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Journal Pain

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Intergenerational transmission of chronic pain-related disability: the explanatory effects of depressive symptoms.

Donnamay Brown, Nicola Rosenthal, Anna Könning, Julia Wager,

<h4>Abstract</h4>Parents with chronic pain have a higher likelihood of having depression and anxiety and more often have children with these conditions. Depressive and anxious symptoms in children worsen pain-related disability and may be derived from exposure to their parents' symptoms. We assessed a model of intergenerational chronic pain-related disability that ... Read more >>

Pain (Pain)
[2021, 162(2):653-662]

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Relationship of prosthesis ownership and phantom limb pain: results of a survey in 2383 limb amputees.

Robin Bekrater-Bodmann, Iris Reinhard, Martin Diers, Xaver Fuchs, Herta Flor,

<h4>Abstract</h4>Phantom limb pain (PLP) accounts for a significant reduction in quality of life and is difficult to treat. Prosthesis use has been shown to negatively covary with PLP. Recent research on body perception in amputees suggest that prosthesis ownership, defined as the extent to which a prosthesis is experienced as ... Read more >>

Pain (Pain)
[2021, 162(2):630-640]

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Unveiling new mechanisms for cold sensitization.

Kali Esancy, Ajay Dhaka,

Pain (Pain)
[2021, 162(2):323-324]

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Effects of sex on placebo effects in chronic pain participants: a cross-sectional study.

Elizabeth M Olson, Titilola Akintola, Jane Phillips, Maxie Blasini, Nathaniel R Haycock, Pedro E Martinez, Joel D Greenspan, Susan G Dorsey, Yang Wang, Luana Colloca,

<h4>Abstract</h4>Sex-related differences can influence outcomes of randomized clinical trials and may jeopardize the effectiveness of pain management and other therapeutics. Thus, it is essential to understand the mechanistic and translational aspects of sex differences in placebo outcomes. Recently, studies in healthy participants have shed light on how sex-related placebo effects ... Read more >>

Pain (Pain)
[2021, 162(2):531-542]

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High-dose spinal cord stimulation for patients with failed back surgery syndrome: a multicenter effectiveness and prediction study.

Lisa Goudman, Ann De Smedt, Sam Eldabe, Philippe Rigoard, Bengt Linderoth, Mats De Jaeger, Maarten Moens, ,

<h4>Abstract</h4>The use of high-dose spinal cord stimulation (HD-SCS) has increased drastically during the past few years, with positive results. However, there remains a deficit of real-world data of the effectiveness of HD-SCS. Therefore, the primary aim was to evaluate the effectiveness of HD-SCS in patients with failed back surgery syndrome ... Read more >>

Pain (Pain)
[2021, 162(2):582-590]

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Histone deacetylase 3 in hippocampus contributes to memory impairment after chronic constriction injury of sciatic nerve in mice.

Guang-Fen Zhang, Zhi-Qiang Zhou, Jie Guo, Han-Wen Gu, Ming-Zhao Su, Bao-Cong Yu, Feng Zhou, Bao-Yu Han, Min Jia, Mu-Huo Ji, Yuan-Xiang Tao, Chun-Jie Zhao, Jian-Jun Yang,

<h4>Abstract</h4>Chronic neuropathic pain is frequently accompanied by memory impairment, yet the underlying mechanisms remain unclear. Here, we showed that mice displayed memory impairment starting at 14 days and lasting for at least 21 days after chronic constriction injury (CCI) of unilateral sciatic nerve in mice. Systemic administration of the pan ... Read more >>

Pain (Pain)
[2021, 162(2):382-395]

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Attentional bias to somatosensory stimuli in chronic pain patients: a systematic review and meta-analysis.

Philippa Broadbent, Christina Liossi, Daniel E Schoth,

<h4>Abstract</h4>This systematic review and meta-analysis aimed to evaluate the evidence pertaining to attentional bias for painful and nonpainful somatosensory stimuli in individuals with chronic pain. Eligible studies were identified through searches of Medline, PsycINFO, CINAHL, Web of Science, Scopus, and Cochrane Library databases. Search terms were words and phrases organised ... Read more >>

Pain (Pain)
[2021, 162(2):332-352]

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The use and reporting of neonatal pain scales: a systematic review of randomized trials.

Emma Olsson, Hanna Ahl, Kevin Bengtsson, Dhashini N Vejayaram, Elisabeth Norman, Matteo Bruschettini, Mats Eriksson,

<h4>Abstract</h4>The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized ... Read more >>

Pain (Pain)
[2021, 162(2):353-360]

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Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state.

Mehnaz I Ferdousi, Patricia Calcagno, Morgane Clarke, Sonali Aggarwal, Connie Sanchez, Karen L Smith, David J Eyerman, John P Kelly, Michelle Roche, David P Finn,

<h4>Abstract</h4>Chronic pain is often comorbid with anxiety and depression, altering the level of perceived pain, which negatively affects therapeutic outcomes. The role of the endogenous mu-opioid receptor (MOP) system in pain-negative affect interactions and the influence of genetic background thereon are poorly understood. The inbred Wistar-Kyoto (WKY) rat, which mimics ... Read more >>

Pain (Pain)
[2021, 162(2):405-420]

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Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain.

Anna Piotrowska, Joanna Starnowska-Sokół, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Dagmara Tymecka, Angelika Ignaczak, Beata Wilenska, Aleksandra Misicka, Barbara Przewłocka,

<h4>Abstract</h4>The purpose of our work was to determine the role of nonopioid peptides derived from opioid prohormones in sensory hypersensitivity characteristics of neuropathic pain and to propose a pharmacological approach to restore the balance of these endogenous opioid systems. Nonopioid peptides may have a pronociceptive effect and therefore contribute to ... Read more >>

Pain (Pain)
[2021, 162(2):432-445]

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Differential actions of indomethacin: clinical relevance in headache.

Oliver Summ, Anna P Andreou, Simon Akerman, Philip R Holland, Jan Hoffmann, Peter J Goadsby,

<h4>Abstract</h4>Nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibitors, are used routinely in the treatment of primary headache disorders. Indomethacin is unique in its use in the diagnosis and treatment of hemicrania continua and paroxysmal hemicrania. The mechanism of this specific action is not fully understood, although an interaction with nitric oxide (NO) signaling ... Read more >>

Pain (Pain)
[2021, 162(2):591-599]

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A combination of pain indices based on momentary assessments can predict placebo response in patients with fibromyalgia syndrome.

Alexander Obbarius, Stefan Schneider, Arthur A Stone,

<h4>Abstract</h4>Many factors are known to affect assay sensitivity; however, limited attention has been devoted to understanding whether characteristics of patients' baseline pain impact assay sensitivity. In this study, we tested whether a combination of 3 baseline pain indices based on ecological momentary assessments (EMA) could detect patients with enhanced responses ... Read more >>

Pain (Pain)
[2021, 162(2):543-551]

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Prism adaptation treatment for upper-limb complex regional pain syndrome: a double-blind randomized controlled trial.

Monika Halicka, Axel D Vittersø, Hayley McCullough, Andreas Goebel, Leila Heelas, Michael J Proulx, Janet H Bultitude,

<h4>Abstract</h4>Initial evidence suggested that people with complex regional pain syndrome (CRPS) have reduced attention to the affected side of their body and the surrounding space, which might be related to pain and other clinical symptoms. Three previous unblinded, uncontrolled studies showed pain relief after treatment with prism adaptation, an intervention ... Read more >>

Pain (Pain)
[2021, 162(2):471-489]

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A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome.

Fernanda C Cardoso, Joel Castro, Luke Grundy, Gudrun Schober, Sonia Garcia-Caraballo, Tianjiao Zhao, Volker Herzig, Glenn F King, Stuart M Brierley, Richard J Lewis,

<h4>Abstract</h4>Chronic pain is a serious debilitating condition that affects ∼20% of the world's population. Currently available drugs fail to produce effective pain relief in many patients and have dose-limiting side effects. Several voltage-gated sodium (NaV) and calcium (CaV) channels are implicated in the etiology of chronic pain, particularly NaV1.1, NaV1.3, ... Read more >>

Pain (Pain)
[2021, 162(2):569-581]

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Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex.

Jae-Hwan Jang, Eun-Mo Song, Young-Ho Do, Sora Ahn, Ju-Young Oh, Tae-Yeon Hwang, Yeonhee Ryu, Songhee Jeon, Mi-Yeon Song, Hi-Joon Park,

<h4>Abstract</h4>Chronic pain reduces life quality and is an important clinical problem associated with emotional and cognitive dysfunction. Epigenetic regulation of DNA methylation is involved in the induction of abnormal behaviors and pathological gene expression. We examined whether acupuncture can restore epigenetic changes caused by chronic pain, and identified the underlying ... Read more >>

Pain (Pain)
[2021, 162(2):514-530]

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Sex-dependent role of microglia in disulfide high mobility group box 1 protein-mediated mechanical hypersensitivity.

Nilesh M Agalave, Resti Rudjito, Alex Bersellini Farinotti, Payam Emami Khoonsari, Katalin Sandor, Yuki Nomura, Thomas A Szabo-Pardi, Carlos Morado Urbina, Vinko Palada, Theodore J Price, Helena Erlandsson Harris, Michael D Burton, Kim Kultima, Camilla I Svensson,

<h4>Abstract</h4>High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly addressed. Here, we ... Read more >>

Pain (Pain)
[2021, 162(2):446-458]

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Trigeminal neuralgia diffusivities using Gaussian process classification and merged group tractography.

David Qixiang Chen, Jidan Zhong, Powell P W Chu, Cathy Meng Fei Li, Mojgan Hodaie,

<h4>Abstract</h4>Imaging of trigeminal neuralgia (TN) has demonstrated key diffusion tensor imaging-based diffusivity alterations in the trigeminal nerve; however, imaging has primarily focused on the peripheral nerve segment because of previous limitations in reliably segmenting small fiber bundles across multiple subjects. We used Selective Automated Group Integrated Tractography to study 36 ... Read more >>

Pain (Pain)
[2021, 162(2):361-371]

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Neural effects of placebo analgesia in fibromyalgia patients and healthy individuals.

Eleni Frangos, Marta Čeko, Binquan Wang, Emily A Richards, John L Gracely, Luana Colloca, Petra Schweinhardt, M Catherine Bushnell,

<h4>Abstract</h4>Placebo analgesia is hypothesized to involve top-down engagement of prefrontal regions that access endogenous pain inhibiting opioid pathways. Fibromyalgia (FM) patients have neuroanatomical and neurochemical alterations in pathways relevant to placebo analgesia. Thus, it remains unclear whether placebo analgesic mechanisms would differ in FM patients compared to healthy controls (HCs). ... Read more >>

Pain (Pain)
[2021, 162(2):641-652]

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Virtual reality approaches to pain: toward a state of the science.

Zina Trost, Christopher France, Monima Anam, Corey Shum,

Pain (Pain)
[2021, 162(2):325-331]

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Nociceptive afferent phenotyping reveals that transient receptor potential ankyrin 1 promotes cold pain through neurogenic inflammation upstream of the neurotrophic factor receptor GFRα3 and the menthol receptor transient receptor potential melastatin 8.

Shanni Yamaki, Amanda Chau, Luigi Gonzales, David D McKemy,

<h4>Abstract</h4>The proper detection and behavioral response to painfully cold temperatures is critical for avoiding potentially harmful tissue damage. Cold allodynia and hyperalgesia, pain associated with innocuous cooling and exaggerated pain with noxious cold, respectively, are common in patients with chronic pain. In peripheral somatosensory afferents, the ion channels transient receptor ... Read more >>

Pain (Pain)
[2021, 162(2):609-618]

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Prevalence and predictors of burnout symptoms in multidisciplinary pain clinics: a mixed-methods study.

Claire E Ashton-James, Amy G McNeilage, Nicholas S Avery, Luci H E Robson, Daniel Costa,

<h4>Abstract</h4>Frequent exposure to patient distress is associated with a higher prevalence of clinician distress and burnout. Patients with chronic pain often present with high levels of emotional distress. The current study examined the prevalence of burnout symptoms among a multidisciplinary sample of pain clinicians in Australia, the relationship between clinician ... Read more >>

Pain (Pain)
[2021, 162(2):503-513]

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Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial.

Ian Gilron, Sylvia Robb, Dongsheng Tu, Ronald Holden, Tanveer Towheed, Dan Ziegler, Louie Wang, Roumen Milev, Christopher Gray,

<h4>Abstract</h4>Fibromyalgia is a common and challenging chronic pain disorder with few, if any, highly effective and well-tolerated treatments. Alpha-lipoic acid (ALA) is a nonsedating antioxidant with evidence of efficacy in the treatment of symptomatic diabetic neuropathy that has not been evaluated in the setting of fibromyalgia treatment. Thus, we conducted ... Read more >>

Pain (Pain)
[2021, 162(2):561-568]

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Identification of neural and psychophysical predictors of headache reduction after cognitive behavioral therapy in adolescents with migraine.

Hadas Nahman-Averbuch, Victor J Schneider, Leigh Ann Chamberlin, Ashley M Kroon Van Diest, James L Peugh, Gregory R Lee, Rupa Radhakrishnan, Andrew D Hershey, Scott W Powers, Robert C Coghill, Christopher D King,

<h4>Abstract</h4>Cognitive behavioral therapy (CBT) is a psychological intervention that involves development of coping strategies to reduce the experience of pain. Although CBT is a promising intervention to reduce headache days in patients with migraine, it may not be effective for all patients. Thus, there is a need to identify markers ... Read more >>

Pain (Pain)
[2021, 162(2):372-381]

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Cross-sectional study of psychosocial and pain-related variables among patients with chronic pain during a time of social distancing imposed by the coronavirus disease 2019 pandemic.

Valerie Hruschak, K Mikayla Flowers, Desiree R Azizoddin, Robert N Jamison, Robert R Edwards, Kristin L Schreiber,

<h4>Abstract</h4>The COVID-19 pandemic has had a tremendous impact, including on individuals with chronic pain. The social distancing policies necessary to slow the spread of SARS-CoV-2 have involved increased levels of social isolation. This cross-sectional survey study examined pain severity and interference among individuals with chronic pain during an early phase ... Read more >>

Pain (Pain)
[2021, 162(2):619-629]

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Foxo1 selectively regulates static mechanical pain by interacting with Nav1.7.

Xiao-Long Zhang, Ren-Chun Lai, Zi-Hang Chen, Xiong-Xiong Zhong, Xian-Ying Cao, Xi Zhang, Yi-Bin Xiao, Jun-Chao Wang, Xian-Guo Liu, Man-Xiu Xie,

<h4>Abstract</h4>Mechanical allodynia is a debilitating condition for millions of patients with chronic pain. Mechanical allodynia can manifest in distinct forms, including brush-evoked dynamic and filament-evoked static allodynia. In the nervous system, the forkhead protein Foxo1 plays a critical role in neuronal structures and functions. However, the role of Foxo1 in ... Read more >>

Pain (Pain)
[2021, 162(2):490-502]

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