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Circulating RNAs, circ_4911 and circ_4302, are novel regulators of endothelial cell function under a hepatocellular carcinoma microenvironment.

Kun Yan, Wei Cheng, Xin Xu, Gang Cao, Zongzheng Ji, Yiming Li,

Hepatocellular carcinoma (HCC) is a common hypervascular tumor disease. Endothelial cells, as a crucial component of the tumor microenvironment, have been reported to participate in angiogenesis and influence the development of tumors, including HCC. Recent studies have demonstrated that circulating RNAs (circRNAs) participate in the functional regulation of endothelial cells. ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, :]

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MicroRNAs target the Wnt/β‑catenin signaling pathway to regulate epithelial‑mesenchymal transition in cancer (Review).

Yuhe Lei, Lei Chen, Ge Zhang, Aiyun Shan, Chunfeng Ye, Bin Liang, Jiayu Sun, Xin Liao, Changfeng Zhu, Yueyue Chen, Jing Wang, Enxin Zhang, Lijuan Deng,

Epithelial‑mesenchymal transition (EMT), during which cancer cells lose the epithelial phenotype and gain the mesenchymal phenotype, has been verified to result in tumor migration and invasion. Numerous studies have shown that dysregulation of the Wnt/β‑catenin signaling pathway gives rise to EMT, which is characterized by nuclear translocation of β‑catenin and ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, :]

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CTLA‑4 blockade combined with 5‑aza‑2'‑deoxycytidine enhances the killing effect of MAGE‑A family common antigen peptide‑specific cytotoxic T cells on breast cancer.

Weijing Li, Meixiang Sang, Xiaoguang Hao, Yunyan Wu, Baoen Shan,

Breast cancer is the leading cause of cancer‑-associated deaths in women. Combination immunotherapy attracts great interest as a treatment for breast cancer. However, there are no studies on the use of cytotoxic T‑lymphocyte antigen 4 (CTLA‑4) monoclonal antibody in combination with the melanoma‑associated antigen A family (MAGE‑As) co‑antigen peptide (p248V9) ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, :]

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Sensitivity of allyl isothiocyanate to induce apoptosis via ER stress and the mitochondrial pathway upon ROS production in colorectal adenocarcinoma cells.

Jo-Hua Chiang, Fuu-Jen Tsai, Yuan-Man Hsu, Mei-Chin Yin, Hong-Yi Chiu, Jai-Sing Yang,

Allyl isothiocyanate (AITC), a bioactive phytochemical compound that is a constituent of dietary cruciferous vegetables, possesses promising chemopreventive and anticancer effects. However, reports of AITC exerting antitumor effects on apoptosis induction of colorectal cancer (CRC) cells in vitro are not well elucidated. The present study focused on the functional mechanism of ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, :]

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Paxillin knockdown suppresses metastasis and epithelial‑mesenchymal transition in colorectal cancer via the ERK signalling pathway.

Long Wen, Xiaoqian Zhang, Junling Zhang, Shanwen Chen, Yongchen Ma, Jianwen Hu, Taohua Yue, Jingui Wang, Jing Zhu, Tao Wu, Xin Wang,

Paxillin (PXN) is a cytoplasmic protein that plays an important role in regulating focal adhesion, cytoskeletal rearrangements and cell motility. The present study aimed to investigate the role of PXN in the metastasis of human colorectal cancer (CRC) and its possible mechanisms. Immunohistochemical staining of tissues from 102 surgical CRC ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1105-1115]

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What is considered cardiotoxicity of anthracyclines in animal studies.

Nikolaos Georgiadis, Konstantinos Tsarouhas, Ramin Rezaee, Haritini Nepka, George E N Kass, Jean-Lou C M Dorne, Dimitrios Stagkos, Konstantinos Toutouzas, Demetrios A Spandidos, Dimitrios Kouretas, Christina Tsitsimpikou,

Anthracyclines are commonly used anticancer drugs with well‑known and extensively studied cardiotoxic effects in humans. In the clinical setting guidelines for assessing cardiotoxicity are well‑established with important therapeutic implications. Cardiotoxicity in terms of impairment of cardiac function is largely diagnosed by echocardiography and based on objective metrics of cardiac function. ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):798-818]

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Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in osteosarcoma.

Salim F A Jeddo, Xianfu Wei, Ka Li, Xin Li, Qiang Yang, Samina Dongol, Jianmin Li,

Osteosarcoma is the most common primary malignancy of bones and frequently affects young children and adolescents. There are several challenges associated with treating osteosarcoma owing to the aggressiveness of the disease, as well as the risk of chemoresistance. Numerous studies are being performed with the aim of identifying improved prognostic ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1037-1048]

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Knockdown of lncRNA ANRIL inhibits the development of cisplatin resistance by upregulating miR‑98 in lung cancer cells.

Xi Wang, Guojun Zhang, Zhe Cheng, Lingling Dai, Liuqun Jia, Xiaogang Jing, Huan Wang, Rui Zhang, Meng Liu, Tianci Jiang, Yuanjian Yang, Meng Yang,

Emerging evidence has demonstrated that abnormally expressed long non‑coding (lnc) RNAs contribute to drug resistance in various types of malignancy. LncRNA antisense non‑coding RNA in the inhibitor of cyclin‑dependent kinase 4 locus (ANRIL) exerts oncogenic activity and acts as a key player in a variety of carcinomas, including non‑small cell ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1025-1036]

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Retinoic acid induces differentiation in neuroblastoma via ROR1 by modulating retinoic acid response elements.

Abhinav Illendula, Norman Fultang, Bela Peethambaran,

Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has been ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1013-1024]

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Selective inhibition of PI3K110α as a novel therapeutic strategy for cetuximab‑resistant oral squamous cell carcinoma.

Hiroki Tsuchihashi, Tomofumi Naruse, Souichi Yanamoto, Kohei Okuyama, Kohei Furukawa, Keisuke Omori, Masahiro Umeda,

High expression of the 110 kDa catalytic subunit of the class IA PI3K (PI3Kp110α) may play an important role in cetuximab resistance exhibited by both colorectal cancer and head and neck squamous cell carcinoma. Therefore, the present study aimed to examine the association between the expression of proteins in the PI3Kp110α pathway ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):863-872]

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Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.

Kang An, Yuehan Zhang, Yingjiao Liu, Shengxi Yan, Zhaowei Hou, Meng Cao, Guangkuo Liu, Congcong Dong, Juncha Gao, Gaifang Liu,

Current treatments for esophageal squamous cell carcinoma (ESCC) have limited efficacy. Therefore, the development of novel therapeutic targets to effectively manage the disease and boost survival rates is imperative Neferine, a natural product extracted from Nelumbo nucifera (lotus) leaves, has been revealed to inhibit the growth of hepatocarcinoma, breast cancer and ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1116-1126]

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MicroRNA‑16‑5p regulates cell survival, cell cycle and apoptosis by targeting AKT3 in prostate cancer cells.

Fang Wang, Wendi Wang, Lina Lu, Yi Xie, Junfang Yan, Yuhong Chen, Cuixia Di, Lu Gan, Jing Si, Hong Zhang, Aihong Mao,

Prostate cancer (PCa) is a malignancy with the highest morbidity rate in 105 countries worldwide and was a major cause of cancer‑associated death in men in 2018. Accumulating evidence suggests that microRNAs (miRNAs/miRs) have important functions in the carcinogenesis of PCa, and may provide novel treatment targets. Previous studies have ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1282-1292]

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Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL‑6/STAT3 signaling pathway.

Tao Pan, Fang Zhang, Fakai Li, Xingchun Gao, Zhikui Li, Xia Li, Xinling Ren,

Increasing evidence indicates that the inflammatory tumor microenvironment can lead to cancer cell metastasis. Shikonin, which is extracted from the Chinese herb Zicao (the dried root of Lithospermum erythrorhizon), possesses various pharmacological effects, but its effect on tumor metastasis in the inflammatory microenvironment remains unknown. In the present study, we aimed ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1049-1063]

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Involvement of RNase 7 in the malignant potential of oral squamous cell carcinoma cells.

Puja Neopane, Yoshihito Kurashige, Koki Yoshida, Osamu Uehara, Durga Paudel, Tetsuro Morikawa, Jun Sato, Masato Saitoh, Yoshihiro Abiko,

RNase 7 is involved in the innate immunity of the oral epithelium. Variations in the expression levels of RNase 7 have been reported in cutaneous squamous cell carcinoma, but not in oral squamous cell carcinoma (OSCC). The present study investigated the expression levels of RNase 7 in OSCC and its ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1216-1223]

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Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer.

Chenlei Zheng, Tan Zhang, Ding Li, Chongchu Huang, Hengjie Tang, Xiao-Feng Ni, Bicheng Chen,

Pancreatic cancer is a severe disease with high morbidity and mortality. However, the primary molecular mechanisms of pancreatic tumor formation and progression remain unclear. The present study using sequencing technology revealed that the centromere protein M (CENPM) gene was overexpressed in pancreatic cancer tissues. CENPM is one of the components ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1003-1012]

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Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells.

Chao Li, Li Yuan, Shuangshuang Han, Mingda Xuan, Dehua Liu, Bo Tian, Weifang Yu,

Gastric cancer (GC) causes high morbidity and mortality in patients largely due to its invasion and metastasis. Kiss‑1 has been shown to be a metastasis suppressor in various malignancies. However, its clinical significance and biological functions in GC have not been thoroughly investigated. The present study investigated the association between ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1149-1157]

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lncRNA TTN‑AS1 upregulates RUNX1 to enhance glioma progression via sponging miR‑27b‑3p.

Keliang Chang, Genwei Wang, Jinfeng Lou, Sha Hao, Ranbo Lv, Desheng Duan, Wanhong Zhang, Yingchang Guo, Pengfei Wang,

Long non‑coding RNAs (lncRNAs) contribute to the tumorigeneses of numerous types of cancer, including glioma. The present study was designed to unveil a novel lncRNA functioning in glioma and explore the underlying mechanisms. lncRNA titin‑antisense RNA1 (TTN‑AS1), miR‑27b‑3p and Runt‑related transcription factor 1 (RUNX1) expression in glioma tissues and cell ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1064-1074]

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Long non‑coding RNA BCYRN1 promotes prostate cancer progression via elevation of HDAC11.

Wei Huo, Fei Qi, Kaichen Wang,

Prostate cancer is a serious threat to men's health worldwide. While previous studies have demonstrated that long non‑coding RNAs (lncRNAs) are closely associated with the initiation and development of several types of cancer, the role of lncRNAs in the progression of prostate cancer remains incompletely understood. In the present study, ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1233-1245]

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Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.

Yingying Zhao, Xia Ye, Ruifang Chen, Qian Gao, Daguo Zhao, Chunhua Ling, Yulan Qian, Chun Xu, Min Tao, Yufeng Xie,

Increasing evidence has indicated the roles of sirtuin 7 (SIRT7) in numerous human cancers. However, the effects and the clinical significance of SIRT7 in human lung cancer is largely unknown. The present research demonstrated that SIRT7 was increased in human lung cancer tumor tissues. SIRT7 upregulation was associated with clinicopathological ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):959-972]

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Low‑intensity low‑frequency ultrasound enhances the chemosensitivity of gemcitabine‑resistant ASPC‑1 cells via PI3K/AKT/NF‑κB pathway‑mediated ABC transporters.

Fuqiang Qiu, Jifan Chen, Jing Cao, Feng Diao, Pintong Huang,

Tumor drug resistance (TDR) invariably leads to the failure of chemotherapy. In addition, current treatment strategies for TDR are not satisfactory due to limitations in terms of safety and feasibility. The aim of the present study was to determine whether low‑intensity low‑frequency ultrasound (LILFU) could improve the effect of chemotherapy ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1158-1168]

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Long noncoding RNA UCID sponges miR‑152‑3p to promote colorectal cancer cell migration and invasion via the Wnt/β‑catenin signaling pathway.

Li-Bin Sun, Shu-Fen Zhao, Jing-Juan Zhu, Yue Han, Ti-Dong Shan,

Research has shown that long noncoding RNAs (lncRNAs) play significant roles in colorectal cancer (CRC). However, the role of lnc‑UCID (lncRNA upregulating CDK6 by interacting with DHX9) in CRC remains largely unknown. In the present study, analyses revealed that lnc‑UCID was markedly upregulated in CRC compared with that in normal ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1194-1205]

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Synergistic effects of low‑dose chemotherapy and T cells in renal cell carcinoma.

Dan-Dan Xu, Men Ding, Pan Tong, Yan-Yun Chong, Wei-Yu Gu, Yang Li, Xin-Jiang Fang, Ning Li,

Renal cell carcinoma (RCC) is not sensitive to conventional radiotherapy and chemotherapy, and the effectiveness rate of molecular targeted therapy is low. Therefore, it is urgent to identify new treatment methods. Recently, adoptive T‑cell therapy has provided a new option for cancer treatment. Furthermore, low‑dose chemotherapy not only has no ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):897-908]

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Comparative proteomic analysis uncovers potential biomarkers involved in the anticancer effect of Scutellarein in human gastric cancer cells.

Venu Venkatarame Gowda Saralamma, Preethi Vetrivel, Ho Jeong Lee, Seong Min Kim, Sang Eun Ha, Rajeswari Murugesan, Eun Hee Kim, Jeong Doo Heo, Gon Sup Kim,

Scutellarein (SCU), a flavone that belongs to the flavonoid family and abundantly present in Scutellaria baicalensis a flowering plant in the family Lamiaceae, has been reported to exhibit anticancer effects in several cancer cell lines including gastric cancer (GC). Although our previous study documented the mechanisms of Scutellarein‑induced cytotoxic effects, ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):939-958]

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Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma.

Yuuki Ohara, Atsushi Enomoto, Yuta Tsuyuki, Kotaro Sato, Tadashi Iida, Hiroki Kobayashi, Yasuyuki Mizutani, Yuki Miyai, Akitoshi Hara, Shinji Mii, Jun Suzuki, Kyoko Yamashita, Fumiya Ito, Yashiro Motooka, Nobuaki Misawa, Takayuki Fukui, Koji Kawaguchi, Kohei Yokoi, Shinya Toyokuni,

Malignant mesothelioma is an aggressive neoplasm for which effective treatments are lacking. We often encounter mesothelioma cases with a profound desmoplastic reaction, suggesting the involvement of cancer‑associated fibroblasts (CAFs) in mesothelioma progression. While the roles of CAFs have been extensively studied in other tumors and have led to the view ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):838-848]

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A small molecule STAT3 inhibitor, LLL12, enhances cisplatin‑ and paclitaxel‑mediated inhibition of cell growth and migration in human ovarian cancer cells.

Ruijie Zhang, Xiang Chen, Shengling Fu, Liang Xu, Jiayuh Lin,

Ovarian cancer is one of the most lethal cancer types in American women. The platinum agent cisplatin, and/or paclitaxel, remains the first‑line chemotherapy for ovarian cancer, but the treatment success is severely limited by chemoresistance. As previously reported, persistent STAT3 signaling is associated with resistance to cisplatin and paclitaxel. To ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1224-1232]

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