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Journal Pediatr Dermatol

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Multidisciplinary management of a previously unreported presentation of severe aplasia cutis congenita.

Matthew J Davis, Lindsey M Voller, Santiago R Gonzalez, Amjed Abu-Ghname, Lesley W Davies, Joshua R Bedwell, Grace L Lee, Raegan D Hunt, Thuy L Phung, Edward P Buchanan,

Aplasia cutis congenita (ACC) is characterized by the complete or partial absence of skin at birth, with 85% of cases of ACC involving the scalp vertex. The etiology of ACC is unclear and appears to be multifactorial. We present the case of a 3-month-old boy who presented with a diagnosis ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Penile and scrotal infundibular cysts in an adolescent treated with sorafenib.

Ana Mateos-Mayo, Isabel Colmenero, Mar Ramírez-Lluch, Luisa Martos-Cabrera, Ángela Hernández-Martín, Antonio Torrelo,

Sorafenib is a multikinase inhibitor increasingly used for the treatment of several solid tumors. Different types of keratotic lesions, such as squamous cell carcinoma, actinic keratosis, or infundibular cyst, have been reported in association with this therapy. We present a 15-year-old male diagnosed with desmoid fibromatosis who developed multiple penile ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Nevus comedonicus syndrome: A systematic review of the literature.

Daniele Torchia,

Nevus comedonicus (NC) syndrome is a condition first identified in 1978. The cause of NC syndrome has been recently proven to be a gain-of-function, mosaic postzygotic mutation of the NEK9 gene. A systematic review of the literature retrieved 43 well-established cases of NC syndrome reported so far. Three morphological variants ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Toxic erythema of chemotherapy affecting the ears of an infant: A case report.

Shant Tamazian, Michelle Oboite, Mary Larijani, Brittany Oliver, Heather Milbar, Melinda Jen, James R Treat,

A 15-month-old boy presented with new onset symmetric erythema of the conchal bowls bilaterally in the setting of treatment with cytarabine. Findings were consistent with a diagnosis of toxic erythema of chemotherapy, an adverse effect of chemotherapy. In this report, we detail this uncommon manifestation in a young child along ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Epidermolysis bullosa simplex due to bi-allelic DST mutations: Case series and review of the literature.

Dalit Ganani, Kiril Malovitski, Ofer Sarig, Andrea Gat, Eli Sprecher, Liat Samuelov,

<h4>Background</h4>Epidermolysis bullosa simplex (EBS) is a heterogeneous group of inherited disorders characterized by skin fragility due to intraepidermal separation. Most cases result from heterozygous mutations in KRT5 or KRT14; however, a minority of affected individuals carry mutations in non-keratin genes including DST encoding an epithelial isoform of dystonin. DST-associated EBS ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Atypical aplasia cutis in association with Xia Gibbs syndrome.

Carter Ellis, Gurpur Shashidhar Pai, Lara Wine Lee,

Xia Gibbs syndrome is a genetic disorder first defined in 2014 characterized by hypotonia, intellectual disability, global developmental delay, and dysmorphic facial features. While many additional features may be present, there are few reports of dermatologic findings. We report a case of atypical aplasia cutis in a female infant who ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Fingernail onychomycosis caused by Microsporum canis in a teenager.

Pichaya Limphoka, Sumanas Bunyaratavej, Charussri Leeyaphan,

A healthy 15-year-old girl presented with a total dystrophic nail plate and subungual hyperkeratosis over her left 3rd fingernail. Her 2-year-old shorthair cat had circular erythematous patches of alopecia on the left aspect of its forehead. Fungal culture from the affected nail and her cat both grew Microsporum canis. The ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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In Memoriam.

Elena Pope,

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Clinical characteristics and management of clinically amyopathic juvenile dermatomyositis across four academic centers.

Flora Bradley, Michelle L Bayer, Dominic O Co, Yvonne Chiu, Adam M Huber, Regina-Celeste Ahmad, Hatice E Baris, Edward J Oberle, Susan Kim,

<h4>Background/objectives</h4>Clinically amyopathic juvenile dermatomyositis (CAJDM) is an uncommon but important subset of patients with juvenile dermatomyositis, characterized by pathognomonic cutaneous findings without clinically evident muscle weakness. With limited data available and lack of standardized management guidelines for CAJDM, we sought to describe common features, including early indicators that may be ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Readability of online patient education materials for juvenile dermatomyositis.

Melissa A Nickles, Santhoshini L Ramani, Kyle Tegtmeyer, Jeffrey Zhao, Peter A Lio,

In this study, we sought to analyze the readability of online patient education materials (PEMs) related to juvenile dermatomyositis (JDM). We analyzed the top 100 Google results and using six different readability scores, found 53 PEMs which had an average grade reading level of 17.4 (graduate level). PEMs by health ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Acute urticaria preceding other COVID-19-associated manifestations-A case report.

Vivien Chen, Julia Escandon Brehm, Fernanda Bellodi Schmidt,

The novel coronavirus SARS-CoV-2 has been associated with a variety of dermatologic manifestations, often the predominant finding in otherwise asymptomatic or oligosymptomatic patients. Urticarial eruption is one example, but few cases have been reported among pediatric patients. We present a case of acute urticaria in a 6-month-old boy preceding other ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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New-onset head and neck dermatitis in adolescent patients after dupilumab therapy for atopic dermatitis.

Christina E Bax, Michele C Khurana, James R Treat, Leslie Castelo-Soccio, Adam I Rubin, Patrick J McMahon,

<h4>Background/objectives</h4>Head and neck dermatitis after dupilumab therapy for atopic dermatitis has been frequently reported in adults and only rarely in adolescents. No cases detailing disease course and treatment response have previously been described in adolescents.<h4>Methods/results</h4>This case series presents five adolescent patients who developed new-onset or worsening head and neck dermatitis ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Nodular fasciitis on the cheek of a child.

Deep Patel, Thomas D Samson, Eric L Cochran, Andrea L Zaenglein,

Nodular fasciitis is a benign proliferation of myofibroblastic cells affecting subcutaneous tissue, muscles, and fascia. This rare disorder is most commonly observed on the upper extremity of adults. We present a case of nodular fasciitis of the cheek of a 12-year-old girl. ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Fatal GNAQ-mutated CNS melanoma in an adolescent with nevus of Ota.

Andrew R Blundell, Danna Moustafa, Wesley R Samore, Elena B Hawryluk,

Nevus of Ota is an uncommon benign mesodermal melanosis that involves the first and second divisions of the trigeminal nerve. Primary non-cutaneous melanoma often involves distinct genetic mutations compared to cutaneous melanoma. In primary central nervous system (CNS) melanomas associated with nevus of Ota, somatic mutations most commonly occur at ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Chronic urticaria in children under 15 years of age: Clinical experience beyond the clinical trials.

Oriol Corral-Magaña, José Antonio Gil-Sánchez, Catalina Bover-Bauzá, Patricia Martinez-Cepas, María Concepción Montis-Palos, Ana Martín-Santiago,

<h4>Background/objectives</h4>The aim of the study was to describe the clinical characteristics, management, and outcome of a series of children with chronic urticaria (CU).<h4>Methods</h4>We retrospectively studied children aged <15 years diagnosed with CU in a tertiary teaching hospital in Palma de Mallorca, Spain, between January 2014 and March 2019. CU was defined ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Pigmented purpuric dermatosis in an infant.

Luisa Martos-Cabrera, Pablo López-Balboa, Mar Ramírez-Lluch, Isabel Colmenero, Ana Mateos-Mayo, Antonio Torrelo, Ángela Hernández-Martin,

Pigmented purpuric dermatoses (PPDs) are a group of idiopathic, chronic, and self-resolving conditions easily recognizable in adults but extremely uncommon in infants. We present the youngest patient with PPD reported to date. ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Long-term sirolimus treatment in blue rubber bleb nevus syndrome: Case report and review of the literature.

Doris Weiss, Anne Teichler, Peter H Hoeger,

Blue rubber bleb nevus syndrome is a rare vascular syndrome characterized by continuous eruption of vascular nodules in the skin, mucous membranes, and solid organs due to somatic activating mutations of the angiopoietin receptor TEK gene. It may be complicated by acute life-threatening hemorrhage and localized intravascular coagulation. We report ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, :]

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Ecthyma gangrenosum: The critical role of biofilms and other mechanisms of antibiotic resistance and implications for management.

Kristen Russomanno, Michael Cardis, Anna Yasmine Kirkorian,

Ecthyma gangrenosum is a rare cutaneous infection that occurs classically in immunocompromised patients with Pseudomonas aeruginosa bacteremia and is associated with a high mortality rate. Causative pathogens may exhibit various antibiotic evasion mechanisms, and thus, treatment may be challenging. We present a case of ecthyma gangrenosum in association with an ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Assessing vaccination reactions in pediatric patients with maculopapular cutaneous mastocytosis.

Maija L Johansen, Leslie P Lawley,

Immunization compliance in the United States is declining, in part due to misinformation and fear surrounding adverse vaccination reactions. Recently, there have been data published in the allergy and immunology literature to show that there may be a relationship between routine vaccinations and induction of symptoms in cutaneous mastocytosis patients; ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2021, :]

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Cutaneous reactions to pediatric cancer treatment part II: Targeted therapy.

Valerie M Carlberg, Olivia M T Davies, Heather A Brandling-Bennett, Sarah E S Leary, Jennifer T Huang, Carrie C Coughlin, Deepti Gupta,

Cancer remains a leading cause of morbidity and mortality among children. Targeted therapies may improve survivorship; however, unique side-effect profiles have also emerged with these novel therapies. Changes in hair, skin, and nails-termed dermatologic adverse events (AEs)-are among the most common sequelae and may result in interruption or discontinuation of ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, :]

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Nevocentric erythema multiforme in a child.

Eugenia Veronica Di Brizzi, Federico Tartari, Federica Filippi, Annalucia Virdi, Carlotta Gurioli, Iria Neri,

A 9-year-old girl presented with multiple, ring-shaped, erythematous, nonscaly plaques on the trunk, face and arms, most surrounding preexisting melanocytic nevi. She had experienced recurring episodes of herpes simplex labialis over several years (average 4/year), the last occurring 10 days prior. ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, :]

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Autoimmune progesterone dermatitis in the adolescent population.

Nessa Aghazadeh, Asma J Chattha, Martha F Hartz, Dawn Marie R Davis,

<h4>Background/objective</h4>Autoimmune progesterone dermatitis (APD) is a rare autoimmune hypersensitivity reaction that occurs cyclically at the peak of endogenous progesterone production during the menstrual cycle in women. No study characterizing APD in the adolescent population is found; it appears likely to be underdiagnosed and undertreated.<h4>Methods</h4>A retrospective, single-center, review of all adolescent ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, :]

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Adverse cutaneous effects of mitogen-activated protein kinase inhibitors in children.

Victoria Lucia Dávila Osorio, María Asunción Vicente, Eulalia Baselga, Hector Salvador, Ofelia Cruz, Carolina Prat,

<h4>Background</h4>Mitogen-activated protein kinase inhibitors (MEKi) are currently used for the treatment of central nervous system tumors in children and have shown promising results. Cutaneous adverse effects are among the most common toxicities described in adults, but few studies exist in pediatric patients.<h4>Objective</h4>We aimed to describe the cutaneous adverse effects associated ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, :]

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Light-based treatment of pediatric port-wine birthmarks.

Jennifer M Tran, Kristen M Kelly, Beth A Drolet, Andrew C Krakowski, Lisa M Arkin,

Port-wine birthmarks (PWBs) are progressive vascular malformations with significant disfigurement and psychosocial morbidity; early light-based treatment has shown improved outcomes in the pediatric population. Somatic mosaic mutations underly the progressive nature of PWBs and explain the significant differences in response and heterogeneity of vessel architecture in the pediatric population when ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, :]

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Disparities in telemedicine access for Spanish-speaking patients during the COVID-19 crisis.

Andrew R Blundell, Daniela Kroshinsky, Elena B Hawryluk, Shinjita Das,

The rapid rise of telemedicine during the COVID-19 pandemic raised the prospect of worsening health care disparities for vulnerable populations. We retrospectively compared pediatric teledermatology visits scheduled during the pandemic (03/17/2020-07/31/2020) with in-person appointments scheduled during the same period in 2019 and found that Spanish-speaking patients had significantly fewer scheduled ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, :]

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