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Journal Pediatr Allergy Immunol

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A male infant with COVID-19 in the context of ARPC1B deficiency.

Lina Maria Castano-Jaramillo, Marco Antonio Yamazaki-Nakashimada, Selma Cecilia Scheffler Mendoza, Juan Carlos Bustamante-Ogando, Sara Elva Espinosa-Padilla, Saul O Lugo Reyes,

The current pandemic of the novel SARS-CoV-2 infection has affected over 10 million humans around the planet. The clinical manifestations of Coronavirus disease 2019 (COVID-19) are diverse, ranging from asymptomatic or mild flu-like symptoms to atypical pneumonia, severe respiratory distress syndrome, systemic inflammation, immune dysregulation and coagulopathy. ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Predicting inadequate treatment response in children with chronic spontaneous urticarial.

Yu-Mi Park, Min-Su Oh, Ji-Won Kwon,

BACKGROUND:We aimed to investigate the treatment response and associated factors for loss of control in children with chronic spontaneous urticaria (CSU). METHODS:A total of 240 CSU patients (aged 0-17 years) were enrolled in a single-center study in Korea from May 2014 to May 2019. We retrospectively reviewed the medical records ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Clinical, Immunological and Genetic findings in Patients with UNC13D Deficiency (FHL3): a Systematic Review.

Parisa Amirifar, Mohammad Reza Ranjouri, Hassan Abolhassani, Tannaz Moeini Shad, Amir Almasi-Hashiani, Gholamreza Azizi, Soraya Moamer, Asghar Aghamohammadi, Reza Yazdani,

BACKGROUND:Familial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive immune disorder that is caused by mutations in 6 different genes related to the formation and function of secretory lysosomes within cytotoxic T lymphocytes and natural killer (NK) cells. Thus defect in these genes are associated with the accumulation of antigens due to ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Maternal periconceptional folate status and infant atopic dermatitis: a prospective cohort study.

Ying Ye, Li-Min Dou, Yi Zhang, Ya-Lan Dou, Piao-Ping Zhao, Yuan Jiang, Wei Gao, Mi Ji, Lin-Feng He, Da-Yan Niu, Lei Zhang, Xiao-Hua Gao, Yun Li, Li-Ping Xiao, Jun Huang, Xiao-Hua Zhang, Liu-Hui Wang, Wei-Li Yan,

BACKGROUND:Maternal folate status is linked with the risk of allergic disorders including atopic dermatitis (AD) in children, but findings remain inconclusive. We aim to assess the relationship between maternal folate status in early gestation and early-onset infant AD, based on a prospective mother-child cohort study. METHODS:Pregnant women were recruited at ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Childhood wheeze trajectory-specific risk factors: a systematic review and meta-analysis.

Arthur H Owora, Yijia Zhang,

BACKGROUND:There is growing interest in the use of latent trajectory methodology to identify wheeze patterns inheterogenous populations of children. This study systematically reviewed and meta-analyzed childhood wheeze trajectory studies to identify childhood wheeze trajectory group-specific risk factors among children from birth through to adolescence. METHODS:We included studies that used latent ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Pulmonary function testing with tidal breath analyze technique is useful in predicting persistant small airway damage in infants with acute bronchiolitis.

Elif Çelik, Pınar Uysal,

BACKGROUND:Due to technical difficulties, lung function in infants is less studied. This prospective cross-sectional study investigatedbreathing parameters by using tidal breath analyze (TBA) technique in hospitalized infants with the first time acute bronchiolitis (AB). METHODS:This study enrolled 111 infants aged 1month-2 years: 61 with AB, and 50 healthy controls. Lung ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Maternal microbiome regulation prevents early allergic airway diseases in mouse offspring.

Jing Liu, Changli Tu, Jinyan Yu, Meizhu Chen, Cuiyan Tan, Xiaobin Zheng, Zhenguo Wang, Yingjian Liang, Kongqiu Wang, Jian Wu, Yanlei Li,

BACKGROUND:Asthma is a serious global health problem, severely affecting the lives of sufferers and their families. An exceptionally hygienic home and reduced microbial exposure can aggravate the incidence of childhood asthma. METHODS:Specific-pathogen-free BALB/c mice were pre-treated with bacterial lysate (BL; 1 mg/kg) as a high microbial load maternal mouse model, and ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Bronchiolitis and recurrent wheezing are distinguished by type 2 innate lymphoid cells and immune response.

Beatriz Sastre, María Luz García-García, José Antonio Cañas, Cristina Calvo, José Manuel Rodrigo-Muñoz, Inmaculada Casas, Ignacio Mahíllo-Fernández, Victoria Del Pozo,

BACKGROUND:Recurrent wheezing (RW) is frequently developed in infants that have suffered bronchiolitis (BCH) during first months of life, but the immune mechanism underlying is not clear. The goal was to analyze the innate immune response that characterizes BCH and RW. METHODS:Ninety-eight and seventy hospitalized infants with BCH or RW diagnosis, ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Assessment of adherence to asthma controllers in children and adolescents.

Mads Marckmann, Mette N Hermansen, Kirsten S Hansen, Bo L Chawes,

BACKGROUND:Low adherence to asthma controllers is known to increase the risk of uncontrolled disease and poor health outcomes. We aimed to study risk factors of long-term adherence to preventive medications in children and adolescents with asthma. METHODS:Adherence was assessed during a two-year period in 155 children with asthma followed in ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Novel insights regarding anaphylaxis in children - With a focus on prevalence, diagnosis, and treatment.

Ken-Ichi Nagakura, Sakura Sato, Tomoyuki Asaumi, Noriyuki Yanagida, Motohiro Ebisawa,

Anaphylaxis is a serious allergic reaction that occurs rapidly and causes a life-threatening response involving the whole body. This reaction often leads to difficulty in breathing and can result in death. The estimated prevalence of anaphylaxis is 0.05%-2%, which is reported to be increasing in children. Although drugs and venom ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Postnatal SARS-CoV-2 infection and immunological reaction: A prospective family cohort study.

Julia Preßler, Sara Fill Malfertheiner, Michael Kabesch, Heike Buntrock-Döpke, Sebastian Häusler, Andreas Ambrosch, Sven Wellmann,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Hereditary angioedema in children and adolescents - A consensus update on therapeutic strategies for German-speaking countries.

Volker Wahn, Werner Aberer, Emel Aygören-Pürsün, Konrad Bork, Wolfgang Eberl, Maria Faßhauer, Renate Krüger, Markus Magerl, Inmaculada Martinez-Saguer, Peter Späth, Petra Staubach-Renz, Christina Weber-Chrysochoou,

BACKGROUND/METHODS:At a consensus meeting in August 2018, pediatricians and dermatologists from German-speaking countries discussed the therapeutic strategy for the treatment of pediatric patients with type I and II hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) for Germany, Austria, and Switzerland, taking into account the current marketing approval status. HAE-C1-INH ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Pediatric allergic diseases in the Indian subcontinent-Epidemiology, risk factors and current challenges.

Mamidipudi Thirumala Krishna, Padukudru Anand Mahesh, Pudupakkam K Vedanthan, Vinay Mehta, Saibal Moitra, Devasahayam Jesudas Christopher,

INTRODUCTION:India is low-middle-income country (LMIC) with a population of 1.3bn, comprising about 20% of the global population. While the high-income Western countries faced an "allergy epidemic" during the last three decades, there has been a gradual rise in prevalence of allergic diseases in India. METHODS:Narrative review. RESULTS AND DISCUSSION:Allergic diseases ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Transient childhood wheeze is associated with less atopy in adolescence.

Caroline Jane Lodge, Adrian John Lowe, Michael John Abramson, Cecilie Svanes, Sophie G Zaloumis, Paul S Thomas, Shyamali Chandrika Dharmage,

BACKGROUND:The relationships between childhood wheeze phenotypes and subsequent allergic conditions other than asthma, including hay fever, eczema and sensitization, have not been widely reported. We aimed to investigate this relationship up to late adolescence. METHODS:Using five childhood wheeze phenotypes defined from 620 children in a high-atopy risk birth cohort (Melbourne ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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House dust mites: Does a clean mattress mean Der p 1-free breastmilk?

Patricia Macchiaverni, Ulrike Gehring, Akila Rekima, Alet H Wijga, Valerie Verhasselt,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype depending on genetic risk in school children.

Hea Young Oh, So-Yeon Lee, Jisun Yoon, Hyun-Ju Cho, Young-Ho Kim, Dong In Suh, Song-I Yang, Ji-Won Kwon, Gwang Cheon Jang, Yong Han Sun, Sung-Il Woo, You-Sook Youn, Kang Seo Park, Hwa Jin Cho, Myung-Hee Kook, Hye Ryoung Yi, Hai Lee Chung, Ja Hyeong Kim, Hyung Young Kim, Sungsu Jung, Jin-A Jung, Hyang-Ok Woo, Kyeong Ok Koo, Sung-Ok Kwon, Jeom-Kyu Lee, Woo-Sung Chang, Eunseol Kim, Jeongrim Lee, Sangrok Kim, Soo-Jong Hong,

BACKGROUND:The effect of diet on allergic rhinitis (AR), its severity in children, and whether it modifies AR depending on genetic susceptibility are unknown. We investigated the association between dietary patterns and AR in school children and the influence of diet on AR according to a genetic risk score (GRS). METHODS:Totally, ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Dietary factors during pregnancy and atopic outcomes in childhood: a systematic review from the European Academy of Allergy and Clinical Immunology.

C Venter, C Agostoni, S H Arshad, M Ben-Abdallah, G Du Toit, D M Fleischer, M Greenhawt, D H Glueck, M Groetch, N Lunjani, K Maslin, A Maiorella, R Meyer, A Muraro, M J Netting, B I Nwaru, D J Palmer, M P Palumbo, G Roberts, C Roduit, P K Smith, E Untersmayr, L Vanderlinden, L O'Mahony,

RATIONALE:Allergic diseases are an increasing public health concern and early life environment is critical to immune development. Maternal diet during pregnancy has been linked to offspring allergy risk. In turn, maternal diet is a potentially modifiable factor, which could be targeted as an allergy prevention strategy. In this systematic review, ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

Evelien R van Meel, Vincent W V Jaddoe, Kirsten I M Looman, Johan C de Jongste, Henriëtte A Moll, Liesbeth Duijts,

BACKGROUND:Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal carriage with Staphylococcus aureus or nasopharyngeal carriage with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse respiratory health. OBJECTIVE:To examine the association of early-life airway bacterial carriage with respiratory tract infections and vice ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: A systematic review and network meta-analysis.

Carol Stephanie C Tan-Lim, Natasha Ann R Esteban-Ipac, Jacinto Blas V Mantaring, Edwin Chan Shih Yen, Marysia Stella T Recto, Olivia T Sison, Marissa M Alejandria,

BACKGROUND:The current evidence on the use of probiotics in treating atopic dermatitis is inconclusive. This study determined the comparative effectiveness of the different types of probiotic strains in treating pediatric atopic dermatitis. METHODOLOGY:Systematic and manual search for all randomized controlled trials available from inception until January 31, 2020, was done. ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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African American children are at higher risk of COVID-19 infection.

Sindhura Bandi, Michael Z Nevid, Mahboobeh Mahdavinia,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Vitamin deficiencies in pediatric eosinophilic esophagitis: A systematic review.

Alexis Fissinger, Keith C Mages, Aliza B Solomon,

BACKGROUND:Nutritional deficiencies are seen in patients with food allergy. Low vitamin D levels have been found in patients with atopic conditions. Eosinophilic esophagitis (EoE) is a chronic immune antigen-mediated disease found to be highly associated in patients with atopic disease and treated with dietary elimination with recommendations to utilize a ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Natural History and Predictors of recovery in Children with Chronic Spontaneous Urticaria.

Luisa Cortellazzo Wiel, Ester Conversano, Manuela Giangreco, Laura Fagotto, Maria Rita Lucia Genovese, Laura Badina, Giorgio Longo, Egidio Barbi, Irene Berti,

BACKGROUND:Limited data are available about the natural history of chronic spontaneous urticaria in children (CSU), and management guidelines are mostly extrapolated from evidence in adults. METHODS:The objective of this study was toevaluate the natural history of CSU in children and to identify predictors for remission. We performed an observational study, ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.

Michimasa Fujiogi, Carlos A Camargo, Yoshihiko Raita, Yury A Bochkov, James E Gern, Jonathan M Mansbach, Pedro A Piedra, Kohei Hasegawa,

BACKGROUND:Bronchiolitis is the leading cause of infant hospitalizations in the United States. Growing evidence supports the heterogeneity of bronchiolitis. However, little is known about the interrelationships between major respiratory viruses (and their species), host systemic metabolism, and disease pathobiology. METHODS:In an ongoing multicenter prospective cohort study, we profiled the serum ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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A randomized controlled trial of different young child formulas on upper respiratory and gastrointestinal tract infections in Chinese toddlers.

Ting F Leung, Laurien H Ulfman, Marc K C Chong, Kam L Hon, Ilse M S L Khouw, Paul K S Chan, Dianne J Delsing, Guus A M Kortman, Ingeborg M J Bovee-Oudenhoven,

BACKGROUND:Bioactive proteins and human milk oligosaccharides (HMOs), important ingredients in breast milk, that protect against infections are lacking in young child formula (YCF). This study investigated the effects of new YCFs on respiratory and gastrointestinal infections in toddlers. METHODS:Four hundred and sixty one healthy Chinese children aged 1-2.5 years were recruited ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Pertussis vaccination and allergic illness in Australian children.

Brett G Toelle, Frances L Garden, Peter B McIntyre, Nicholas Wood, Guy B Marks,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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