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Journal Pediatr Crit Care Med

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A Framework for Pediatric Intensivists Providing Compassionate Extubation at Home.

Alan G Woodruff, Sarah B Bingham, Rima J Jarrah, Andora L Bass, Savithri Nageswaran,

For families facing end-of-life decisions for their critically ill children, compassionate extubation at home is a valuable service that pediatric intensivists can provide. Compassionate extubation at home is resource intensive and can be logistically challenging. Discouragingly, guidance on compassionate extubation at home in the literature is limited. We developed an ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, :]

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Hyperoxia During Cardiopulmonary Bypass Is Associated With Mortality in Infants Undergoing Cardiac Surgery.

Asaad G Beshish, Ozzie Jahadi, Ashley Mello, Vamsi V Yarlagadda, Andrew Y Shin, David M Kwiatkowski,

<h4>Objectives</h4>Patients undergoing cardiac surgery using cardiopulmonary bypass have variable degrees of blood oxygen tension during surgery. Hyperoxia has been associated with adverse outcomes in critical illness. Data are not available regarding the association of hyperoxia and outcomes in infants undergoing cardiopulmonary bypass. We hypothesize that among infants undergoing cardiac surgery, ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, :]

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Intraosseous or Peripheral Intravenous Access in Pediatric Cardiac Arrest? Results From the French National Cardiac Arrest Registry.

Morgan Recher, Valentine Baert, Joséphine Escutnaire, Quentin Le Bastard, François Javaudin, Hervé Hubert, Stéphane Leteurtre,

<h4>Objectives</h4>Despite the evolving recommendations that favor the use of intraosseous access in pediatric resuscitation, the impact of vascular access type on survival in young children has not been demonstrated. The aim of this study was to assess the impact of the intravascular injection route on the return on spontaneous circulation, ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, Publish Ahead of Print:]

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Caring for Critically Ill Children With Coronavirus Disease 2019: Uncharted Territory and Fuzzy Maps.

Niranjan Kissoon,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):127-130]

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Hemophagocytic Lymphohistiocytosis in a PICU of a Developing Economy: Clinical Profile, Intensive Care Needs, Outcome, and Predictors of Mortality.

Biraj Parajuli, Suresh Kumar Angurana, Puspraj Awasthi, Karthi Nallasamy, Arun Baranwal, Arun Bansal, Deepak Bansal, Amit Rawat, Neelam Varma, Muralidharan Jayashree,

<h4>Objectives</h4>To describe the clinical profile, intensive care needs, outcome, and predictors of mortality in critically ill children with hemophagocytic lymphohistiocytosis.<h4>Design</h4>Retrospective case series.<h4>Setting</h4>PICU of a tertiary care teaching hospital in North India.<h4>Patients</h4>Children 2 months to 12 years old with the diagnosis of hemophagocytic lymphohistiocytosis admitted to PICU from January 2012 to ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):e44-e57]

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The Relationship Between Preoperative Feeding Exposures and Postoperative Outcomes in Infants With Congenital Heart Disease.

Jasmeet Kataria-Hale, Acacia Cognata, Joseph Hagan, Jill Zender, Paige Sheaks, Scott Osborne, Jeramy Roddy, Amy Hair,

<h4>Objectives</h4>To evaluate the association of preoperative risk factors and postoperative outcomes in infants with complex congenital heart disease.<h4>Design</h4>Single-center retrospective cohort study.<h4>Setting</h4>Neonatal ICU and cardiovascular ICU.<h4>Patients</h4>Infants of all gestational ages, born at Texas Children's Hospital between 2010 and 2016, with complex congenital heart disease requiring intervention prior to discharge.<h4>Interventions</h4>None.<h4>Measurements and main ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):e91-e98]

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Biomarkers for Estimating Risk of Hospital Mortality and Long-Term Quality-of-Life Morbidity After Surviving Pediatric Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation Investigation.

Hector R Wong, Ron W Reeder, Russell Banks, Robert A Berg, Kathleen L Meert, Mark W Hall, Patrick S McQuillen, Peter M Mourani, Ranjit S Chima, Samuel Sorenson, James W Varni, Julie McGalliard, Jerry J Zimmerman, ,

<h4>Objectives</h4>The Life After Pediatric Sepsis Evaluation investigation recently reported that one-third of children who survive sepsis experience significant health-related quality-of-life impairment compared with baseline at 1 year after hospitalization. Pediatric Sepsis Biomarker Risk Model is a multibiomarker tool for estimating baseline risk of mortality among children with septic shock. We ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):8-15]

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Pediatric Sepsis Biomarker Risk Model With Outcome After PICU Discharge: A Strong Research Tool, but Let Us Not Forget Composite Prognostic Factors!

Stéphane Leteurtre, Morgan Recher,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):125-127]

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Prevalence of ICU Delirium in Postoperative Pediatric Cardiac Surgery Patients.

Sandra L Staveski, Rita H Pickler, Philip R Khoury, Nicholas J Ollberding, Amy L Donnellan, Jennifer A Mauney, Patricia A Lincoln, Jennifer D Baird, Frances L Gilliland, Amber D Merritt, Laura B Presnell, Alexa R Lanese, Amy Jo Lisanti, Belinda J Large, Lori D Fineman, Katherine H Gibson, Leigh A Mohler, Louise Callow, Sean S Barnes, Ruby L Whalen, Mary Jo C Grant, Cathy Sheppard, Andrea M Kline-Tilford, Page W Steadman, Heidi C Shafland, Karen M Corlett, Serena P Kelly, Laura A Ortman, Christine E Peyton, Sandra K Hagstrom, Ashlee M Shields, Tracy Nye, T Christine E Alvarez, Lindsey B Justice, Seth T Kidwell, Andrew N Redington, Martha A Q Curley,

<h4>Objectives</h4>The objective of this study was to determine the prevalence of ICU delirium in children less than 18 years old that underwent cardiac surgery within the last 30 days. The secondary aim of the study was to identify risk factors associated with ICU delirium in postoperative pediatric cardiac surgical patients.<h4>Design</h4>A ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):68-78]

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Serum Amylase and Lipase for the Prediction of Pancreatic Injury in Critically Ill Children Admitted to the PICU.

Pingping Liu, Zhenghui Xiao, Haipeng Yan, Xiulan Lu, Xinping Zhang, Lan Luo, Caixia Long, Yimin Zhu,

<h4>Objectives</h4>Pancreatic injury is multifactorial and potentially devastating for critically ill children. We aimed to evaluate whether serum amylase and lipase among critically ill children could serve as an independent biomarker to predict pancreatic injury.<h4>Design</h4>Retrospective cohort.<h4>Setting</h4>PICU of a tertiary, pediatric medical center.<h4>Patients</h4>Seventy-nine autopsies.<h4>Interventions</h4>None.<h4>Measurements and main results</h4>A group of 79 children who ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):e10-e18]

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Functional Outcomes at 1 Year After PICU Discharge in Critically Ill Children With Severe Sepsis.

Jhuma Sankar, Sravanthi Moodu, Kiran Kumar, M Jeeva Sankar, Sushil K Kabra, Rakesh Lodha,

<h4>Objectives</h4>To evaluate the functional outcomes in critically ill children with severe sepsis using the Pediatric Overall Performance Category scale and Pediatric Cerebral Performance Category scale and to evaluate the risk factors for "worse outcomes."<h4>Design</h4>Prospective observational cohort study.<h4>Setting</h4>Tertiary care PICU from September 2017 to October 2019.<h4>Patients</h4>One hundred twenty-one children with severe ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):40-49]

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Early Use of Antiseizure Medication in Mechanically Ventilated Traumatic Brain Injury Cases: A Retrospective Pediatric Health Information System Database Study.

Kelly D Haque, Zachary M Grinspan, Elizabeth Mauer, Marianne E Nellis,

<h4>Objectives</h4>Traumatic brain injury is a leading cause of morbidity and mortality in children. Post-traumatic seizures occur in 25% of children with severe traumatic brain injury and may worsen outcomes. Our objective was to use a retrospective cohort study to examine the association between the early seizure occurrence and the choice ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):90-100]

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Caring for Critically Ill Children With Suspected or Proven Coronavirus Disease 2019 Infection: Recommendations by the Scientific Sections' Collaborative of the European Society of Pediatric and Neonatal Intensive Care.

Peter C Rimensberger, Martin C J Kneyber, Akash Deep, Mehak Bansal, Aparna Hoskote, Etienne Javouhey, Gilles Jourdain, Lynne Latten, Graeme MacLaren, Luc Morin, Marti Pons-Odena, Zaccaria Ricci, Yogen Singh, Luregn J Schlapbach, Barnaby R Scholefield, Ulrich Terheggen, Pierre Tissières, Lyvonne N Tume, Sascha Verbruggen, Joe Brierley, ,

<h4>Objectives</h4>In children, coronavirus disease 2019 is usually mild but can develop severe hypoxemic failure or a severe multisystem inflammatory syndrome, the latter considered to be a postinfectious syndrome, with cardiac involvement alone or together with a toxic shock like-presentation. Given the novelty of severe acute respiratory syndrome coronavirus 2, the ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):56-67]

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Association of Acute Kidney Injury With Subsequent Sepsis in Critically Ill Children.

Cassandra L Formeck, Emily L Joyce, Dana Y Fuhrman, John A Kellum,

<h4>Objectives</h4>Acute kidney injury is a major cause of morbidity and mortality in critically ill children. A growing body of evidence has shown that acute kidney injury affects immune function, yet little is known about the association between acute kidney injury and subsequent infection in pediatric patients. Our objective was to ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):e58-e66]

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Out-of-Hospital Cardiac Arrest-Is International Agreement on Guidelines for Limits of Treatment Possible?

Warwick Butt, Anna Butlinski,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):130-132]

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Pediatric Critical Care Medicine 2021: The Five Rs.

Robert C Tasker,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):1-2]

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Hemodynamic Response to Fluid Boluses for Hypotension in Children in a Cardiac ICU.

Ben Gelbart, Anatole Harrois, Lauren Gardiner, Cherie Mcgregor, Laurent Bitker, Eva Van Zanten, Emma Beel, Rinaldo Bellomo, Trevor Duke, Warwick Butt,

<h4>Objectives</h4>To describe the hemodynamic response to fluid boluses for hypotension in children in a cardiac ICU.<h4>Design</h4>A prospective, observational study.<h4>Setting</h4>Single-centered cardiac ICU.<h4>Patients</h4>Children in a cardiac ICU with hypotension.<h4>Interventions</h4>Clinician prescribed fluid bolus.<h4>Measurements and main results</h4>Sixty-four fluid boluses were administered to 52 children. Fluid composition was 4% albumin in 36/64 (56%), 0.9% saline ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):79-89]

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Development and Validation of a Model to Predict Pediatric Septic Shock Using Data Known 2 Hours After Hospital Arrival.

Halden F Scott, Kathryn L Colborn, Carter J Sevick, Lalit Bajaj, Sara J Deakyne Davies, Diane Fairclough, Niranjan Kissoon, Allison Kempe,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):16-26]

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Timing and Cause of Death in Children Following Return of Circulation After Out-of-Hospital Cardiac Arrest: A Single-Center Retrospective Cohort Study.

Maayke Hunfeld, Vinay M Nadkarni, Alexis Topjian, Jasmijn Harpman, Dick Tibboel, Joost van Rosmalen, Matthijs de Hoog, Coriene E Catsman-Berrevoets, Corinne M P Buysse,

<h4>Objectives</h4>To determine timing and cause of death in children admitted to the PICU following return of circulation after out-of-hospital cardiac arrest.<h4>Design</h4>Retrospective observational study.<h4>Setting</h4>Single-center observational cohort study at the PICU of a tertiary-care hospital (Erasmus MC-Sophia, Rotterdam, The Netherlands) between 2012 and 2017.<h4>Patients</h4>Children younger than 18 years old with out-of-hospital cardiac ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):101-113]

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Shock Index, Coronary Perfusion Pressure, and Rate Pressure Product As Predictors of Adverse Outcome After Pediatric Cardiac Surgery.

Jonathon A Hagel, Francesca Sperotto, Peter C Laussen, Joshua W Salvin, Akash Bachu, John N Kheir,

<h4>Objectives</h4>To determine whether shock index, coronary perfusion pressure, or rate pressure product in the first 24 hours after congenital heart surgery are independent predictors of subsequent clinically significant adverse outcomes.<h4>Design</h4>A retrospective cohort study.<h4>Setting</h4>A tertiary care center.<h4>Patients</h4>All patients less than 18 years old who underwent cardiac surgery at Boston Children's Hospital ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):e67-e78]

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Dr. Patrick Kochanek: A "Wild Ride" Olé!… 20 Years of Editorial Genius, Drive, and Vision.

Vinay Nadkarni, Niranjan Kissoon,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):5-7]

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Rhinovirus Detection in the Nasopharynx of Children Undergoing Cardiac Surgery Is Not Associated With Longer PICU Length of Stay: Results of the Impact of Rhinovirus Infection After Cardiac Surgery in Kids (RISK) Study.

Peter Paul Roeleveld, Anneloes L Van Rijn, Rob B P de Wilde, Erik W van Zwet, Jeroen Wink, Lieke Rozendaal, Karin Hogenbirk, Mark G Hazekamp, Wing Ho Man, Igor Sidorov, Margriet E M Kraakman, Eric C J Claas, Evert de Jonge, Aloys C M Kroes, Jutte J C de Vries,

<h4>Objectives</h4>To determine whether children with asymptomatic carriage of rhinovirus in the nasopharynx before elective cardiac surgery have an increased risk of prolonged PICU length of stay.<h4>Study design</h4>Prospective, single-center, blinded observational cohort study.<h4>Setting</h4>PICU in a tertiary hospital in The Netherlands.<h4>Patients</h4>Children under 12 years old undergoing elective cardiac surgery were enrolled in ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):e79-e90]

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Criticality: A New Concept of Severity of Illness for Hospitalized Children.

Eduardo A Trujillo Rivera, Anita K Patel, James M Chamberlain, T Elizabeth Workman, Julia A Heneghan, Douglas Redd, Hiroki Morizono, Dongkyu Kim, James E Bost, Murray M Pollack,

<h4>Objectives</h4>To validate the conceptual framework of "criticality," a new pediatric inpatient severity measure based on physiology, therapy, and therapeutic intensity calibrated to care intensity, operationalized as ICU care.<h4>Design</h4>Deep neural network analysis of a pediatric cohort from the Health Facts (Cerner Corporation, Kansas City, MO) national database.<h4>Setting</h4>Hospitals with pediatric routine inpatient ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):e33-e43]

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Editor's Choice Articles for January.

Robert C Tasker,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):3-4]

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Rapid Transition of a PICU Space and Staff to Adult Coronavirus Disease 2019 ICU Care.

Emily Wasserman, Megan Toal, Marianne E Nellis, Chani Traube, Christine Joyce, Robert Finkelstein, James S Killinger, Umesh Joashi, John S Harrington, Lisa K Torres, Bruce M Greenwald, Joy Howell,

<h4>Objectives</h4>We describe the process by which a PICU and a PICU care team were incorporated into a hospital-wide ICU care model during the coronavirus disease 2019 pandemic.<h4>Design</h4>A descriptive, retrospective report from a single-center PICU.<h4>Setting</h4>Twenty-three bed, quaternary PICU, within an 862-bed hospital.<h4>Patients</h4>Critically ill adults, with coronavirus disease 2019-related disease.<h4>Interventions</h4>ICU care provided ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):50-55]

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