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Correction: Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals

Pengjun Zhou, Rong Zhang, Ying Wang, Dandan Xu, Li Zhang, Jinhong Qin, Guifeng Su, Yue Feng, Hongce Chen, Siyuan You, Wen Rui, Huizhong Liu, Suhong Chen, Hongyuan Chen, Yifei Wang,

Oncotarget (Oncotarget)
[2021, 12(1):61-62]

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Total lesion glycolysis in oral squamous cell carcinoma as a biomarker derived from pre-operative FDG PET/CT outperforms established prognostic factors in a newly developed multivariate prediction model

Gerrit Spanier, Daniela Weidt, Dirk Hellwig, Johannes K.H. Meier, Torsten E. Reichert, Jirka Grosse,

Purpose: Retrospective study to investigate the impact of image derived biomarkers from [18F]FDG PET/CT prior to surgical resection in patients with initial diagnosis of oral squamous cell carcinoma (OSCC), namely SUVmax, SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary tumor to predict overall survival (OS). ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(1):37-48]

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Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment

Juyeon Ko, April N. Meyer, Martin Haas, Daniel J. Donoghue,

Metastatic castrate-resistant prostate cancer (CRPC) remains uncurable and novel therapies are needed to better treat patients. Aberrant Fibroblast Growth Factor Receptor (FGFR) signaling has been implicated in advanced prostate cancer (PCa), and FGFR1 is suggested to be a promising therapeutic target along with current androgen deprivation therapy. We established a ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(1):22-36]

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Glioma immunoediting, a driver of tumor evolution, and the next battle for immunotherapy

Adam M. Sonabend, Roger Stupp, Catalina Lee-Chang, Hideho Okada,

Oncotarget (Oncotarget)
[2021, 12(1):8-9]

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Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer

Krastan B. Blagoev, Roumen Iordanov, Mengxi Zhou, Tito Fojo, Susan E. Bates,

Most metastatic cancers develop drug resistance during treatment and continue to grow, driven by a subpopulation of cancer cells unresponsive to the therapy being administered. There is evidence that metastases are formed by phenotypically plastic cancer cells with stem-cell like properties. Currently the population structure and growth dynamics of the ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(1):15-21]

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Carving a niche for immunotherapy in ovarian cancer

Nitasha Gupta, Erika Lampert, Jung-Min Lee,

Oncotarget (Oncotarget)
[2021, 12(1):4-7]

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The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation

Karim Abid, Maja Beck Popovic, Katia Balmas Bourloud, Jacqueline Schoumans, Joana Grand-Guillaume, Eric Grouzmann, Annick Mühlethaler-Mottet,

Metanephrines (MNs; normetanephrine (NMN), metanephrine (MN) and methoxytyramine (MT)) detected in urine or plasma represent the best biomarker for neuroblastoma (NB) diagnosis, however the metabolism of both catecholamine (CAT) and MNs remains enigmatic in NB. Using patient-derived xenograft (PDX) models derived from primary NB cells, we observed that the plasma ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(1):49-60]

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Combination therapies for MPNSTs targeting RABL6A-RB1 signaling

Jordan L. Kohlmeyer, David J. Gordon, Munir R. Tanas, Rebecca D. Dodd, Varun Monga, Benjamin W. Darbro, Dawn E. Quelle,

Precision medicine relies on a detailed molecular understanding of disease pathogenesis. Here, we consider urgently needed therapeutic options for malignant peripheral nerve sheath tumors (MPNSTs) based on emerging insights into druggable pathway alterations found to drive this deadly cancer. Recent observations demonstrate an essential role for an oncogenic GTPase, RABL6A, ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(1):10-14]

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Cancer vaccines: the importance of targeting oncogenic drivers and the utility of combinations with immune checkpoint inhibitors

Erika J. Crosby, H. Kim Lyerly, Zachary C. Hartman,

Oncotarget (Oncotarget)
[2021, 12(1):1-3]

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Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma.

Yuji Morine, Tohru Utsunomiya, Yu Saito, Shinichiro Yamada, Satoru Imura, Tetsuya Ikemoto, Akihiro Kitagawa, Yuta Kobayashi, Seiichiro Takao, Keisuke Kosai, Koshi Mimori, Yasuhito Tanaka, Mitsuo Shimada,

Genome-wide analysis is widely applied to detect molecular alterations during oncogenesis and tumor progression. We analyzed DNA methylation profiles of hepatocellular carcinoma (HCC), and investigated the clinical role of most heypermethylated of tumor, encodes T-box 15 (TBX15), which was originally involved in mesodermal differentiation. We conducted a genome-wide analysis of ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(52):4803-4812]

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Correction: Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer.

Shuai Zhang, Dehai Che, Fang Yang, Chunling Chi, Hongxue Meng, Jing Shen, Li Qi, Fang Liu, Liyan Lv, Yue Li, Qingwei Meng, Junning Liu, Lihua Shang, Yan Yu,

[This corrects the article DOI: 10.18632/oncotarget.21068.]. ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(52):4845-4846]

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Damage-associated molecular pattern (DAMP) activation in melanoma: investigation of the immunogenic activity of 15-deoxy, Δ12,14 prostamide J2.

Ahmed Elhassanny, Rene Escobedo, Daniel Ladin, Colin Burns, Rukiyah Van Dross,

Metastatic melanoma is the most deadly skin neoplasm in the United States. Outcomes for this lethal disease have improved dramatically due to the use of both targeted and immunostimulatory drugs. Immunogenic cell death (ICD) has emerged as another approach for initiating antitumor immunity. ICD is triggered by tumor cells that ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(52):4788-4802]

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Successful administration of sequential TVEC and pembrolizumab followed by Temozolomide in immunotherapy refractory intracranial metastatic melanoma with acquired B2M mutation.

Karam Khaddour, Joshua Dowling, Jiayi Huang, Martha Council, David Chen, Lynn Cornelius, Tanner Johanns, Sonika Dahiya, George Ansstas,

Despite the substantial advances in the management of metastatic melanoma with the introduction of immune checkpoint inhibitors (ICI), many patients develop disease progression during treatment with immunotherapy. This has been suggested to be mediated by several mechanisms that contribute to acquired resistance to ICI, one of which is acquired beta-2 ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(52):4836-4844]

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Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma.

Hector A Cuello, Gretel M Ferreira, Cynthia A Gulino, Alejandro Gomez Toledo, Valeria I Segatori, Mariano R Gabri,

Gliomas are the most common intracranial primary tumors, for which very few therapeutic options are available. The most malignant subtype is the glioblastoma, a disease associated with a 5-year survival rate lower than 5%. Given that research in glycobiology continues highlighting the role of glycans in tumor cell biology, it ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(52):4822-4835]

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Estrogen receptor α polymorphism is associated with dementia in a Brazilian cohort.

Rafaella Papalino Lopes Magnago, Valerio Garrone Barauna, Bruna Ferro Brun, Ana Cristina Lo Prete, Aline Morgan Alvarenga, Luciene C Gastalho Campos, Neuza Felix Gomes Rochette, Letícia Batista Azevedo Rangel, Rodrigo Alves Faria, Paulo Caleb Junior Lima Santos, Ian Victor Silva,

The growth of the elderly population is a worldwide phenomenon and it is associated with chronic diseases, including dementia. In this scenario, the present study aimed to evaluate a possible association of estrogen receptor α polymorphisms with dementia in a Brazilian cohort. The subject sample was divided into two groups, ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(50):4655-4660]

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Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas.

Syed M Faisal, Flor M Mendez, Fernando Nunez, Maria G Castro, Pedro R Lowenstein,

Diffuse intrinsic pontine glioma (DIPG) is a rare brainstem tumor which carries a dismal prognosis. To date. there are no effective treatments for DIPG. Transcriptomic studies have shown that DIPGs have a distinct profile compared to hemispheric high-grade pediatric gliomas. These specific genomic features coupled with the younger median age ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(50):4607-4612]

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Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model.

Dileep Kumar M Guruswamy, Kyathegowdana Doddi Srivinavasa Balaji, Kattepura Krishnappa Dharmappa, Shankar Jayarama,

In the present investigation, we synthesized chalcone bearing naphthalene compound d1, and on the basis of <sup>1</sup>H-NMR, <sup>13</sup>C NMR, and LC-MS data we had specified the structure of the synthesized compound. The resultant compound d1 was assessed for their antiproliferative action against human cancer cell lines (HeLa, HCT116, HT29, MDA-MB-231, ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(50):4661-4676]

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Inhibitors of cytoskeletal dynamics in malignant mesothelioma.

Katarina Reis, Jack L Arbiser, Anders Hjerpe, Katalin Dobra, Pontus Aspenström,

Malignant mesotheliomas (MMs) are highly aggressive mesenchymal tumors that originate from mesothelial cells lining serosal cavities; i.e., the pleura, peritoneum, and pericardium. Classically, there is a well-established link between asbestos exposure, oxidative stress, release of reactive oxygen species, and chronic inflammatory mediators that leads to progression of MMs. MMs have ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(50):4637-4647]

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Comparative genomic analysis of primary tumors and paired brain metastases in lung cancer patients by whole exome sequencing: a pilot study.

Pascale Tomasini, Fabrice Barlesi, Sophie Gilles, Isabelle Nanni-Metellus, Riccardo Soffietti, Emilie Denicolai, Eric Pellegrino, Emilie Bialecki, L'Houcine Ouafik, Philippe Metellus,

Lung cancer brain metastases (BMs) are frequent and associated with poor prognosis despite a better knowledge of lung cancer biology and the development of targeted therapies. The inconstant intracranial response to systemic treatments is partially due to tumor heterogeneity between the primary lung tumor (PLT) and BMs. There is therefore ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(50):4648-4654]

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Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells.

Madhav Sankunny, Charis Eng,

Germline and somatic promoter hypermethylation of <i>KLLN</i> has been found in diverse heritable and sporadic cancers, respectively. KLLN has many identified tumor suppressor functions, and when first reported, was thought to be exclusively nuclear. Here, we report on KLLN localization in both the nucleus and cytoplasm and the identification of ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(50):4625-4636]

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Inorganic polyphosphate as an energy source in tumorigenesis.

Jerusha Boyineni, Simone T Sredni, Naira V Margaryan, Lusine Demirkhanyan, Michael Tye, Robert Johnson, Fernando Gonzalez-Nilo, Mary J C Hendrix, Evgeny Pavlov, Marcelo B Soares, Eleonora Zakharian, Sergey Malchenko,

Cancer cells have high demands for energy to maintain their exceedingly proliferative growth. However, the mechanism of energy expenditure in cancer is not well understood. We hypothesize that cancer cells might utilize energy-rich inorganic polyphosphate (polyP), as energetic reserve. PolyP is comprised of orthophosphates linked by phosphoanhydride bonds, as in ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(50):4613-4624]

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Unraveling the role of fibroblasts, FGF5 and FGFR2 in HER2-targeted therapies resistance and tumor progression.

Paloma Bragado, Patricia Fernández-Nogueira, Neus Carbó, Pere Gascón,

Oncotarget (Oncotarget)
[2020, 11(49):4541-4543]

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Advances in meningioma genomics, proteomics, and epigenetics: insights into biomarker identification and targeted therapies.

Ahmad A Nazem, Jacob Ruzevick, Manuel J Ferreira,

Meningiomas are a heterogeneous group of tumors, defined histo-pathologically by World Health Organization (WHO) grading. The WHO grade of meningiomas does not always correlate with clinical aggressiveness. Despite maximal surgical resection and adjuvant radiation, a subset of tumors are clinically aggressive; displaying early recurrence and invasion. Current methods for identifying ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(49):4544-4553]

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High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages.

Jackie Bader, Meredith Carson, Reilly Enos, Kandy Velazquez, Alexander Sougiannis, Udai Singh, William Becker, Mitzi Nagarkatti, Daping Fan, Angela Murphy,

<h4>Background</h4>The association between obesity and colorectal cancer (CRC) risk has been well established. This relationship appears to be more significant in men than in women, which may be attributable to sex hormones. However, controlled animal studies to substantiate these claims and the mechanisms involved are lacking.<h4>Materials and methods</h4>MC38 murine colon ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(49):4554-4569]

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Identification of international metastatic renal cell carcinoma database consortium (IMDC) intermediate-risk subgroups in patients with metastatic clear-cell renal cell carcinoma.

Annalisa Guida, Gwénaël Le Teuff, Carolina Alves, Emeline Colomba, Vincenzo Di Nunno, Lisa Derosa, Ronan Flippot, Bernard Escudier, Laurence Albiges,

Majority of patients with clear-cell renal cell carcinoma (ccRCC) at first line (1L) treatment are classified in the intermediate-risk (IR) subgroup according to International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) score. As these patients have different prognosis, the aim of this study is to better characterize IR patients in ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(49):4582-4592]

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