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Journal Open Forum Infect Dis

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Correlation between Chest CT Findings and Clinical Features of 211 COVID-19 Suspected Patients in Wuhan, China.

Songlin Song, Feihong Wu, Yiming Liu, Hongwei Jiang, Fu Xiong, Xiaopeng Guo, Hongsen Zhang, Fan Yang, Chuansheng Zheng,

AbstractBackgroundChest CT has been widely used to assess the pulmonary involvement in COVID-19. We aimed to investigate the correlation between chest CT and clinical features in COVID-19 suspected patients with or without fever.MethodsWe retrospectively enrolled 211 COVID-19 suspected patients who underwent both chest CT and RT-PCR in Wuhan, China. The ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
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Differentiating Between 2019 Novel Coronavirus Pneumonia and Influenza Using a Nonspecific Laboratory Marker–Based Dynamic Nomogram.

Linghang Wang, Yao Liu, Ting Zhang, Yuyong Jiang, Siyuan Yang, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Ying Fan, Cheng Cheng, Jingjing Wang, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Zhihai Chen, Jingyuan Liu, Xianbo Wang,

AbstractBackgroundThere is currently a lack of nonspecific laboratory indicators as a quantitative standard to distinguish between the 2019 coronavirus disease (COVID-19) and an influenza A or B virus infection. Thus, the aim of this study was to establish a nomogram to detect COVID-19.MethodsA nomogram was established using data collected from ... Read more >>

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Differentiating Between 2019 Novel Coronavirus Pneumonia and Influenza Using a Nonspecific Laboratory Marker-Based Dynamic Nomogram.

Linghang Wang, Yao Liu, Ting Zhang, Yuyong Jiang, Siyuan Yang, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Ying Fan, Cheng Cheng, Jingjing Wang, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Zhihai Chen, Jingyuan Liu, Xianbo Wang,

Background:There is currently a lack of nonspecific laboratory indicators as a quantitative standard to distinguish between the 2019 coronavirus disease (COVID-19) and an influenza A or B virus infection. Thus, the aim of this study was to establish a nomogram to detect COVID-19. Methods:A nomogram was established using data collected ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa169]

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A Young Diabetic Patient With Sepsis After Gardening.

Nataly Camargo, Giovanna K Casadiego, Dinno A Fernandez, Lina V Millan, Angie K Hernandez, Sandra Vargas, Rafael Rios, Adriana Marin-Osorio, Soraya Salcedo, Deisy L Rodriguez, Ilich V Bayuelo-Charris, Cesar A Arias, Lorena Diaz, Jinnethe Reyes,

AbstractWe report a case of soft tissue infection, sepsis, and bacteremia due to Burkholderia pseudomallei (melioidosis) in a diabetic young patient and the genomic characterization of Burkholderia pseudomallei isolate (COL-5428). ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
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Home-Based Outpatient Parenteral Antibiotic Therapy at an Urban Safety Net Hospital: Comparing Outcomes in Persons With and Without Noninjection Drug Use.

Ayesha Appa, Carina Marquez, Vivek Jain,

AbstractAs stimulant use and infections among persons using drugs rise nationally, evidence remains limited on how best to deliver outpatient parenteral antimicrobial therapy (OPAT) to persons using noninjection drugs. In an urban safety net population including persons using noninjection drugs, home-based OPAT completion rates were similarly high as those of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
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A Young Diabetic Patient With Sepsis After Gardening.

Nataly Camargo, Giovanna K Casadiego, Dinno A Fernandez, Lina V Millan, Angie K Hernandez, Sandra Vargas, Rafael Rios, Adriana Marin-Osorio, Soraya Salcedo, Deisy L Rodriguez, Ilich V Bayuelo-Charris, Cesar A Arias, Lorena Diaz, Jinnethe Reyes,

We report a case of soft tissue infection, sepsis, and bacteremia due to Burkholderia pseudomallei (melioidosis) in a diabetic young patient and the genomic characterization of Burkholderia pseudomallei isolate (COL-5428). ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa159]

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Home-Based Outpatient Parenteral Antibiotic Therapy at an Urban Safety Net Hospital: Comparing Outcomes in Persons With and Without Noninjection Drug Use.

Ayesha Appa, Carina Marquez, Vivek Jain,

As stimulant use and infections among persons using drugs rise nationally, evidence remains limited on how best to deliver outpatient parenteral antimicrobial therapy (OPAT) to persons using noninjection drugs. In an urban safety net population including persons using noninjection drugs, home-based OPAT completion rates were similarly high as those of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa162]

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Clinical Characteristics, Etiology, and Initial Management Strategy of Newly Diagnosed Periprosthetic Joint Infection: A Multicenter, Prospective Observational Cohort Study of 783 Patients.

Laurens Manning, Sarah Metcalf, Benjamin Clark, James Owen Robinson, Paul Huggan, Chris Luey, Stephen McBride, Craig Aboltins, Renjy Nelson, David Campbell, Lucian Bogdan Solomon, Kellie Schneider, Mark Loewenthal, Piers Yates, Eugene Athan, Darcie Cooper, Babak Rad, Tony Allworth, Alistair Reid, Kerry Read, Peter Leung, Archana Sud, Vana Nagendra, Roy Chean, Chris Lemoh, Nora Mutalima, Kate Grimwade, Marjorie Sehu, Adrienne Torda, Thi Aung, Steven Graves, David Paterson, Josh Davis,

Background:Periprosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. Most observational studies of PJI are retrospective or single-center, and reported management approaches and outcomes vary widely. We hypothesized that there would be substantial heterogeneity in PJI management and that most PJIs would present as late acute infections ... Read more >>

Open Forum Infect Dis (Open Forum Infectious Diseases)
[2020, 7(5):ofaa068]

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Health Care–Seeking Behaviors and Perceptions of Provider-Initiated Discussion of Pre-exposure Prophylaxis Among PrEP-Naïve HIV-Negative Men Who Have Sex With Men in Atlanta, Georgia.

Susanna L Trost, Udodirim N Onwubiko, Derick B Wilson, David P Holland, Allison T Chamberlain,

AbstractBackgroundGiven high rates of HIV among men who have sex with men (MSM) in the United States, there is a need to more effectively leverage the health care system to bolster promotion of pre-exposure prophylaxis (PrEP) to at-risk MSM.MethodsUsing data collected from a 2018 venue-based cross-sectional survey, we examined factors ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
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Health Care-Seeking Behaviors and Perceptions of Provider-Initiated Discussion of Pre-exposure Prophylaxis Among PrEP-Naïve HIV-Negative Men Who Have Sex With Men in Atlanta, Georgia.

Susanna L Trost, Udodirim N Onwubiko, Derick B Wilson, David P Holland, Allison T Chamberlain,

Background:Given high rates of HIV among men who have sex with men (MSM) in the United States, there is a need to more effectively leverage the health care system to bolster promotion of pre-exposure prophylaxis (PrEP) to at-risk MSM. Methods:Using data collected from a 2018 venue-based cross-sectional survey, we examined ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa165]

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A Case–Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis.

Dalila Y Martínez, Alejandro Llanos-Cuentas, Jean-Claude Dujardin, Katja Polman, Vanessa Adaui, Marleen Boelaert, Kristien Verdonck,

AbstractBackgroundEndemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb5+) fails in 10%–30% of patients. The study objective was to assess the etiological role of intestinal helminthiasis in CL treatment failure.MethodsAn unmatched case–control study was done in 4 CL treatment sites in ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
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A Case-Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis.

Dalila Y Martínez, Alejandro Llanos-Cuentas, Jean-Claude Dujardin, Katja Polman, Vanessa Adaui, Marleen Boelaert, Kristien Verdonck,

Background:Endemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb5+) fails in 10%-30% of patients. The study objective was to assess the etiological role of intestinal helminthiasis in CL treatment failure. Methods:An unmatched case-control study was done in 4 CL treatment sites ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa155]

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Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing.

Chayanika Biswas, Qinning Wang, Sebastiaan J van Hal, David W Eyre, Bernard Hudson, Catriona L Halliday, Krystyna Mazsewska, Alice Kizny Gordon, Andie Lee, Laszlo Irinyi, Christopher H Heath, Arunaloke Chakrabarti, Nelesh P Govender, Wieland Meyer, Vitali Sintchenko, Sharon C-A Chen,

Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa158]

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Chagas Disease in the New York City Metropolitan Area.

Crystal Zheng, Orlando Quintero, Elizabeth K Revere, Michael B Oey, Fabiola Espinoza, Yoram A Puius, Diana Ramirez-Baron, Carlos R Salama, Luis F Hidalgo, Fabiana S Machado, Omar Saeed, Jooyoung Shin, Snehal R Patel, Christina M Coyle, Herbert B Tanowitz,

Background:Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chagas disease among the ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa156]

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Chagas Disease in the New York City Metropolitan Area.

Crystal Zheng, Orlando Quintero, Elizabeth K Revere, Michael B Oey, Fabiola Espinoza, Yoram A Puius, Diana Ramirez-Baron, Carlos R Salama, Luis F Hidalgo, Fabiana S Machado, Omar Saeed, Jooyoung Shin, Snehal R Patel, Christina M Coyle, Herbert B Tanowitz,

AbstractBackgroundChagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chagas disease among the ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):]

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The Impact of Multidrug-Resistant Organisms on Outcomes in Patients With Diabetic Foot Infections.

Oryan Henig, Jason M Pogue, Emily Martin, Umar Hayat, Mahmoud Ja’ara, Paul E Kilgore, Raymond Cha, Sorab Dhar, Keith S Kaye,

AbstractBackgroundMultidrug-resistant organisms (MDROs) are important diabetic foot infection (DFI) pathogens. This study evaluated the impact of DFIs associated with MDRO pathogens (DFI-MDRO) on clinical outcomes.MethodsAdults admitted to Detroit Medical Center from January 2012 to December 2015 with culture-positive DFI were included. Associations between outcomes and DFI-MDRO (evaluated as a single ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):]

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Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing.

Chayanika Biswas, Qinning Wang, Sebastiaan J van Hal, David W Eyre, Bernard Hudson, Catriona L Halliday, Krystyna Mazsewska, Alice Kizny Gordon, Andie Lee, Laszlo Irinyi, Christopher H Heath, Arunaloke Chakrabarti, Nelesh P Govender, Wieland Meyer, Vitali Sintchenko, Sharon C-A Chen,

AbstractWhole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):]

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The Impact of Multidrug-Resistant Organisms on Outcomes in Patients With Diabetic Foot Infections.

Oryan Henig, Jason M Pogue, Emily Martin, Umar Hayat, Mahmoud Ja'ara, Paul E Kilgore, Raymond Cha, Sorab Dhar, Keith S Kaye,

Background:Multidrug-resistant organisms (MDROs) are important diabetic foot infection (DFI) pathogens. This study evaluated the impact of DFIs associated with MDRO pathogens (DFI-MDRO) on clinical outcomes. Methods:Adults admitted to Detroit Medical Center from January 2012 to December 2015 with culture-positive DFI were included. Associations between outcomes and DFI-MDRO (evaluated as a ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa161]

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The Central Role of Nondisclosed Men Who Have Sex With Men in Human Immunodeficiency Virus-1 Transmission Networks in Guangzhou, China.

Huanchang Yan, Weiyun He, Liping Huang, Hao Wu, Yuanhao Liang, Qingmei Li, Jingwei Shui, Cheng Wang, Emmanuel E Dzakah, Zhigang Han, Shixing Tang,

AbstractBackgroundMen who have sex with men (MSM) are vulnerable risk group for human immunodeficiency virus (HIV)-1 infection. However, some MSM do not disclose their same-sex behavior and could impact the transmission and prevention of HIV-1 infection. Here, we evaluated the role of nondisclosed MSM in HIV-1 transmission in Guangzhou, China.MethodsThe ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):]

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The Central Role of Nondisclosed Men Who Have Sex With Men in Human Immunodeficiency Virus-1 Transmission Networks in Guangzhou, China.

Huanchang Yan, Weiyun He, Liping Huang, Hao Wu, Yuanhao Liang, Qingmei Li, Jingwei Shui, Cheng Wang, Emmanuel E Dzakah, Zhigang Han, Shixing Tang,

Background:Men who have sex with men (MSM) are vulnerable risk group for human immunodeficiency virus (HIV)-1 infection. However, some MSM do not disclose their same-sex behavior and could impact the transmission and prevention of HIV-1 infection. Here, we evaluated the role of nondisclosed MSM in HIV-1 transmission in Guangzhou, China. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa154]

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Vancomycin-Nonsusceptible Enterococci Mediated by vanC at a Large Children's Hospital: Prevalence, Susceptibility, and Impact on Care of Enterococcal Bacteremia.

Daniel S Dodson, Samuel R Dominguez, Christine E MacBrayne, Manon C Williams, Sarah K Parker,

Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in pediatric patients. We identified a significant prevalence of these enterococcal species among immunocompromised patients at a large pediatric institution and describe the impact on patient care, antibiotic stewardship, and infection control. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa160]

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Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol.

Michael Dagher, Felicia Ruffin, Steven Marshall, Magdalena Taracila, Robert A Bonomo, Rachel Reilly, Vance G Fowler, Joshua T Thaden,

Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to extensively drug-resistant Acinetobacter baumannii. Bacterial whole-genome sequencing identified the strain and antibiotic resistance determinants. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa150]

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Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol.

Michael Dagher, Felicia Ruffin, Steven Marshall, Magdalena Taracila, Robert A Bonomo, Rachel Reilly, Vance G Fowler, Joshua T Thaden,

Cefiderocol is a novel catechol siderophore cephalosporin developed to treat resistant gram-negative infections. We report its successful use in conjunction with surgical debridement to treat osteomyelitis due to extensively drug-resistant Acinetobacter baumannii. Bacterial genome sequencing revealed the determinants of resistance. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
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Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma.

William F Wright, Paul G Auwaerter,

Fever has preoccupied physicians since the earliest days of clinical medicine. It has been the subject of scrutiny in recent decades. Historical convention has mostly determined that 37.0°C (98.6°F) should be regarded as normal body temperature, and more modern evidence suggests that fever is a complex physiological response involving the ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(5):ofaa132]

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Inpatient and Discharge Fluoroquinolone Prescribing in Veterans Affairs Hospitals Between 2014 and 2017.

Valerie M Vaughn, Sarah M Seelye, Xiao Qing Wang, Wyndy L Wiitala, Michael A Rubin, Hallie C Prescott,

Between 2014 and 2017, inpatient fluoroquinolone—particularly ciprofloxacin—prescribing declined in US Veterans Affairs hospitals. In contrast, fluoroquinolone prescribing at discharge has been relatively stable with small increases in levofloxacin prescribing at discharge. ... Read more >>

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