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Journal Pediatr Res

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Recurrent or progressive pediatric brain tumors: population pharmacokinetics and exposure-response analysis of pomalidomide.

Ken Ogasawara, Nastya Kassir, Xiaomin Wang, Bouchra Benettaib, Simon Zhou, Maria Palmisano, Yan Li,

<h4>Background</h4>Pomalidomide, an immunomodulatory drug, was investigated for pediatric brain tumors. The objectives of this analysis were to characterize the PK of pomalidomide and to examine exposure-response relationship in pediatric patients with recurrent or progressive primary brain tumors.<h4>Methods</h4>Nonlinear mixed effects modeling was employed in developing a population PK model of pomalidomide ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Bilirubin/albumin (B/A) ratios correlate with unbound bilirubin levels in preterm infants.

Shinya Abe, Kazumichi Fujioka, Ruka Nakasone, Shutaro Suga, Mariko Ashina, Kosuke Nishida, Ronald J Wong, Kazumoto Iijima,

<h4>Background</h4>A strong correlation between the bilirubin/albumin (B/A) ratio and unbound bilirubin (UB) levels in newborns ≥35 weeks of gestation has been reported. However, in preterm infants, the usefulness of B/A ratios remains unclear.<h4>Methods</h4>We obtained serum from 381 newborns <35 weeks of gestation. UB levels were measured using the glucose oxidase-peroxidase ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Daily physical activity patterns in children and adolescents with inflammatory bowel disease.

Jérémy Vanhelst, Laurent Béghin, Dominique Turck, Julien Labreuche, Stéphanie Coopman, Frédéric Gottrand, Delphine Ley,

<h4>Background</h4>The aim of this study was to assess PA patterns among children and adolescents with inflammatory bowel disease (IBD).<h4>Methods</h4>Sixty participants with IBD (42 Crohn's disease [CD], 10 ulcerative colitis [UC], and 8 IBD-unclassified [IBD-U], 30 male patients) in remission (n = 45) or with mild disease (n = 15) were compared with 60 healthy ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Evaluation of angiogenic signaling molecules associated with reactive thrombocytosis in an iron-deficient rat model.

Jessica Garcia, Peggy Mankin, Manu Gnanamony, Pedro A de Alarcon,

<h4>Background</h4>Iron deficiency anemia (IDA)-induced reactive thrombocytosis can occur in children and adults. The underlying mechanism for this phenomenon is indeterminate. Traditional cytokines such as thrombopoietin (TPO), interleukin-6 (IL-6), and IL-11 involved in megakaryopoiesis have not been shown to be the cause. Recent studies suggest that growth factors and signaling molecules ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Cerebellar volumes and language functions in school-aged children born very preterm.

Lottie W Stipdonk, Marlijne Boumeester, Kay J Pieterman, Marie-Christine J P Franken, Joost van Rosmalen, Irwin K Reiss, Jeroen Dudink,

<h4>Background</h4>Volumes of cerebellar posterior lobes have been associated with cognitive skills, such as language functioning. Children born very preterm (VPT) often have language problems. However, only total cerebellar volume has been associated with language functioning, with contradicting results. The objective of this study was to ascertain whether total cerebellar structures ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Maternal antibiotic exposure disrupts microbiota and exacerbates hyperoxia-induced lung injury in neonatal mice.

Chung-Ming Chen, Yu-Chen S H Yang, Hsiu-Chu Chou,

<h4>Background</h4>Perinatal antibiotic treatment alters intestinal microbiota and augments hyperoxia-induced lung injury in mice offspring. The effect of maternal antibiotic treatment (MAT) during pregnancy on the lung microbiota and its relationship with lung injury remains unknown.<h4>Methods</h4>We fed timed-pregnant C57BL/6N mice sterile drinking water containing antibiotics from gestational day 15 to delivery. ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Neuroimaging and neurodevelopmental outcome after early fetal growth restriction: NEUROPROJECT-FGR.

Gloria Brembilla, Andrea Righini, Barbara Scelsa, Gianluca Lista, Marina Balestriero, Elena Cesari, Francesca Maria Castoldi, Martina Di Stasi, Chiara Ciardi, Elisa Ligato, Emanuela Taricco, Irene Cetin,

<h4>Background</h4>Adverse neurodevelopmental outcomes and MRI alterations are reported in infants born after fetal growth restriction (FGR). This study evaluates the additional role of FGR over prematurity in determining brain impairment.<h4>Methods</h4>Retrospective observational study comparing 48 FGR and 36 appropriate for gestational age infants born between 26 and 32 weeks' gestation who ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Continuous chest compressions with asynchronous ventilations increase carotid blood flow in the perinatal asphyxiated lamb model.

Payam Vali, Amy Lesneski, Morgan Hardie, Ziad Alhassen, Peggy Chen, Houssam Joudi, Deepika Sankaran, Satyan Lakshminrusimha,

<h4>Background</h4>The neonatal resuscitation program (NRP) recommends interrupted chest compressions (CCs) with ventilation in the severely bradycardic neonate. The conventional 3:1 compression-to-ventilation (C:V) resuscitation provides 90 CCs/min, significantly lower than the intrinsic newborn heart rate (120-160 beats/min). Continuous CC with asynchronous ventilation (CCCaV) may improve the success of return of spontaneous ... Read more >>

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[2021, :]

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Improving care for adolescents with substance use disorder: more than screening.

Zachary W Adams, Scott C Denne, ,

Pediatr Res (Pediatric research)
[2021, :]

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Early Career Investigator: Biocommentary.

Shina Menon,

Pediatr Res (Pediatric research)
[2021, :]

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Lung function between 8 and 15 years of age in very preterm infants with fetal growth restriction.

Michele Arigliani, Chiara Stocco, Elena Valentini, Carlo De Pieri, Luigi Castriotta, Maria Elena Ferrari, Cristina Canciani, Lorenza Driul, Maria Orsaria, Luigi Cattarossi, Paola Cogo,

<h4>Background</h4>The impact of intrauterine growth restriction (IUGR) on lung function in very preterm children is largely unknown as current evidence is mainly based on studies in children born small for gestational age but not necessarily with IUGR.<h4>Methods</h4>Spirometry, transfer factor of the lung for carbon monoxide (TLco), and lung clearance index ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Transcutaneous carbon dioxide pattern and trend over time in preterm infants.

Katherine P Sullivan, Heather O White, Lindsay E Grover, Jordi J Negron, Austin F Lee, Lawrence M Rhein,

<h4>Background</h4>Chronic lung disease remains a burden for extremely preterm infants. The changes in ventilation over time and optimal ventilatory management remains unknown. Newer, non-invasive technologies provide insight into these patterns.<h4>Methods</h4>This single-center prospective cohort study enrolled infants ≤32 0/7 weeks. We obtained epochs of transcutaneous carbon dioxide (TcCO<sub>2</sub>) measurements twice each ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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The TGF-β1 pathway is early involved in neurogenic bladder fibrosis of juvenile rats.

Yan Chen, Yuan Ma, Yulin He, Dong Xing, Erpeng Liu, Xinghuan Yang, Wen Zhu, Qingwei Wang, Jian Guo Wen,

<h4>Background</h4>This study investigated whole neurogenic bladder's progression changes, as well as the expression of TGF-β1 fibrosis pathway-related proteins in bilateral spinal nerve-amputated juvenile rats.<h4>Methods</h4>Sixty-four 8-week-old rats (32 bilateral L6 + S1 spinal nerve amputated and 32 sham operated) were selected. Cystometry was performed. General assessments, Masson, Sirius red, immunohistochemical staining, and western ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Perspectives from the Society for Pediatric Research: advice on sustaining science and mentoring during COVID-19.

Catherine S Forster, Suong T Nguyen, Weston T Powell, Daniel J Moore, Jacqueline Ho, Melvin B Heyman, Tara L Wenger, Fernando Gonzalez, Margaret Hostetter, Andrew Nowalk, Caroline E Rassbach, Debra Boyer, Pnina Weiss, Rebecca L Blankenburg, Jordan S Orange, Kate G Ackerman, Audrea M Burns, ,

The COVID-19 pandemic will leave an indelible mark on the careers of current medical trainees. Given the disruptions to medical education, economic impact on institutions, and the uncertainties around future job prospects, trainees are facing unprecedented challenges. This situation is especially concerning for futures of pediatric physician-scientist trainees, where concerns ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Cannabis use and measurement of cannabinoids in plasma and breast milk of breastfeeding mothers.

Michael J Moss, Ittai Bushlin, Steven Kazmierczak, Dennis Koop, Robert G Hendrickson, Katharine E Zuckerman, Tamara M Grigsby,

<h4>Background</h4>Information on cannabinoids in breast milk and maternal cannabis use is limited. We quantified cannabinoids in plasma and breast milk of breastfeeding mothers and assessed cannabis use patterns.<h4>Methods</h4>This is a prospective study at a university hospital in a state with legal medical and recreational cannabis. Breast milk and plasma samples ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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The cerebellum's role in neonatal brain injury.

Lina Chalak,

Pediatr Res (Pediatric research)
[2021, :]

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Necrotizing enterocolitis intestinal barrier function protection by antenatal dexamethasone and surfactant-D in a rat model.

Lei Lu, Jing Lu, Yueyue Yu, Erika Claud,

<h4>Background</h4>Necrotizing enterocolitis (NEC) is the most common gastrointestinal disorder in premature neonates. Possible therapeutic approaches are centered on promoting maturation of the gastrointestinal mucosal barrier. Studies have demonstrated that antenatal administration of corticosteroids can decrease NEC incidence and mortality.<h4>Methods</h4>Pregnant rat dams were administered dexamethasone 48 h prior to delivery. The pups ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Blood metabolomics in infants enrolled in a dose escalation pilot trial of budesonide in surfactant.

Philip L Ballard, Dara Torgerson, Rajan Wadhawan, Mark L Hudak, Joern-Hendrik Weitkamp, Julia Harris, Jeanette Asselin, Cheryl Chapin, Roberta A Ballard, Cindy T McEvoy,

<h4>Background</h4>The pathogenesis of BPD includes inflammation and oxidative stress in the immature lung. Corticosteroids improve respiratory status and outcome, but the optimal treatment regimen for benefit with low systemic effects is uncertain.<h4>Methods</h4>In a pilot dose escalation trial, we administered ≤5 daily doses of budesonide in surfactant to 24 intubated premature ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Combating racism: the role of the pediatrician.

Andrea J Matthew, Marie A Clark, Lolita M McDavid,

Pediatr Res (Pediatric research)
[2021, :]

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Dendritic cells and monocyte subsets in children with Gaucher disease.

Asmaa M Zahran, Khaled Saad, Alam-Eldin M Abdallah, Eman F Gad, Yasser F Abdel-Raheem, Zeinab Albadry M Zahran, Eman M Nagiub Abdelsalam, Amira Elhoufey, Thamer Alruwaili, Khaled Hashim Mahmoud, Khalid I Elsayh,

<h4>Background</h4>There are minimal data on the frequencies of monocyte subsets and dendritic cells (DCs) in children with Gaucher disease (GD), as nearly all previous studies have involved adult patients. Consequently, we aimed to describe the changes in these cell subpopulations in children with GD type 1 who were on regular ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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The social ecology of childhood and early life adversity.

Marcela Lopez, Monica O Ruiz, Cynthia R Rovnaghi, Grace K-Y Tam, Jitka Hiscox, Ian H Gotlib, Donald A Barr, Victor G Carrion, Kanwaljeet J S Anand,

An increasing prevalence of early childhood adversity has reached epidemic proportions, creating a public health crisis. Rather than focusing only on adverse childhood experiences (ACEs) as the main lens for understanding early childhood experiences, detailed assessments of a child's social ecology are required to assess "early life adversity." These should ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Investing in mentorship for our future patients' needs.

Alex R Kemper, Rebecca G Wallihan,

Pediatr Res (Pediatric research)
[2021, :]

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Passive acute kidney injury alerts: less is not more.

Erika R OʼNeil, Ayse Akcan Arikan, Gregory J Buffone, Laura L Loftis, Andrea T Cruz, Sridevi Devaraj,

Pediatr Res (Pediatric research)
[2021, :]

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Gut priming with bovine colostrum and T regulatory cells in preterm neonates: a randomized controlled trial.

Rania I H Ismail, Hisham A Awad, Safaa S Imam, Ghada I Gad, Nancy M Aboushady, Rania M Abdou, Deena S Eissa, Nesmahar T Azzam, Maha M Barakat, Mostafa M Yassin, Noha M Barakat,

<h4>Background</h4>Necrotizing enterocolitis (NEC) and neonatal sepsis are still considered major problems, especially in formula-fed preterm neonates. This study aimed to investigate the effect of bovine colostrum on T regulatory cells, NEC, and late-onset sepsis in preterm neonates ≤34 weeks.<h4>Methods</h4>This prospective double-blind randomized controlled trial was conducted on 80 preterm infants ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Alternative pediatric metabolic syndrome definitions impact prevalence estimates and socioeconomic gradients.

Alexander Lepe, Marlou L A de Kroon, Andrea F de Winter, Sijmen A Reijneveld,

<h4>Background</h4>There is no consensus regarding the definition of pediatric metabolic syndrome (MetS). This study assessed the impact of alternative definitions on the prevalence, children identified, and association with socioeconomic status (SES).<h4>Methods</h4>Data were from the prospective multigenerational Dutch Lifelines Cohort Study. At baseline, 9754 children participated, and 5085 (52.1%) with average ... Read more >>

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[2021, :]

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