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First report of border disease virus in Melophagus ovinus (sheep ked) collected in Xinjiang, China.

Yong-Hong Liu, Bo He, Kai-Rui Li, Fei Li, Lu-Yao Zhang, Xian-Qiang Li, Li Zhao,

Melophagus ovinus (sheep ked) is a blood-sucking ectoparasite that is parasitic primarily on sheep. It is widely distributed in different geographical regions worldwide. In China, it has been mainly found in Xinjiang, Gansu, and Tibet in recent years. In addition to causing direct damage to the animal hosts, M. ovinus ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221435]

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Correction: Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children.

Yi-De Yang, Jie-Yun Song, Shuo Wang, Fang-Hong Liu, Yi-Ning Zhang, Xiao-Rui Shang, Hai-Jun Wang, Jun Ma,

[This corrects the article DOI: 10.1371/journal.pone.0177973.]. ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221612]

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Flagella-dependent inhibition of biofilm formation by sub-inhibitory concentration of polymyxin B in Vibrio cholerae.

Sean Giacomucci, Candice Danabé-Nieto Cros, Xavier Perron, Annabelle Mathieu-Denoncourt, Marylise Duperthuy,

Biofilm formation is a common strategy used by bacteria in order to survive and persist in the environment. In Vibrio cholerae (V. cholerae), a Gram-negative pathogen responsible for the cholera disease, biofilm-like aggregates are important for the pathogenesis and disease transmission. Biofilm formation is initiated by the attachment of the ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221431]

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Experimental-numerical analysis of added resistance to container ships under presence of wind-wave loads.

Wei Wang, Tiecheng Wu, Dagang Zhao, Chunyu Guo, Wanzhen Luo, Yongjie Pang,

Experimental and numerical analyses performed on a scaled-down model of a 1900TEU container-ship are reported herein. Wind-tunnel and towing-tank experiments along with computational-fluid-dynamic simulations were performed to obtain (1) wind-load coefficients for superstructure of container ship at different wind angles under full-load operating conditions; (2) wave resistance of the model ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221453]

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Conjugation of an scFab domain to the oligomeric HIV envelope protein for use in immune targeting.

Hannah A D King, Christopher A Gonelli, Kirsteen M Tullett, Mireille H Lahoud, Damian F J Purcell, Heidi E Drummer, Pantelis Poumbourios, Rob J Center,

A promising strategy for the enhancement of vaccine-mediated immune responses is by directly targeting protein antigens to immune cells. Targeting of antigens to the dendritic cell (DC) molecule Clec9A has been shown to enhance antibody affinity and titers for model antigens, and influenza and enterovirus antigens, and may be advantageous ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220986]

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Vision with different presbyopia corrections simulated with a portable binocular visual simulator.

Aiswaryah Radhakrishnan, Daniel Pascual, Susana Marcos, Carlos Dorronsoro,

Presbyopes can choose today among different corrections to provide them with functional vision at far and near, and the outcomes and patient satisfaction depend on the selection. In this study, we present a binocular and portable vision simulator, based on temporal multiplexing of two synchronized tunable lenses allowing see-through and ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221144]

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Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians.

Fabrice Ruiz, Thibault Vallet, Amélie Dufaÿ Wojcicki, Émilie Belissa, Jean-Eudes Fontan, Loïc de Pontual, Sylvie Nathanson, Alain Chevallier, Sandra Laribe-Caget, Vincent Boudy,

Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusing on paracetamol, this study has explored the appropriateness of pharmaceutical products in ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221261]

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Performance of HIV pre-exposure prophylaxis indirect adherence measures among men who have sex with men and transgender women: Results from the PrEP Brasil Study.

Luana M S Marins, Thiago S Torres, Iuri da C Leite, Ronaldo I Moreira, Paula M Luz, Brenda Hoagland, Esper G Kallas, José Valdez Madruga, Albert Y Liu, Peter L Anderson, Beatriz Grinsztejn, Valdilea G Veloso,

Efficacy of daily emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) for PrEP is strongly dependent on the adherence. We examined the concordance between indirect adherence measures and protective drug levels among participants retained through 48 weeks in the PrEP Brasil Study. PrEP Brasil was a prospective, multicenter, open-label demonstration project evaluating PrEP provision ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221281]

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The efficacy of a brief intervention to reduce alcohol use in persons with HIV in South Africa, a randomized clinical trial.

Diana Huis In 't Veld, Chellafe Ensoy-Musoro, Supa Pengpid, Karl Peltzer, Robert Colebunders,

Since there is a high prevalence of high risk alcohol use in patients with HIV in Africa, with negative health effects, there is a need for short interventions to reduce alcohol use. We studied the efficacy of a short intervention aiming to reduce alcohol use based on the Information-Motivation-Behavioural Skills ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220799]

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Hate speech detection: Challenges and solutions.

Sean MacAvaney, Hao-Ren Yao, Eugene Yang, Katina Russell, Nazli Goharian, Ophir Frieder,

As online content continues to grow, so does the spread of hate speech. We identify and examine challenges faced by online automatic approaches for hate speech detection in text. Among these difficulties are subtleties in language, differing definitions on what constitutes hate speech, and limitations of data availability for training ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221152]

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A cross-sectional survey on patient safety culture among healthcare providers in the Upper East region of Ghana.

Alexander Akologo, Aaron Asibi Abuosi, Emmanuel Anongeba Anaba,

Adverse events pose a serious threat to quality patient care. Promoting a culture of safety is essential for reducing adverse events. This study aims to assess healthcare providers' perceptions of patient safety culture in three selected hospitals in the Upper East region of Ghana. The English version of the Hospital ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221208]

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Trans,trans-farnesol, an antimicrobial natural compound, improves glass ionomer cement properties.

Aline Rogéria Freire de Castilho, Pedro Luiz Rosalen, Isaac Jordão de Souza Araújo, Igor Lebedenco Kitagawa, Cecilia Atem Gonçalves de Araújo Costa, Malvin N Janal, Marcelo Corrêa Alves, Simone Duarte, Paulo Noronha Lisboa Filho, Rafael Nobrega Stipp, Regina Maria Puppin-Rontani,

A series of experiments were conducted to characterize a novel restorative material. We explored the effect on biological, physical and chemical properties of glass ionomer cement (GIC) adding-the naturally occurring tt-farnesol (900 mM). Two groups were accomplished for all assays: GIC+tt-farnesol and GIC (control). Biological assays: 1) agar diffusion against ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220718]

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A fractionated analysis of hot and cool self-regulation in cigarette smokers from different socioeconomic backgrounds.

Raquel de Luna Antonio, Sabine Pompeia,

Smoking cigarettes and low socioeconomic status (SES) are both related to impaired cognition. However, it is unknown whether people of lower SES, who comprise most tobacco smokers worldwide, are more susceptible to cognitive impairment associated with smoking. In this non-randomized, cross-sectional study we investigated the effects of cigarette smoking, SES ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220222]

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Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function.

Pablo Reyes-Gutierrez, Jake W Carrasquillo-Rodríguez, Anthony N Imbalzano,

JMJD6 is a member of the Jumonji C domain containing enzymes that demethylate and/or hydroxylate substrate proteins. It is a multi-functional protein that has been implicated in disparate aspects of transcriptional and post-transcriptional control of gene expression, including but not limited to enhancer and promoter binding, release of paused RNA ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0216015]

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Constitutive activation of mTORC1 signaling induced by biallelic loss-of-function mutations in SZT2 underlies a discernible neurodevelopmental disease.

Yuji Nakamura, Kohji Kato, Naomi Tsuchida, Naomichi Matsumoto, Yoshiyuki Takahashi, Shinji Saitoh,

There have been increasing number of reports of SZT2-related neurological diseases, the main symptoms of which are epilepsy, developmental delay, macrocephaly and a dysmorphic corpus callosum. SZT2 functions as a regulator of mechanistic target of rapamycin complex 1 (mTORC1) signaling in cultured human cell lines and mouse tissues. However, it ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221482]

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Patent pledges, open IP, or patent pools? Developing taxonomies in the thicket of terminologies.

Jonas Fabian Ehrnsperger, Frank Tietze,

Recently, a range of organisations, including car and consumer electronics manufacturers, have applied so-called patent pledges. A patent pledge is a publicly announced intervention by patent-owning entities ('pledgers') to out-license active patents to the restricted or unrestricted public free from or bound to certain conditions for a reasonable or no ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221411]

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Measures of predator diet alone may underestimate the collective impact on prey: Common buzzard Buteo buteo consumption of economically important red grouse Lagopus lagopus scotica.

Richard M Francksen, Nicholas J Aebischer, Sonja C Ludwig, David Baines, Mark J Whittingham,

Human-wildlife conflicts often centre on economic loss caused by wildlife. Yet despite being a major issue for land-managers, estimating total prey losses to predation can be difficult. Estimating impacts of protected wildlife on economically important prey can also help management decisions to be evidence-led. The recovery in population and range ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221404]

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The prevalence of depression and associated risk factors among medical students: An untold story in Vietnam.

Tung Pham, Linh Bui, Anh Nguyen, Binh Nguyen, Phung Tran, Phuong Vu, Linh Dang,

Depression is a common mental health problem in medical students worldwide. The association between depression and motivation in Vietnamese medical students is not well-documented. To estimate the prevalence of self-reported depression and to identify associated risk factors among medical students at Hanoi Medical University (HMU). A cross-sectional study was conducted ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221432]

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Amyloid-β PET-Correlation with cerebrospinal fluid biomarkers and prediction of Alzheimer´s disease diagnosis in a memory clinic.

Ebba Gløersen Müller, Trine Holt Edwin, Caroline Stokke, Sigrid Stensby Navelsaker, Almira Babovic, Nenad Bogdanovic, Anne Brita Knapskog, Mona Elisabeth Revheim,

Alzheimer's disease (AD) remains a clinical diagnosis but biomarkers from cerebrospinal fluid (CSF) and more lately amyloid imaging with positron emission tomography (PET), are important to support a diagnosis of AD. To compare amyloid-β (Aβ) PET imaging with biomarkers in CSF and evaluate the prediction of Aβ PET on diagnosis ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221365]

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Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro.

Ayelet Lenz, Gal Lenz, Hsun Teresa Ku, Kevin Ferreri, Fouad Kandeel,

Gastrin is a peptide hormone, which in combination with other factors such as TGFα, EGF or GLP-1, is capable of increasing beta cell mass and lowering blood glucose levels in adult diabetic mice. In humans, administration of a bolus of gastrin alone induces insulin secretion suggesting that gastrin may target ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221456]

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Patterns and risk factors of double burden of malnutrition among adolescent girls and boys in Indonesia.

Masumi Maehara, Jee Hyun Rah, Airin Roshita, Julia Suryantan, Asrinisa Rachmadewi, Doddy Izwardy,

As an emerging middle-income country, Indonesia is grappling with the double burden of malnutrition across all age groups, including adolescents. Slow gains in reducing undernutrition are compounded by rapidly increasing overnutrition. This study aims to determine the patterns and determinants of this double burden, particularly stunting, thinness and overweight, among ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221273]

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The effect of diagnosis-related group payment system on the quality of medical care for pelvic organ prolapse in Korean tertiary hospitals.

Myung Jae Jeon, Sung Pil Choo, Young Hwa Kwak, Dong Wook Kim, Eui Hyeok Kim,

To assess changes in clinical practice patterns after implementing diagnosis-related group (DRG) payment system in July 2013 and its effect on the quality of care for pelvic organ prolapse (POP). Using the 2011-2016 administrative database from National Health Insurance claim data, we reviewed medical information of 7362 patients who underwent ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220895]

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Non-invasive assessment of portal hypertension by multi-parametric magnetic resonance imaging of the spleen: A proof of concept study.

Christina Levick, Jane Phillips-Hughes, Jane Collier, Rajarshi Banerjee, Jeremy F Cobbold, Lai Mun Wang, Stefan K Piechnik, Matthew D Robson, Stefan Neubauer, Eleanor Barnes, Michael Pavlides,

Non-invasive assessment of portal hypertension is an area of unmet need. This proof of concept study aimed to evaluate the diagnostic accuracy of a multi-parametric magnetic resonance technique in the assessment of portal hypertension. Comparison to other non-invasive technologies was a secondary aim. T1 and T2* maps through the liver ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221066]

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Darcy-Forchheimer nanofluidic flow manifested with Cattaneo-Christov theory of heat and mass flux over non-linearly stretching surface.

Ghulam Rasool, Ting Zhang,

This research article aims to disclose the features of nanofluidic flow manifested with Cattaneo-Christov model of heat and mass flux over non-linearly stretching surface. An incompressible visco-elastic nanofluid saturates the given porous medium through Darcy-Forchheimer relation. A non-uniformly induced magnetic effect is considered to accentuate the electro-magnetic and thermal conductivity ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221302]

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Multi-group diagnostic classification of high-dimensional data using differential scanning calorimetry plasma thermograms.

Shesh N Rai, Sudhir Srivastava, Jianmin Pan, Xiaoyong Wu, Somesh P Rai, Chongkham S Mekmaysy, Lynn DeLeeuw, Jonathan B Chaires, Nichola C Garbett,

The thermoanalytical technique differential scanning calorimetry (DSC) has been applied to characterize protein denaturation patterns (thermograms) in blood plasma samples and relate these to a subject's health status. The analysis and classification of thermograms is challenging because of the high-dimensionality of the dataset. There are various methods for group classification ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220765]

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