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Synergistic effects of low‑dose chemotherapy and T cells in renal cell carcinoma.

Dan-Dan Xu, Men Ding, Pan Tong, Yan-Yun Chong, Wei-Yu Gu, Yang Li, Xin-Jiang Fang, Ning Li,

Renal cell carcinoma (RCC) is not sensitive to conventional radiotherapy and chemotherapy, and the effectiveness rate of molecular targeted therapy is low. Therefore, it is urgent to identify new treatment methods. Recently, adoptive T‑cell therapy has provided a new option for cancer treatment. Furthermore, low‑dose chemotherapy not only has no ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):897-908]

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A small molecule STAT3 inhibitor, LLL12, enhances cisplatin‑ and paclitaxel‑mediated inhibition of cell growth and migration in human ovarian cancer cells.

Ruijie Zhang, Xiang Chen, Shengling Fu, Liang Xu, Jiayuh Lin,

Ovarian cancer is one of the most lethal cancer types in American women. The platinum agent cisplatin, and/or paclitaxel, remains the first‑line chemotherapy for ovarian cancer, but the treatment success is severely limited by chemoresistance. As previously reported, persistent STAT3 signaling is associated with resistance to cisplatin and paclitaxel. To ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1224-1232]

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MDM2 as a target for ellagic acid‑mediated suppression of prostate cancer cells in vitro.

Yasir I Mohammed Saleem, Mustafa I Selim,

Prostate cancer (PCa) is the most common cancer in men. Despite the available treatments for PCa, a significant number of patients relapse as the disease becomes hormonal‑independent. p53 is a common tumor suppressor; however, its activity is diminished via the overexpression of murine double minute‑2 (MDM2). The pomegranate, walnuts, and ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(3):1255-1265]

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Long non‑coding RNA MIAT knockdown potentiates the therapeutic effect of transcatheter arterial embolization in liver cancer by regulating the miR‑203a/HIF‑1α axis.

Jian Liu, Guangshao Cao, Jianwen Liu, Xiaoyang Zhao, Huicun Cao,

Transcatheter arterial embolization (TAE) and transcatheter arterial chemoembolization (TACE) are often used for palliative treatment of liver cancer. TAE and TACE can induce severe hypoxia. The present study investigated the effect of the myocardial infarction associated transcript (MIAT)/microRNA (miR)‑203a/hypoxia‑inducible factor 1‑α (HIF‑1α) axis on the therapeutic activity of TAE for liver ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(2):722-734]

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Molecularly targeted therapy and immunotherapy for hormone receptor‑positive/human epidermal growth factor receptor 2‑negative advanced breast cancer (Review).

Yuhua Song, Lin He, Yaling Wang, Qian Wu, Wenzhi Huang,

The advent of targeted therapy for hormone receptor‑positive/human epidermal growth factor receptor 2‑negative advanced breast cancer (HR+/HER2‑ aBC) provides a novel therapeutic approach other than endocrine therapy. One targeted signaling pathway and three immune‑checkpoints have been demonstrated to be in association with tumor proliferation and growth in HR+/HER2‑ aBC. A ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 44(1):3-13]

Cited: 2 times

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WIPI2 depletion inhibits the growth of hepatocellular carcinoma cells through the AMPK signaling pathway.

Chunsheng Liu, Feng Li, Xiaoning Li, Minggang Cao, Gang Feng, Xianwen Yuan, Xiaolei Shi,

WD‑repeat domain phosphoinositide‑interacting protein 2 (WIPI2) is a protein that regulates the assembly of multiprotein complexes by presenting a beta‑propeller platform for simultaneous and reversible protein‑protein interactions. This study was designed to investigate the association between the expression of WIPI2 and the growth of hepatocellular carcinoma (HCC). Publicly‑available data from ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 43(5):1467-1478]

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A radiomics model to predict the invasiveness of thymic epithelial tumors based on contrast‑enhanced computed tomography.

Xiangmeng Chen, Bao Feng, Changlin Li, Xiaobei Duan, Yehang Chen, Zhi Li, Zhuangsheng Liu, Chaotong Zhang, Wansheng Long,

In the present study, we aimed to construct a radiomics model using contrast‑enhanced computed tomography (CT) to predict the pathological invasiveness of thymic epithelial tumors (TETs). We retrospectively reviewed the records of 179 consecutive patients (89 females) with histologically confirmed TETs from two hospitals. The 82 low‑ and 97 high‑risk ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, 43(4):1256-1266]

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Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.

Shu Li, Zhou Jiang, Yirun Li, Yang Xu,

The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well‑studied in lung adenocarcinoma (LUAD). In the present study, the expression, prognostic value and functions of MCMs in LUAD were investigated using several databases and bioinformatic ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 42(6):2279-2292]

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RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer.

Hong Huo, Xinqing Ye, Honghe Yang, Qiuyun Li, Yi Jiang,

Estrogen (E2) receptor (ER) upregulation has been associated with tumor progression and is the most commonly used clinical biomarker in breast cancer. X‑linked ribosomal S6 kinase 4 (RSK4) is downregulated in breast cancer and may act as a tumor suppressor gene. In order to understand the association between the ER and ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 42(6):2777-2787]

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DNA‑PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy.

Wei Geng, Dalong Tian, Qiang Wang, Shunlin Shan, Jianwei Zhou, Wenxia Xu, Husheng Shan,

Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was designed to investigate the ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 42(2):561-570]

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Identification of a long non‑coding RNA‑mediated competitive endogenous RNA network in hepatocellular carcinoma.

Hui He, Di Chen, Shimeng Cui, Hailong Piao, Haibo Tang, Xun Wang, Peng Ye, Shi Jin,

The present study was designed to identify the endogenous RNA regulatory networks involved in hepatocellular carcinoma (HCC) by bioinformatic analysis. Both miRNA interaction network‑based correlation analysis and expression‑based Spearman correlation coefficients were utilized to identify potential mRNA‑lncRNA interactions. Then, a competitive endogenous (ce)RNA network was constructed from these interactions, and ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 42(2):745-752]

Cited: 4 times

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Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma.

Radka Vaclavikova, Jovana Klajic, Veronika Brynychova, Katerina Elsnerova, Grethe I G Alnaes, Jörg Tost, Vessela N Kristensen, Lukas Rob, Roman Kodet, Petr Skapa, Marcela Mrhalova, Pavel Soucek,

Multidrug resistance to anticancer drugs, which is often associated with enhanced expression of the ATP‑binding cassette (ABC) transporter P‑glycoprotein (encoded by the ABCB1 gene) may limit the effects of cancer therapy. Epigenetic regulation of ABCB1 expression may thus have a clinical impact. A detailed assessment of ABCB1 promoter methylation is ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 42(2):763-774]

Cited: 1 time

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Pomolic acid exhibits anticancer potential against a docetaxel‑resistant PC3 prostate cell line.

Carollina De Araujo Martins, Gleice Da Graça Rocha, Cerli Rocha Gattass, Christina Maeda Takiya,

Prostate cancer (PC) is one of the leading causes of cancer‑related death in the male population worldwide. Mortality of PC is dependent on tumor recurrence and its progression to metastatic disease. We examined the effects of pentacyclic triterpene pomolic acid (PA) on docetaxel‑resistant PC3 cells. Cell viability was evaluated using ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 42(1):328-338]

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Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics.

Jinsong Zhang, Jiansong Wang, Ting Luan, Yigang Zuo, Jian Chen, Heng Zhang, Zhenni Ye, Haifeng Wang, Bing Hai,

The ubiquitin‑specific protease 9X (USP9X) is a conserved deubiquitinase that has been investigated in several types of human cancer. However, the clinical significance and the biological roles of USP9X in prostate cancer remain unexplored. In the present study, an investigation into the expression and clinical significance of USP9X in prostate cancer ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(6):3292-3304]

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Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway.

Jiayi Jiang, You Li, Zheng Jiang,

Colorectal cancer (CRC) is one of the most common tumor types of the digestive tract. Its incidence and mortality rates are among the highest of all gastrointestinal tumor types. The expression of leucine zipper downregulated in cancer 1 (LDOC1) is decreased in numerous cancer types. In the present study, the ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(6):3281-3291]

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JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal type.

Jumei Liu, Li Liang, Dong Li, Lin Nong, Yalin Zheng, Sixia Huang, Bo Zhang, Ting Li,

The inactivation of tumor suppressor gene positive regulatory domain containing I (PRDM1) and activation of signal transducer and activator of transcription 3 (STAT3) have been detected in the majority of extranodal NK/T‑cell lymphoma, nasal type (EN‑NK/T‑NT) cases. In the present study, their association with and effects on the clinicopathologic features ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(6):3219-3232]

Cited: 4 times

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TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway.

Xiaoyan Mu, Hegen Li, Lei Zhou, Weijie Xu,

As a major cause of cancer‑associated mortalities, lung cancer is frequently diagnosed in males and females with an incidence ratio of 2.1:1. Tripartite motif 52 (TRIM52), an E3 ubiquitin ligase, has been reported to be involved in various biological functions, including cell proliferation and invasiveness. In the present study, an ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(6):3325-3334]

Cited: 1 time

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Overexpression of calpain‑1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA.

Changzhao Xu, Xiaoxiao Yu, Yuesheng Zhu, Zhenzhai Cai, Lingmin Yu, Ying Lin, Hejie Yu, Zhanxiong Xue, Lingling Zhou,

Several studies have demonstrated that calpain‑1 is involved in a variety of pathophysiological processes, including tumorigenesis. However, the clinical relevance and role of calpain‑1 in colorectal cancer (CRC) are unclear. Filamin A (FLNA) is an actin‑binding protein that participates in cancer progression and can be cleaved by calpain‑1. In the ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(6):3424-3434]

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TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways.

Ye Gi Han, Miyong Yun, Minji Choi, Seok-Geun Lee, Hongtae Kim,

Histone H2B monoubiquitination has been shown to play critical roles in diverse cellular processes including DNA damage response. Although recent data indicate that H2B monoubiquitination is strongly connected with tumor progression and regulation, the implications of this modification in lung adenocarcinoma are relatively unknown. In the present study, we demonstrated ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(6):3305-3312]

Cited: 1 time

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Prodigiosin isolated from Serratia marcescens in the Periplaneta americana gut and its apoptosis‑inducing activity in HeLa cells.

Pei-Bin Lin, Juan Shen, Pei-Yu Ou, Ling-Yan Liu, Zhi-Yu Chen, Fu-Jiang Chu, Jie Wang, Xiao-Bao Jin,

Serratia marcescens are considered to be abundant and optimal resources for obtaining prodigiosin, which can be isolated from soil, water, plants and air but rarely from insects. In the present study, a strain of Serratia marcescens named WA12‑1‑18 was isolated from the gut of Periplaneta americana, which was capable of producing high levels ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(6):3377-3385]

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Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.

Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Sheng-Liang Qiu, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chang-Ming Huang, Chao-Hui Zheng,

Cyclin‑dependent kinase 5 regulatory subunit‑​associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms. The present study aimed to clone human C53 isoform d (IC53d) and explore its role in ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(5):2739-2752]

Cited: 1 time

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TNF‑α inhibits xenograft tumor formation by A549 lung cancer cells in nude mice via the HIF‑1α/VASP signaling pathway.

Wen Liu, Xiang Chen, Yanqi He, Yihao Tian, Liu Xu, Yanbin Ma, Pengchao Hu, Ke Su, Zhenyu Luo, Lei Wei, Jingwei Zhang,

Lung cancer is the leading cause of cancer‑associated mortality worldwide. Tumor necrosis factor α (TNF‑α) is an important cytokine in the tumor microenvironment that serves a function in the balance of cell survival and cell death pathways. Our previous studies indicated that hypoxia‑inducible factor 1α (HIF‑1α) acts downstream of TNF‑α ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(4):2418-2430]

Cited: 1 time

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Low expression of AIM2 combined with high expression of p‑STAT3 is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.

Zhen Li, Xinli Shi, Hui Li, Weiyi Wang, Xiaoming Li,

Studies indicate that the AIM2 inflammasome plays an important role in tumor occurrence and development. The present study examined the prognostic significance of AIM2 expression and the correlation between AIM2 expression and p‑STAT3 expression in hypopharyngeal squamous cell carcinoma (HSCC), which remain unknown. AIM2 and p‑STAT3 were detected using immunohistochemistry ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(4):2396-2408]

Cited: 1 time

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Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer.

Aya Sugyo, Winn Aung, Atsushi B Tsuji, Hitomi Sudo, Hiroki Takashima, Masahiro Yasunaga, Yasuhiro Matsumura, Tsuneo Saga, Tatsuya Higashi,

Tissue factor (TF) has emerged as a critical factor in oncogenic events, leading to the development of TF‑targeted diagnostic and therapeutic approaches. A non‑invasive imaging method to evaluate target molecule expression with high sensitivity and high quantitative ability is imperative for selecting the appropriate patients for TF‑targeted therapy. To elucidate ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(4):2371-2378]

Cited: 1 time

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Organic anion‑transporting polypeptides contribute to the uptake of curcumin and its main metabolites by human breast cancer cells: Impact on antitumor activity.

Nattharat Jaerapong, Qurratul Ain Jamil, Juliane Riha, Daniela Milovanovic, Georg Krupitza, Bruno Stieger, Kanokwan Jarukomjorn, Walter Jäger,

Curcumin is a natural polyphenolic compound with pronounced anticancer properties, despite its low bioavailability caused by extensive glucuronidation and sulfation. Information on the cellular uptake mechanisms and their contribution to the anticancer effects of curcumin and its biotransformation products is limited. The present study, therefore, investigated the role of organic ... Read more >>

Oncol. Rep. (Oncology reports)
[2019, 41(4):2558-2566]

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