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Journal Pediatr Transplant

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Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience.

Yöntem Yaman, Murat Elli, Şifa Şahin, Kürşat Özdilli, Hülya Bilgen, Nihan Bayram, Serdar Nepesov, Sema Anak,

Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogeneic HSCT thrombocytopenia, appears efficacious, and offers transfusion ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2021, :e13962]

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Growing up in a virtual world - A new look for transitioning to adult transplant care.

Mary Moss Chandran, Eliza Blanchette, Adrianne Sikora, Megan Bisek, Elizabeth Steinberg Christofferson, Margret Bock,

Pediatr Transplant (Pediatric transplantation)
[2021, :e13967]

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Outflow vein venoplasty of left lateral section graft for living donor liver transplantation in infant recipients.

Jung-Man Namgoong, Shin Hwang, Gil-Chun Park, Chul-Soo Ahn, Ki-Hun Kim, Kyoung-Mo Kim, Seok-Hee Oh, Hyunhee Kwon, Yong Jae Kwon,

The orifice size of the LHV trunk in LLS grafts is often too small for direct anastomosis. Several methods were developed to enlarge the graft and recipient hepatic vein orifices. This study described our surgical techniques to secure hepatic vein reconstruction in infant recipients and analyzed the patency outcomes. Twelve ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2021, :e13970]

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Pediatric discard risk index for predicting pediatric liver allograft discard.

Tahir Malik, Manasi Joshi, Elizabeth Godfrey, Thao Galvan, Christine A O'Mahony, Ronald Cotton, John Goss, Abbas Rana,

<h4>Background</h4>Of the 600 pediatric candidates added to the liver waiting list annually, 100 will remain waiting while over 100 liver allografts are discarded, often for subjective reasons.<h4>Methods</h4>We created a risk index to predict discard to better optimize donor supply. We used the UNOS database to retrospectively analyze 17 367 deceased donors ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2021, :e13963]

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Hematopoietic cell transplant for reversal of liver fibrosis in a pediatric patient with erythropoietic protoporphyria.

Saman K Hashmi, Elaine Harstead, Mansi Sachdev, Dennis D Black, Ian Clark, Ibrahim Ortanca, Brandon M Triplett, Aimee C Talleur,

<h4>Background</h4>EPP is a rare disorder of heme biosynthesis in which patients present with disabling photosensitivity. A subset of patients develop severe liver disease with progressive liver failure necessitating an OLT. A HCT can potentially cure EPP by replacing the native bone marrow, which is the primary site of heme synthesis. ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2021, :e13966]

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Fontan-associated plastic bronchitis waitlist and heart transplant outcomes: A PHTS analysis.

David W Bearl, Ryan Cantor, Devin Koehl, Jeffrey G Gossett, Matthew J Bock, Nancy Halnon, Lauren Glass, Vernat Exil, Courtney Musselwhite, James K Kirklin, Justin Godown, Chitra Ravishankar,

Plastic bronchitis is a rare post-Fontan complication with limited treatment options. Heart transplantation has evolved as a potential curative option, but outcomes have not been well-defined. This study aims to assess contemporary waitlist and post-transplant outcomes in patients with plastic bronchitis. All Fontan patients were identified in the PHTS database ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2021, :e13951]

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Post-transplant hepatic fibrosis in pediatric liver-small bowel transplant recipients: A single-center, retrospective, observational study.

Hanh D Vo, Stanley J Radio, Emille M Reyes-Santiago, Teri J Mauch,

<h4>Background</h4>Little is known about the prevalence of hepatic graft fibrosis in combined LSBT children. We aimed to determine the prevalence of and identify potential predictors for hepatic graft fibrosis in LSBT children and to compare them with those in LT children.<h4>Methods</h4>We retrospectively included children younger than 19 years who had received ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13965]

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Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome.

Lutz T Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F Hoyer, Gregor Novljan, Stephen D Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape,

Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13955]

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Successful engraftment of haploidentical stem cell transplant with post-transplantation cyclophosphamide in a patient with adenosine deaminase deficiency.

Diego Medina, Ana M Aristizabal, Tatiana Madroñero, Paola Perez, Jaime Patiño Niño, Manuela Olaya,

<h4>Background</h4>SCID are characterized by an imbalance in cellular and humoral immunity. Enzyme ADA deficiency represents from 10% to 15% of the SCID. This generates diminished maturation of the cell precursors. Treatments include enzyme replacement therapy, allogenic, or autologous HSCT with gene therapy, with HSCT being of choice when an identical ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13954]

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Sequential infection of Epstein-Barr virus and cryptococcal encephalitis after umbilical cord blood transplantation in a child with X-linked adrenoleukodystrophy.

Na Zhang, Kai Chen, Jia-Shi Zhu, Hong Li, Jing-Bo Shao, Hui Jiang,

Dual infection with two pathogens can be found in few cases of encephalitis. Cases of sequential infection with EBV and cryptococcal encephalitis in post-transplant patients are rare. We describe a 5-year-old boy with X-linked adrenoleukodystrophy who presented sequential infection with EBV and cryptococcal encephalitis after umbilical cord blood transplant. The ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13956]

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A case series of medication-related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia.

Bárbara Soldatelli Ballardin, Rafael Zancan Mobile, Fábio Luiz Coracin, Lisandro Lima Ribeiro, Carmem Maria Sales Bonfim, Juliana Lucena Schussel, Cassius Carvalho Torres-Pereira,

Systemic medications categorized as diphenylhydantoin, calcineurin inhibitor and calcium channel blocker may have effects on the oral cavity by modifying the inflammatory and immune response and causing undesired tissue proliferative reactions. Calcineurin inhibitors are medications commonly used for long periods in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) and ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13947]

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Uptake of next-generation sequencing in children with end-stage renal disease secondary to focal segmental glomerulosclerosis and parental decision for kidney transplantation-Experience from a low resource setting: A Retrospective Cohort Study.

Rajiv Sinha, Subhankar Sarkar, Kausik Mandal, Yincent Tse,

<h4>Background</h4>Transplantation is the optimal modality for children with ESRD. High risk of disease recurrence and graft loss with FSGS, and its financial implications, may result in families refusing transplantation. Deceased donation is often preferred for FSGS, but access is limited in many low- and middle-income group countries (LMIC; per capita ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13960]

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Late first acute rejection in pediatric kidney transplantation: A North American Pediatric Renal Trials and Collaborative Studies special study.

Kevin T Barton, Khalif Halani, Shirley Galbiati, Raja Dandamudi, Stanley Paul Hmiel, Vikas R Dharnidharka, ,

Rates of early AR in pediatric kidney transplantation have declined in every era but the most recent NAPRTCS cohort has shown an increase in late first AR rates. We hypothesized this was due to an increased proportion of deceased donor utilization and early steroid taper utilization. Using the NAPRTCS database, ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13953]

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Survivors of allogeneic bone marrow transplants in childhood report no significant long-term respiratory symptoms: A single-center analysis over 20 years.

Jessica Ball, Siona Growcott, Alison Cameron,

Pulmonary toxicity is documented in long-term survivors of allogeneic BMT. No studies have specifically evaluated late pulmonary symptomatology in these patients. 85 long-term pediatric survivors were sent a validated questionnaire of pulmonary symptomatology. Demographic and clinical data were retrospectively collected from the respondents medical records. Response rate was 52.9%. Mean ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13957]

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Risk-adapted therapy for the management of cytokine release syndrome in children undergoing unmanipulated haploidentical stem cell transplantation.

Indira Jayakumar, Ramya Uppuluri, Chidhambharam Lakshmanan, Anand Kumar Gowdhaman, Venkateswaran Vellaichamy Swaminathan, Revathi Raj,

<h4>Background</h4>We aimed to describe an algorithm for the management of cytokine release syndrome (CRS) associated with haploidentical hematopoietic stem cell transplantation (haploSCT).<h4>Patients and methods</h4>We performed a prospective study where children up to 18 years of age undergoing haploSCT with post-transplant cyclophosphamide from September 2014 to March 2020 were included. Supportive care ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13964]

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Fatal Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with virus-infected T cells after pediatric multivisceral transplantation: A proof-of-concept case report.

Masaki Yamada, Seisuke Sakamoto, Kenichi Sakamoto, Hajime Uchida, Seiichi Shimizu, Tomoo Osumi, Motohiro Kato, Kensuke Shoji, Katsuhiro Arai, Osamu Miyazaki, Noriyuki Nakano, Takako Yoshioka, Akinari Fukuda, Mureo Kasahara, Ken-Ichi Imadome,

<h4>Background</h4>EBV-associated HLH driven by EBV-infected CD8<sup>+</sup> T cells is a rare complication after pediatric solid organ transplantation. The etiology and disease spectrum of post-transplant EBV-HLH are poorly understood, and making a precise diagnosis and providing optimal treatment remain a challenge.<h4>Methods/case description/results</h4>We report a 2-year-old multivisceral transplant recipient who developed fever ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13961]

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Promoting bone health in children and adolescents following solid organ transplantation.

Kirstin Kusumi, Ala Shaikhkhalil, Hiren P Patel, John D Mahan,

Solid organ transplantation in children and adolescents provides many benefits through improving critical organ function, including better growth, development, cardiovascular status, and quality of life. Unfortunately, bone status may be adversely affected even when overall status is improving, due to issues with pre-existing bone disease as well as medications and ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13940]

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Percutaneous endovascular management of ascending aortic pseudoaneurysm after heart transplantation in a pediatric patient.

Antonio Skrabonja-Crespo, Fernando Chavarri-Velarde, Miguel Pinto-Salinas, Astrid Tauma-Arrué,

Ascending aortic pseudoaneurysm is a rare complication after HT. Surgery is the most conventional management, but in some patients, it is risky. We report the case of a ten-year-old child who underwent HT and developed an ascending aortic pseudoaneurysm in the aortic anastomosis. He was successfully treated with two covered ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13958]

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Patterns and correlates of preserved humoral immunity to vaccines in children following allogeneic hematopoietic stem cell transplantation.

Eman Al-Antary, Meret Henry, Jessica Spruit, Maxim Yankelevich, Roland Chu, Yaddanapudi Ravindranath, Süreyya Savaşan,

Data on preservation of vaccine immunity following allogeneic HSCT in children is limited. We investigated vaccine titers and sought correlations with patient characteristics in this study. Twenty-eight cases were retrospectively analyzed. Antibody concentrations against hepatitis A, hepatitis B, 3 poliovirus serotypes, tetanus, diphtheria, measles, mumps, rubella, varicella, and 13 pneumococcus ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13936]

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Primary pediatric live-donor-kidney transplant-recipients' outcomes by immunosuppression induction received in the United States.

Samy Riad, Scott Jackson, Srinath Chinnakotla, Priya Verghese,

<h4>Objective</h4>We examined the association between induction type and outcomes of live-donor pediatric kidney recipients on tacrolimus and mycophenolate maintenance.<h4>Material and methods</h4>We analyzed the SRTR standard analysis file to evaluate primary live-donor pediatric kidney recipients between 2000 and 2018. Recipients were grouped by induction type into three groups: alemtuzumab n = 289, anti-thymocyte ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13925]

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Age and sex determine conversion from immediate-release to extended-release tacrolimus in a multi-center cohort of Canadian pediatric renal transplant recipients.

Samantha Lang, Atul Sharma, Beth Foster, Ian W Gibson, Julie Ho, Peter Nickerson, David Wishart, Tom Blydt-Hansen,

ER-Tac, taken once per day, is associated with improved adherence. This study examined the potential patient and clinical factors that influence clinicians to convert pediatric patients from immediate-release to ER-Tac. This prospective multi-center observational study followed Canadian pediatric kidney transplant recipients up to 5 years post-transplant. Cox Proportional Hazards Regression was ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13959]

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Impact of sarcopenia in infants with liver transplantation for biliary atresia.

Masahiro Takeda, Seisuke Sakamoto, Hajime Uchida, Seiichi Shimizu, Yusuke Yanagi, Akinari Fukuda, Shunsuke Nosaka, Mureo Kasahara,

While sarcopenia is an important predictor of LT outcomes in adults, few studies have examined the association of sarcopenia with LT outcomes in pediatric patients. We investigated the clinical influence of sarcopenia on the post-transplant outcomes in infants with BA. To define sarcopenia in infants, the cross-sectional area of the ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13950]

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The extracorporeal circulation with transdiaphragmatic approach in living-donor liver transplantation for HB with atrial extension of tumor thrombus: A case report.

Seiichi Shimizu, Seisuke Sakamoto, Akinari Fukuda, Yusuke Yanagi, Hajime Uchida, Chiaki Baba, Yasuyuki Suzuki, Ryoichi Kondo, Yukihiro Kaneko, Noriyuki Nakano, Chizuko Haga, Takako Yoshioka, Kimikazu Matsumoto, Mureo Kasahara,

Surgical intervention for HB with tumor thrombi extending into the IVC and the RA might requires careful planning of the surgical procedures, including vascular reconstruction and extracorporeal circulation. We herein report a successful case of LDLT for HB with atrial extension of a tumor thrombus by extracorporeal circulation with a ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13948]

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Comparison of pediatric brain-dead donors to donation after circulatory death donors in the United States.

Ahmeneh Ghavam, Nathan E Thompson, Jane Lee,

In pediatrics, an increasing need for transplantable organs exists. This study aimed to describe the epidemiology of pediatric deceased donors in the United States. This retrospective observational study utilized data from the Organ Procurement and Transplantation Network (OPTN) from 2000 to 2015. Patients were stratified based on method of organ ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13926]

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Prognostic factors for survival in children who relapsed after allogeneic hematopoietic stem cell transplantation for acute leukemia.

Volkan Hazar, Gülsün Tezcan Karasu, Gülyüz Öztürk, Alphan Küpesiz, Serap Aksoylar, Namık Özbek, Vedat Uygun, Talia İleri, Fatma Visal Okur, Ülker Koçak, Suar Çakı Kılıç, Arzu Akçay, Elif Güler, Savaş Kansoy, Musa Karakükcü, İbrahim Bayram, Tekin Aksu, Akif Yeşilipek, Barbaros Şahin Karagün, Şebnem Yılmaz, Mehmet Ertem, Duygu Uçkan, Tunç Fışgın, Orhan Gürsel, Yöntem Yaman, Ceyhun Bozkurt, Müge Gökçe, ,

<h4>Background</h4>Post-transplant relapse has a dismal prognosis in children with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Data on risk factors, treatment options, and outcomes are limited.<h4>Procedure</h4>In this retrospective multicenter study in which a questionnaire was sent to all pediatric transplant centers reporting relapse after allo-HSCT for a cohort ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13942]

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