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CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer.

Hiroya Matsuoka, Koji Ando, Emma J Swayze, Elizabeth C Unan, Joseph Mathew, Quingjiang Hu, Yasuo Tsuda, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Ajit K Bharti, Masaki Mori,

Irinotecan specifically targets topoisomerase I (topoI), and is used to treat various solid tumors, but only 13-32% of patients respond to the therapy. Now, it is understood that the rapid rate of topoI degradation in response to irinotecan causes irinotecan resistance. We have published that the deregulated DNA-PKcs kinase cascade ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0228002]

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Association between GDF15, poverty and mortality in urban middle-aged African American and white adults.

David W Freeman, Nicole Noren Hooten, Yoonseo Kim, Nicolle A Mode, Ngozi Ejiogu, Alan B Zonderman, Michele K Evans,

Mortality disparities are influenced by race and poverty. There is limited information about whether poverty influences biologic markers of mortality risk. Emerging data suggests that growth differentiation factor 15 (GDF15) is associated with mortality; however, the interplay between GDF15, sociodemographic factors and mortality is not known. We sought to evaluate ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237059]

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Correction: RNA profiling identifies novel, photoperiod-history dependent markers associated with enhanced saltwater performance in juvenile Atlantic salmon.

Marianne Iversen, Teshome Mulugeta, Børge Gellein Blikeng, Alexander Christopher West, Even Hjalmar Jørgensen, Simen Rød Sandve, David Hazlerigg,

[This corrects the article DOI: 10.1371/journal.pone.0227496.]. ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237623]

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Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study.

Cornelia Then, Barbara Thorand, Holger L Then, Christa Meisinger, Margit Heier, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Martin Bidlingmaier, Andreas Lechner, Martin Reincke, Jürgen E Scherberich, Jochen Seissler,

OBJECTIVES:Uromodulin has been associated with arterial hypertension in genome-wide association studies, but data from clinical and preclinical studies are inconsistent. We here analyzed the association of serum uromodulin (sUmod) with arterial hypertension and vasoactive hormones in a population-based study. METHODS:In 1108 participants of the KORA F4 study aged 62-81 years, ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237364]

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The Mont Blanc Study: The effect of altitude on intra ocular pressure and central corneal thickness.

Carlo Bruttini, Alice Verticchio Vercellin, Catherine Klersy, Annalisa De Silvestri, Carmine Tinelli, Ivano Riva, Francesco Oddone, Andreas Katsanos, Luciano Quaranta,

The aim of the Mont Blanc Study was to investigate the relationship between intraocular pressure (IOP), central corneal thickness (CCT), and altitude in healthy subjects. Thirty-three eyes of 33 healthy volunteers (mean age: 24.8 years, 17 females) had their IOP measured with Perkins and I-Care tonometers and their CCT using ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237343]

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Malaria preventive practices and delivery outcomes: A cross-sectional study of parturient women in a tertiary hospital in Eastern Uganda.

Rebecca Nekaka, Julius Nteziyaremye, Paul Oboth, Jacob Stanley Iramiot, Julius Wandabwa,

BACKGROUND:Uganda ranks third in the number of deaths attributable to malaria and has some of the highest recorded malaria transmission rates in the general population. Malaria in Pregnancy is associated with detrimental effects for the mother and unborn baby and these effects seem to have long term effects and consequences ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237407]

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Flexible sensor matrix film-based wearable plantar pressure force measurement and analysis system.

Shumi Zhao, Rong Liu, Chengwei Fei, Abdul Wasy Zia, Lingxiao Jing,

Plantar pressure force data derived from gait and posture are commonly used as health indicators for foot diagnosis, injury prevention, and rehabilitation. This study developed a wearable plantar pressure force measurement and analysis (WPPFMA) system based on a flexible sensor matrix film to monitor plantar pressure force in real time. ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237090]

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Identification of chemosensory genes from the antennal transcriptome of Semiothisa cinerearia.

Panjing Liu, Xiaofang Zhang, Runjie Meng, Chang Liu, Min Li, Tao Zhang,

Olfaction plays vital roles in the survival and reproduction of insects. The completion of olfactory recognition requires the participation of various complex protein families. However, little is known about the olfactory-related proteins in Semiothisa cinerearia Bremer et Grey, an important pest of Chinese scholar tree. In this study, we sequenced ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237134]

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Modelling the distribution of Mustela nivalis and M. putorius in the Azores archipelago based on native and introduced ranges.

Lucas Lamelas-López, Xosé Pardavila, Paulo A V Borges, Margarida Santos-Reis, Isabel R Amorim, Maria J Santos,

The aims of this study were to predict the potential distribution of two introduced Mustelidae, Mustela nivalis and M. putorius in the Azores archipelago (Portugal), and evaluate the relative contribution of environmental factors from native and introduced ranges to predict species distribution ranges in oceanic islands. We developed two sets ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237216]

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Associations between fucosyltransferase 3 gene polymorphisms and ankylosing spondylitis: A case-control study of an east Chinese population.

Guangming Jiang, Renfang Han, Mengya Chen, Rui Liu, Meng Wu, Xu Zhang, Yubo Ma, Yaping Yuan, Ran Wang, Zongwen Shuai, Faming Pan,

Many susceptibility genes of inflammatory bowel disease (IBD) are associated with ankylosing spondylitis (AS). Fucosyltransferase 2 (FUT2) and FUT3 genes are related to IBD. This study aimed to investigate whether these genes correlated with the susceptibility to AS. Questionnaires of 673 patients with AS, and peripheral blood specimens of the ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237219]

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Evaluation of sexual minority identity as a moderator of the association between intimate partner violence and suicidal ideation and attempts among a national sample of youth.

Liesl A Nydegger, Lyzette Blanco, C Nathan Marti, Daniel Kreitzberg, Katherine Quinn,

Sexual minority (SM) youth are at high risk for intimate partner violence (IPV) and suicidal ideation/attempts compared to their heterosexual peers. We examined whether SM identity enhanced the relationship between experiences of IPV and suicidal ideation/attempts. Weighted logistic regression models were run using the 2017 Youth Risk Behavior Survey. All ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0236880]

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Resistance training prevents right ventricle hypertrophy in rats exposed to secondhand cigarette smoke.

Ana Caroline Rippi Moreno, Gisele Alborghetti Nai, Caroline Pancera Laurindo, Karen Cristina Rego Gregorio, Tiago Olean-Oliveira, Marcos Fernando Souza Teixeira, Patricia Monteiro Seraphim,

Exposure to secondhand cigarette smoke is associated with the development of diverse diseases. Resistance training has been considered one of the most useful tools for patients with pulmonary disease, improving their quality of life. This study aimed to evaluate the effect of resistance training (RT) on the prevention of thickening ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0236988]

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Tongue thickness measured by ultrasonography is associated with tongue pressure in the Japanese elderly.

Masahiro Nakamori, Eiji Imamura, Masako Fukuta, Keisuke Tachiyama, Teppei Kamimura, Yuki Hayashi, Hayato Matsushima, Kanami Ogawa, Masami Nishino, Akiko Hirata, Tatsuya Mizoue, Shinichi Wakabayashi,

The term "oral frailty" reflects the fact that oral health is associated with physical frailty and mortality. The gold standard methods for evaluating the swallowing function have several problems, including the need for specialized equipment, the risk of radiation exposure and aspiration, and general physicians not possessing the requisite training ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0230224]

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Feasibility and acceptability of a pilot, peer-led HIV self-testing intervention in a hyperendemic fishing community in rural Uganda.

Joseph K B Matovu, Laura M Bogart, Jennifer Nakabugo, Joseph Kagaayi, David Serwadda, Rhoda K Wanyenze, Albert I Ko, Ann E Kurth,

BACKGROUND:Novel interventions are needed to reach young people and adult men with HIV services given the low HIV testing rates in these population sub-groups. We assessed the feasibility and acceptability of a peer-led oral HIV self-testing (HIVST) intervention in Kasensero, a hyperendemic fishing community (HIV prevalence: 37-41%) in Rakai, Uganda. ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0236141]

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Understanding the participation of breast screening among women born in predominantly Muslim countries living in Victoria, Australia from record-linkage data.

Tahira Yeasmeen, Margaret Kelaher, Julia M L Brotherton, Michael J Malloy,

BACKGROUND:Early detection of breast cancer can improve survival rates and decrease mortality rates. This study investigates whether there are significant differences in participation in breast screening among women born in Muslim countries compared to women born in Non-Muslim countries and Australia. METHODS:Screening data from January 1st, 2000 to December 31st, ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237341]

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Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure.

Marcella Groeger, Gerrit Spanier, Michael Wolf, James Deschner, Peter Proff, Agnes Schröder, Christian Kirschneck,

As type-I-allergies show an increasing prevalence in the general populace, orthodontic patients may also be affected by histamine release during treatment. Human periodontal ligament fibroblasts (PDLF) are regulators of orthodontic tooth movement. However, the impact of histamine on PDLF in this regard is unknown. Therefore PDLF were incubated without or ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237040]

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Does type of active workstation matter? A randomized comparison of cognitive and typing performance between rest, cycling, and treadmill active workstations.

Kayla M Frodsham, Nicholas R Randall, Kaylie A Carbine, Rebekah E Rodeback, James D LeCheminant, Michael J Larson,

Active workstations are associated with improved health outcomes, but differences in cognitive and typing outcomes between the types of active workstations are unclear. We addressed two main questions: (1) Are there differences in cognitive and typing performance between seated and active workstations? (2) Are there differences in cognitive and typing ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237348]

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Empirical vs. light-use efficiency modelling for estimating carbon fluxes in a mid-succession ecosystem developed on abandoned karst grassland.

Koffi Dodji Noumonvi, Mitja Ferlan,

Karst systems represent an important carbon sink worldwide. However, several phenomena such as the CO2 degassing and the exchange of cave air return a considerable amount of CO2 to the atmosphere. It is therefore of paramount importance to understand the contribution of the ecosystem to the carbon budget of karst ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237351]

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In vivo two-photon microscopic observation and ablation in deeper brain regions realized by modifications of excitation beam diameter and immersion liquid.

Kazushi Yamaguchi, Ryoji Kitamura, Ryosuke Kawakami, Kohei Otomo, Tomomi Nemoto,

In vivo two-photon microscopy utilizing a nonlinear optical process enables, in living mouse brains, not only the visualization of morphologies and functions of neural networks in deep regions but also their optical manipulation at targeted sites with high spatial precision. Because the two-photon excitation efficiency is proportional to the square ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237230]

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Transcriptome analysis of the eggs of the silkworm pale red egg (rep-1) mutant at 36 hours after oviposition.

Meina Wu, Pingyang Wang, Mengjie Gao, Dongxu Shen, Qiaoling Zhao,

The egg stage is one of the most critical periods in the life history of silkworms, during which physiological processes such as sex determination, tissue organ formation and differentiation, diapause and pigmentation occur. In addition, egg color gradually emerges around 36h after oviposition. The red egg mutant rep-1, which was ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237242]

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Exposure to family and domestic violence is associated with increased childhood hospitalisations.

Carol Orr, Colleen M Fisher, David B Preen, Rebecca A Glauert, Melissa O'Donnell,

BACKGROUND:Children's exposure to family and domestic violence (FDV) is a global public health concern and is considered one of the most common and severe stressors children can experience. While it is acknowledged that children who are exposed to FDV have poorer general health, there is a lack of data on ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237251]

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The Earth's magnetic field in Jerusalem during the Babylonian destruction: A unique reference for field behavior and an anchor for archaeomagnetic dating.

Yoav Vaknin, Ron Shaar, Yuval Gadot, Yiftah Shalev, Oded Lipschits, Erez Ben-Yosef,

Paleomagnetic analysis of archaeological materials is crucial for understanding the behavior of the geomagnetic field in the past. As it is often difficult to accurately date the acquisition of magnetic information recorded in archaeological materials, large age uncertainties and discrepancies are common in archaeomagnetic datasets, limiting the ability to use ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237029]

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Factors associated with single-room assignment among patients admitted through the emergency department during influenza epidemics.

Donia Bouzid, Benoit Visseaux, Anne Perozziello, Xavier Lescure, Xavier Duval, Enrique Casalino, Jean Christophe Lucet, ,

INTRODUCTION:Every winter, emergency departments (EDs) face overcrowding with patients presenting influenza-like symptoms, and organisational issues such as single room assignment and droplet precautions to avoid hospital-acquired influenza. Our main objective was to assess the impact of PCR results and patient's severity on single room assignment. METHODS:All patients admitted to Bichat-Claude ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237214]

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Beliefs, perceptions, and behaviors impacting healthcare utilization of Syrian refugee children.

Riham M Alwan, Daniel J Schumacher, Sevsem Cicek-Okay, Sarah Jernigan, Ahmed Beydoun, Tasnim Salem, Lisa M Vaughn,

BACKGROUND:Approximately 18,000 Syrian refugees have resettled to the United States. Half of these refugees are children, whose age and refugee status jeopardize their abilities to attain quality healthcare. Information on Syrian refugees' health in the U.S. is limited. This qualitative study sought to explore Syrian refugee parents' beliefs, perspectives, and ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237081]

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Lingual electrotactile discrimination ability is associated with the presence of specific connective tissue structures (papillae) on the tongue surface.

Tyler S Allison, Joel Moritz, Philip Turk, Leslie M Stone-Roy,

Electrical stimulation of nerve endings in the tongue can be used to communicate information to users and has been shown to be highly effective in sensory substitution applications. The anterior tip of the tongue has very small somatosensory receptive fields, comparable to those of the finger tips, allowing for precise ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237142]

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