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Journal Pain

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A delicate balance: risks vs benefits of opioids in cancer pain.

Judith A Paice,

Pain (Pain)
[2020, 161(3):459-460]

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Graded chronic pain scale revised: mild, bothersome, and high-impact chronic pain.

Michael Von Korff, Lynn L DeBar, Erin E Krebs, Robert D Kerns, Richard A Deyo, Francis J Keefe,

Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pain (pain present most ... Read more >>

Pain (Pain)
[2020, 161(3):651-661]

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Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes.

Sandra Sif Gylfadottir, Diana Hedevang Christensen, Sia Kromann Nicolaisen, Henning Andersen, Brian Christopher Callaghan, Mustapha Itani, Karolina Snopek Khan, Alexander Gramm Kristensen, Jens Steen Nielsen, Søren Hein Sindrup, Niels Trolle Andersen, Troels Staehelin Jensen, Reimar Wernich Thomsen, Nanna Brix Finnerup,

Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5514 (82%) patients ... Read more >>

Pain (Pain)
[2020, 161(3):574-583]

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Neuromodulation: more than a placebo effect?

Sophie W Kjær, Andrew S C Rice, Karolina Wartolowska, Lene Vase,

Pain (Pain)
[2020, 161(3):491-495]

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Brain signatures of threat-safety discrimination in adolescent chronic pain.

Lauren C Heathcote, Inge Timmers, Corey A Kronman, Farah Mahmud, J Maya Hernandez, Jason Bentley, Andrew M Youssef, Daniel S Pine, David Borsook, Laura E Simons,

Approximately 1.7 million youth suffer from debilitating chronic pain in the US alone, conferring risk of continued pain in adulthood. Aberrations in threat-safety (T-S) discrimination are proposed to contribute to pain chronicity in adults and youth by interacting with pain-related distress. Yet, few studies have examined the neural circuitry underlying ... Read more >>

Pain (Pain)
[2020, 161(3):630-640]

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A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients.

Rodrigo Benavides, Olga Vsevolozhskaya, Stefano Cattaneo, Dmitri Zaykin, Ashley Brenton, Marc Parisien, Vivek Verma, Samar Khoury, Ian Gilron, Luda Diatchenko,

Many genetic markers have been associated with variations in treatment response to analgesics, but none have been assessed in the context of combination therapies. In this study, the treatment effects of nortriptyline and morphine were tested for an association with genetic markers relevant to pain pathways. Treatment effects were determined ... Read more >>

Pain (Pain)
[2020, 161(3):619-629]

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Evaluating the impact of gabapentinoids on sleep health in patients with chronic neuropathic pain: a systematic review and meta-analysis.

Daniel Kapustin, Anuj Bhatia, Aidan McParland, Aditya Trivedi, Alexandra Davidson, Richard Brull, Mandeep Singh,

Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this systematic review and meta-analysis was to assess the relationship between GB ... Read more >>

Pain (Pain)
[2020, 161(3):476-490]

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Implications of the putamen in pain and motor deficits in complex regional pain syndrome.

Monica Azqueta-Gavaldon, Andrew M Youssef, Claudia Storz, Jordan Lemme, Heike Schulte-Göcking, Lino Becerra, Shahnaz C Azad, Anselm Reiners, Birgit Ertl-Wagner, David Borsook, Jaymin Upadhyay, Eduard Kraft,

Complex regional pain syndrome (CRPS) develops after-limb injury, with persistent pain and deficits in movement frequently co-occurring. The striatum is critical for mediating multiple mechanisms that are often aberrant in CRPS, which includes sensory and pain processing, motor function, and goal-directed behaviors associated with movement. Yet, much remains unknown with ... Read more >>

Pain (Pain)
[2020, 161(3):595-608]

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Pain, aging, and the brain: new pieces to a complex puzzle.

Yenisel Cruz-Almeida, James Cole,

Pain (Pain)
[2020, 161(3):461-463]

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Avoid or engage? Outcomes of graded exposure in youth with chronic pain using a sequential replicated single-case randomized design.

Laura E Simons, Johan W S Vlaeyen, Lies Declercq, Allison M Smith, Justin Beebe, Melinda Hogan, Eileen Li, Corey A Kronman, Farah Mahmud, Jenelle R Corey, Christine B Sieberg, Christine Ploski,

Pain-related fear is typically associated with avoidance behavior and pain-related disability in youth with chronic pain. Youth with elevated pain-related fear have attenuated treatment responses; thus, targeted treatment is highly warranted. Evidence supporting graded in vivo exposure treatment (GET) for adults with chronic pain is considerable, but just emerging for ... Read more >>

Pain (Pain)
[2020, 161(3):520-531]

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Rapid identification and clinical indices of fear-avoidance in youth with chronic pain.

Lauren C Heathcote, Rashmi P Bhandari, Inge Timmers, Lauren E Harrison, Laura E Simons,

Pain-related fear and avoidance are increasingly demonstrated to play an important role in adult and childhood chronic pain. The Fear of Pain Questionnaire for Children (FOPQC) is a 24-item measure of pain-related fear-avoidance in youth that has demonstrated good indices of reliability and validity, treatment responsiveness, and associations with brain ... Read more >>

Pain (Pain)
[2020, 161(3):565-573]

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Chronic noncancer pain is not associated with accelerated brain aging as assessed by structural magnetic resonance imaging in patients treated in specialized outpatient clinics.

Peter Sörös, Carsten Bantel,

Chronic pain is often associated with changes in brain structure and function, and also cognitive deficits. It has been noted that these chronic pain-related alterations may resemble changes found in healthy aging, and thus may represent accelerated or premature aging of the brain. Here, we test the hypothesis that patients ... Read more >>

Pain (Pain)
[2020, 161(3):641-650]

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Pain behavior without pain sensation: an epileptic syndrome of "symbolism for pain"?

Koichi Hagiwara, Luis Garcia-Larrea, Léon Tremblay, Alexandra Montavont, Hélène Catenoix, Sylvain Rheims, Marc Guénot, Jean Isnard,

"Asymbolia for pain" has shown the potentiality of diseased insular networks to dissociate sensory from affective-behavioral dimensions of pain, resulting in the lack of appropriate motor and affective responses despite preserved sensory aspect of pain. Here, we describe 4 patients with an inverse phenomenon of asymbolia for pain, namely an ... Read more >>

Pain (Pain)
[2020, 161(3):502-508]

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Biomarkers for predicting central neuropathic pain occurrence and severity after spinal cord injury: results of a long-term longitudinal study.

Hila Gruener, Gabi Zeilig, Evgeni Gaidukov, Orna Rachamim-Katz, Erez Ringler, Nava Blumen, Einat Engel-Haber, Ruth Defrin,

Central neuropathic pain (CNP) after spinal cord injury (SCI) is debilitating and immensely impacts the individual. Central neuropathic pain is relatively resistant to treatment administered after it develops, perhaps owing to irreversible pathological processes. Although preemptive treatment may overcome this shortcoming, its administration necessitates screening patients with clinically relevant biomarkers ... Read more >>

Pain (Pain)
[2020, 161(3):545-556]

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Pain, opioid therapy, and survival: a needed discussion.

Diane M Novy, David V Nelson, Dhanalakshmi Koyyalagunta, Juan P Cata, Pankaj Gupta, Kalpna Gupta,

Pain (Pain)
[2020, 161(3):496-501]

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Alterations in pronociceptive and antinociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Megan E McPhee, Henrik Bjarke Vaegter, Thomas Graven-Nielsen,

Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are well-established, but in populations with low back pain (LBP), there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to ... Read more >>

Pain (Pain)
[2020, 161(3):464-475]

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Reducing the use of opioids by patients with chronic pain: an effectiveness study with long-term follow-up.

Michael K Nicholas, Ali Asghari, Louise Sharpe, Lee Beeston, Charles Brooker, Paul Glare, Rebecca Martin, Allan Molloy, Paul J Wrigley,

This study addresses the problem of long-term opioid use by chronic pain patients. The study involved a secondary analysis of unanalyzed data from a published study of 2 versions of cognitive-behavioural therapy-based interdisciplinary treatment for chronic pain. In this study, we examined whether the use of opioids by 140 chronic ... Read more >>

Pain (Pain)
[2020, 161(3):509-519]

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Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.

Mingzheng Wu, Zehua Li, Lei Liang, Pingchuan Ma, Dong Cui, Peng Chen, Genhao Wu, Xue-Jun Song,

Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits neuronal alterations and recapitulates events during development. Here, ... Read more >>

Pain (Pain)
[2020, 161(3):532-544]

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Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex.

Edita Navratilova, Kelsey Nation, Bethany Remeniuk, Volker Neugebauer, Kirsty Bannister, Anthony H Dickenson, Frank Porreca,

The amygdala is a key subcortical region believed to contribute to emotional components of pain. As opioid receptors are found in both the central (CeA) and basolateral (BLA) nuclei of the amygdala, we investigated the effects of morphine microinjection on evoked pain responses, pain-motivated behaviors, dopamine release in the nucleus ... Read more >>

Pain (Pain)
[2020, 161(3):609-618]

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Offset analgesia: somatotopic endogenous pain modulation in migraine.

Tibor M Szikszay, Waclaw M Adamczyk, Gabriela F Carvalho, Arne May, Kerstin Luedtke,

The complex mechanisms underlying migraine are not entirely understood. It has been suggested that descending endogenous pain modulation is an important contributing factor, although research is controversial. A frequently used method to quantify the inhibitory pain modulation system is offset analgesia (OA), defined as a disproportionally large decrease in pain ... Read more >>

Pain (Pain)
[2020, 161(3):557-564]

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Evaluating the efficacy of an attention modification program for patients with fibromyalgia: a randomized controlled trial.

R Nicholas Carleton, Gordon J G Asmundson, Stephanie L Korol, Daniel M LeBouthillier, Kadie Hozempa, Joel D Katz, Johan W S Vlaeyen, Geert Crombez,

Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in persons with several diagnoses, including fibromyalgia. Scalability and economic ... Read more >>

Pain (Pain)
[2020, 161(3):584-594]

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A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain.

Hilary M Gould, J Hampton Atkinson, Tatiana Chircop-Rollick, John D'Andrea, Steven Garfin, Shetal M Patel, Stephen D Funk, Edmund V Capparelli, Donald B Penzien, Mark Wallace, Anne L Weickgenant, Mark Slater, Thomas Rutledge,

This clinical trial evaluated the independent and combined effects of a tricyclic antidepressant (desipramine) and cognitive behavioral therapy (CBT) for chronic back pain relative to an active placebo treatment. Participants (n=142) were patients experiencing daily chronic back pain at an intensity of ≥4/10 who were randomized to a single center, ... Read more >>

Pain (Pain)
[2020, :]

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Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Sarina J Iwabuchi, Yue Xing, William J Cottam, Marianne M Drabek, Arman Tadjibaev, Gwen S Fernandes, Kristian K Petersen, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Ana M Valdes, Weiya Zhang, Michael Doherty, David Walsh, Dorothee P Auer,

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity following e.g. post-operative pain after knee replacement. Other factors such as low mood, anxiety and tendency to catastrophize are also important contributors. We aimed to investigate brain imaging features ... Read more >>

Pain (Pain)
[2020, :]

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Differential modulation of excitatory and inhibitory populations of superficial dorsal horn neurons in lumbar spinal cord by Aβ-fiber electrical stimulation.

Wei Fan, Andrei D Sdrulla,

Activation of Aβ-fibers is fundamental to numerous analgesic therapies, yet its effects on dorsal horn neuronal activity remain unclear. We used multiphoton microscopy of the genetically encoded calcium indicator GCaMP6s to characterize the effects of Aβ-fiber electrical stimulation (Aβ-ES) on neural activity. Specifically, we quantified somatic responses evoked by C-fiber ... Read more >>

Pain (Pain)
[2020, :]

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Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy.

Li-Hsien Chen, Yu-Min Yeh, Yi-Fan Chen, Yu-Hsiang Hsu, Hsiao-Hsuan Wang, Peng-Chan Lin, Lian-Yun Chang, Chou-Ching K Lin, Ming-Shi Chang, Meng-Ru Shen,

The role of immune mediators, including pro-inflammatory cytokines in chemotherapy-induced peripheral neuropathy (CIPN), remains unclear. Here we studied the contribution of interleukin-20 (IL-20) to the development of paclitaxel-induced peripheral neuropathy. Increased serum levels of IL-20 in cancer patients with chemotherapy were accompanied by increased CIPN risk. In mouse models, proinflammatory ... Read more >>

Pain (Pain)
[2020, :]

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