis.<h4>Materials and methods</h4>Network pharmacology combined with transcriptomics analysis was used to analyze the XYS decoction and liver depression and spleen deficiency ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1594-1606]

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Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner.

Tongtong Sui, Bojun Qiu, Jiaorong Qu, Yuxin Wang, Kunnian Ran, Wei Han, Xiaozhong Peng,

<h4>Context</h4>Gambogic amide (GA-amide) is a non-peptide molecule that has high affinity for tropomyosin receptor kinase A (TrkA) and possesses robust neurotrophic activity, but its effect on angiogenesis is unclear.<h4>Objective</h4>The study investigates the antiangiogenic effect of GA-amide on endothelial cells (ECs).<h4>Materials and methods</h4>The viability of endothelial cells (ECs) treated with 0.1, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1566-1575]

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Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness.

Xiaoning Yan, Jie Liu, Meixia Zhu, Lirong Liu, Yijun Chen, Yinhuan Zhang, Menghan Feng, Zhixin Jia, Hongbin Xiao,

<h4>Context</h4><i>Rhodiola crenulata</i> (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear.<h4>Objective</h4>To investigate the effect of <i>Rhodiola crenulata</i> on cellular metabolism in the central nervous system.<h4>Materials and methods</h4>The viability and Hif-1α ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1540-1550]

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Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages.

Chun Li, Xin-You Pan, Mingyun Ma, Jun Zhao, Fengda Zhao, Ya-Ping Lv,

<h4>Context</h4><i>Astragalus</i> polysaccharin (APS), an extract of <i>Astragalus propinquus</i> Schischk, exerts antitumor effects in hepatocellular carcinoma (HCC).<h4>Objective</h4>This study investigated the mechanism of action of APS in HCC.<h4>Materials and methods</h4>Tumour-associated macrophages (TAMs) were treated with APS (0, 8, 16 mg/mL) for 24 h. APS (16 mg/mL)-treated TAMs were co-cultured with MHCC97H/Huh7 cells for 24 h. Finally, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1533-1539]

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Neochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [Morus Alba L. (Moraceae)].

Jing Li, Lu Dou, Shuangfeng Chen, Honghao Zhou, Fangzheng Mou,

<h4>Context</h4>Chinese herbs such as Cortex Mori [<i>Morus alba</i> L. (Moraceae)] may inhibit human immunodeficiency virus (HIV), but active compounds are unknown.<h4>Objective</h4>Screening of Cortex Mori and other herbs for anti-HIV active compounds.<h4>Materials and methods</h4>HIV-1 virus (multiplicity of infection: 20), and herbs (dissolved in dimethyl sulfoxide, working concentrations: 10, 1, and 0.1 mg/mL) ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1517-1527]

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Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia.

Zhen-Tao Mo, Jie Zheng, Yu-Ling Liao,

<h4>Context</h4>Icariin (ICA), a flavonol glycoside extracted from <i>Epimedium brevicornum</i> Maxim (Berberidaceae), has been proven to inhibit inflammatory response in ischaemic rats in our laboratory's previous work. However, its underlying mechanism is still unclear.<h4>Objective</h4>This study investigates the effects of ICA on endoplasmic reticulum (ER) stress mediated inflammation induced by cerebral ischaemia-reperfusion ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1473-1479]

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Clinacanthus nutans attenuates atherosclerosis progression in rats with type 2 diabetes by reducing vascular oxidative stress and inflammation.

Ahmad Khusairi Azemi, Siti Safiah Mokhtar, Sharifah Emilia Tuan Sharif, Aida Hanum Ghulam Rasool,

<h4>Context</h4>Atherosclerosis predisposes individuals to adverse cardiovascular events. <i>Clinacanthus nutans</i> L. (Acanthaceae) is a traditional remedy used for diabetes and inflammatory conditions.<h4>Objectives</h4>To investigate the anti-atherosclerotic activity of a <i>C. nutans</i> leaf methanol extract (CNME) in a type 2 diabetic (T2D) rat model induced by a high-fat diet (HFD) and low-dose streptozotocin.<h4>Materials ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1432-1440]

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Yang-Yin-Jie-Du decoction overcomes gefitinib resistance in non-small cell lung cancer via down-regulation of the PI3K/Akt signalling pathway.

Shu-Yi Chen, Gao-Chen-Xi Zhang, Qi-Jin Shu,

<h4>Context</h4>Yang-Yin-Jie-Du Decoction (YYJDD) was used to improve gefitinib efficacy in our clinical practice, but its mechanism remains unclear.<h4>Objective</h4>This study explored if YYJDD could reverse gefitinib resistance.<h4>Materials and methods</h4>H1975 cells were exposed to control, 10 μM gefitinib, 3.2 mg/mL YYJDD or combination treatment. Cell viability was detected by MTT during 0-96 h. Apoptosis and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1294-1304]

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Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet.

Khuzaidatul Azidah Ahmad Nazri, Qodriyah Haji Mohd Saad, Norsyahida Mohd Fauzi, Fhataheya Buang, Ibrahim Jantan, Zakiah Jubri,

<h4>Context</h4><i>Gynura procumbens</i> (Lour.) Merr. (Asteraceae) has been reported to have various pharmacological activities including anti-inflammatory effects.<h4>Objective</h4>This study sought to determine whether <i>Gynura procumbens</i> (GP) could improve vascular reactivity by suppressing inflammation in postmenopausal rats fed with five-times heated palm oil (5HPO) diet.<h4>Materials and methods</h4>Forty-eight female Sprague-Dawley rats were randomly divided ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1203-1215]

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Long-term toxicological studies on the Chinese medicine 2036 Specialty-Qiangxin recipe in rats.

Andong Zhao, Yi Yang, Xiaohua Pan, Manhon Chung, Sa Cai, Yu Pan,

<h4>Context</h4>The traditional medicine 2036 Specialty-Qiangxin recipe (2036S-QXR) has been widely used in China to improve cardiac function, prevent stroke, and strengthen the immune system. However, its long-term toxicity remains unknown.<h4>Objective</h4>The present study evaluates the long-term toxicity of 2036S-QXR in rats.<h4>Materials and methods</h4>2036S-QXR (0.6, 1.2, and 2.4 g/kg body weight per day) ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1181-1190]

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Kazak faecal microbiota transplantation induces short-chain fatty acids that promote glucagon-like peptide-1 secretion by regulating gut microbiota in db/db mice.

Xue Han, Ye Wang, Peipei Zhang, Manli Zhu, Ling Li, Xinmin Mao, Xiaoting Sha, Linlin Li,

<h4>Context</h4>Faecal microbiota transplantation (FMT) from Kazak individuals with normal glucose tolerance (KNGT) significantly reduces plasma glycolipid levels in type 2 diabetes mellitus <i>db/db</i> mice. However, the mechanism behind this effect has not been reported.<h4>Objective</h4>To study the mechanism of improved glycolipid disorders in <i>db/db</i> mice by FMT from a KNGT donor.<h4>Materials ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1077-1087]

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Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.

Yousef A Bin Jardan, Abdul Ahad, Mohammad Raish, Mohd Aftab Alam, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi,

<h4>Context</h4>Garden cress (GC), fenugreek (FG), and black seed (BS) are traditional herbal medicine for managing hypertension.<h4>Objective</h4>The effects of the three herbs on the pharmacodynamics of metoprolol tartrate (MT) in hypertensive rats were investigated.<h4>Materials and methods</h4>Wistar rats were divided in five groups (<i>n</i> = 6). Group I served as normal control group and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1088-1097]

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α-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects of Melicope latifolia bark extracts and identification of bioactive constituents using in vitro and in silico approaches.

Alexandra Quek, Nur Kartinee Kassim, Pei Cee Lim, Dai Chuan Tan, Muhammad Alif Mohammad Latif, Amin Ismail, Khozirah Shaari, Khalijah Awang,

<h4>Context</h4><i>Melicope latifolia</i> (DC.) T. G. Hartley (Rutaceae) was reported to contain various phytochemicals including coumarins, flavonoids, and acetophenones.<h4>Objective</h4>This study investigates the antidiabetic and antioxidant effects of <i>M. latifolia</i> bark extracts, fractions, and isolated constituents.<h4>Materials and methods</h4><i>Melicope latifolia</i> extracts (hexane, chloroform, and methanol), fractions, and isolated constituents with varying concentrations (0.078-10 mg/mL) ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):964-973]

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Pien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway.

Xiaoqin Zhang, Qing Zhang, Lili Huang, Mingzhen Liu, Zaixing Cheng, Yanfang Zheng, Wen Xu, Jinjian Lu, Jian Liu, Mingqing Huang,

<h4>Context</h4><i>Pien-Tze-Huang</i> (PTH) is traditionally applied to treat various inflammation-related diseases including stroke. However, literature regarding the anti-inflammatory effects and possible mechanisms of PTH in ischaemic stroke is unavailable.<h4>Objective</h4>This study investigates the anti-inflammatory effects and its underlying mechanism of PTH on ischaemic stroke.<h4>Materials and methods</h4>Cerebral ischaemia-reperfusion injury was induced through 2 h ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):828-839]

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Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model.

Lu Dou, Xue Gong, Qing Wu, Fangzheng Mou,

<h4>Context</h4>Sheng Xue Fang (SXF) has been used to treat anaemia for decades with good efficacy.<h4>Objective</h4>To study the effect and possible mechanism of SXF to restore haematopoietic function.<h4>Materials and methods</h4>Balb/c mice (10 per/group, half male, half female) were treated with SXF (three dose groups, 8.5, 17, and 22.1 g/kg) by gavage for ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):789-798]

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Extract of Ganoderma sinensis spores induces cell cycle arrest of hepatoma cell via endoplasmic reticulum stress.

Weiming Lin, Li Gu, Ling-Yan Zhu, Sha Zhou, Danhong Lian, Yongquan Xu, Limin Zheng, Xin Liu, Lian Li,

<h4>Context</h4><i>Ganoderma sinensis</i> Zhao, Xu et Zhang (Ganodermataceae) has been used for the prevention or treatment of a variety of diseases, including cancer.<h4>Objective</h4>We investigated the antitumor activity and mechanism of an extract from <i>G. sinensis</i> against hepatocellular carcinoma.<h4>Materials and methods</h4>A <i>G. sinensis</i> extract (GSE) was obtained from sporoderm-broken <i>G. sinensis</i> spores ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):704-714]

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Selenium-containing protein from selenium-enriched Spirulina platensis antagonizes oxygen glucose deprivation-induced neurotoxicity by inhibiting ROS-mediated oxidative damage through regulating MPTP opening.

Xiaojie Song, Lijun Zhang, Xin Hui, Xiangfu Sun, Juntao Yang, Jinlei Wang, Hualian Wu, Xianjun Wang, Zuncheng Zheng, Fengyuan Che, Guojun Wang,

<h4>Context</h4>Selenium-containing protein from selenium-enriched <i>Spirulina platensis</i> (Se-SP) (syn. <i>Arthrospira platensis</i> [Microcoleaceae]) showed novel antioxidant activity. However, the protective effect of Se-SP against oxygen glucose deprivation (OGD)-induced neural apoptosis has not been reported yet.<h4>Objective</h4>To verify whether Se-SP can inhibit OGD-induced neural apoptosis and explore the underlying mechanism.<h4>Materials and methods</h4>Primary hippocampal neurons ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):629-638]

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Xinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway.

Yaolu Zhu, Yabin Sun, Shichang Zhang, Chuyuan Li, Yiwei Zhao, Boxin Zhao, Guofeng Li,

<h4>Context</h4>Xinmai 'an tablet has been used to improve myocardial blood supply. Recently, some compounds from its formula have shown that they can treat pulmonary arterial hypertension (PAH).<h4>Objective</h4>This study investigates the effects of Xinmai 'an extract (XMA) on PAH and further tests the co-therapeutic enhancement with sildenafil (SIL).<h4>Materials and methods</h4>Pulmonary artery ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):594-605]

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Quantification of thonningianin a in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.

Qian Liu, Chunmin Li, Pan Zhao, Jing Li, Zhipeng Deng,

<h4>Context</h4>Thonningianin A is an ellagitannin substance and displays multiple pharmacological activities.<h4>Objective</h4>This study investigated the pharmacokinetic characteristics of thonningianin A after oral administration in rats using a fully validated liquid chromatography tandem mass spectrometry (LC-MS/MS) method.<h4>Materials and methods</h4>A sensitive and selective LC-MS/MS assay was developed for quantifying thonningianin A. Eighteen Wistar ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):525-531]

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Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene.

Yangjie Zhou, Wei Wei, Julian Shen, Lu Lu, Taotao Lu, Hong Wang, Xiehua Xue,

<h4>Context</h4>Alisol A 24-acetate has been used to treat vascular diseases. However, the underlying mechanisms still remain unclear.<h4>Objective</h4>The present study evaluated the antiapoptotic effect of alisol A 24-acetate on brain microvascular endothelial cells (BMECs) and explored the underlying mechanisms.<h4>Materials and methods</h4>BMECs were injured through oxygen -glucose deprivation (OGD) after alisol A ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):513-524]

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