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Journal Oncotarget

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Juvenile polyposis without a germline variant in SMAD4/BMPR1A: defining a clinically distinct polyposis syndrome.

Suzanne P MacFarland, Bryson W Katona,

Oncotarget (Oncotarget)
[2021, 12(18):1848-1849]

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Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia.

Taylor J Chen, Wa Du, Jacob J Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R Rabin, H Daniel Lacorazza,

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric leukemia with a worse prognosis than most frequent B-cell ALL due to a high incidence of treatment failures and relapse. Our previous work showed that loss of the pioneer factor KLF4 in a NOTCH1-induced T-ALL mouse model accelerated the development of ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1787-1801]

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Anti-aging: senolytics or gerostatics (unconventional view).

Mikhail V Blagosklonny,

Senolytics are basically anti-cancer drugs, repurposed to kill senescent cells selectively. It is even more difficult to selectively kill senescent cells than to kill cancer cells. Based on lessons of cancer therapy, here I suggest how to exploit oncogene-addiction and to combine drugs to achieve selectivity. However, even if selective ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1821-1835]

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Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication.

Mario Scarpa, Shivani Kapoor, Eric S Tvedte, Kshama A Doshi, Ying S Zou, Prerna Singh, Jonelle K Lee, Aditi Chatterjee, Moaath K Mustafa Ali, Robin E Bromley, Julie C Dunning Hotopp, Feyruz V Rassool, Maria R Baer,

Acute myeloid leukemia (AML) with fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) relapses with new chromosome abnormalities following chemotherapy, implicating genomic instability. Error-prone alternative non-homologous end-joining (Alt-NHEJ) DNA double-strand break (DSB) repair is upregulated in FLT3-ITD-expresssing cells, driven by c-Myc. The serine/threonine kinase Pim-1 is upregulated downstream of FLT3-ITD, ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1763-1779]

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Targeting cancer stem cells via integrin β4.

Hannah E Dobson, Shasha Ruan, Alfred E Chang, Max S Wicha, Qiao Li,

Integrins mediate cell-cell interactions and communication with the extracellular matrix (ECM). These transmembrane protein receptors allow binding between a cell and its surroundings, initiating a breadth of intracellular signaling resulting in proliferation, differentiation, survival, or migration. Such responses have made integrins an attractive target for cancer therapy. Self-renewing and highly ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1850-1858]

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Correlation between PD-L1 expression and MET gene amplification in patients with advanced non-small cell lung cancer and no other actionable oncogenic driver.

Marta Domènech, Ana M Muñoz Marmol, Jose Luis Mate, Anna Estival, Teresa Moran, Marc Cucurull, Maria Saigi, Ainhoa Hernandez, Carolina Sanz, Alba Hernandez-Gallego, Aintzane Urbizu, Anna Martinez-Cardus, Adrià Bernat, Enric Carcereny,

Non-small cell lung cancers (NSCLC) are the most common type of lung cancer and can be classified according to the presence of mutually exclusive oncogenic drivers. The majority of NSCLC patients present a non-actionable oncogenic driver, and treatment resistance through the amplification of the <i>MET</i> <i>proto-oncogene</i> (<i>MET</i>) or the expression ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1802-1810]

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Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice.

Zachary R Wakefield, Mai Tanaka, Christine Pampo, Sharon Lepler, Lori Rice, Joy Guingab-Cagmat, Timothy J Garrett, Dietmar W Siemann,

Aerobic exercise is receiving increased recognition in oncology for its multiple purported benefits. Exercise is known to induce physiologic adaptations that improve patient quality-of-life parameters as well as all-cause mortality. There also is a growing body of evidence that exercise may directly alter the tumor microenvironment to influence tumor growth, ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1737-1748]

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The value of comprehensive genomic sequencing to maximize the identification of clinically actionable alterations in advanced cancer patients: a case series.

Kevin Drenner, Gargi D Basu, Laurie J Goodman, Audrey A Ozols, Janine R LoBello, Thomas Royce, Michael S Gordon, Erkut H Borazanci, Margaux A Steinbach, Jeffrey Trent, Sunil Sharma,

<h4>Purpose</h4>We present seven cases of advanced cancer patients who initially underwent tumor testing utilizing smaller, panel-based tests, followed by a variety of therapeutic treatments which ultimately resulted in progression of their disease. These cases demonstrate the value of utilizing WES/RNA seq and characterization following disease progression in these patients and ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1836-1847]

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Impact factor and citation metrics in phase III cancer trials.

Joseph Abi Jaoude, Ramez Kouzy, Michael Rooney, Petria Thompson, Roshal Patel, Maddie C Turner, Marc Ghabach, C David Fuller, Bruce D Minsky, Cullen M Taniguchi, Ethan B Ludmir,

<h4>Purpose</h4>Journal impact factor (IF) is often used to measure research quality and importance. We assessed trial factors associated with the publication of cancer trials in journals with higher IF and publications receiving higher citations.<h4>Materials and methods</h4>Cancer-specific phase III RCTs were screened through https://clinicaltrials.gov. We identified trials with published primary endpoints, ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1780-1786]

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Correction: MicroRNA-126 inhibits tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression.

Ming-Hua Hu, Chen-Yang Ma, Xiao-Ming Wang, Chen-Dong Ye, Guang-Xian Zhang, Lin Chen, Jin-Guo Wang,

[This corrects the article DOI: 10.18632/oncotarget.11877.]. ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1859-1860]

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Effect of hypertension and medication use regularity on postoperative delirium after maxillofacial tumors radical surgery.

Shuyi Kong, Jing Wang, Hui Xu, Kaiqiang Wang,

The incidence of postoperative delirium (POD) after maxillofacial tumors radical surgery is relatively high. There are a number of evidences showing the relationship between hypertension and decreased cerebral blood flow, as well as the relationship between cerebral ischemia and postoperative cognitive impairment. However, the impact of hypertension in the process ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1811-1820]

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Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status.

Hélène Marijon, Sigal Gery, Hua Chang, Yosef Landesman, Sharon Shacham, Dhong Hyun Lee, Aimery de Gramont, Harold Phillip Koeffler,

Triple negative breast cancer (TNBC) is a deadly disease with limited treatment options. Selinexor is a selective inhibitor of nuclear export that binds covalently to exportin 1 thereby reactivating tumor suppressor proteins and downregulating expression of oncogenes and DNA damage repair (DDR) proteins. Olaparib is a poly (ADP-ribose) polymerase (PARP) ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(18):1749-1762]

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Mantle cell lymphoma patients in first relapse: we pretty much know what to do.

Francesca Maria Quaglia, Carlo Visco,

Oncotarget (Oncotarget)
[2021, 12(17):1724-1726]

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The protective role of prolyl oligopeptidase (POP) inhibition in acute lung injury induced by intestinal ischemia-reperfusion.

Giovanna Casili, Sarah Adriana Scuderi, Marika Lanza, Alessia Filippone, Rossella Basilotta, Deborah Mannino, Michela Campolo, Emanuela Esposito, Irene Paterniti,

Intestinal ischemia-reperfusion (II/R) develops when the blood flow to the intestines decreases, followed by the reestablishment of the blood supply to the ischemic tissue, resulting in intestinal mucosal barrier dysfunction, with consequent severe local and systemic inflammation. Acute lung injury (ALI) represents the most serious complication after II/R. KYP-2047 is ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1663-1676]

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Correction: Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach.

Zhiguang Xiao, Bianca Sperl, Silvia Gärtner, Tatiana Nedelko, Elvira Stacher-Priehse, Axel Ullrich, Pjotr G Knyazev,

[This corrects the article DOI: 10.18632/oncotarget.26817.]. ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1734-1735]

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The role of circulating miRNAs and CA19-9 in pancreatic cancer diagnosis.

Nivaldo Faria Vieira, Luciano Neder Serafini, Paulo Cezar Novais, Fermino Sanches Lizarte Neto, Mucio Luiz de Assis Cirino, Rafael Kemp, José Celso Ardengh, Fabiano Pinto Saggioro, Alberto Facury Gaspar, Ajith Kumar Sankarankutty, Jorge Resende Lopes Júnior, Daniela Pretti da Cunha Tirapelli, José Sebastião Dos Santos,

Diagnosis and treatment of pancreatic ductal adenocarcinoma (PA) remains a challenge in clinical practice. The aim of this study was to assess the role of microRNAs (miRNAs-21, -23a, -100, -107, -181c, -210) in plasma and tissue as possible biomarkers in the diagnosis of PA. Samples of plasma (PAp-n = 13), ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1638-1650]

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UBE2T: A new molecular regulator of cancer stemness in hepatocellular carcinoma.

Rainbow Wing Hei Leung, Nicole Pui Yu Ho, Carmen Oi Ning Leung, Terence Kin Wah Lee,

Oncotarget (Oncotarget)
[2021, 12(17):1727-1728]

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Quantitative difference of oral pathogen between individuals with gastric cancer and individuals without cancer.

Gyselle Ribeiro de Carvalho Oliveira, Carla de Castro Sant' Anna, Letícia Martins Lamarão, Adriana Costa Guimarães, Carlos Machado da Rocha, Marcelo de Oliveira Bahia, Carolina Rosal de Souza, Danielle Queiroz Calcagno, Paulo Pimentel de Assumpção, Rommel Rodriguez Burbano,

The loss of teeth and lack of oral hygiene have been associated with the risk of developing gastric cancer (GC) in several populations evidenced in epidemiological studies. In this study, we quantitatively compared the proportion of oral pathogens in individuals with gastric cancer and individuals without cancer in a referral ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1677-1686]

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Correction: HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer.

Teru Hideshima, Ralph Mazitschek, Jun Qi, Naoya Mimura, Jen-Chieh Tseng, Andrew L Kung, James E Bradner, Kenneth C Anderson,

[This corrects the article DOI: 10.18632/oncotarget.19019.]. ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1736]

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Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing.

Miguel Vizoso, Jacco van Rheenen,

DNA methylation is an epigenetic process that controls DNA accessibility and serves as a transcriptomic switch when deposited at regulatory regions. The adequate functioning of this process is indispensable for tissue homeostasis and cell fate determination. Conversely, altered DNA methylation patterns result in abnormal gene transcription profiles that contribute to ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1651-1662]

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Hypofractionation: less is more?

Neethu Billy Graham Mariam, Yee Pei Song, Nuradh Joseph, Peter Hoskin, Kimberley Reeves, Nuria Porta, Nicholas James, Ananya Choudhury,

One third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. In the UK, both conventional fractionation with 64 Gy ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1729-1733]

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Scent test using Caenorhabditis elegans to screen for early-stage pancreatic cancer.

Ayumu Asai, Masamitsu Konno, Miyuki Ozaki, Koichi Kawamoto, Ryota Chijimatsu, Nobuaki Kondo, Takaaki Hirotsu, Hideshi Ishii,

Although early detection and diagnosis are indispensable for improving the prognosis of patients with pancreatic cancer, both have yet to be achieved. Except for pancreatic cancer, other cancers have already been screened through scent tests using animals or microorganisms, including <i>Caenorhabditis elegans</i>. While such a method may greatly improve the ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(17):1687-1696]

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Correction: Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers.

Ye Zhang, Xiujuan Qu, Yuee Teng, Zhi Li, Ling Xu, Jing Liu, Yanju Ma, Yibo Fan, Ce Li, Shizhou Liu, Zhenning Wang, Xuejun Hu, Jingdong Zhang, Yunpeng Liu,

[This corrects the article DOI: 10.18632/oncotarget.3253.]. ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(16):1634-1637]

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Genetic testing for homologous recombination repair (HRR) in metastatic castration-resistant prostate cancer (mCRPC): challenges and solutions.

Rodney J Scott, Anurag Mehta, Gabriel S Macedo, Pavel S Borisov, Ravindran Kanesvaran, Wafaa El Metnawy,

Patients with metastatic castration-resistant prostate cancer (mCRPC) have an average survival of only 13 months. Identification of novel predictive and actionable biomarkers in the homologous recombination repair (HRR) pathway in up to a quarter of patients with mCRPC has led to the approval of targeted therapies like <i>poly-ADP ribose polymerase ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(16):1600-1614]

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Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11high cancer cells.

Xiaoguang Liu, Boyi Gan,

Oncotarget (Oncotarget)
[2021, 12(16):1629-1630]

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