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Journal Open Forum Infect Dis

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Reactivation of Chagas Disease in a Patient With an Autoimmune Rheumatic Disease: Case Report and Review of the Literature.

Mary M Czech, Ashwin K Nayak, Kavitha Subramanian, Jose F Suarez, Jessica Ferguson, Karen Blake Jacobson, Susan P Montgomery, Michael Chang, Gordon H Bae, Shyam S Raghavan, Hannah Wang, Eugenia Miranti, Indre Budvytiene, Stanford Mervyn Shoor, Niaz Banaei, Kerri Rieger, Stan Deresinski, Marisa Holubar, Brian G Blackburn,

Reactivation of Chagas disease has been described in immunosuppressed patients, but there is a paucity of literature describing reactivation in patients on immunosuppressive therapies for the treatment of autoimmune rheumatic diseases. We describe a case of Chagas disease reactivation in a woman taking azathioprine and prednisone for limited cutaneous systemic ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofaa642]

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The Response Measures to the Coronavirus Disease 2019 Outbreak in China

Junyan Qu, Xiaoju Lv,

Abstract For China, the coronavirus disease 2019 (COVID-19) outbreak is a major public health emergency with the fastest spread, the most extensive infection, and the hardest to contain over the past 70 years. The different organizations and institutions in China have taken unprecedented public health responses to interrupt the virus ... Read more >>

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Prospective Cohort of Fluvoxamine for Early Treatment of Coronavirus Disease 19.

David Seftel, David R Boulware,

We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Overall, 65 persons opted to receive fluvoxamine (50 mg twice daily) and 48 declined. Incidence of hospitalization was 0% (0 of 65) with fluvoxamine and 12.5% (6 ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab050]

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Prospective Cohort of Fluvoxamine for Early Treatment of Coronavirus Disease 19

David Seftel, David R Boulware,

Abstract We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Overall, 65 persons opted to receive fluvoxamine (50 mg twice daily) and 48 declined. Incidence of hospitalization was 0% (0 of 65) with fluvoxamine and 12.5% ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):]

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Impact of Coronavirus Disease 2019 on Infectious Diseases Fellows in the United States: Perspectives From the First National Infectious Diseases Fellows Call.

Saman Nematollahi, Victoria J L Konold, David C Gaston, Jessica Howard-Anderson, John L Kiley, Mary C Masters, Michael T Melia, Gayle P Balba, Augusto Dulanto Chiang, Nupur Gupta,

The coronavirus disease 2019 (COVID-19) pandemic has affected many providers, but its impact on Infectious Diseases (ID) fellows in the United States is largely undescribed. In this study, we discuss key issues that emerged from the first national ID Fellows Call with respect to the ID fellow's role during the ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab021]

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Impact of Coronavirus Disease 2019 on Infectious Diseases Fellows in the United States: Perspectives From the First National Infectious Diseases Fellows Call

Saman Nematollahi, Victoria J L Konold, David C Gaston, Jessica Howard-Anderson, John L Kiley, Mary C Masters, Michael T Melia, Gayle P Balba, Augusto Dulanto Chiang, Nupur Gupta,

Abstract The coronavirus disease 2019 (COVID-19) pandemic has affected many providers, but its impact on Infectious Diseases (ID) fellows in the United States is largely undescribed. In this study, we discuss key issues that emerged from the first national ID Fellows Call with respect to the ID fellow’s role during ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):]

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HIV-1 Infection Does Not Change Disease Course or Inflammatory Pattern of SARS-CoV-2-Infected Patients Presenting at a Large Urban Medical Center in New York City.

Justin Laracy, Jason Zucker, Delivette Castor, Donald J McMahon, Tai Wei Guo, Michael Yan, Noga Shalev, Matthew Scherer, Peter Gordon, Magdalena Sobieszczyk, Michael T Yin,

<h4>Background</h4>The clinical impact of coronavirus disease 2019 (COVID-19) among people with HIV (PWH) remains unclear. In this retrospective cohort study of COVID-19, we compared clinical outcomes and laboratory parameters among PWH and controls.<h4>Methods</h4>Sixty-eight PWH diagnosed with COVID-19 were matched 1:4 to patients without known HIV diagnosis, drawn from a study ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab029]

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Rifampicin Mono-Resistant Tuberculosis—A Review of an Uncommon But Growing Challenge for Global Tuberculosis Control

Jason H Malenfant, Timothy F Brewer,

Abstract Tuberculosis (TB) remains the leading cause of death by an infectious pathogen worldwide, and drug-resistant TB is a critical and rising obstacle to global control efforts. Most scientific studies and global TB efforts have focused on multidrug-resistant TB (MDR-TB), meaning isolates resistant to both isoniazid (INH) and rifampicin (RIF). ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):]

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Rifampicin Mono-Resistant Tuberculosis-A Review of an Uncommon But Growing Challenge for Global Tuberculosis Control.

Jason H Malenfant, Timothy F Brewer,

Tuberculosis (TB) remains the leading cause of death by an infectious pathogen worldwide, and drug-resistant TB is a critical and rising obstacle to global control efforts. Most scientific studies and global TB efforts have focused on multidrug-resistant TB (MDR-TB), meaning isolates resistant to both isoniazid (INH) and rifampicin (RIF). Newer ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab018]

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Colistin Nephrotoxicity: Meta-Analysis of Randomized Controlled Trials

Khalid Eljaaly, Monique R Bidell, Ronak G Gandhi, Samah Alshehri, Mushira A Enani, Ahmed Al-Jedai, Todd C Lee,

Abstract <h4>Background</h4> Nephrotoxicity is a known adverse effect of polymyxin antibiotics, including colistin. Although previous meta-analyses have aimed to characterize colistin-associated nephrotoxicity risk relative to other antibiotics, included studies were observational in nature with high risk of confounding and heterogeneity. We conducted this systematic review and meta-analysis of exclusively randomized ... Read more >>

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Voter Registration Among People With HIV in North Carolina.

Asher J Schranz, Nadya Belenky, Haley A Moss, Sonia Napravnik, David L Rosen,

Persons with HIV (PWH) represent a socially and medically vulnerable population who often depend on public resources. We examined voter registration among PWH in North Carolina. Sixty-four percent were registered to vote. Registration was lower among PWH who were young, Hispanic, publicly insured or uninsured, and who had poor HIV ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab037]

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Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases.

Jean Claude S Ngabonziza, Tom Decroo, Rodrigue Maniliho, Yves M Habimana, Armand Van Deun, Bouke C de Jong,

We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab034]

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Corrigendum to: Renal Impairment, C. difficile Recurrence, and the Differential Effect of Bezlotoxumab: A Post Hoc Analysis of Pooled Data From 2 Randomized Clinical Trials.

Yoav Golan, Herbert L DuPont, Fernando Aldomiro, Erin H Jensen, Mary E Hanson, Mary Beth Dorr,

[This corrects the article DOI: 10.1093/ofid/ofaa248.]. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(1):ofaa629]

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Colistin Nephrotoxicity: Meta-Analysis of Randomized Controlled Trials.

Khalid Eljaaly, Monique R Bidell, Ronak G Gandhi, Samah Alshehri, Mushira A Enani, Ahmed Al-Jedai, Todd C Lee,

<h4>Background</h4>Nephrotoxicity is a known adverse effect of polymyxin antibiotics, including colistin. Although previous meta-analyses have aimed to characterize colistin-associated nephrotoxicity risk relative to other antibiotics, included studies were observational in nature with high risk of confounding and heterogeneity. We conducted this systematic review and meta-analysis of exclusively randomized controlled trials ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab026]

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Strength of Recommendation and Quality of Evidence for Recommendations in Current Infectious Diseases Society of America Guidelines.

Kaitlin E Miles, Ryan Rodriguez, Alan E Gross, Andre C Kalil,

<h4>Background</h4>Grading of Recommendations Assessment, Development, and Evaluation (GRADE) is a systematic approach to grading strength of recommendation (SOR) and quality of evidence (QOE) for guideline recommendations. We aimed to assess the relationship between SOR and QOE in current Infectious Diseases Society of America (IDSA) guidelines.<h4>Methods</h4>In this cross-sectional analysis, we analyzed ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab033]

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Association of Incomplete Adherence to Antiretroviral Therapy With Cardiovascular Events and Mortality in Virologically Suppressed Persons With HIV: The Swiss HIV Cohort Study.

Jose R Castillo-Mancilla, Matthias Cavassini, Marie Paule Schneider, Hansjakob Furrer, Alexandra Calmy, Manuel Battegay, Giulia Scanferla, Enos Bernasconi, Huldrych F Günthard, Tracy R Glass, ,

<h4>Background</h4>Incomplete antiretroviral therapy (ART) adherence, even if sufficient to maintain viral suppression, is associated with enhanced inflammation in persons with HIV (PWH). However, its clinical implications remain unknown.<h4>Methods</h4>PWH enrolled in the Swiss HIV Cohort Study without a history of cardiovascular disease (CVD) who initiated ART between 2003 and 2018 and ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab032]

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The COVID-19 Symptom to Isolation Cascade in a Latinx Community: A Call to Action.

Luis A Rubio, James Peng, Susy Rojas, Susana Rojas, Emily Crawford, Douglas Black, Jon Jacobo, Valerie Tulier-Laiwa, Christopher M Hoover, Jackie Martinez, Diane Jones, Darpun Sachdev, Chesa Cox, Eduardo Herrera, Rebecca Valencia, Karla G Zurita, Gabriel Chamie, , Joe DeRisi, Maya Petersen, Diane V Havlir, Carina Marquez,

<h4>Background</h4>Rapid coronavirus disease 2019 (COVID-19) diagnosis and isolation of infectious persons are critical to stopping forward transmission, and the care cascade framework can identify gaps in the COVID-19 response.<h4>Methods</h4>We described a COVID-19 symptom to isolation cascade and barriers among symptomatic persons who tested polymerase chain reaction positive for severe acute ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab023]

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The COVID-19 Symptom to Isolation Cascade in a Latinx Community: A Call to Action

Luis A Rubio, James Peng, Susy Rojas, Susana Rojas, Emily Crawford, Douglas Black, Jon Jacobo, Valerie Tulier-Laiwa, Christopher M Hoover, Jackie Martinez, Diane Jones, Darpun Sachdev, Chesa Cox, Eduardo Herrera, Rebecca Valencia, Karla G Zurita, Gabriel Chamie, The CLIAHUB Consortium, Joe DeRisi, Maya Petersen, Diane V Havlir, Carina Marquez,

Abstract <h4>Background</h4> Rapid coronavirus disease 2019 (COVID-19) diagnosis and isolation of infectious persons are critical to stopping forward transmission, and the care cascade framework can identify gaps in the COVID-19 response. <h4>Methods</h4> We described a COVID-19 symptom to isolation cascade and barriers among symptomatic persons who tested polymerase chain reaction ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):]

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Effective Containment of a COVID-19 Subregional Outbreak in Italy Through Strict Quarantine and Rearrangement of Local Health Care Services.

Sara Tedeschi, Lorenzo Badia, Fabio Berveglieri, Rodolfo Ferrari, Simona Coladonato, Sabrina Gabrielli, Antonio Maestri, Gabriele Peroni, Maddalena Giannella, Andrea Rossi, Pierluigi Viale, ,

<h4>Background</h4>Since the beginning of the pandemic, the epidemiology of coronavirus disease 2019 (COVID-19) in Italy has been characterized by the occurrence of subnational outbreaks. The World Health Organization recommended building the capacity to rapidly control COVID-19 clusters of cases in order to avoid the spread of the disease. This study ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab024]

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Effective Containment of a COVID-19 Subregional Outbreak in Italy Through Strict Quarantine and Rearrangement of Local Health Care Services

Sara Tedeschi, Lorenzo Badia, Fabio Berveglieri, Rodolfo Ferrari, Simona Coladonato, Sabrina Gabrielli, Antonio Maestri, Gabriele Peroni, Maddalena Giannella, Andrea Rossi, Pierluigi Viale, COVID-19 Fighting Team ,

Abstract <h4>Background</h4> Since the beginning of the pandemic, the epidemiology of coronavirus disease 2019 (COVID-19) in Italy has been characterized by the occurrence of subnational outbreaks. The World Health Organization recommended building the capacity to rapidly control COVID-19 clusters of cases in order to avoid the spread of the disease. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):]

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Peritoneal Dialysis-Related Peritonitis With Carbapenem-Resistant Klebsiella pneumoniae and Vancomycin-Resistant Enterococcus faecium.

Michael A Moso, Nenad Macesic,

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(1):ofaa525]

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Preprocedural SARS-CoV-2 Testing to Sustain Medically Needed Health Care Delivery During the COVID-19 Pandemic: A Prospective Observational Study.

Ghady Haidar, Ashley Ayres, Wendy C King, Mackenzie McDonald, Alan Wells, Stephanie L Mitchell, Andrew L Bilderback, Tami Minnier, John W Mellors,

<h4>Background</h4>We implemented a preprocedural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening initiative designed to sustain health care during a time when the extent of SARS-CoV-2 infection was unknown.<h4>Methods</h4>This was a prospective study of patients undergoing procedures at 3 academic hospitals in Pittsburgh, Pennsylvania (April 21-June 11), and 19 community ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab022]

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Health Care Providers' Testing Practices for Coccidioidomycosis and Histoplasmosis in Patients With Community-Acquired Pneumonia-United States, 2020.

Kaitlin Benedict, Yiman Li, Noelle Angelique M Molinari, Brendan R Jackson,

Laboratory testing is required to distinguish coccidioidomycosis and histoplasmosis from other types of community-acquired pneumonia (CAP). In this nationwide survey of 1258 health care providers, only 3.7% reported frequently testing CAP patients for coccidioidomycosis and 2.8% for histoplasmosis. These diseases are likely underdiagnosed, and increased awareness is needed. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab020]

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Prevalence and Longevity of SARS-CoV-2 Antibodies Among Health Care Workers.

Michael Brant-Zawadzki, Deborah Fridman, Philip A Robinson, Matthew Zahn, Clayton Chau, Randy German, Marcus Breit, Elmira Burke, Jason R Bock, Junko Hara,

<h4>Background</h4>Understanding severe acute respiratory syndrome coronavirus 2 antibody prevalence in a spectrum of health care workers (HCWs) may provide benchmarks of susceptibility, help us understand risk stratification, and support enactment of better health policies and procedures.<h4>Methods</h4>Blood serum was sampled at enrollment and 8-week follow-up from HCWs (n = 3458) and from community ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab015]

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Pancytopenia and Profound Neutropenia as a Sequela of Severe SARS-CoV-2 Infection (COVID-19) With Concern for Bone Marrow Involvement.

Jarelys M Hernandez, Ross Quarles, Seetha Lakshmi, Beata Casanas, Jennifer Eatrides, Erin McCoy, Charurut Somboonwit,

Pancytopenia and neutropenia due to coronavirus disease 2019 (COVID-19) are rare. Here we report a case of neutropenia as a sequela of COVID-19 with concern for bone marrow infiltration. The patient was successfully treated with granulocyte colony-stimulating factor. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(2):ofab017]

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