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Regional development potentials of Industry 4.0: Open data indicators of the Industry 4.0+ model.

Tímea Czvetkó, Gergely Honti, János Abonyi,

This paper aims to identify the regional potential of Industry 4.0 (I4.0). Although the regional background of a company significantly determines how the concept of I4.0 can be introduced, the regional aspects of digital transformation are often neglected with regard to the analysis of I4.0 readiness. Based on the analysis ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250247]

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Stillbirth rates, service outcomes and costs of implementing NHS England's Saving Babies' Lives care bundle in maternity units in England: A cohort study.

Kate Widdows, Stephen A Roberts, Elizabeth M Camacho, Alexander E P Heazell,

<h4>Objective</h4>To assess implementation of the Saving Babies Lives (SBL) Care Bundle, a collection of practice recommendations in four key areas, to reduce stillbirth in England.<h4>Design</h4>A retrospective cohort study of 463,630 births in 19 NHS Trusts in England using routinely collected electronic data supplemented with case note audit (n = 1,658), ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250150]

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Estimating an individual-level deprivation index for HIV/HCV coinfected persons in Canada.

Adam Palayew, Alexandra M Schmidt, Sahar Saeed, Curtis L Cooper, Alexander Wong, Valérie Martel-Laferrière, Sharon Walmsley, Joseph Cox, Marina B Klein, ,

<h4>Background</h4>HIV-HCV coinfected individuals are often more deprived than the general population. However, deprivation is difficult to measure, often relying on aggregate data which does not capture individual heterogeneity. We developed an individual-level deprivation index for HIV-HCV co-infected persons that encapsulated social, material, and lifestyle factors.<h4>Methods</h4>We estimated an individual-level deprivation index ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249836]

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A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats.

Johanna A Huhtakangas, Jere Huovinen, Sakari Laaksonen, Hanna-Marja Voipio, Olli Vuolteenaho, Mikko A J Finnilä, Jérôme Thevenot, Petri P Lehenkari,

1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing. The purpose of this preliminary study was to test the efficacy and safety of calcipotriol, vitamin D analog, as a treatment for a fully-developed knee arthritis in Zymosan-induced arthritis (ZIA) model. Forty 5-month-old ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250352]

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Community knowledge, attitude and practices to SARS-CoV-2 disease 2019 (COVID-19): A cross-sectional study in Woldia town, Northeast Ethiopia.

Kindu Alem Molla, Silamlak Birhanu Abegaz,

SARS-CoV-2 disease 2019 (COVID-19) is pandemic and currently becomes a serious cause of death worldwide. It is caused by a SARS-CoV-2 belonging to a family known as corona virus. The aim of this study is to assess the community knowledge, attitude and practice strategy implementation on SARS-CoV-2 disease 2019 (COVID-19). ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250465]

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Prevalence and associated factors of hemorrhoids among adult patients visiting the surgical outpatient department in the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

Anteneh Ayelign Kibret, Mohammed Oumer, Abebe Muche Moges,

<h4>Introduction</h4>Hemorrhoidal disease is a very common benign anorectal disease. It affects millions of people around the world, and represent a major medical and socioeconomic problem. However, studies that determine the magnitude and risk factors are limited. Therefore, the aim this study is to assess the prevalence and associated factors of ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249736]

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Knowledge, attitude, perception, and preventative practices towards COVID-19 in sub-Saharan Africa: A scoping review.

Ugochinyere Ijeoma Nwagbara, Emmanuella Chinonso Osual, Rumbidzai Chireshe, Obasanjo Afolabi Bolarinwa, Balsam Qubais Saeed, Nelisiwe Khuzwayo, Khumbulani W Hlongwana,

<h4>Background</h4>Knowledge, attitudes, perception, and preventative practices regarding coronavirus- 2019 (COVID-19) are crucial in its prevention and control. Several studies have noted that the majority of people in sub-Saharan African are noncompliant with proposed health and safety measures recommended by the World Health Organization (WHO) and respective country health departments. In ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249853]

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Sources of individual differences in adults' ICT skills: A large-scale empirical test of a new guiding framework.

Alexandra Wicht, Stephen Reder, Clemens M Lechner,

We develop an integrative conceptual framework that seeks to explain individual differences in the ability to use information and communication technologies (ICT skills). Building on practice engagement theory, this framework views the continued usage of digital technologies at work and in everyday life (ICT use) as the key prerequisite for ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249574]

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EmoTIC: Impact of a game-based social-emotional programme on adolescents.

Usue de la Barrera, Estefanía Mónaco, Silvia Postigo-Zegarra, José-Antonio Gil-Gómez, Inmaculada Montoya-Castilla,

<h4>Introduction</h4>Technologies provide a brilliant opportunity to promote social-emotional competences, well-being and adjustment in adolescence. Game-based programmes and serious games are digital tools that pursue an educational goal in an attractive environment for adolescents. The purpose of this study was therefore to determine the effectiveness of emoTIC, a game-based social-emotional programme ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250384]

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Inadequate preparedness for response to COVID-19 is associated with stress and burnout among healthcare workers in Ghana.

Patience A Afulani, Akua O Gyamerah, Jerry J Nutor, Amos Laar, Raymond A Aborigo, Hawa Malechi, Mona Sterling, John K Awoonor-Williams,

<h4>Introduction</h4>The COVID-19 pandemic has compounded the global crisis of stress and burnout among healthcare workers. But few studies have empirically examined the factors driving these outcomes in Africa. Our study examined associations between perceived preparedness to respond to the COVID-19 pandemic and healthcare worker stress and burnout and identified potential ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250294]

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Results from a malaria indicator survey highlight the importance of routine data capture in high-risk forest and farm transmission sites in Vietnam to tailor location-specific malaria elimination interventions.

Thang Duc Ngo, Sara E Canavati, Dang Viet Dung, Thuan Huu Vo, Duong Thanh Tran, Long Khanh Tran, Rosalie J Whedbee, Ekaterina I Milgotina, Gerard C Kelly, Kimberly A Edgel, Nicholas J Martin,

In-line with the World Health Organization's (WHO) Global Technical Strategy for Malaria (2016-2030), Vietnam is striving to eliminate malaria by 2030. Targeting appropriate interventions in high-risk populations such as forest and forest-fringe communities is a critical component of malaria elimination efforts in Vietnam. In 2016, a household-level malaria indicator survey ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250045]

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Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A retrospective cohort study.

Takahiro Yagyuu, Naoki Funayama, Mitsuhiko Imada, Tadaaki Kirita,

Tobacco smoking is associated with an increased risk of oral leukoplakia and head and neck cancer. Although it has recently been reported that the establishment of an immunosuppressive microenvironment in oral potentially malignant disorders may lead to malignant transformation, it is unclear whether the microenvironments of oral potentially malignant disorders ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250359]

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Determinants of post cesarean section surgical site infection at public hospitals in Dire Dawa administration, Eastern Ethiopia: Case control study.

Samuel Dessu, Serawit Samuel, Feleke Gebremeskel, Alemu Basazin, Zerihun Tariku, Meles Markos,

<h4>Introduction</h4>Post cesarean section surgical site infection increases both the duration of a patient's hospital stay and unplanned hospital costs. It can delays recovery, prolongs hospitalization, necessitates readmission, and adds to hospital bills and other morbidities as well as mortalities.<h4>Method</h4>Facility-based case-control study was conducted from 1st March to 20th April, 2019 ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250174]

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Patient reported outcomes in a large cohort of patients receiving osteopathic care in the United Kingdom.

Carol Fawkes, Dawn Carnes,

<h4>Objective</h4>The use of Patient Reported Outcome Measures (PROMs) to evaluate care is being advocated increasingly in clinical settings. Electronic data capture is both resource and environmentally friendly and convenient. This purpose of this study was to test and implement a nationwide system to collect routine PROM data from osteopathic patients ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249719]

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Pathological complete response of adding targeted therapy to neoadjuvant chemotherapy for inflammatory breast cancer: A systematic review.

Sudpreeda Chainitikun, Jose Rodrigo Espinosa Fernandez, James P Long, Toshiaki Iwase, Kumiko Kida, Xiaoping Wang, Sadia Saleem, Bora Lim, Vicente Valero, Naoto T Ueno,

<h4>Background</h4>The current use of targeted therapy plus neoadjuvant chemotherapy for inflammatory breast cancer (IBC) is based on data extrapolated from studies in non-IBC. We conducted a systematic review to determine whether neoadjuvant chemotherapy plus targeted therapy results in a higher pathologic complete response (pCR) rate than neoadjuvant chemotherapy alone in ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250057]

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La Crosse virus spread within the mosquito population in Knox County, TN.

Cameron Cook, Annastashia Blesi, Samantha Brozak, Suzanne Lenhart, Hanna Reed, Cassandra Urquhart, Abelardo Moncayo, Rebecca Trout Fryxell,

In Appalachia, La Crosse virus (LACV) is a leading pediatric arbovirus and public health concern for children under 16 years. LACV is transmitted via the bite of an infected Aedes mosquito. Thus, it is imperative to understand the dynamics of the local vector population in order to assess risk and ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249811]

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Relationships of irrigation water and soil physical and chemical characteristics with yield, chemical composition and antimicrobial activity of Damask rose essential oil.

Mansureh Ghavam,

Damask rose (Rosa damascena Mill.) is an aromatic medicinal plant rich in bioactive compounds with high value in the food, pharmaceutical and cosmetic industries. Knowledge of the factors affecting the quantitative and qualitative properties of the compounds in its essential oil (EO) and the bioactivity of this EO is important ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249363]

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No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection-Subanalysis of the prospective randomised VIPP study.

Pascale Mazzola, Elke Schaeffeler, Oliver Witzke, Martin Nitschke, Volker Kliem, Max Zortel, Eva-Maria Wagner, Matthias Schwab, Ingeborg A Hauser,

<h4>Background</h4>Cytomegalovirus (CMV) infection is amongst the most important factors complicating solid organ transplantation. In a large prospective randomized clinical trial, valganciclovir prophylaxis reduced the occurrence of CMV infection and disease compared with preemptive therapy in CMV-positive renal allograft recipients (VIPP study; NCT00372229). Here, we present a subanalysis of the VIPP ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0246118]

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Correction: Opposite associations of collective narcissism and in-group satisfaction with intergroup aggression via belief in the hedonistic function of revenge.

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[This corrects the article DOI: 10.1371/journal.pone.0247814.]. ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250537]

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Correction: Transient changes in white matter microstructure during general anesthesia.

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[This corrects the article DOI: 10.1371/journal.pone.0247678.]. ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250449]

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Correction: Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.

Jun-Ichi Kashiwakura, Kodai Saitoh, Takeru Ihara, Yuto Sasaki, Kota Kagohashi, Shiyo Enohara, Yuka Morioka, Hiroshi Watarai, Ryuta Muromoto, Yuichi Kitai, Kazuya Iwabuchi, Kenji Oritani, Tadashi Matsuda,

[This corrects the article DOI: 10.1371/journal.pone.0241440.]. ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250536]

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Relationship between peripheral vasospasm and visual field progression rates in patients with normal-tension glaucoma with low-teen intraocular pressure.

Do Young Park, Jong Chul Han, Eun Jung Lee, Changwon Kee,

<h4>Purpose</h4>To investigate the association between peripheral vasospasm and the visual field (VF) progression rate in patients with normal-tension glaucoma (NTG) with low-teen intraocular pressure (IOP).<h4>Methods</h4>The finger temperature of 113 NTG patients was measured before and after exposure to ice water using a Temperature gun (cold pressor test). These patients had ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250085]

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Prognostic value of serial neutrophil-to-lymphocyte ratio measurements in hospitalized community-acquired pneumonia.

Heock Lee, Insu Kim, Bo Hyoung Kang, Soo-Jung Um,

<h4>Introduction</h4>Several serum inflammatory markers are associated with poor clinical outcomes in community-acquired pneumonia (CAP). However, the prognosis and early treatment response in hospitalized CAP patients based on serial neutrophil-to-lymphocyte ratio (NLR) measurement has never been investigated.<h4>Methods</h4>We performed a retrospective observational study for 175 consecutive patients hospitalized with CAP between February ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250067]

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Development and validation of the Trauma-Related Cognitions Scale.

Christine E Valdez, Melissa J London, Steven E Gregorich, Michelle M Lilly,

Cognitive theories suggest the manner in which individuals process trauma-related information influences posttraumatic sequelae. Interpretations about trauma can be maladaptive and lead to cognitive distortions implicated in the development of posttraumatic stress disorder (PTSD) through the processes of overaccommodation and assimilation. Alternatively, adaptive interpretations about trauma through the process of ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250221]

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Leveraging mobile phone surveys during the COVID-19 pandemic in Ecuador and Sri Lanka: Methods, timeline and findings.

Rachael Phadnis, Champika Wickramasinghe, Juan Carlos Zevallos, Stacy Davlin, Vindya Kumarapeli, Veronica Lea, Juliette Lee, Udara Perera, Francisco Xavier Solórzano, Juan Francisco Vásconez,

Effective and rapid decision making during a pandemic requires data not only about infections, but also about human behavior. Mobile phone surveys (MPS) offer the opportunity to collect real-time data on behavior, exposure, knowledge, and perception, as well as care and treatment to inform decision making. The surveys aimed to ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250171]

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