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Journal Otol Neurotol

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Intratympanic Administration of OTO-313 Reduces Tinnitus in Patients With Moderate to Severe, Persistent Tinnitus: A Phase 1/2 Study.

Kenneth S Maxwell, James M Robinson, Ines Hoffmann, Huiying J Hou, Grant Searchfield, David M Baguley, Gordon McMurry, Fabrice Piu, Jeffery J Anderson,

<h4>Objective</h4>To evaluate the safety and exploratory efficacy of intratympanic administration of OTO-313 in patients with tinnitus.<h4>Study design</h4>Single intratympanic injection of OTO-313 evaluated in a randomized, double-blind, placebo-controlled Phase 1/2 clinical study.<h4>Setting</h4>Tertiary referral centers.<h4>Patients</h4>Patients with unilateral tinnitus (moderate-severe) with tinnitus duration 1 to 6 months.<h4>Interventions</h4>Intratympanic OTO-313.<h4>Main outcome measures</h4>Safety and change from baseline ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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Cochlear Implant Electrode Tip Fold-Over: Our Experience with Long and Flexible Electrode.

Catalina Högerle, Anna Englhard, Florian Simon, Ivo Grüninger, Robert Mlynski, John-Martin Hempel, Joachim Müller,

<h4>Objective</h4>The aim of this study was to retrospectively investigate if there is any incidence of electrode tip fold-over with 31.5 mm long and flexible lateral wall electrodes implanted in two high-volume Cochlear Implant (CI) centers in Germany. In addition, a detailed literature review was performed to capture all the peer-reviewed publications ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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Diagnosing Pulsatile Tinnitus: A Review of 251 Patients.

Patrick Lynch, Tanner Mitton, Daniel E Killeen, Joe Walter Kutz, Mark Newcomer,

<h4>Objective</h4>To analyze the underlying etiologies, presenting characteristics, and diagnostic workup of patients with pulsatile tinnitus (PT).<h4>Study design</h4>Retrospective review.<h4>Setting</h4>Tertiary referral center.<h4>Patients</h4>All patients who received a diagnostic workup for PT from January 01, 2015 and May 31, 2020.<h4>Main outcome measure</h4>Diagnostic rate of imaging studies.<h4>Results</h4>Among 251 patients with PT, the most common etiologies ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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The Cochlear Implant Use Questionnaire: Assessing Habits and Barriers to Use.

Jourdan T Holder, Lindsay S Mayberry, René Gifford,

<h4>Objective</h4>The objective was to design a questionnaire to identify daily cochlear implant (CI) use habits and barriers to daily CI use and to administer this questionnaire to adult CI users. We hypothesized that recipients who reported a greater number of barriers to daily CI use would show lower daily CI ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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Audiologic Outcomes of Footplate Drillout for Obliterative Otosclerosis.

Robert M Conway, Pedrom C Sioshansi, Seilesh C Babu, Nathan C Tu, Amy E Schettino, Dennis I Bojrab, Christopher A Schutt,

<h4>Objective</h4>To evaluate the audiologic outcomes of microdrill fenestration for obliterative otosclerosis compared to traditional stapedotomy technique.<h4>Study design</h4>Retrospective chart review.<h4>Setting</h4>Tertiary referral center.<h4>Patients</h4>Adult patients undergoing stapedotomy for otosclerosis.<h4>Main outcome measures</h4>Patients were separated into groups that underwent either microdrill or laser fenestration based on intraoperative severity of disease. Audiologic outcomes and complications were ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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Long-Term Outcome With an Active Middle Ear Implant in Patients to Bilateral Aural Atresia.

Luiz Fernando Manzoni Lourençone, Marina Matuella, Tyuana Sandim da Silveira Sassi, Jeniffer de Cássia Rillo Dutka, Rubens Brito,

<h4>Objective</h4>To describe the audiological results and complications following active middle ear implant (AMEI) surgery in users with bilateral ear atresia.<h4>Study design</h4>Observational and retrospective longitudinal follow-up.<h4>Setting</h4>A tertiary referral hospital for hearing rehabilitation and craniofacial malformations.<h4>Patients</h4>Medical records of 27 patients with bilateral congenital aural atresia (34 ears) who underwent surgery for AMEI ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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The Curious Rise and Incomplete Fall of "Paracusis Willisii".

Kevin J Quinn, Daniel H Coelho,

<h4>Abstract</h4>In 1672, Dr. Thomas Willis, a founder of the Royal Society and accomplished anatomist, described a peculiar phenomenon he had heard about "from a Credible Person" wherein two people with hearing loss appreciated some recovery of hearing when in the presence of increased background noise. Over time, this clinical entity ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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Hearing Outcomes with Percutaneous and Transcutaneous BAHA® Technology in Conductive and Mixed Hearing Loss.

Amjad Tobia, Noam Yehudai, Riad Khnifes, Talma Shpak, Osnat Roth, Ranin Khayr, Michal Luntz,

<h4>Objectives</h4>To evaluate outcomes of BAHA Connect® and BAHA Attract® implantations, and to examine the prognostic utility of a preimplantation Softband®-attached processor trial.<h4>Study design</h4>Retrospective case review.<h4>Setting</h4>Tertiary referral center.<h4>Patients</h4>Patients who underwent Connect® (19 ears) and Attract® (25 ears) implantation between 2007 and 2017.<h4>Intervention</h4>BAHA® implantation.<h4>Main outcome measures</h4>Unaided air conduction (AC), bone conduction (BC), ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1382-1389]

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Transtympanic Tripod-shaped Angiocatheter Insertion for Patients With Intractable Patulous Eustachian Tube.

Jung Mee Park, Jae Sang Han, So Young Park, Shi Nae Park,

<h4>Objective</h4>Despite the efforts to treat patients with patulous Eustachian tube (PET), intractable symptoms of PET may require surgical intervention. In this study, we introduce our surgical technique of "transtympanic tripod-shaped angiocatheter" (TTA) insertion and evaluate the safety and efficacy of the procedure in patients with intractable PET.<h4>Study design</h4>Retrospective chart review.<h4>Setting</h4>Tertiary ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):e1273-e1278]

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Digital Live Imaging of Intraoperative Electrocochleography - First Description of Feasibility and Hearing Preservation During Cochlear Implantation.

Diana Arweiler-Harbeck, Victoria D'heygere, Moritz Meyer, Stefan Hans, Laura Waschkies, Stephan Lang, Kristina Anton, Horst Hessel, Armin Schneider, Thomas Heiler, Benedikt Höing,

<h4>Introduction</h4>Intraoperative electrocochleography (ECochG) during cochlear implantation is a promising tool to preserve residual hearing. However, the time gap between insertion of the electrode and acoustic feedback from the audiologist to the surgeon can cause delay and subsequently irreparable damage to cochlear structures. In this feasibility study, for the first time, ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1342-1346]

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Sudden Sensorineural Hearing Loss and Metabolic Syndrome: A Systematic Review and Meta-analysis.

Megan Lam, Yueyang Bao, Gordon B Hua, Doron D Sommer,

<h4>Objective</h4>The objective of this systematic review and meta-analysis is to examine the association between sudden sensorineural hearing loss (SSNHL) and risk of metabolic syndrome (MetS), and the association between MetS and prognosis of SSNHL.<h4>Databases reviewed</h4>We systematically searched MEDLINE, Embase, and Cochrane Central Register electronic databases from their dates of conception ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1308-1313]

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On the Accuracy of Clinical Insertion Angle Predictions With a Surgical Planning Platform for Cochlear Implantation.

Emilio Avallone, Thomas Lenarz, Max E Timm,

<h4>Hypothesis</h4>Various studies over the last few decades have shown that the cochlea is not a uniform structure, but that its size and shape may vary quite substantially in between subjects. The surgical planning platform enables the user to quickly approximate the size of a cochlea within clinical imaging data by ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):e1242-e1249]

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Admission Rates Following Day-Case Major Otologic Surgery: A Systematic Review.

Laura S M Derks, Isabelle L A Borgstein, Marc J W Lammers, Digna M A Kamalski, Hans G X M Thomeer, Wilko Grolman, Robert J Stokroos, Inge Wegner,

<h4>Objective</h4>To assess whether day-case major otologic ear surgery is a safe and feasible alternative to inpatient surgery, while maintaining equal complication rates, and to identify causes of admission after day-case surgery.<h4>Data sources</h4>PubMed, Embase, and Cochrane.<h4>Review methods</h4>A systematic search was conducted. Studies reporting original data on the effect of day-case ear ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1291-1299]

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Opioids Are Infrequently Required following Ambulatory Otologic Surgery.

Maria A Mavrommatis, Caleb J Fan, Dillan F Villavisanis, Vivian F Kaul, Zachary G Schwam, Kevin Wong, Enrique Perez, George B Wanna, Maura K Cosetti,

<h4>Objective</h4>To determine the frequency with which postoperative opioid prescriptions are required after ambulatory otologic surgery.<h4>Study design</h4>Retrospective chart review.<h4>Setting</h4>Tertiary otology-neurotology practice.<h4>Patients</h4>Patients (n = 447) given over-the-counter acetaminophen and ibuprofen following ambulatory otologic surgery between July 1, 2018 and June 30, 2020.<h4>Intervention</h4>Opioid prescription upon request.<h4>Main outcome measures</h4>Patient, disease, and surgical variables such as age, ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1360-1365]

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Novel Web-Based Music Re-Engineering Software for Enhancement of Music Enjoyment Among Cochlear Implantees.

Tiffany Peng Hwa, Lisa Likun Tian, Francesco Caruana, Michael Chun, Dean Mancuso, Ilana P Cellum, Anil K Lalwani,

<h4>Objectives</h4>Cochlear implant (CI) listeners experience diminished music perception and enjoyment from a variety of patient-related and implant-related factors. We investigate the hypothesis that patient-directed music re-engineering may enhance music enjoyment with CI.<h4>Study design</h4>Prospective cohort study.<h4>Setting</h4>Academic cochlear implant center.<h4>Subjects and methods</h4>A multidisciplinary team of neurotologists, audiologists, and a sound/audio engineer collaborated ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1347-1354]

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Rupture-Like Shrinkage and Regrowth of Endolymphatic Hydrops in Ménière's Disease During Remission.

Munehisa Fukushima, Yu Suekata, Takuya Kusumoto, Shiro Akahani, Hidehiko Okamoto, Hidenori Inohara, Noriaki Takeda,

<h4>Objective</h4>To clarify pathophysiological characteristics of Ménière's disease during the remission phase.<h4>Patients</h4>Two Ménière's disease patients with different disease durations, whose endolymphatic hydrops was longitudinally observed using 3-T magnetic resonance imaging.<h4>Interventions</h4>Diagnostic.<h4>Main outcomes and measures</h4>Morphological changes of endolymphatic hydrops visualized using 3-T magnetic resonance imaging.<h4>Results</h4>Rupture-like shrinkage and regrowth of endolymphatic hydrops during the ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1390-1393]

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Topical Therapy Failure in Chronic Suppurative Otitis Media is Due to Persister Cells in Biofilms.

Peter L Santa Maria, Adam C Kaufman, Brian Bacacao, Anthony Thai, Xiaohua Chen, Anping Xia, Zhixin Cao, Ayman Fouad, Laurent A Bekale,

<h4>Objective</h4>Chronic suppurative otitis media (CSOM) is characterized by a chronically draining middle ear. CSOM is typically treated with multiple courses of antibiotics or antiseptics which are successful in achieving quiescence; however, the disease is prone to relapse. Understanding why these treatment failures occur is essential.<h4>Study design</h4>The minimum inhibitory concentration (MIC), ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):e1263-e1272]

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Morphological Effect of Vitamin D Deficiency on Globular Substances in Mice.

Penglong Song, Xianshu Zhao, Yanjun Xu, Zhigang Zhao, Yang Liu, Qian Gao,

<h4>Objective</h4>Many authors, including us, elucidated that vitamin D deficiency was a risk factor for benign paroxysmal position vertigo. We speculated vitamin D deficiency was likely to intervene otoconia formation by globular substance (GS).<h4>Methods</h4>Kunming mice were randomly divided into three groups: vitamin D sufficient group (12-wk standard control diet), vitamin D ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):e1313-e1317]

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The Value of Ultrashort Echo Time MR in Depiction of the Eustachian Tube at 3 Tesla.

Chao Wu, Qiang Xu,

<h4>Objectives</h4>To investigate the feasibility of ultrashort echo time (UTE) imaging in the visualization of Eustachian tubes (ETs).<h4>Methods</h4>The local institutional review board approved the study protocol. Twenty volunteers were involved in this study. The scanning scheme consisted of T2-sampling perfection with application-optimized contrasts by using different flip angle evolutions (T2-SPACE) MR ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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Validation of a Moroccan Arabic Version of the Tinnitus Handicap Inventory (THI-M).

Sara Halily, Hamida Ardhaoui, Sofia Zoukal, Redallah Larbi Abada, Youssef Oukessou, Sami Rouadi, Mohamed Roubal, Mohamed Mahtar,

<h4>Objective</h4>Cultural adaptation of the tinnitus handicap inventory questionnaire to the Moroccan dialect version.<h4>Method</h4>We conducted a prospective study over a 3 years period (January 2017-January 2020) in the Otolaryngology Department of Casablanca University hospital. Translation was produced by a forward-backward procedure with analysis of the psychometric properties of the Moroccan version ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, :]

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A Cohort Study Comparing Importance of Clinical Factors in Determining Diagnosis and Treatment for Superior Semicircular Canal Dehiscence Syndrome.

Lisa Zhang, Francis X Creighton, John P Carey,

<h4>Objective</h4>To determine which clinical factors have the strongest impact on determining diagnosis and decision for surgical repair for superior semicircular canal dehiscence syndrome (SCDS).<h4>Patients</h4>A total of 81 patients presented with a suspicion for SCDS between October 2017 and October 2018. 38 patients ultimately were diagnosed with SCDS, and 28 chose ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1429-1433]

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The Impact of the Frequency-Specific Preoperative Sensorineural Hearing Loss to Postoperative Overclosure of Bone Conduction in Stapedotomy.

Yanqing Fang, Kun Zhang, Jack H Ersbo, Bing Chen,

<h4>Objective</h4>To evaluate the frequency-specific relationships between the preoperative sensorineural hearing loss and postoperative overclosure of bone conduction (BC) threshold after stapedotomy.<h4>Methods</h4>We conducted a retrospective analysis of 207 otosclerosis patients who underwent stapedotomy in our hospital. Pre- and postoperative audiometry were collected between patients with or without preoperative sensorineural hearing loss ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1314-1322]

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Risk Factors for Complications Following Lateral Skull Base Surgery and the Utility of ICU Monitoring.

Pedrom C Sioshansi, Robert M Conway, Brian Anderson, Katrina Minutello, Dennis I Bojrab, Robert S Hong, Eric W Sargent, Christopher A Schutt, John J Zappia, Seilesh C Babu,

<h4>Objective</h4>To examine the role of intensive care unit (ICU) management following lateral skull base surgery for vestibular schwannoma and identify risk factors for complications warranting admission to the ICU.<h4>Study design</h4>Retrospective review.<h4>Setting</h4>Tertiary referral center.<h4>Patients</h4>Two hundred consecutive patients undergoing lateral skull base surgery for vestibular schwannomas.<h4>Intervention</h4>Lateral skull base approach for resection of ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):e1362-e1368]

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Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians.

Ishan Sunilkumar Bhatt, Raquel Dias, Ali Torkamani,

<h4>Introduction</h4>Subjective tinnitus, a perception of phantom sound, is a common otological condition that affects almost 15% of the general population. It is known that noise-induced hearing loss (NIHL) and tinnitus exhibit a high level of comorbidity in individuals exposed to intense noise and music. However, the influence of genetic variants ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):e1203-e1212]

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Otologic Manifestations After COVID-19 Vaccination: The House Ear Clinic Experience.

Helena Wichova, Mia E Miller, M Jennifer Derebery,

<h4>Objective</h4>With the increasing numbers of COVID-19 vaccinations available there are some reports of new onset of otologic symptoms. We present our experience in recently vaccinated patients over a 30-day time frame.<h4>Study design</h4>Retrospective chart review.<h4>Setting</h4>Tertiary otology ambulatory practice.<h4>Patients</h4>All patients with available diagnostic codes, COVID-19 questionnaires and clinical notes.<h4>Interventions</h4>Observational recordings.<h4>Main outcome measures</h4>Within ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):e1213-e1218]

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