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Expression of Glioma-associated oncogene homolog 1 as biomarker with sonidegib in advanced basal cell carcinoma.

Reinhard Dummer, Li Liu, Nicholas Squittieri, Ralf Gutzmer, John Lear,

The pivotal BOLT (Basal cell carcinoma Outcomes with LDE225 [sonidegib] Treatment) study established the durable efficacy and manageable toxicity of sonidegib 200 mg once daily (QD) through 42 months in patients with advanced basal cell carcinoma (BCC). This secondary analysis used expression of Glioma-associated oncogene homolog 1 (GLI1) as a ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(37):3473-3483]

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Small ceramide tames big p53 mutant beast.

Ronald A Hill, Zhijun Liu, Yong-Yu Liu,

Oncotarget (Oncotarget)
[2020, 11(37):3418-3419]

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Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism.

Archis Bagati, Timothy C Hutcherson, Zethan Koch, Joseph Pechette, Hossein Dianat, Cory Higley, Lisa Chiu, Yesul Song, Jay Shah, Elana Chazen, Andrew Nicolais, Peter Casey, Kyle Thompson, Kevin Burke, Mikhail A Nikiforov, Jennifer Zirnheld, Shoshanna N Zucker,

Metastatic melanoma cells overexpressing gap junctions were assayed for their ability to propagate cell death by a novel combination therapy that generates reactive oxygen species (ROS) by both 1) non-thermal plasma (NTP) and 2) tirapazamine (TPZ) under hypoxic conditions. Results demonstrate additive-to-synergistic effects of combination therapy compared to each agent ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(37):3443-3458]

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Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma.

Barbara Marengo, Elda Meta, Chiara Brullo, Chiara De Ciucis, Renata Colla, Andrea Speciale, Ombretta Garbarino, Olga Bruno, Cinzia Domenicotti,

Pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea compounds (STIRUR 13, STIRUR 41 and BUR 12) have been demonstrated to exert a strong inhibitory effect on interleukin 8 or N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of human neutrophils. Since the migration of cancer cells is comparable to that of neutrophils, the purpose of this study is to evaluate the ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(37):3459-3472]

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ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest.

Luigi Scotto, Xavier J Serrano, Kelly Zullo, Cristina Kinahan, Changchun Deng, Ahmed Sawas, Susan Bates, Owen A O'Connor,

The antiproliferative effect induced by histone deactylase inhibitors (HDACi) is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21. Paradoxically, the increased expression of p21 correlates with a reduced cell killing to the drug. The direct targeting of p21 is not feasible. An alternate approach could selectively target ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(37):3432-3442]

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Correction: Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer.

Yuzhu Hu, Ting Yu, Xiaoxiao Liu, Yihong He, Lihong Deng, Jiajuan Guo, Yuanqi Hua, Ting Luo, Xiang Gao,

[This corrects the article DOI: 10.18632/oncotarget.23507.]. ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(37):3484-3485]

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SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.

Angel Núñez-Marrero, Nelly Arroyo, Lenin Godoy, Mohammad Zillur Rahman, Jaime L Matta, Julie Dutil,

Interleukin-12 (IL-12) is a proinflammatory cytokine that links innate and adaptive immune responses against tumor cells. Single Nucleotide Polymorphisms (SNPs) in IL-12 genes have been associated with cancer risk. However, limited studies have assessed the role of IL-12 in breast cancer (BC) risk comprehensively, and these were done in European ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(37):3420-3431]

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Diversifying the platinum-based chemotherapy toolkit for immunogenic cancer cell death.

Abhishek D Garg, Patrizia Agostinis,

Oncotarget (Oncotarget)
[2020, 11(36):3352-3353]

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Down syndrome iPSC model: endothelial perspective on tumor development.

Mariana Perepitchka, Yekaterina Galat, Igor P Beletsky, Philip M Iannaccone, Vasiliy Galat,

Trisomy 21 (T21), known as Down syndrome (DS), is a widely studied chromosomal abnormality. Previous studies have shown that DS individuals have a unique cancer profile. While exhibiting low solid tumor prevalence, DS patients are at risk for hematologic cancers, such as acute megakaryocytic leukemia and acute lymphoblastic leukemia. We ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(36):3387-3404]

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Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis.

Victor Hugo de Souza, Josiane Bazzo de Alencar, Bruna Tiaki Tiyo, Hugo Vicentin Alves, Evelyn Castillo Lima Vendramini, Ana Maria Sell, Jeane Eliete Laguila Visentainer,

INTRODUCTION:Interleukin-16 (IL-16) is a chemotactic cytokine that is found to increase in Cancer and cardiovascular diseases (CVD). Single nucleotide polymorphisms (SNPs) in IL16 were associated with diseases. Thus, we conducted a systematic review and meta-analysis to evaluate possible associations between IL16 rs4778889, rs11556218, rs4072111, and rs1131445 SNPs and the risk ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(36):3405-3417]

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Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements.

Adélia Mendes, Ramona Jühlen, Valérie Martinelli, Birthe Fahrenkrog,

Chromosomal translocations fusing the locus of nucleoporin NUP214 each with the proto-oncogenes SET and DEK are recurrent in, largely intractable, acute leukemias. The molecular basis underlying the pathogenesis of SET-NUP214 and DEK-NUP214 are still poorly understood, but both chimeras inhibit protein nuclear export mediated by the β-karyopherin CRM1. In this ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(36):3371-3386]

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Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series.

Christina Walter, Andreas Hartkopf, Andre Koch, Marion Klaumünzer, Martin Schulze, Eva-Maria Grischke, Florin-Andrei Taran, Sara Brucker, Florian Battke, Saskia Biskup,

PURPOSE:High throughput panel sequencing to tailor therapy in precision oncology promises to improve outcome in patients with metastatic breast cancer. However, data that clearly show any benefit from such an approach is still pending. MATERIALS AND METHODS:We performed a retrospective analysis of advanced breast cancer patients that underwent panel sequencing ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(35):3279-3285]

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Delivering a RAS protease halts tumor growth.

Vania Vidimar, Roman A Melnyk, Karla J F Satchell,

Oncotarget (Oncotarget)
[2020, 11(35):3265-3266]

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Correction: Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways.

Jianhong Yang, Heying Pei, Hong Luo, Afu Fu, Hansuo Yang, Jia Hu, Chengjian Zhao, LuLu Chai, Xiang Chen, Ximing Shao, Chunyu Wang, Wenshuang Wu, Li Wan, Haoyu Ye, Qiang Qiu, Aihua Peng, Yuquan Wei, Li Yang, Lijuan Chen,

[This corrects the article DOI: 10.18632/oncotarget.13687.]. ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(35):3350-3351]

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Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer.

Thomas R Holmes, Jenan Al-Matouq, Matti Holmes, Lauren Nicola, Justin C Rudd, Sándor Lovas, Laura A Hansen,

Non-melanoma skin cancer is the most common form of cancer worldwide. We previously documented an anti-apoptotic role for CDC25A in cutaneous squamous cell carcinoma (SCC), an activity dependent on its association with 14-3-3 proteins. We hypothesized that targeting CDC25A-14-3-3ε interactions may be an effective strategy for inducing skin cancer cell ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(35):3267-3278]

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The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model.

Dimitra P Vageli, David Kasle, Sotirios G Doukas, Panagiotis G Doukas, Clarence T Sasaki,

Supraesophageal bile reflux at strongly acidic pH can cause hypopharyngeal squamous cell cancer, through activation of the oncogenic NF-κB-related pathway. We hypothesize that topical pre- or post-application of pharmacologic NF-κB inhibitor, BAY 11-7082 (0.25 μmol), on murine (C57BL/6J) HM (twice a day for 10 days) can effectively inhibit acidic bile ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(35):3303-3314]

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Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways.

Haiming Liu, Jiaohua Luo, Bobby Guillory, Ji-An Chen, Pu Zang, Jordan K Yoeli, Yamileth Hernandez, Ian In-Gi Lee, Barbara Anderson, Mackenzie Storie, Alison Tewnion, Jose M Garcia,

Adipose tissue (AT) atrophy is a hallmark of cancer cachexia contributing to increased morbidity/mortality. Ghrelin has been proposed as a treatment for cancer cachexia partly by preventing AT atrophy. However, the mechanisms mediating ghrelin's effects are incompletely understood, including the extent to which its only known receptor, GHSR-1a, is required ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(35):3286-3302]

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The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL).

Stefan Nagel, Claudia Pommerenke, Roderick A F MacLeod, Corinna Meyer, Maren Kaufmann, Hans G Drexler,

NKL homeobox genes encode developmental transcription factors and display an NKL-code according to their physiological expression pattern in hematopoiesis. Here, we analyzed public transcriptome data from primary innate lymphoid cells (ILCs) for NKL homeobox gene activities and found that ILC3 expressed exclusively HHEX while in ILC1 and ILC2 these genes ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(34):3208-3226]

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A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy.

Matteo Torresetti, Donatella Brancorsini, Francesca Morgese, Valeria Cognigni, Alessandro Scalise, Rossana Berardi, Giovanni Di Benedetto,

Sarcomatoid melanoma is an extremely rare pattern of malignant melanoma, and only few cases have been described throughout the literature. We herein report a case of a patient with newly diagnosed, metastatic giant sarcomatoid melanoma of the arm. The patient underwent surgical removal of the huge mass, and NGS sequencing ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(34):3256-3262]

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Paradox breaker BRAF inhibitors have comparable potency and MAPK pathway reactivation to encorafenib in BRAF mutant colorectal cancer.

Oliver J Pickles, Aneta Drozd, Louise Tee, Andrew D Beggs, Gary W Middleton,

The BEACON CRC trial demonstrated a survival advantage over chemotherapy for a combination of targeted agents comprising the potent BRAF inhibitor encorafenib together with cetuximab and binimetinib. Resistance to BRAF inhibition in CRC arises in part through the generation and activation of RAF dimers resulting in MEK-ERK pathway reactivation. Paradox ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(34):3188-3197]

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Correction: MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression.

Chang Li, Lei Song, Zhuo Zhang, Xiao-Xue Bai, Ming-Fu Cui, Lian-Jun Ma,

[This corrects the article DOI: 10.18632/oncotarget.11888.]. ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(34):3263-3264]

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Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers.

Takeyuki Suzuki, Tetsutaro Suzuki, Yukino Yoshimura, Mitsunori Yahata, Poh Yin Yew, Tetsuya Nakamura, Yusuke Nakamura, Jae-Hyun Park, Ryota Matsuo,

Liquid biopsy is a non-invasive tool to examine the genetic profile of tumors by identification of mutated circulating tumor DNA (ctDNA), which is often analyzed by next generation sequencing (NGS) or droplet digital PCR (ddPCR) assay. We first examined the ctDNA mutation in pre-operative plasma samples obtained from 154 colorectal ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(34):3198-3207]

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Differentially expressed full-length, fusion and novel isoforms transcripts-based signature of well-differentiated keratinized oral squamous cell carcinoma.

Neetu Singh, Dinesh Kumar Sahu, Ratnesh Kumar Tripathi, Archana Mishra, Hari Shyam, Pratap Shankar, Mayank Jain, Nawazish Alam, Anil Kumar, Abhishek Mishra, Rebecca Chowdhry, Anjana Singh, Sameer Gupta, Divya Mehrotra, Preeti Agarwal, Madhu Mati Goel, Arun Chaturvedi, Satya Prakash Agarwal, Manish Bajpai, Devendra Kumar Gupta, Madan Lal Brahma Bhatt, Ravi Kant,

Highly keratinized oral squamous cell carcinoma (OSCC) exhibits an improved response to treatment and prognosis compared with weakly keratinized OSCC. Therefore, we aimed to develop gene transcript signature and to identify novel full-length isoforms, fusion transcript and non-coding RNA to differentiate well-differentiated (WD) with Moderately Differentiated (MD)/Poorly Differentiated (PD)/WD-lymphadenopathy OSCC ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(34):3227-3243]

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Superior prognosis stratification for stage III colon cancer using log odds of positive lymph nodes (LODDS) compared to TNM stage classification: the Japanese study group for postoperative follow-up of colorectal cancer.

Shimpei Ogawa, Michio Itabashi, Yoshiko Bamba, Masakazu Yamamoto, Kenichi Sugihara,

OBJECTIVES:The aim of this study is to examine whether prognosis stratification in staging of Stage III colon cancer using T factor and log odds of positive lymph nodes (LODDS) categories is superior to that of the TNM staging system. MATERIALS AND METHODS:The subjects were 5,919 patients with Stage III colon ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(33):3144-3152]

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Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases.

Gino K In, Kelsey Poorman, Michelle Saul, Steven O'Day, Jeffrey M Farma, Anthony J Olszanski, Michael S Gordon, Jacob S Thomas, Burton Eisenberg, Lawrence Flaherty, Amy Weise, Steven Daveluy, Geoffrey Gibney, Michael B Atkins, Ari Vanderwalde,

BACKGROUND:Brain metastases are a significant cause of mortality and morbidity for patients with melanoma. We hypothesize that the development of brain metastases may be explained by molecular heterogeneity between primary cutaneous melanoma (PCM) or extracranial (ECM) and brain (MBM) melanoma metastases. MATERIALS AND METHODS:We compared next-generation sequencing, tumor mutational burden ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(33):3118-3128]

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