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Journal Pak J Pharm Sci

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Whole exome sequencing identifies a novel FANCD2 gene splice site mutation associated with disease progression in chronic myeloid leukemia: Implication in targeted therapy of advanced phase CML.

Muhammad Absar, Amer Mahmood, Tanveer Akhtar, Sulman Basit, Khushnooda Ramzan, Abid Jameel, Sibtain Afzal, Anhar Ullah, Kulsoom Qureshi, Nawaf Alanazi, Zafar Iqbal,

Tyrosine Kinase Inhibitors (TKIs) have significantly improved the clinical outcome of BCR-ABL+ Chronic Phase-Chronic Myeloid Leukemia (CP-CML). Nonetheless, approximately one-third of the CP-CML patient's progress to advanced phases of CML (accelerated and blast phase). Impaired DNA repair including mutations in Fanconi anemia (FA) pathway genes are responsible for progression of ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1419-1426]

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Effect of hesperidin on CORT-induced apoptosis and oxidative stress of mouse hippocampal nerve cells by up-regulating miR-146a-5p.

Zhiheng Wang, Lijun Han, Huizi ShangTing, Ping Chen,

This study aims to investigate the effect of hesperidin on CORT-induced apoptosis and oxidative stress of mouse hippocampal nerve cells by up-regulating miR-146a-5p and related mechanism. Hesperidin was applied to CORT-induced HT-22 cells, or HT-22 cells whose expression of mir-146a-5p was up-regulated or down-regulated by CORT. The apoptosis rate was ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1383-1388]

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Application of dopamine combined with dobutamine in children with pneumonia and heart failure.

Yang Cun, Wang Jianlong,

Pediatric pneumonia and heart failure is a common critical illness in pediatrics. This article observes the clinical effects of dopamine and dobutamine in the treatment of pneumonia and heart failure. As a key neurotransmitter in the hypothalamus and pituitary gland, dopamine plays a very important role in the central nervous ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1355-1359]

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Mini-Review: molecular elucidations of hutchinson-gilford progeria syndrome: A hope for managing horrors of premature aging in children.

Bilal Ahmed, Ruby Basheer, Muhammad Irfan, Muhammad Sajid Hamid Akash, Syed Aun Muhammad, Muhammad Imran Qadir,

Hutchinson-Gilford Progeria syndrome (or Progeria) is an exceptionally rare genetic disorder in children. It is caused by a rare point mutation in the lamin gene. It encodes lamin A protein, resulting in the de-shaping of nuclear membrane. This altered structure of the nuclear membrane renders the nucleus unstable. The shortened ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1179-1182]

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In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones.

- Arshia, Sanaullah Abbasi, Saima Rasheed, Jalaluddin Aj Khan, Syed Muhammad Saad, Khalid Mohammed Khan, M Iqbal Choudhary,

Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54μM. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1147-1153]

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Rapid detection of the metformin illegally added of in TCM and health food by TLC-IR.

Zhang Honglian, Li Li, Wang Huiyu, Sun Jikai, Li Hongling, Dong Wei, Zhang Meijuan,

Based on TLC-IR, the study established an effective method for rapid detection of metformin illegally added in hypoglycemic traditional Chinese medicine and health food products. 12 batches of hypoglycemic traditional Chinese medicine and health products were purchased in the pharmacy, which were produced by different manufacturers. TLC was used to ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1115-1119]

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Antidiarrheal potential of lactobacillus strains isolated from pharmaceutical formulations for the treatment of pediatric diarrhea.

Syed Imran Ali, Syed Baqir Shyum Naqvi, Rabia Ismail Yousuf,

The consumption of probiotics in the prevention and treatment of diarrhea have been clinically justified, comprehensive studied and explored in many products around the world. In Pakistan, recommendation of probiotic formulations is being emerged to control the increased mortality and morbidity from diarrhea under 5 years of age children. The ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1073-1078]

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Poria ameliorates the side effects of rhubarb in pair treatment.

Lianlian Zhu, Xia Liu, Haixue Kuang, Bin Li, Deqiang Dou,

To investigate the effect of Poria and effective constituents on gastrointestinal injury animals in the area of the side effects which caused by Rhubarb. Mice were administered i.g. with Rhubarb until the induction of diarrhea followed by gastrointestinal injury. The gastrointestinal injured mice were treated with high, medium and low ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):977-986]

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Comparison of the antidepressant like activity of homeopathic remedies (Argentum nitricum, Staphysagria and Ignatia amara) and their effect on the behavior of rodents.

Humaira Anser, Rahila Ikram, Humera Khatoon, Sadaf Naeem, Saira Saeed Khan, Urooj Nazim, Shahlla Imam, Yusra Shafiq, Sumaira Ishaque,

The majority of the world population suffers from mental and behavioral disorder. It is the need of the time to find an alternate of presently available medicines in order to decrease the medical expense. Homeopathic remedies are available and prescribed by homeopaths for treatment of anxiety and depression. Unfortunately, no ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):937-945]

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Galactose protects pancreatic acinar cells from cerulein induced damage by regulating FGF21 and Klotho.

Kuo Wang, Nan Zhang, Zhanbiao Yu, Ning Li,

To investigate the effect and mechanism of galactose on cerulean-induced pancreatic acinar cell injury. Acute pancreatitis cell injury model was established by arbusin-induced pancreatic acinar cell AR42J injury; galactose (25, 50, 100 mmol / L) was used to treat the injured cells, and the optimal concentration was 50 mmol / ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1413-1417]

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Effect of dexmedetomidine and cholinergic anti-inflammatory pathways in myocardial ischemia-reperfusion injury.

Youting Ju, Fan Xiao, Jun Lu, Bin Zhou, Junying Cai, Shoulin Chen,

The aim of the current study was to determine the effect and mechanism underlying the cholinergic anti-inflammatory pathway of dexmedetomidine and the cholinergic anti-inflammatory pathway on myocardial ischemia-reperfusion injury by establishing a myocardial ischemia-reperfusion model in rats. Sixty healthy rats were randomly divided into 4 groups with 15 rats in ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1377-1382]

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Efficacy and safety of MAO-B inhibitor versus donepezil in Chinese elderly stroke patients with Alzheimer disease: A potential therapeutic option.

Huaqing Yang, Weidong Han, Hui Li,

This pilot study designed to evaluate the efficacy and safety of MAO-B inhibitor in comparison with Donepezil (DNP) in elderly Chinese patients with Alzheimer disease (AD). In the present clinical trial, Chinese elderly patients aged ≥65 years with a confirmed diagnosis of AD were enrolled. The patients received MAO-B inhibitor ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1349-1354]

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Short Communication: Antiviral activity of Ribes uva-crispa L. extracts in vitro.

Hasan Huseyin Dogan, Rustem Duman, Muhittin Dinc,

There is currently no approved vaccine or a useful antiviral drug against respiratory syncytial virus (RSV) that causes viral infection worldwide. Crude plant extracts can be an important resource for the development of new anti-RSV agents. In this study, cytotoxic and anti-RSV effect of the extracts Ribes uva-crispa, which has ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1173-1178]

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Pharmacoeconomic evaluation of different doses of Curosurf for treating neonatal acute respiratory distress syndrome.

Na Wang, Lin Wang,

Neonatal acute respiratory distress syndrome (ARDS) is a serious stage of acute lung injury (ALI) which can be treated by exogenous surfactant. The aim of this study was to explore the clinical efficacy of two different doses of Poractant alfa (Curosurf®) for treating neonatal ARDS and to perform an economic ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1139-1146]

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Developing and validation of impurity and the simultaneous quantity determination methods for tablet forms containing Ciprofloxacin HCl and Ornidazole.

Aysel Kucuk Tunca, Devrim Karakaya, Serdar Bulbul,

In this study simple, effective, fast and economic reverse-phase HPLC methods have been developed for the purposes of identifying impurities and quantities of the two active ingredients in the tablet dosage products containing Ciprofloxacin HCl and Ornidazole together. These methods have been validated according to the parameters of International Conference ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1105-1114]

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Chlorogenic acid inhibits forming of diabetes mellitus in rats induced by high-fat high-sucrose and streptozotocin.

Yan Wang, Shuguang Peng, Zihan Mei, Chenzhong Jin, Jinhe Kang, Minghui Xiang, Zheng Wang, Yihong Hu,

To evaluate the inhibitory effect of chlorogenic acid on the forming of type 2 diabetes mellitus (T2DM), using Sprague Dawley (SD) rats, a recognized T2DM model induced by high-fat high-sucrose diet (HFSD) and streptozotocin (STZ). Thirty female SD rats were assigned equally to three groups randomly: normal control with standard ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1063-1072]

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Pharmacological evaluation of Acacia modesta bark for antipyretic, anti-inflammatory, analgesic, antidepressant and anticoagulant activities in Sprague Dawley rats.

Sara Latif, Hammad Ismail, Muhammad Rashid Khan, Amna Abdul Rahim, Ramsha Mehboob, Erum Dilshad, Moniba Sajid, Syed Ihtisham Haider, Sadaf Anwaar, Muhammad Naveed Majeed,

In this study the bark of Acacia modesta was evaluated for anti-inflammatory, antipyretic, analgesic, antidepressant and anticoagulant activity by carrageenan, hot plat, forced swim and capillary tube method respectively in rats. Highest anti-inflammatory activity was exhibited by chloroform (AMC) extract (74.96% inhibition) while other two active fractions being n-hexane (AMH) ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1015-1023]

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Rat alpha glucosidase inhibitor and phytochemicals activities of endophytic actinobacteria from Ficus deltoidea.

Isra Janatiningrum, Dedy Duryadi Solihin, Anja Meryandini, Yulin Lestari,

Ficus deltoidea is a medicinal plant that has high endophytic actinobacteria diversity. Endophytic actinobacteria play an important role in producing various types of bioactive compounds including α-glucosidase inhibitor. Screening of 40 endophytic actinobacteria isolates from F. deltoidea showed that 77% of them had inhibitory activity against rat α-glucosidase. The 64% ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):969-975]

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Dose-dependent effect of aqueous extract from Dendrobium officinale on blood lipids and lipid peroxidation in hyperlipidemic rats.

Ming Zhao, Jungang Han,

Dendrobium officinale is a traditional Chinese herbal medicine exhibiting multiple bioactivities, showing antitumor and immune-enhancing effects. The purpose of the study is to explore the effect of aqueous extract from Dendrobium officinale on blood lipids and lipid peroxidation in hyperlipidemic rats. Hyperlipidemic rats were prepared and daily given an intragastric ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):929-935]

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Screening of anticancer, hepatoprotective and nephroprotective effects of ethanol extract of Elephantopus scaber L.

Nanik Sulistyani, - Nurkhasanah,

7.12-dimethylbenz (α)anthracene (DMBA) is a carcinogenic compound. It is metabolized in the liver by cytochrome P450 enzyme into 7.12-dimethylbenz (α) anthracene-3.4-diol-1.2-epoxide (DMBA-DE) which is more reactive and can damage the hepatic cell. Furthermore, DMBA also can damage the kidneys and cause Reactive Oxygen Species (ROS) accumulation resulting in oxidative stress. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):901-907]

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Effects of velvet antler polypeptides on Alzheimer's disease cell model via miR-613 HDAC6 pathway.

Jindong Guo, Meng Lu, Yuhui Zhou, Bowen Wu, Mishan Wu,

To study the effect of velvet antler polypeptides (VAP) on Alzheimer's disease (AD) cell model, Aβ<sub>25-35</sub> was used to induce SK-N-SH cells to obtain AD cell model. The MDA, SOD, GSH-Px levels were determined using relevant kits. Flow cytometry was conducted to detect apoptosis, Western blot was employed to measure ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1427-1433]

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Effect of pharmacist interventions on antibiotic use in the general pediatric ward.

Jiao Tian, Meng-Meng Wang, Xun Jiang, Lei Liu, Zhen Tian,

Antibiotics are widely prescribed and often used irrationally in Chinese hospitals. This study aimed to evaluate the pharmacist's influence on antibiotic use in the pediatric ward. We conducted this pre-to-post intervention study in the pediatrics of a Chinese tertiary hospital. The patients hospitalized from April to June 2018 were assigned ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1389-1395]

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Efficacy of moxifloxacin combined with levofloxacin in the treatment of drug-resistant tuberculosis.

Feng Qiujing, Wang Weiwei,

Drug-resistant tuberculosis is a clinically common respiratory-borne chronic infectious disease. Fluoroquinolone drugs can inhibit the replication and transcription of bacterial DNA and cause bacteria to die, and the antibacterial spectrum of such drugs is broad, especially for Mycobacterium tuberculosis-induced diseases. This article observes and compares the clinical efficacy of levofloxacin ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3(Special)):1361-1366]

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Pharmacognostic standardization and DNA fingerprinting of leaves of Datura stramonium, growing naturally in Asir region of Saudi Arabia.

Hussain Arshad, Wahab Shadma, Mahmoud Moustafa,

Evaluation of the various pharmacognostic quality parameters and DNA fingerprint of Saudi Arabian medicinal plant namely Datura stramonium growing in Asir region was the objective of the study. The pharmacognostical parameters were done in terms of macroscopic characters, microscopic details, physico-chemical evaluations, phytochemical analysis, fluorescence analysis and DNA fingerprint by ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1155-1161]

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Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice.

- Alamgeer, Pernia Nasreen, Ambreen Malik Uttra, Hira Asif, Waqas Younis, Umme Habiba Hasan, Hafiz Muhammad Irfan, Amber Sharif,

Ranunculus muricatus (Ranunculaceae) is commonly used by inhabitants of Pakistan for the treatment of gout and rheumatism, both of which are inflammatory disorders. The present study attempts to evaluate the anti-inflammatory and analgesic activities of aqueous methanolic extract of R. muricatus in mice. The plant extract at doses of 50, ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1121-1126]

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